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2.
Virus Res ; 244: 71-74, 2018 01 15.
Artigo em Inglês | MEDLINE | ID: mdl-29129607

RESUMO

INTRODUCTION: Several genetic polymorphisms may be related to susceptibility or resistance to viral disease outcomes. Immunological or genetic factors may act as major triggers of the immune pathogenesis of HAM/TSP. This study investigated the association of immune related genetic polymorphisms with viral and immunological markers. METHODS: 247 HTLV-1-infected volunteers, drawn from a larger group of HTLV-infected subjects followed at the Institute of Infectious Diseases "Emilio Ribas" (IIER) for up to 19 years, participated in this study, which ran from June 2011 to July 2016. The subjects were classified according to their neurological status into two groups: Group 1 (160 asymptomatic individuals) and Group 2 (87 HAM/TSP patients). Samples were tested for spontaneous lymphocyte proliferation (LPA) and HTLV-1 proviral load (PVL) and for IFN-λ4, HLA-C and KIR genotypes using qPCR. RESULTS: We found associations between LPA (p=0.0001) with HAM/TSP and confirmed the IFN-λ4 polymorphism rs8099917, allele GG, as a protective factor using a recessive model (OR=3.22, CI=1.10-9.47). Polymorphisms in HLA-C and KIR alleles were not associated with risk of developing HAM/TSP. CONCLUSION: We demonstrated that age, LPA and an IFN-λ4 polymorphism were associated with progression to HAM/TSP. Understanding HAM/TSP pathogenesis can provide important markers of prognostic value for clinical management, and contribute to the discovery of new therapeutic interventions in the future.


Assuntos
Antígenos HLA-C/genética , Infecções por HTLV-I/genética , Vírus Linfotrópico T Tipo 1 Humano/patogenicidade , Interleucinas/genética , Paraparesia Espástica Tropical/genética , Receptores KIR/genética , Adulto , Idoso , Doenças Assintomáticas , Proliferação de Células , Progressão da Doença , Feminino , Expressão Gênica , Antígenos HLA-C/imunologia , Infecções por HTLV-I/diagnóstico , Infecções por HTLV-I/imunologia , Infecções por HTLV-I/patologia , Vírus Linfotrópico T Tipo 1 Humano/imunologia , Humanos , Interleucinas/imunologia , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Modelos Genéticos , Paraparesia Espástica Tropical/diagnóstico , Paraparesia Espástica Tropical/imunologia , Paraparesia Espástica Tropical/patologia , Polimorfismo Genético , Prognóstico , Receptores KIR/imunologia , Índice de Gravidade de Doença , Linfócitos T/imunologia , Linfócitos T/virologia , Fatores de Tempo , Carga Viral
3.
Colomb Med (Cali) ; 48(2): 82-87, 2017 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-28883668

RESUMO

OBJECTIVE: To describe the profile of the practice of physical activity in the daily life of Brazilian adults with arterial hypertension and to analyze whether the practice performed complies with the recommendations of the World Health Organization. METHODS: Cross-sectional data were obtained from the Surveillance System of Risk Factors and Protection for Chronic Noncommunicable Diseases of 2014, involving 40,853 adults aged 18 years and over in all Brazilian capitals, interviewed by telephone survey. RESULTS: Walking, soccer and water aerobics were the main modalities of exercise and sport practiced. The weekly volume of effort led 35% of practitioners to reach the recommended goal of the World Health Organization. The low weekly frequency of activities stood out among hypertensives who did not reach the goal. CONCLUSION: Health services should clarify the need for regularity of physical activity for hypertensive individuals to benefit substantially.


OBJETIVO: Describir el perfil de la actividad física diaria en brasileños adultos con hipertensión arterial y analizar si la actividad practicada cumple con las recomendaciones de la Organización Mundial de la Salud. MÉTODOS: Los datos transversales se obtuvieron del Sistema de Vigilancia de Factores de Riesgo y Protección para Enfermedades Crónicas no Transmisibles de 2014, donde cerca de 40,853 adultos mayores de 18 años fueron entrevistados por la encuesta telefónica. RESULTADOS: La caminata, fútbol y Hidrogimnasia fueron las principales formas de ejercicio y el deporte practicado. Volumen semanal del esfuerzo llevó el 35% de los hipertensos para alcanzar el objetivo AF recomendado por la Organización Mundial de la Salud. La frecuencia reducida de actividades semanales se destacó entre los hipertensos que no alcanzaron el objetivo. CONCLUSIÓN: Los servicios de salud deben hacer explícita la necesidad de la regularidad de la actividad física a hipertensos para su beneficio sustancial.


Assuntos
Exercício Físico/fisiologia , Hipertensão/epidemiologia , Vigilância da População , Adulto , Idoso , Brasil/epidemiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
4.
BMC Public Health ; 14: 333, 2014 Apr 09.
Artigo em Inglês | MEDLINE | ID: mdl-24712381

RESUMO

BACKGROUND: In the last decade, sedentary behavior has emerged as a new risk factor for health. The elderly spend most of their awake time in sedentary activities. Despite this high exposure, the impact of this sedentary behavior on the health of this population has not yet been reviewed. We systematically reviewed evidence for associations between sedentary behavior and multiple health outcomes in adults over 60 years of age. METHODS: We searched the Medline, Embase, Web of Science, SPORTDiscus, PsycINFO, CINAHL, LILLACS, and Sedentary Research Database for observational studies published up to May 2013. Additionally, we contacted members of the Sedentary Behaviour Research Network to identify articles that were potentially eligible. After inclusion, the methodological quality of the evidence was assessed in each study. RESULTS: We included 24 eligible articles in our systematic review, of which only 2 (8%) provided high-quality evidence. Greater sedentary time was related to an increased risk of all-cause mortality in the older adults. Some studies with a moderate quality of evidence indicated a relationship between sedentary behavior and metabolic syndrome, waist circumference, and overweightness/obesity. The findings for other outcomes such as mental health, renal cancer cells, and falls remain insufficient to draw conclusions. CONCLUSION: This systematic review supports the relationship between sedentary behavior and mortality in older adults. Additional studies with high methodological quality are still needed to develop informed guidelines for addressing sedentary behavior in older adults.


Assuntos
Síndrome Metabólica/etiologia , Mortalidade , Sobrepeso/etiologia , Comportamento Sedentário , Idoso , Idoso de 80 Anos ou mais , Biomarcadores/sangue , Feminino , Humanos , Masculino , Saúde Mental , Fatores de Risco
5.
BMC Public Health ; 14: 317, 2014 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-24708760

RESUMO

BACKGROUND: Despite an increasing body of knowledge concerning gender and lifestyle factors as determinants of sickness absence in well-developed countries, the relationship between these variables has not been elucidated in emerging economic power countries, where the burden of non-communicable diseases is particularly high. This study aimed to analyze the relationships among lifestyle-related factors and sick leave and to examine whether gender differences in sickness absence can be explained by differences in socio-demographic, work and lifestyle-related factors among Brazilian workers. METHODS: In this longitudinal study with a one year follow-up among 2.150 employees of a Brazilian airline company, sick leave was the primary outcome of interest. Independent variables collected by interview at enrolment in the study were gender, age, educational level, type of work, stress, and lifestyle-related factors (body mass index, physical activity and smoking). In addition, the risk for coronary heart disease was determined based on measurement of blood pressure, total cholesterol and glucose levels. The total number of days on sick leave during 12 months follow-up was available from the company register. Logistic regression analysis was used to determine the influence of socio-demographic, type of work and lifestyle-related factors on sick leave. RESULTS: Younger employees, those with lower educational level, those who worked as air crew members and those with higher levels of stress were more likely to have sick leave. Body mass index and level of physical activity were not associated with sick leave. After adjustment by socio-demographic variables, increased odds for 10 or more days of sick leave were found in smokers (OR=1.51, CI=1.05-2.17), and ex-smokers (OR=1.45, CI=1.01-2.10). Women were more likely to have 10 or more days of sick leave. Gender differences were reduced mainly when adjusted for type of work (15%) and educational level (7%). CONCLUSIONS: The higher occurrence of sick leave among women than among men was partly explained by type of work and educational level. Our results suggest that type of work, a stressful life, and smoking are important targets for health promotion in this study population.


Assuntos
Absenteísmo , Estilo de Vida , Ocupações , Licença Médica , Fumar , Estresse Psicológico , Trabalho , Adulto , Fatores Etários , Brasil , Escolaridade , Feminino , Humanos , Modelos Logísticos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fatores Sexuais , Adulto Jovem
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