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2.
Artigo em Inglês | MEDLINE | ID: mdl-34364826

RESUMO

BACKGROUND: The optimal regimen for intravenous administration of intraoperative fluids remains unclear. Our goal was to analyze intraoperative crystalloid volume administration practices and their association with postoperative outcomes. METHODS: We extracted clinical data from two multicenter observational studies including adult patients undergoing colorectal surgery and total hip (THA) and knee arthroplasty (TKA). We analyzed the distribution of intraoperative fluid administration. Regression was performed using a general linear model to determine factors predictive of fluid administration. Patient outcomes and intraoperative crystalloid utilization were summarized for each surgical cohort. Regression models were developed to evaluate associations of high or low intraoperative crystalloid with the likelihood of increased postoperative complications, mainly acute kidney injury (AKI) and hospital length of stay (LOS). RESULTS: 7580 patients were included. The average adjusted intraoperative crystalloid infusion rate across all surgeries was to 7.9 (SD 4) mL/kg/h. The regression model strongly favored the type of surgery over other patient predictors. We found that high fluid volume was associated with 40% greater odds ratio (OR 1.40; 95% confidence interval 1.01-1.95, p = 0.044) of postoperative complications in patients undergoing THA, while we found no associations for the other types of surgeries, AKI and LOS CONCLUSIONS: A wide variability was observed in intraoperative crystalloid volume administration; however, this did not affect postoperative outcomes.


Assuntos
Hidratação , Adulto , Estudos de Coortes , Soluções Cristaloides , Humanos , Estudos Prospectivos , Estudos Retrospectivos
3.
Radiología (Madr., Ed. impr.) ; 62(1): 13-27, ene.-feb. 2020. ilus, tab, graf
Artigo em Espanhol | IBECS | ID: ibc-194142

RESUMO

El manejo de los pacientes con cáncer de cabeza y cuello implica un tratamiento multidisciplinar con cirugía, radioterapia y quimioterapia. Las pruebas de imagen son cruciales en su seguimiento, sobre todo cuando la recurrencia tumoral no sea clínicamente evidente. Distinguir radiológicamente los cambios postratamiento de una recidiva tumoral constituye un reto debido a la alteración anatómica que suponen las técnicas quirúrgicas y sus reconstrucciones, al tratamiento radioterápico y a las pautas quimioterápicas. El diagnóstico diferencial debe incluir las posibles complicaciones derivadas de la radioterapia (necrosis mucosa, osteorradionecrosis, vasculopatía, radionecrosis cerebral) y de la cirugía (infecciones de la herida, necrosis del colgajo, fístulas, etc.). Un amplio conocimiento de los hallazgos esperables del tratamiento multimodal y sus complicaciones es esencial para un diagnóstico preciso de recurrencia tumoral. Por último, elegir la prueba de imagen adecuada y disponer de un estudio basal postratamiento es igualmente relevante para un control radiológico idóneo


The management of patients with head and neck cancer implies a multidisciplinary treatment with surgery, radiotherapy and chemotherapy. Imaging is crucial in their follow-up, especially when the tumor recurrence is not clinically evident. Radiologically distinguishing post-treatment changes from a tumor recurrence is a challenge due to the anatomical alteration due to surgical techniques and their reconstructions, radiotherapy treatment and chemotherapeutic guidelines. The differential diagnosis must include the possible complications derived from radiotherapy (mucosal necrosis, osteoradionecrosis, vasculopathy, cerebral radionecrosis) and surgery (wound infections, flap necrosis, fistulas,...). A wide knowledge of the expected findings of multimodal treatment and its complications is essential for an accurate diagnosis of tumor recurrence. Finally, choosing the appropriate image study and having a baseline post-treatment study is also relevant for a suitable radiological control


Assuntos
Humanos , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Terapia Combinada , Reprodutibilidade dos Testes , Diagnóstico Diferencial , Radioterapia/efeitos adversos , Necrose/diagnóstico por imagem , Osteorradionecrose/diagnóstico por imagem , Retalhos Cirúrgicos , Complicações Pós-Operatórias
4.
Radiologia (Engl Ed) ; 62(1): 13-27, 2020.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-31668715

RESUMO

The management of patients with head and neck cancer implies a multidisciplinary treatment with surgery, radiotherapy and chemotherapy. Imaging is crucial in their follow-up, especially when the tumor recurrence is not clinically evident. Radiologically distinguishing post-treatment changes from a tumor recurrence is a challenge due to the anatomical alteration due to surgical techniques and their reconstructions, radiotherapy treatment and chemotherapeutic guidelines. The differential diagnosis must include the possible complications derived from radiotherapy (mucosal necrosis, osteoradionecrosis, vasculopathy, cerebral radionecrosis) and surgery (wound infections, flap necrosis, fistulas,...). A wide knowledge of the expected findings of multimodal treatment and its complications is essential for an accurate diagnosis of tumor recurrence. Finally, choosing the appropriate image study and having a baseline post-treatment study is also relevant for a suitable radiological control.


Assuntos
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Recidiva Local de Neoplasia/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Lesões por Radiação/diagnóstico por imagem , Radiologistas , Terapia Combinada/efeitos adversos , Terapia Combinada/métodos , Diagnóstico Diferencial , Neoplasias de Cabeça e Pescoço/terapia , Humanos , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Retalhos Cirúrgicos , Tomografia Computadorizada por Raios X , Ultrassonografia
7.
Rev Esp Sanid Penit ; 13(1): 15-20, 2011.
Artigo em Espanhol | MEDLINE | ID: mdl-21484074

RESUMO

OBJECTIVE: To study the agreement of Tuberculin Skin Tests (TST) and Interferon Gamma Release Assays (IGRA) when screening tuberculosis infection amongst inmates recently admitted to prison. MATERIALS AND METHODS: Prospective study conducted in a prison during the months of May and June 2009. Inmates without a TB history, with previous TST negatives or without prior TSTs were included. Participants signed an informed consent form and the study was approved by an independent Ethical Committee. TST (positive 10 > or = mm) and IGRA (Quantiferon TB-Gold) were performed and standardized data collection was carried out. The agreement between both tests was analysed using the Kappa index. RESULTS: A total of 181 people were included. 62% were foreign-born, 17% had previous BCG vaccination, 8.4% were IDUs and 4% HIV-infected. Foreign born subjects were more frequently vaccinated and presented less drug use and HIV infection than people born in Spain. (p=0.02, p=0.02 and p=0.01 respectively). TST results were positive in 24% and IGRA in 26%. Both tests were performed in 149 people (82%). Discordant results were observed in 15.8%. Agreement of the Kappa coefficient was 0.6 (CI 0.4-0.7). Agreement was better in the native population (K=0.8) and worse in BCG vaccinated (K=0.4) and foreign-born subjects (K=0.8). CONCLUSION: Overall agreement was moderate and was less amongst vaccinated subjects and those born abroad. Extension of the study could be useful to evaluate which test better predicts the risk of progression to active TB and the cost-benefit of both tests among the prison population.


Assuntos
Interferon gama/sangue , Prisioneiros , Teste Tuberculínico , Tuberculose/sangue , Tuberculose/diagnóstico , Adulto , Idoso , Estudos Transversais , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
8.
Rev. esp. sanid. penit ; 13(1): 15-20, 2011. tab
Artigo em Espanhol | IBECS | ID: ibc-86229

RESUMO

Objetivo: Estudiar en población penitenciaria la concordancia de la prueba de la tuberculina (PT) y las pruebas de interferón gamma (IFG). Material y Métodos: Estudio prospectivo realizado en una prisión en mayo-junio de 2009. Se estudian los ingresos sin antecedente de tuberculosis (TB) o con PT previa negativa o no realizada. Se realizó IDR de Mantoux (positivo ³ 10 mm) y extracción sanguínea para prueba de IFG (QuantiFERON®-TB Gold). En los infectados, se realizó despistaje de TB. Se pasó un cuestionario y se solicitó consentimiento informado. El estudio fue aprobado por un Comité Ético ajeno a instituciones penitenciarias. La concordancia entre PT e IFG se basó en el índice Kappa. Resultados: Se incluyeron 181 casos. El 62% eran extranjeros, el 17% vacunados por BCG, el 8,4% UDI y el 4% VIH+. En los extranjeros había más vacunados, menos UDI y menos infectados por VIH que en autóctonos (p=0,02, p=0,02, y p=0,01, respectivamente). La PT fue positiva en el 24% y la IFG en el 26%. Hubo información de ambas en 149 (82%) casos. El 15,8% fueron discordantes. El índice Kappa fue de 0,6 (0,4-0,7). La concordancia varió según subgrupos, siendo mayor en autóctonos (kappa= 0,8) y menor en vacunados (kappa=0,4) e inmigrantes (kappa=0,5). Conclusión: La concordancia global fue moderada-buena, pero en vacunados e inmigrantes fue menor. El nivel de discordancia aconseja ampliar el estudio, así como evaluar que prueba predice mejor el riesgo de progresión a TB y el coste-beneficio de ambas en la población reclusa de nuestro país(AU)


Objective: To study the agreement of Tuberculin Skin Tests (TST) and Interferon Gamma Release Assays (IGRA) when screening tuberculosis infection amongst inmates recently admitted to prison. Materials and Methods: Prospective study conducted in a prison during the months of May and June 2009. Inmates without a TB history, with previous TST negatives or without prior TSTs were included. Participants signed an informed consent form and the study was approved by an independent Ethical Committee. TST (positive 10 >= mm) and IGRA (Quantiferon TB-Gold) were performed and standardized data collection was carried out. The agreement between both tests was analysed using the Kappa index. Results: A total of 181 people were included. 62% were foreign-born, 17% had previous BCG vaccination, 8.4% were IDUs and 4% HIV-infected. Foreign born subjects were more frequently vaccinated and presented less drug use and HIV infection than people born in Spain. (p=0.02, p=0.02 and p=0.01 respectively). TST results were positive in 24% and IGRA in 26%. Both tests were performed in 149 people (82%). Discordant results were observed in 15.8%. Agreement of the Kappa coefficient was 0.6 (CI 0.4-0.7). Agreement was better in the native population (K=0.8) and worse in BCG vaccinated (K=0.4) and foreign-born subjects (K=0.8) Conclusion: Overall agreement was moderate and was less amongst vaccinated subjects and those born abroad. Extension of the study could be useful to evaluate which test better predicts the risk of progression to active TB and the cost-benefit of both tests among the prison population(AU)


Assuntos
Humanos , Masculino , Adulto , Teste Tuberculínico/instrumentação , Teste Tuberculínico/métodos , Prisioneiros/estatística & dados numéricos , Interferon gama , Infecções por HIV/complicações , Infecções por HIV/diagnóstico , Soroprevalência de HIV/tendências , Teste Tuberculínico/estatística & dados numéricos , Teste Tuberculínico/tendências , Teste Tuberculínico , Estudos Prospectivos , Estudos Transversais , Consentimento Livre e Esclarecido/estatística & dados numéricos , Inquéritos e Questionários
9.
Radiología (Madr., Ed. impr.) ; 52(4): 342-350, jul.-ago. 2010. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-80853

RESUMO

Objetivo. Estudiar con espectroscopia univóxel por resonancia magnética (1,5T) el efecto regional, de la edad y el sexo en las ratios metabólicas del lóbulo temporal medial, la región cerebral posteromedial (RPM) y el lóbulo frontal. Material y métodos. Estudiamos 31 personas sanas mayores de 55 años (grupo 1) y 20 menores de 30 años (grupo 2) con espectroscopia univóxel en el lóbulo frontal izquierdo, el lóbulo temporal medial izquierdo y la RPM, especialmente afectadas por las enfermedades neurodegenerativas. Se calcularon las ratios NAA/Cr, NAA/Cho, NAA/mI, Cho/Cr, y mI/Cr, de cada vóxel. En cada grupo se compararon regionalmente las ratios metabólicas, y se estudió la correlación ratio-edad dentro de sus rangos de edad. Finalmente, se analizaron las diferencias de las ratios metabólicas entre grupos y entre sexos. Resultados. En el grupo 1, las ratios Cho/Cr frontal y NAA/mI temporal se correlacionaron negativamente con la edad. En el grupo 2, las correlaciones con la edad fueron negativas para las ratios temporales mI/Cr y NAA/Cho, y positiva para la NAA/mI temporal. En el lóbulo frontal y la RPM, las ratios NAA/Cr, NAA/Cho y NAA/mI fueron menores en el grupo 1 (P<=0,003). Las ratios Cho/Cr y mI/Cr nunca mostraron diferencias entre grupos. Los valores de las ratios difirieron regionalmente en todos los casos (P<0,001). NAA/Cr y Cho/Cr en el lóbulo temporal medial fueron mayores en las mujeres (P<=0,034). Conclusiones. Cuando se utilice la espectroscopia univóxel por resonancia magnética, en particular en las enfermedades neurodegenerativas, siempre deben considerarse las variaciones inducidas por la región, la edad y el sexo (AU)


Objective. To determine the regional effects of age and sex on the metabolic ratios obtained in the medial temporal lobe, the posteromedial region, and the frontal lobe at 1.5T single-voxel magnetic resonance spectroscopy. Material and methods. We used single-voxel magnetic resonance spectroscopy to study the areas of the brain most affected in neurodegenerative disease (the left frontal lobe, the left medial temporal lobe, and the posteromedial region) in 31 healthy subjects older than 55 years of age (group 1) and in 20 healthy subjects under 30 years of age (group 2). We calculated the following ratios for each voxel: N-acetyl-aspartate/creatine-phosphocreatine (NAA/Cr), N-acetyl-aspartate/choline (NAA/Cho), N-acetyl-aspartate /myoinositol (NAA/mI), choline/creatine-phosphocreatine (Cho/Cr), and myoinositol (mI/Cr). We compared the metabolic ratios in each region in each group and the correlation between age and the ratios within age ranges. Finally, we analyzed the differences in the metabolic ratios between groups and between sexes. Results. In group 1, we found negative correlations between age and Cho/Cr in the frontal region and NAA/mI in the temporal region. In group 2, we found negative correlations between age and mI/Cr and NAA/Cho in the temporal region as well as a positive correlation between age and NAA/mI in the temporal region. In the frontal lobe and the posteromedial region, NAA/Cr, NAA/Cho, and NAA/mI were lower in group 1 (P<=0.003). No differences between groups were seen in Cho/Cr or mI/Cr. The values of the ratios differed regionally in all cases (P<0.001). In the temporal lobe, NAA/Cr and Cho/Cr were higher in women (P<=0.034). Conclusions. When using single-voxel magnetic resonance spectroscopy, especially in patients with neurodegenerative disease, variations due to region, age, and sex should always be taken into account (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Espectroscopia de Ressonância Magnética/métodos , Lobo Temporal/patologia , Lobo Temporal , Lobo Frontal/patologia , Lobo Frontal , Giro do Cíngulo , Espectroscopia de Ressonância Magnética/instrumentação , Espectroscopia de Ressonância Magnética/normas , Imageamento por Ressonância Magnética , Neuropsicologia/métodos , Seio Sagital Superior
10.
Radiologia ; 52(4): 342-50, 2010.
Artigo em Espanhol | MEDLINE | ID: mdl-20557913

RESUMO

OBJECTIVE: To determine the regional effects of age and sex on the metabolic ratios obtained in the medial temporal lobe, the posteromedial region, and the frontal lobe at 1.5 T single-voxel magnetic resonance spectroscopy. MATERIAL AND METHODS: We used single-voxel magnetic resonance spectroscopy to study the areas of the brain most affected in neurodegenerative disease (the left frontal lobe, the left medial temporal lobe, and the posteromedial region) in 31 healthy subjects older than 55 years of age (group 1) and in 20 healthy subjects under 30 years of age (group 2). We calculated the following ratios for each voxel: N-acetyl-aspartate/creatine-phosphocreatine (NAA/Cr), N-acetyl-aspartate/choline (NAA/Cho), N-acetyl-aspartate /myoinositol (NAA/mI), choline/creatine-phosphocreatine (Cho/Cr), and myoinositol (mI/Cr). We compared the metabolic ratios in each region in each group and the correlation between age and the ratios within age ranges. Finally, we analyzed the differences in the metabolic ratios between groups and between sexes. RESULTS: In group 1, we found negative correlations between age and Cho/Cr in the frontal region and NAA/mI in the temporal region. In group 2, we found negative correlations between age and mI/Cr and NAA/Cho in the temporal region as well as a positive correlation between age and NAA/mI in the temporal region. In the frontal lobe and the posteromedial region, NAA/Cr, NAA/Cho, and NAA/mI were lower in group 1 (P≤0.003). No differences between groups were seen in Cho/Cr or mI/Cr. The values of the ratios differed regionally in all cases (P<0.001). In the temporal lobe, NAA/Cr and Cho/Cr were higher in women (P≤0.034). CONCLUSIONS: When using single-voxel magnetic resonance spectroscopy, especially in patients with neurodegenerative disease, variations due to region, age, and sex should always be taken into account.


Assuntos
Encefalopatias/diagnóstico , Espectroscopia de Ressonância Magnética , Adulto , Fatores Etários , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fatores Sexuais , Adulto Jovem
11.
Radiología (Madr., Ed. impr.) ; 51(4): 385-395, jul.-ago. 2009.
Artigo em Espanhol | IBECS | ID: ibc-72745

RESUMO

Objetivo: Analizar el efecto de la edad, el sexo y el valor b en el coeficiente de difusión aparente (CDA) de áreas cerebrales alteradas en las enfermedades neurodegenerativas. Material y métodos: Se estudió el CDA de hipocampo, rodilla y esplenio del cuerpo calloso en 50 pacientes normales, con difusión por resonancia magnética b1.000 y b3.000s/mm2. Para cada localización se calcularon las diferencias entre los CDA b1.000 y b3.000 (diferencial de difusión [DD]). Se separaron los pacientes en grupos de edad (⩽30, 31–60 y >60 años). El análisis de las diferencias de CDA y DD entre grupos de edad y entre sexos se hizo con los tests de ANOVA y Kruskal-Wallis, y la corrección de Bonferroni. Para la correlación del CDA y el DD con la edad se utilizó el test de Pearson. Resultados: En el hipocampo derecho hubo diferencias de CDA (b1.000, p=0,011; b3.000, p=0,024) y DD (p=0,006) con la edad. Las diferencias del CDA se observaron entre los grupos de 31–60 años y >60 (p=0,009) para b 1.000, y entre<30 y 31–60 años (p=0,036) para b 3.000. El DD varió entre los >60 años y el resto. En el cuerpo calloso hubo diferencias significativas entre sexos en el DD de la rodilla (p=0,016). El DD mostró correlación con la edad en el hipocampo derecho (r=0,321, p=0,023). Conclusiones: Nuestros datos indican mayor estabilidad de los valores de CDA medidos con b3.000 durante el envejecimiento. El análisis del CDA con valor b más alto puede ser de utilidad en las enfermedades neurodegenerativas (AU)


Objective: To analyze the effects of age, sex, and b value on the apparent diffusion coefficient (ADC) in brain areas affected by neurodegenerative diseases. Material and methods: We studied the ADC of the genu and splenium of the corpus callosum and of the hippocampus in normal patients using diffusion magnetic resonance imaging (dMRI) with b1,000s/mm2 and b3,000s/mm2. We calculated the differences between the ADC (diffusion differential [DD]) with b1,000 and with b3,000 for each region. Patients were classified into the following age groups (⩽30 years old, 31–60 years old, >60 years old). We used a Kruskal-Wallis one-way ANOVA and the Bonferroni correction to analyze the differences in ADC and DD between age groups and between sexes. Pearson's chi-square test was used to correlate the ADC and DD with age. Results: In the right hippocampus, we observed differences in ADC (b1,000, p=0.011; b3,000, p=0.024) and DD (p=0.006) with age. Differences in ADC were observed between the 31–60 year-old age group and the >60 year-old age group (p=0.009) for b1,000, and between the<30 year-old age group and the 31–60 year-old age group (p=0.036) for b3,000. The DD in the >60 year-old age group was different from the rest. In the corpus callosum, there were significant differences between sexes in the DD of the genu (p=0.016). The DD was correlated with age in the right hippocampus (r=0.321, p=0.023). Conclusions: Our data indicate greater stability in mean ADC values with b3000 during aging. It might be useful to analyze the ADC with a higher b in patients with neurodegenerative diseases (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Doenças Neurodegenerativas/complicações , Doenças Neurodegenerativas , Hipocampo/patologia , Hipocampo , Corpo Caloso , Análise de Variância , Envelhecimento/patologia , Envelhecimento/fisiologia , Estudos Transversais , Protocolos Clínicos
12.
Radiologia ; 51(4): 385-95, 2009.
Artigo em Espanhol | MEDLINE | ID: mdl-19410268

RESUMO

OBJECTIVE: To analyze the effects of age, sex, and b value on the apparent diffusion coefficient (ADC) in brain areas affected by neurodegenerative diseases. MATERIAL AND METHODS: We studied the ADC of the genu and splenium of the corpus callosum and of the hippocampus in normal patients using diffusion magnetic resonance imaging (dMRI) with b1,000 s/mm2 and b3,000 s/mm2. We calculated the differences between the ADC (diffusion differential [DD]) with b1,000 and with b3,000 for each region. Patients were classified into the following age groups (60 years old). We used a Kruskal-Wallis one-way ANOVA and the Bonferroni correction to analyze the differences in ADC and DD between age groups and between sexes. Pearson's chi-square test was used to correlate the ADC and DD with age. RESULTS: In the right hippocampus, we observed differences in ADC (b1,000, p=0.011; b3,000, p=0.024) and DD (p=0.006) with age. Differences in ADC were observed between the 31-60 year-old age group and the >60 year-old age group (p=0.009) for b1,000, and between the<30 year-old age group and the 31-60 year-old age group (p=0.036) for b3,000. The DD in the >60 year-old age group was different from the rest. In the corpus callosum, there were significant differences between sexes in the DD of the genu (p=0.016). The DD was correlated with age in the right hippocampus (r=0.321, p=0.023). CONCLUSIONS: Our data indicate greater stability in mean ADC values with b3000 during aging. It might be useful to analyze the ADC with a higher b in patients with neurodegenerative diseases.


Assuntos
Encéfalo/patologia , Imagem de Difusão por Ressonância Magnética , Doenças Neurodegenerativas/patologia , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores Sexuais , Adulto Jovem
13.
Dement Geriatr Cogn Disord ; 26(1): 15-25, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-18566544

RESUMO

BACKGROUND/AIMS: To evaluate (1)H-labelled magnetic resonance spectroscopy (MRS) in patients with a low Mini Mental State Examination (MMSE) score identified during a dementia community-based survey. METHODS: A population sample of 1,500 individuals (>64 years old) was randomly selected. Two hundred and fifteen individuals (MMSE < or =24) were sorted into clinical groups: dementia, Alzheimer's disease, mild cognitive impairment (MCI), normal. Up to 56 of these individuals attended the MRS appointment. Two single-voxel sequences (TR 1,500, TE 35/144 ms) were carried out in the posterior cingulate gyrus of each individual, and the ratios N-acetylaspartate (NAA)/creatine (Cr), choline (Cho)/Cr, myo-inositol (mI)/Cr, NAA/mI and NAA/Cho were compared statistically. The ability of MRS to distinguish clinical groups was assessed by receiver-operating characteristics analysis. Cognition effects on metabolite ratios were estimated, with gender and cognition as categorical variables and age as a continuous covariate. RESULTS: NAA/Cr and NAA/Cho ratios were lower in dementia or Alzheimer's disease than in MCI and normal groups. The NAA/Cr ratio at TE 35 ms performed best when distinguishing dementia or Alzheimer's disease from non-demented subjects (cut-off point 1.40). MRS could not distinguish between MCI patients and normal subjects. Dementia was an independent predictor of metabolite values. CONCLUSION: In a population sample, conventional MRS still proved to be a useful tool for dementia discrimination, but it is potentially far less useful as a surrogate marker for MCI.


Assuntos
Doença de Alzheimer/diagnóstico , Transtornos Cognitivos/diagnóstico , Demência/diagnóstico , Espectroscopia de Ressonância Magnética/métodos , Índice de Gravidade de Doença , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/metabolismo , Ácido Aspártico/análogos & derivados , Ácido Aspártico/metabolismo , Encéfalo/metabolismo , Colina/metabolismo , Transtornos Cognitivos/metabolismo , Creatina/metabolismo , Coleta de Dados , Demência/metabolismo , Feminino , Humanos , Inositol/metabolismo , Masculino , Valor Preditivo dos Testes , Prótons , Características de Residência , Sensibilidade e Especificidade
15.
Farm Hosp ; 30(3): 187-92, 2006.
Artigo em Espanhol | MEDLINE | ID: mdl-16999566

RESUMO

OBJECTIVE: The therapeutic armamentarium of developed countries has experienced a great advance; however, increased drug therapy not only provides benefits, as the inappropriate use of drugs results in relevant consequences for patients. METHOD: A 3-month, descriptive, cross-sectional, randomized study in 125 patients seen at the emergency department observation area of a third-level hospital to identify drug-related problems (DRPs). A hospital adaptation of Dader s method was used. RESULTS: A mean of 0.94 DRPs per patient was obtained. Major DRPs (mDRPs) represented 50% of all DRPs; 69.50% of DRPs were avoidable; 44% were moderate, 38% mild, and 18% serious; 54.4% of patients were admitted to hospital, which originated in a mDRP in 25% of cases--this represents 50% of all patients with a mDRP. CONCLUSIONS: A significant portion of patients admitted to the observation area present there as a result of a DRP.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Serviço Hospitalar de Emergência , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
16.
Farm. hosp ; 30(3): 187-192, mayo-jun. 2006. ilus, tab, graf
Artigo em Es | IBECS | ID: ibc-048210

RESUMO

Objetivo: Describir los problemas relacionados con los medicamentosen pacientes ingresados en el área de observación deurgencias y evitabilidad.Método: Estudio descriptivo transversal, aleatorizado en elárea de observación del servicio de urgencias general de un hospitalde tercer nivel durante 3 meses en 125 pacientes para detectarproblemas relacionados con los medicamentos (PRM). Se usó elmétodo Dáder adaptado a hospital.Resultados: Se obtuvo un promedio de 0,94 PRM por paciente.Los PRM principales (PRMp) supusieron el 50% del total dePRM. El 69,50% de los PRM fueron evitables. El 44% moderados,38% leves y 18%, resultaron graves. El 54,4% de los pacientes estudiadosingresaron, de los cuales el 25% fueron originados por unPRMp, esto equivale al 50% de todos los pacientes con PRMp.Conclusiones: Una parte importante de los pacientes queingresan en el área de observación lo hace como consecuencia deun PRM


Objective: The therapeutic armamentarium of developedcountries has experienced a great advance; however, increaseddrug therapy not only provides benefits, as the inappropriate useof drugs results in relevant consequences for patients.Method: A 3-month, descriptive, cross-sectional, randomizedstudy in 125 patients seen at the emergency department observationarea of a third-level hospital to identify drug-related problems(DRPs). A hospital adaptation of Dader's method was used.Results: A mean of 0.94 DRPs per patient was obtained.Major DRPs (mDRPs) represented 50% of all DRPs; 69.50% ofDRPs were avoidable; 44% were moderate, 38% mild, and 18%serious; 54.4% of patients were admitted to hospital, which originatedin a mDRP in 25% of cases - this represents 50% of allpatients with a mDRP.Conclusions: A significant portion of patients admitted to theobservation area present there as a result of a DRP


Assuntos
Humanos , Uso de Medicamentos/estatística & dados numéricos , /epidemiologia , Sistemas de Notificação de Reações Adversas a Medicamentos/organização & administração , Epidemiologia Descritiva , Serviço Hospitalar de Emergência/estatística & dados numéricos
17.
Rev Esp Anestesiol Reanim ; 53(4): 226-36; quiz 236, 260, 2006 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-16711498

RESUMO

Lateral approaches to the sciatic nerve through the popliteal fossa have recently been described as useful for providing adequate anesthesia and postoperative analgesia for foot and ankle surgery. Numerous publications have appeared on the approach in recent years, proposing new anatomical landmarks to facilitate location of the nerve, reduce the rate of complications, and increase the rate of success. When the lateral popliteal approach has been compared to other approaches to the sciatic nerve, similar success rates have been observed. However, when this technique is used certain factors must be borne in mind because they can influence both latency time and success. This review describes the lateral popliteal approach, its main variations, the factors that can affect latency time or success, and the possibility of providing continuous analgesia. We also sought to compare this approach to other techniques for blocking the sciatic nerve.


Assuntos
Bloqueio Nervoso/métodos , Nervo Isquiático , Humanos
20.
Gastroenterol Hepatol ; 22(8): 402-4, 1999 Oct.
Artigo em Espanhol | MEDLINE | ID: mdl-10592674

RESUMO

We present our experience of ultrasound-guided percutaneous drainage with a catheter in 5 splenic abscesses. All the cases were resolved and there was only one relevant complication. The advantages of this treatment compared with surgery and isolated medical treatment are discussed and this technique is proposed as the treatment of choice.


Assuntos
Abscesso/terapia , Drenagem/métodos , Esplenopatias/terapia , Abscesso/diagnóstico por imagem , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Esplenopatias/diagnóstico por imagem , Ultrassonografia
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