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1.
Oral Oncol ; 152: 106779, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38555750

RESUMO

Tongue cancer is more prevalent in male smokers and alcoholics. Although an increased incidence of tongue cancer has been noted in non-smoking and non-alcoholic women, reports of its occurrence in mother and daughter are extremely rare. Here, we report a case of a non-smoking and non-alcoholic mother and her daughter diagnosed and treated surgically for tongue squamous cell carcinoma (SCC). The daughter is still being monitored and the mother died from complications from COVID-19 after 6 years of treatment. This report shows that OSCC should be considered in the differential diagnosis of oral ulcerated lesions in non-smoking and non-alcoholic women, especially if there is a family history of first-degree oral cancer.


Assuntos
Neoplasias da Língua , Feminino , Humanos , Pessoa de Meia-Idade , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/genética , COVID-19/complicações , Mães , não Fumantes/estatística & dados numéricos , Neoplasias da Língua/patologia , Idoso
2.
Sci Rep ; 11(1): 19701, 2021 10 05.
Artigo em Inglês | MEDLINE | ID: mdl-34611221

RESUMO

Chronic stress increases the systemic levels of stress hormones norepinephrine and cortisol. As well as tobacco-specific carcinogen NNK (4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone), they can induce expressive DNA damage contributing to the cancer development. However, it is unknown whether stress hormones have genotoxic effects in oral keratinocytes. This study investigated the effects of stress hormones on DNA damage in a human oral keratinocyte cell line (NOK-SI). NOK-SI cells stimulated with norepinephrine or cortisol showed higher DNA damage compared to untreated cells. Norepinephrine-induced DNA damage was reversed by pre-treatment with beta-adrenergic blocker propranolol. Cells treated with NNK combined to norepinephrine displayed reduced levels of caspases 3 and 7. Cortisol also reduced the activity of pro-apoptotic enzymes. NNK or norepinephrine promoted single-strand breaks and alkali-label side breaks in the DNA of NOK-SI cells. Pre-treatment of cells with propranolol abolished these effects. Carcinogen NNK in the presence or absence of cortisol also induced DNA damage of these cells. The genotoxic effects of cortisol alone and hormone combined with NNK were blocked partially and totally, respectively, by the glucocorticoid receptor antagonist RU486. DNA damage promoted by NNK or cortisol and carcinogen combined to the hormone led to intracellular γH2AX accumulation. The effects caused by NNK and cortisol were reversed by propranolol and glucocorticoid receptor antagonist RU486, respectively. Propranolol inhibited the oxidation of basis induced by NNK in the presence of DNA-formamidopyrimidine glycosylase. DNA breaks induced by norepinephrine in the presence or absence of NNK resulted in higher 8OHdG cellular levels. This effect was also induced through beta-adrenergic receptors. Together, these findings indicate that stress hormones induce DNA damage of oral keratinocytes and could contribute to oral carcinogenesis.


Assuntos
Dano ao DNA , Hormônios/metabolismo , Queratinócitos/metabolismo , Mucosa Bucal/metabolismo , Estresse Fisiológico , 8-Hidroxi-2'-Desoxiguanosina/metabolismo , Apoptose , Quebras de DNA/efeitos dos fármacos , Dano ao DNA/efeitos dos fármacos , Células Epiteliais , Histonas/metabolismo , Hormônios/farmacologia , Humanos , Hidrocortisona/farmacologia , Queratinócitos/efeitos dos fármacos , Nitrosaminas/química , Nitrosaminas/farmacologia , Norepinefrina/farmacologia , Oxirredução , Nicotiana/química
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