Mechanical removal of epithelial hyperplasia leads to successful treatment of irregular astigmatism.

BACKGROUND: Corneal epithelium remodeling in response to changes in the anterior corneal surface (keratoconus, corneal refractive surgery) is well-documented in the literature. However, several conditions may induce a different behavior of the epithelium, in which focal areas of epithelial thickening induce irregular astigmatism. This case report presents a highly unusual case of irregular astigmatism induced by an epithelial hyperplasia of unknown etiology, which was treated by the mechanical removal of only the epithelium. CASE PRESENTATION: A 29-year-old woman underwent implantable collamer lens implantation to correct myopia. The patient provided written informed consent. The procedure was uneventful in both eyes. Twenty months later, she complained of decreased visual acuity in the left eye (uncorrected distance visual acuity (UCDVA) was 20/30; corrected distance visual acuity was 20/20 with + 1.00 -2.25 × 170). Corneal topography revealed a nasal steepening in the left eye. Although the corneal thickness map was normal, epithelial thickness mapping revealed a localized nasal area of epithelial hyperplasia in the left eye that matched the area of steepest curvature. Slit lamp examination showed a total clear cornea with no signs of abnormality. The patient´s medical history was unremarkable and a case of epithelial hyperplasia of unknown etiology, without active inflammation, was considered. The decision was made to perform a mechanical removal of the corneal epithelium after application of diluted alcohol. One month after the procedure, the topography of the epithelized cornea showed a regular bow tie pattern and UCDVA improved to 20/20. No recurrence of the epithelial hyperplasia was detected after twenty-one months. CONCLUSIONS: Focal epithelial hyperplasia may induce irregular astigmatism. Epithelial thickness mapping is a very helpful technological tool to assess cases with irregular topography. De-epithelization as an isolated procedure may be useful for the successful management of these cases. Further research is required to understand the mechanism that triggers the spontaneous development of a focal epithelial hyperplasia.

New mechanism for epithelial ingrowth after small incision lenticule extraction: Vertical epithelial gas breakthrough.

A 41-year-old man underwent SMall Incision Lenticule Extraction (SMILE) to treat myopia in both eyes. The femtosecond procedure was uneventful but a paracentral epithelial blister appeared during the dissection of the anterior plane of the lenticule in the right eye. The posterior surface of the lenticule was dissected without any complication. The surgery of the left eye was uneventful. In the postoperative period, he developed a paracentral epithelial ingrowth in his right eye, exactly underneath the site where the epithelial blister had been noted during the dissection of the lenticule. This induced irregular astigmatism, severely affecting his visual acuity. The decision of surgical treatment was made. After the de-epithelialization of an area of 6mm around the ingrowth, the SMILE incision was opened, and the epithelial ingrowth was dissected and removed from the interface. One month later, uncorrected visual acuity was 20/20, no epithelial ingrowth was observed at the interface, and only the edge of the former ingrowth was barely visible in slit lamp examination. No recurrence was observed. We hypothesize that a vertical epithelial gas breakthrough created a fistula between the interface and the epithelium, forming a pathway for the epithelial cells and giving rise to epithelial ingrowth.

Corneal power measurements by ray tracing in eyes after small incision lenticule extraction for myopia with a combined Scheimpflug Camera-Placido disk topographer.

PURPOSE: To evaluate the accuracy of the measurements of corneal power obtained by ray tracing with a combined Scheimpflug camera-Placido disk corneal topographer (Sirius) in eyes after small incision lenticule extraction for myopia (SMILE). METHODS: Retrospective cases study includes 50 eyes of 50 patients who underwent myopic SMILE. Mean value of simulated keratometry (Kpost), mean pupil power (MPP) (ray tracing, diameter of the entrance pupil range 3-6 mm), anterior and posterior corneal radius, and corneal thickness were obtained with Sirius topographer preoperatively and three months postoperatively, as well as cycloplegic refraction. True net power, equivalent keratometry readings, and Haigis equivalent power formula were calculated, and these measurements, MPP and Kpost, were compared with the corneal power calculated with the clinical history method (CHM). RESULTS: Corneal power measurements obtained with all methods were significantly different from CHM (P < 0.001), except the value of MPP obtained at 5.5 mm (P = 0.927). A good direct correlation was found between CHM and all measurements. The distribution of differences as compared with the CHM showed that the lowest difference corresponded to the value of MMP at 5.5 mm (- 0.002 ± 0.6). The Bland-Altman plots for the MPP at 5.5 mm showed 95% limits of agreement between - 1.1787 D and 1.1741 D. CONCLUSIONS: MPP obtained by ray tracing within a diameter of entrance pupil of 5.5 mm could predict corrected corneal power derived from the CHM in eyes following SMILE surgery.