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1.
Expert Opin Pharmacother ; 10(6): 997-1005, 2009 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-19351276

RESUMO

Glucocorticoid-induced osteoporosis is the most common cause of secondary osteoporosis. The role of the Wnt signaling pathway in bone formation and the ratio of receptor activator for NF-kappaB ligand versus osteoprotegerin in bone resorption are exciting new insights. The absolute fracture risk helps both clinicians and patients to interpret the results of bone density measurement, which may have a positive influence on adherence to therapy. The bisphosphonates alendronate and risedronate are the first-line treatment in the prevention of glucocorticoid-induced osteoporosis, because both increase the bone mineral density of the spine and hips and reduce the vertebral fracture rate. Treatment with the anabolic agent parathyroid hormone (1 - 34) strongly stimulates bone turnover, and seems to be superior to treatment with alendronate. It might be attractive for glucocorticoid-treated patients with new vertebral fractures during treatment with bisphosphonates, and/or with severe fracture risk.


Assuntos
Glucocorticoides/efeitos adversos , Osteoporose/induzido quimicamente , Osteoporose/prevenção & controle , Animais , Densidade Óssea/efeitos dos fármacos , Densidade Óssea/fisiologia , Conservadores da Densidade Óssea/farmacologia , Conservadores da Densidade Óssea/uso terapêutico , Fraturas Ósseas/induzido quimicamente , Fraturas Ósseas/prevenção & controle , Humanos , Osteoporose/metabolismo , Transdução de Sinais/efeitos dos fármacos , Transdução de Sinais/fisiologia
2.
Clin Nephrol ; 69(3): 219-20, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18397722

RESUMO

A hemodialysis patient is described who was suffering from headache during his dialysis sessions. This was due to a neovascular glaucoma causing an increase in intraocular pressure (IOP) during dialysis sessions. After several months his headache decreased but his IOP measurements remained high with almost similar pre- and post dialysis values. Headache during hemodialysis may be due to glaucoma, but this can disappear with time, along with a disappearance in the increase in IOP during dialysis sessions.


Assuntos
Glaucoma Neovascular/complicações , Cefaleia/etiologia , Falência Renal Crônica/terapia , Diálise Renal/efeitos adversos , Idoso de 80 Anos ou mais , Seguimentos , Glaucoma Neovascular/fisiopatologia , Humanos , Pressão Intraocular , Falência Renal Crônica/complicações , Masculino , Remissão Espontânea , Fatores de Tempo
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