1.
Enzyme
; 20(4): 221-33, 1975.
Artigo
em Inglês
| MEDLINE
| ID: mdl-1126338
RESUMO
The activities of alkaline phosphatases of kidney and urine appear similar and identical in action. Both are magnesium-dependent and inhibited by higher concentrations of 2-glycerophosphate. A band of similar mobility is obtained on electrophoresis of kidney and urine enzymes. In vitro magnesium competitively inhibits their activities when the ratio of Mg-+2 ions/2-glycerophosphate is above a definite level. Their activities are not affected by exogenous zinc and follow the Michaelis-Menten equation only when attention is given to the ratio of Mg-+2 ions/substrate. Nitrofuranfuradroxyl is a mixed type inhibitor showing a second-order rate of reaction with kidney and urine phosphatases.
Assuntos
Fosfatase Alcalina/metabolismo , Rim/enzimologia , Nitrofuranos/farmacologia , Fosfatase Alcalina/sangue , Fosfatase Alcalina/urina , Animais , Glicerofosfatos/farmacologia , Rim/efeitos dos fármacos , Cinética , Fígado/enzimologia , Magnésio/farmacologia , Especificidade de Órgãos , Ratos , Semicarbazonas/farmacologia
2.
J Chromatogr
; 93(2): 393-8, 1974 Jun 26.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4844342
3.
Acta Histochem
; 45(1): 1-9, 1973.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4352139