RESUMO
INTRODUCTION: Collagenous colitis (CC) is an uncommon disease with a favorable prognosis. It is included in the group of chronic watery diarrheas. OBJECTIVE: To study epidemiological and clinical characteristics of CC, as well as its course and response to the treatment. MATERIAL AND METHODS: This is a descriptive, retrospective study of the endoscopic colon biopsies performed in Hospital de León during 5 years. Those biopsies that fulfilled the histological criteria of CC were selected. RESULTS: A total of 18 cases with an incidence of 1.25/10(5) inhabitants/year was obtained. Mean age was 66.7 years. There was no difference between both genders. The period of time to diagnosis was long (10 months). A possible association with intake of some drugs, as non-steroidal antiinflammatory drugs (46%) and lansoprazole (42.8%), and smoking (41.6%), as well as autoimmune disease (30.7%) was found. There was a good response to the treatment with mesalazine in 2 of 3 patients who received this treatment. The clinical course was also favorable for the 2 patients treated with budesonide. CONCLUSION: It is important to take multiple biopsies of the colon in order to diagnose CC when there is a case of chronic watery diarrhea even when the colonoscopy is normal. Certain drugs and autoimmune diseases may be involved in the etiology.
Assuntos
Colite Colagenosa , Estudos Retrospectivos , Adulto , Idoso , Idoso de 80 Anos ou mais , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Anti-Inflamatórios não Esteroides/administração & dosagem , Anti-Inflamatórios não Esteroides/uso terapêutico , Biópsia , Budesonida/administração & dosagem , Budesonida/uso terapêutico , Colite Colagenosa/diagnóstico , Colite Colagenosa/tratamento farmacológico , Colite Colagenosa/patologia , Colo/patologia , Colonoscopia , Diarreia/diagnóstico , Diarreia/etiologia , Feminino , Glucocorticoides/administração & dosagem , Glucocorticoides/uso terapêutico , Humanos , Masculino , Mesalamina/administração & dosagem , Mesalamina/uso terapêutico , Pessoa de Meia-Idade , Fatores de Tempo , Resultado do TratamentoAssuntos
Adjuvantes Imunológicos/efeitos adversos , Vacina BCG/efeitos adversos , Mycobacterium bovis , Tuberculose/etiologia , Adjuvantes Imunológicos/administração & dosagem , Administração Intravesical , Idoso , Vacina BCG/administração & dosagem , Carcinoma de Células de Transição/tratamento farmacológico , Humanos , Masculino , Neoplasias da Bexiga Urinária/tratamento farmacológicoRESUMO
A woman with the final diagnosis of non-bacterial thrombotic endocarditis associated to pulmonary adenocarcinoma is reported. She had had repetitive embolic strokes as the first manifestation, with vegetations on the mitral valve and without signs of acute infectious disease. The case is interesting because is an usually case of nonbacterial thrombotic endocarditis and the importance of an early diagnostic.
