RESUMO
The relationship between upper and lower respiratory tract infections has been demonstrated previously, although the effect of chronic infection of one tract on the other has not been well studied. This work analyses the broncho-alveolar lavage fluid of patients with chronic purulent rhino-sinusitis and reveals an increase in total and neutrophil cell counts as well as an increase in immuno-globulin A levels. The associated increase in the neutrophil nitro-blue tetrazolium dye reduction test positivity provides evidence for increased phagocytosis to compensate for the increased contamination of the lower respiratory tract.
Assuntos
Líquido da Lavagem Broncoalveolar/citologia , Rinite/patologia , Sinusite/patologia , Adolescente , Adulto , Doença Crônica , Feminino , Humanos , Imunoglobulina A/análise , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Neutrófilos , Fagocitose , Recidiva , Rinite/imunologia , Sinusite/imunologia , Irrigação TerapêuticaRESUMO
The present study was devoted to assess the humoral and cell mediated immune responsiveness in patients with pulmonary tuberculosis before and after rifampicin therapy. Skin test using PPD and PHA; Rosette forming cells test, serum IgG, M and A; and light chain proteinuria have been tested for 15 newly diagnosed tuberculous patients and 15 normal controls. Rifampicin showed an immunosuppressive effect on both cellular and humoral immune responses as well as by the advent of light chain proteinuria.
