Explorando el vínculo de la inteligencia emocional y la satisfacción con la vida en adultos peruanos / Exploring the link between the emotional intelligence and satisfaction with life in Peruvian adults

La inteligencia emocional y la satisfacción vital pueden estar relacionados diferencialmente, dado que la inteligencia emocional es multidimensional y, en contextos socioculturales como Perú, hay pocos estudios al respecto con estos constructos analizados independientemente y, menos aún, conjuntamente. El objetivo de este estudio fue examinar la asociación entre ambos constructos desde la metodología de ecuaciones estructurales. Participaron 140 personas de edad adulta (entre 16 y 62 años), quienes respondieron al cuestionario Wong-Law Emotional Intelligence Scale y el Satisfaction With Life Scale. Se obtuvo buena validez estructural de los instrumentos y niveles de confiabilidad adecuados (> .70). Únicamente el constructo de uso de emociones fue más influyente sobre el atisfaction With Life Scale (varianza explicada = 12%); el sexo y la edad fueron de influencia trivial. Se discuten las implicanciones de los resultados

Emotional intelligence and satisfaction with life can be differentially related, since it is multidimensional and, in sociocultural contexts like Peru, there are few studies about it with these constructs analyzed separately and, even less jointly. This study is aimed at analyzing the association between both constructs based on the methodology of structural equations. 140 people age 16 to 62 participated in the Wong-Law Emotional Intelligence Scale and the Satisfaction with Life Scale (SWLS) survey. The survey showed a good structural validity of the instruments and suitable reliability instruments ( > .70). The use of emotions construct was only the most influential in SWLS (variance explained = 12%); sex and age had trivial influence. The consequences of the results are discussed

Gene expression analysis of heat shock proteins in the nucleus accumbens of rats with different morphine seeking behaviours.

Heat-shock proteins play functional roles on brain regulatory processes which are deeply involved in drug addiction, such as synaptic plasticity. However, few studies have been focused on gene expression of heat-shock proteins (Hsp) as potential diagnostic tools for addiction risk. This work tries to provide new knowledge on this field by using two rat models of differential vulnerability to morphine addiction in order to study differential gene expression of a selected group of Hsp genes in the nucleus accumbens (NAc). Hsp70-1A, 84, 86 and 105 genes were similarly regulated by an acute injection of morphine in two subpopulations of Sprague Dawley (SD) rats showing different rates of extinction of morphine conditioned preference. However, Lewis and Fischer rats, two strains that differ in many aspects of drug seeking behaviours, exhibited marked differences in their expression patterns of Hsp84, 86 and 105. These results suggest that differential Hsp gene expression could be related to addiction vulnerability and recommend further work to validate these proteins as potential markers for drug addiction risk.

Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction.

Vulnerability to the addictive effects of drugs of abuse varies among individuals, but the biological basis of these differences are poorly known. This work tries to increase this knowledge by comparing the brain proteome of animals with different rate of extinction of cocaine-seeking behaviour. To achieve this goal, we used a place-preference paradigm to separate Sprague Dawley rats in two groups: rats that extinguished (E) and rats that did not extinguish (NE) cocaine-seeking behaviour after a five-day period of drug abstinence. Once the phenotype was established, we compared the protein expression in the nucleus accumbens (NAC) of these animals after a single injection of either saline (SAL) or cocaine (COC, 15 mg/kg). The analysis of protein expression was performed by 2-dimensional electrophoresis followed by matrix-assisted laser desorption/ionization time of flight mass spectrometry. When comparing E SAL and NE SAL animals we found significant differences in the expression level of 5 proteins: ATP synthase subunit alpha, fumarate hydratase, transketolase, NADH dehydrogenase [ubiquinone] flavoprotein 2 and glutathione transferase omega-1. A single injection of COC differently alters the NAC proteome of E and NE rats; thus in E COC animals there was an alteration in the expression of 6 proteins, including dihydropyrimidinase-related protein 2 and NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10; whereas in NE COC rats 9 proteins were altered (including alpha-synuclein, peroxiredoxin-2 and peroxiredoxin-5). These proteins could be potential biomarkers of individual vulnerability to cocaine abuse and may be helpful in designing new treatments for cocaine addiction.