Valoración de la respuesta plaquetaria al uso de antagonistas del receptor p2y12 utilizando el test de reactividad plaquetaria verifynow®, en pacientes sometidos a neurointervencionismo / Monitoring the Plaquetary Response to the Use of P2Y12 Receptor Antagonists Using the Platelet Reactivity Test Verifynow™ in Patients Who Underwent Neurointervencionism Procedures

Objetivo: Valorar la respuesta plaquetaria al uso de los antagonistas del receptor P2Y12 mediante el test VerifyNow® en pacientes sometidos a neurointervencionismo. Metodología: Estudio descriptivo transversal retrospectivo, con 89 pacientes intervenidos entre 2014 y 2017, de los cuales, 78 cumplieron los criterios de inclusión. Todos los casos recibieron protocolo de antiagregación dual. El resultado por evaluar con el test corresponde a la respuesta de los pacientes al uso de antagonistas del receptor P2Y12. La respuesta baja a los inhibidores de P2Y12 se manifestó en aquellos con un valor de PRU > de 240; la respuesta alta se les atribuyó a aquellos con valores de PRU < 60. Resultados: La mayor parte de los intervenidos (69,2 %) respondieron normalmente. Las complicaciones de la población en estudio fueron del 9,1 %, incluidos 2 fallecimientos, de los cuales, uno fue de un paciente de baja respuesta. Conclusiones: La respuesta plaquetaria individual de la población estudiada frente al uso de clopidogrel mediante el test VerifyNow® fue variable y heterogénea. Se evidenció en el estudio que el 14,3 % de los pacientes que tuvieron complicaciones tenían el PRU fuera del rango objetivo y del total de pacientes que presentaron valores dentro del rango objetivo solo el 2 % presentaron complicaciones menores.

[Endovascular coiling of a «true¼ posterior communicating artery aneurysm]. / Tratamiento endovascular de un aneurisma «verdadero¼ de la arteria comunicante posterior.

True posterior communicating artery aneurysms originate exclusively from the wall of this artery and should be differentiated from aneurysms of the posterior communicating segment of the distal carotid artery. As these lesions are rare, their anatomical relationships have been poorly described; likewise, reports concerning their endovascular treatment are extremely rare and the technical aspects poorly detailed. A case of a patient with a true aneurysm of the left posterior communicating artery treated by endovascular coiling is presented. A literature review was also conducted to illustrate the anatomical and technical details relevant to achieving its successful treatment.

[Embolization of skull-base hypervascular tumors: description of a series of cases and proposal of a therapeutic algorithm]. / Embolizacion de tumores hipervasculares de la base del craneo: descripción de una serie de casos y propuesta de un algoritmo terapéutico.

UNLABELLED: Preoperative embolization allows reducing intraoperative blood loss caused by hypervascular intracranial tumors and its undesirable consequences. AIM: To describe the experience with preoperative endovascular embolization of hypervascular skull base tumors, and to develop a therapeutic algorithm. MATERIALS AND METHODS: A retrospective examination of preoperative neuroimaging and results of preoperative embolization was carried out. RESULTS: Fifteen cases were identified, with a median age of 36 years old, most of them harboring meningiomas, nasopharyngeal angiofibromas or paragangliomas. The external carotid artery was involved in 93% of cases and was the only afferent to 60%. In 27%, there were branches from the internal and external carotid arteries simultaneously. An extensive or complete occlusion grade was achieved in 95% of the branches of the external carotid artery. No branch of the internal carotid artery was treated, because poor contribution to tumor irrigation or was not possible to catheterize the pedicle. There were not recorded procedure-related complications. CONCLUSION: Based on the unification of the experiences described in this study and using data from published series, we present an algorithm for rational selection of skull base tumors that can benefit from preoperative embolization.

[Resection of frontal lobe epileptogenic foci identified after corpus callosotomy: long term results]. / Resección de focos epileptogénicos frontales identificados tras la callosotomía: resultados a largo plazo.

OBJECTIVES: To analyse the results of resective surgery in patients in whom it was possible to identify a frontal epileptogenic focus through corpus callosotomy. MATERIAL AND METHODS: Data from patients suffering drug-resistant epilepsy showing persistence of disabling seizures after undergoing corpus callosotomy and subsequent treatment with frontal lobe resective surgery were prospectively reviewed. Classifications according to Engel's scale before and after each intervention were evaluated, as were the percentages of seizure reduction. Additionally, the satisfaction of family members with surgical outcomes was also assessed. RESULTS: Eleven patients were identified. After a median follow-up period of 7 years (IQR: 3-8 years), 63.6% of patients showed improvement of seizures according to Engel's scale, 27.2% remained unchanged and one worsened. One patient was categorised as class i, 8 as class ii, one as class iii and one as class iv. The percentage reduction in the number of seizures was over 90% in 54.5% of patients, between 50% and 90% in 36.4% and less than 50% in 9.1%. Family satisfaction was reported as good or excellent in 90.9% of cases. CONCLUSIONS: In addition to providing better seizure control, corpus callosotomy also appears to be a diagnostic tool allowing the identification of potential targets for resective surgery. Therefore, it should be considered upon suspicion of a frontal epileptogenic focus which could be surgically treated.