1.
Hum Immunol
; 71(9): 920-1, 2010 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20438788
RESUMO
The new human leukocyte antigen (HLA) class I allele, HLA-A*0355 was identified in a Brazilian family. Our sequence analysis detected a mismatch located in exon 2, codon 86, at position 258 (C-->A) that results in a nonsilent and nonconservative substitution with the replacement of asparagine by lysine. Substitutions located at this oligosaccharide attachment site of the protein were observed in only other four classic HLA class I sequences, indicating a highly conserved peptide site however its function remains unknown.