Thin film high temperature superconducting RF coils for low field MRI.

We have built and tested a thin-film high temperature superconducting (HTS) surface coil for MRI at 0.064T. When placed as close as possible to a conductive sample, the 6.7-cm outer diameter HTS coil had a measured signal-to-noise ratio (SNR) 1.8 times higher than a room temperature copper coil of similar size and location. Our results predict that in some cases, SNR gains of about a factor of 2 can be attained in low-field MRI systems by substituting HTS surface coils for copper coils.

Application of an equivalent circuit to signal-to-noise calculations in MRI.

Transfer functions determined from the component values of an equivalent circuit are used to calculate the relative signal-to-noise ratio of rf coils for magnetic resonance imaging. Experimental verification of the method is obtained by directly measuring signals from three solenoidal coils and by measuring the signal-to-noise ratio of these solenoids. The transfer functions separate the total noise voltage into contributions from the coil resistance and contributions from magnetic and electric field interactions with the sample. The use of this technique in understanding and improving coil design is discussed.

Proton relaxation enhancement by manganese(III)TPPS4 in a model tumor system.

Managanese(III)tetraphenylporphine sulfonate [Mn(III)TPPS4] has been investigated as a tumor specific paramagnetic contrast agent for magnetic resonance imaging (MRI) of L1210 solid tumors in mice. Mn(III)TPPS4 was found to clear rapidly from the blood and concentrate in the kidneys, tumor and liver. Although relatively high ratios of tumor to normal tissues could be obtained (e.g., greater than 90 for tumor/muscle), the kidneys were found to have the highest concentration of the metalloporphyrin at all doses and time periods tested. A significant decrease in the longitudinal relaxation time was measured for excised tissues (kidney, tumor, liver, muscle) from mice that were treated with Mn(III)TPPS4. A linear correlation was observed between the longitudinal relaxation rate determined for L1210 tumor and the corresponding concentration of Mn(III)TPPS4 found at various injected doses and time intervals between the injection and analysis. A small animal radiofrequency receiver coil designed for use with a 0.15-T clinical imager was employed to evaluate the ability of Mn(III)TPPS4 to selectively increase the signal intensity of the implanted L1210 tumor. The images show a conspicuous enhancement in the contrast between the tumor and adjacent tissue upon treatment with this agent. The results indicate that Mn(III)TPPS4 is a useful prototype paramagnetic metalloporphyrin MRI contrast agent with a significant affinity for the L1210 tumor.

Equivalent circuit for coil-patient interactions in magnetic resonance imaging.

An equivalent circuit is presented which accurately models the performance of magnetic resonance imaging receiver coils used with conducting samples. Coil-sample interaction is determined by measuring either the complex impedance or the associated resonant frequency and quality factor when samples of different conductivity are placed in the coil. The equivalent circuit component values are obtained from these data using a global nonlinear least squares fit. This equivalent circuit contains a minimum number of components necessary for understanding and quantifying the detuning and losses caused by electric and magnetic field coupling with the sample.

Small animal imaging with a clinical magnetic resonance imager.

Any clinical whole-body MR imager can be adapted for experimental small animal imaging. The design of an rf receiver coil and an efficient magnified imaging technique are presented. Application of this small animal imaging technique is illustrated using a study of paramagnetic contrast enhancement of a tumor in the mouse.