RESUMO
OBJECTIVES: To describe the clinical and epidemiological aspects of post-polio syndrome (PPS) and identify predictors of its severity. MATERIALS AND METHODS: 132 patients with PPS were selected at the Neuromuscular Disease Outpatient Clinic of the Federal University of São Paulo. Descriptive analysis was carried out and predictors of PPS severe forms were investigated using an unconditional logistic regression. RESULTS: The average age at onset was 39.4 years. The most common symptoms were fatigue (87.1%), muscle pain (82.4%) and joint pain (72.0%); 50.4% of the cases were severe. The following were associated with PPS severity: a < or =4-year period of neurological recovery (OR 2.8), permanent damage in two limbs (OR 3.6) and residence at the time of acute polio in a city with more advanced medical assistance (OR 2.5). CONCLUSIONS: Health professionals should carefully evaluate polio survivors for PPS and be aware of the implications of muscle overuse in the neurological recovery period.
Assuntos
Síndrome Pós-Poliomielite/diagnóstico , Síndrome Pós-Poliomielite/epidemiologia , Adulto , Idade de Início , Brasil/epidemiologia , Creatina Quinase/sangue , Avaliação da Deficiência , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Síndrome Pós-Poliomielite/sangue , Prognóstico , Análise de Regressão , Fatores de Risco , Índice de Gravidade de DoençaRESUMO
Embryonic transcription starts about 6 hr postfertilization and increases during the first 72 hr of development. During this stage rRNA is the most abundant transcript, but some premessenger RNAs are also present. At 96 hr of development poly(A+) mRNA starts to be detected concordant with gastrulation movements.
