[Benign schwannoma of the hand. Considerations on a clinical case]. / Schwannoma benigno della mano. Considerazioni di un caso clinico.

The authors here describe, both macroscopically and microscopically, the case of a cellular schwannoma on the hand of a 66 year old man. The tumor had been present asymptomatically for about forty years and macroscopic examination showed it be a softly teseturs fibroma and to have slight transversal mobility. The histologic examination revealed dense tissue formed by elongated cells, which tended towards a layered formation. The mitoses were exceptional. There were also areas scattered with a large number of random vacuolated cells. There were no particular difficulties during the excision, and one year after surgery there was no apparent change or relapse.

[In vitro growth of skin fibroblasts of patients with atypical ductal hyperplasia of the breast: effects of 17 beta-estradiol]. / Crescita in vitro di fibroblasti cutanei di pazienti affette da iperplasia duttale atipica della mammella: effetti del 17-beta-estradiolo.

In this work we investigated the growth of skin fibroblasts, in vitro cultured, drawn from women suffering Atypical Ductal Hyperplasia (I.D.A.) and from healthy women (controls). Whether in basic conditions or after administration of 17, beta-estradiol, in single of repeated dose, cellular growth was valued. The results obtained show that skin fibroblasts drawn from women suffering I.D.A. treated with 100 microliters/ml of estradiol (effective dose), have an increase of the growth. Moreover the increase of the growth seems to be bequest to "effective dose" but not to the number of administrations.

[Different proliferative capacity of human fibroblasts after 17 beta-estradiol administration]. / Differenti capacità proliferative di fibroblasti umani in seguito a somministrazione di 17, beta-estradiolo.

In this study the authors examined the influence of 71, beta-estradiol on cutaneous fibroblasts taken off either from healthy patients with no family history for cancer, or from patients with breast cancer. Fibroblasts were taken from the subcutaneous tissue of the mammary gland by a biopsy carried out in each patients on the same quadrant of the granular surface. Soon after biopsy, the tissue fragments have been washed, dished ed incubated in RPMI at 37 degrees C in a humidified atmosphere of 5% CO2 and 95% air. The action of the hormone was evaluated by the means of cells count for field, in 20 fields in each dish with an inverted microscope (20 x magnification). The results demonstrated that cutaneous fibroblasts from patients with breast cancer show higher values of cell density than those from healthy one. This phenomenon is present both in basal conditions and after hormonal treatment. Two different dosages were used, but only the highest (100 microliters/ml of 17, beta-estradiol) was responsible for an increase of the cell density in all of the treated patients as compared the control groups. These data suggests the presence of a threshold dosage for the estrogens. Below such a dosage there are no effects on cellular growth.

[Effects of estradiol on in vitro cultures of human fibroblasts]. / Studio degli effetti dell'estradiolo su colture in vitro di fibroblasti umani.

This paper assesses the effect of estradiol on the in vitro growth of fibroblast taken from human breast skin. It was observed that estrogens stimulate the proliferation of phenotypically adult fibroblasts; that there is a threshold increase of hormonal concentration which can trigger off this process; and that the size of the single dose is more important than the number of doses of hormone received.