1.
Chem Biodivers
; 18(9): e2100336, 2021 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34369662
RESUMO
Leishmaniasis is a group of tropical diseases caused by parasitic protozoa belonging to the genus Leishmania. The disease is categorized in cutaneous leishmaniasis (CL), mucocutaneous leishmaniasis (MCL), and visceral leishmaniasis (VL). The conventional treatment is complex and can present high toxicity and therapeutic failures. Thus, there is a continuing need to develop new treatments. In this review, we focus on the novel molecules described in the literature with potential leishmanicidal activity, categorizing them in pre-clinical (inâ vitro, inâ vivo), drug repurposing and clinical research.
Assuntos
Antiprotozoários/farmacologia , Leishmania/efeitos dos fármacos , Leishmaniose Cutânea/tratamento farmacológico , Leishmaniose Visceral/tratamento farmacológico , Antiprotozoários/química , Humanos , Testes de Sensibilidade Parasitária
2.
Curr Top Med Chem
; 19(3): 174-177, 2019.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30950334