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1.
Geophys Res Lett ; 49(20): e2022GL098274, 2022 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-36582354

RESUMO

There is a lack of satellite-based aerosol retrievals in the vicinity of low-topped clouds, mainly because reflectance from aerosols is overwhelmed by three-dimensional cloud radiative effects. To account for cloud radiative effects on reflectance observations, we develop a Convolutional Neural Network and retrieve aerosol optical depth (AOD) with 100-500 m horizontal resolution for all cloud-free regions regardless of their distances to clouds. The retrieval uncertainty is 0.01 + 5%AOD, and the mean bias is approximately -2%. In an application to satellite observations, aerosol hygroscopic growth due to humidification near clouds enhances AOD by 100% in regions within 1 km of cloud edges. The humidification effect leads to an overall 55% increase in the clear-sky aerosol direct radiative effect. Although this increase is based on a case study, it highlights the importance of aerosol retrievals in near-cloud regions, and the need to incorporate the humidification effect in radiative forcing estimates.

2.
Water Resour Res ; 58(8): e2022WR031940, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-36249278

RESUMO

Data assimilation (DA) is a powerful tool to optimally combine uncertain model simulations and observations. Among DA techniques, the particle filter (PF) has gained attention for its capacity to deal with nonlinear systems and for its relaxation of the Gaussian assumption. However, the PF may suffer from degeneracy and sample impoverishment. In this study, we propose an innovative approach, based on a tempered particle filter (TPF), aiming at mitigating PFs issues, thus extending over time the assimilation benefits. Probabilistic flood maps derived from synthetic aperture radar data are assimilated into a flood forecasting model through an iterative process including a particle mutation in order to keep diversity within the ensemble. Results show an improvement of the model forecasts accuracy, with respect to the Open Loop: on average the root mean square error (RMSE) of water levels decrease by 80% at the assimilation time and by 60% 2 days after the assimilation. A comparison with the Sequential Importance Sampling (SIS) is carried out showing that although SIS performances are generally comparable to the TPF ones at the assimilation time, they tend to decrease more quickly. For instance, on average TPF-based RMSE are 20% lower compared to the SIS-based ones 2 days after the assimilation. The application of the TPF determines higher critical success index values compared to the SIS. On average the increase in performances lasts for almost 3 days after the assimilation. Our study provides evidence that the application of the variant of the TPF enables more persistent benefits compared to the SIS.

3.
J Geophys Res Atmos ; 127(8): e2021JD036079, 2022 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-35865320

RESUMO

Hurricane Patricia (2015) over the eastern Pacific was a record-breaking tropical cyclone (TC) under a very favorable environment during its rapid intensification (RI) period, which makes it an optimal real case for studying RI dynamics and predictability. In this study, we performed ensemble Kalman filter analyses at Patricia's early development stage using both traditional observations and the Office of Naval Research Tropical Cyclone Intensity (TCI) field campaign data. It is shown that assimilating the inner-core TCI observations produces a stronger initial vortex and significantly improves the prediction of RI. Analysis of observation sensitivity experiments shows that the deep-layer dropsonde observations have high impact on both the primary and secondary circulations for the entire troposphere while the radar observations have the most impact on the primary circulations near aircraft flight level. A wide range of intensification scenarios are obtained through two sets of ensemble forecasts initialized with and without assimilating the TCI data prior to the RI onset. Verification of the ensemble forecasts against the TCI observations during the RI period shows that forecast errors toward later stages can originate from two different error sources at early stages of the vortex structure: One is a timing error from a delayed vortex development such that the TC evolution is the same but shifted in time; the other is due to a totally different storm such that there is no moment in time the simulated storm can obtain a correct TC structure.

4.
J Geophys Res Oceans ; 127(3): e2021JC018025, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35865796

RESUMO

Surface freshening through precipitation can act to stably stratify the upper ocean, forming a rain layer (RL). RLs inhibit subsurface vertical mixing, isolating deeper ocean layers from the atmosphere. This process has been studied using observations and idealized simulations. The present ocean modeling study builds upon this body of work by incorporating spatially resolved and realistic atmospheric forcing. Fine-scale observations of the upper ocean collected during the Dynamics of the Madden-Julian Oscillation field campaign are used to verify the General Ocean Turbulence Model (GOTM). Spatiotemporal characteristics of equatorial Indian Ocean RLs are then investigated by forcing a 2D array of GOTM columns with realistic and well-resolved output from an existing regional atmospheric simulation. RL influence on the ocean-atmosphere system is evaluated through analysis of RL-induced modification to surface fluxes and sea surface temperature (SST). This analysis demonstrates that RLs cool the ocean surface on time scales longer than the associated precipitation event. A second simulation with identical atmospheric forcing to that in the first, but with rainfall set to zero, is performed to investigate the role of rain temperature and salinity stratification in maintaining cold SST anomalies within RLs. Approximately one third, or 0.1°C, of the SST reduction within RLs can be attributed to rain effects, while the remainder is attributed to changes in atmospheric temperature and humidity. The prolonged RL-induced SST anomalies enhance SST gradients that have been shown to favor the initiation of atmospheric convection. These findings encourage continued research of RL feedbacks to the atmosphere.

5.
Q J R Meteorol Soc ; 147(737): 2352-2374, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34262229

RESUMO

A novel particle filter proposed recently, the particle flow filter (PFF), avoids the long-existing weight degeneracy problem in particle filters and, therefore, has great potential to be applied in high-dimensional systems. The PFF adopts the idea of a particle flow, which sequentially pushes the particles from the prior to the posterior distribution, without changing the weight of each particle. The essence of the PFF is that it assumes the particle flow is embedded in a reproducing kernel Hilbert space, so that a practical solution for the particle flow is obtained. The particle flow is independent of the choice of kernel in the limit of an infinite number of particles. Given a finite number of particles, we have found that a scalar kernel fails in high-dimensional and sparsely observed settings. A new matrix-valued kernel is proposed that prevents the collapse of the marginal distribution of observed variables in a high-dimensional system. The performance of the PFF is tested and compared with a well-tuned local ensemble transform Kalman filter (LETKF) using the 1,000-dimensional Lorenz 96 model. It is shown that the PFF is comparable to the LETKF for linear observations, except that explicit covariance inflation is not necessary for the PFF. For nonlinear observations, the PFF outperforms LETKF and is able to capture the multimodal likelihood behavior, demonstrating that the PFF is a viable path to fully nonlinear geophysical data assimilation.

6.
Q J R Meteorol Soc ; 147(734): 573-588, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33867588

RESUMO

Data assimilation is often performed under the perfect model assumption. Although there is an increasing amount of research accounting for model errors in data assimilation, the impact of an incorrect specification of the model errors on the data assimilation results has not been thoroughly assessed. We investigate the effect that an inaccurate time correlation in the model error description can have on data assimilation results, deriving analytical results using a Kalman Smoother for a one-dimensional system. The analytical results are evaluated numerically to generate useful illustrations. For a higher-dimensional system, we use an ensemble Kalman Smoother. Strong dependence on observation density is found. For a single observation at the end of the window, the posterior variance is a concave function of the guessed decorrelation time-scale used in the data assimilation process. This is due to an increasing prior variance with that time-scale, combined with a decreasing tendency from larger observation influence. With an increasing number of observations, the posterior variance decreases with increasing guessed decorrelation time-scale because the prior variance effect becomes less important. On the other hand, the posterior mean-square error has a convex shape as a function of the guessed time-scale with a minimum where the guessed time-scale is equal to the real decorrelation time-scale. With more observations, the impact of the difference between two decorrelation time-scales on the posterior mean-square error reduces. Furthermore, we show that the correct model error decorrelation time-scale can be estimated over several time windows using state augmentation in the ensemble Kalman Smoother. Since model errors are significant and significantly time correlated in real geophysical systems such as the atmosphere, this contribution opens up a next step in improving prediction of these systems.

7.
Geophys Res Lett ; 48(2): e2020GL091236, 2021 Jan 28.
Artigo em Inglês | MEDLINE | ID: mdl-33678926

RESUMO

We introduce new parameterizations for autoconversion and accretion rates that greatly improve representation of the growth processes of warm rain. The new parameterizations capitalize on machine-learning and optimization techniques and are constrained by in situ cloud probe measurements from the recent Atmospheric Radiation Measurement Program field campaign at Azores. The uncertainty in the new estimates of autoconversion and accretion rates is about 15% and 5%, respectively, outperforming existing parameterizations. Our results confirm that cloud and drizzle water content are the most important factors for determining accretion rates. However, for autoconversion, in addition to cloud water content and droplet number concentration, we discovered a key role of drizzle number concentration that is missing in current parameterizations. The robust relation between autoconversion rate and drizzle number concentration is surprising but real, and furthermore supported by theory. Thus, drizzle number concentration should be considered in parameterizations for improved representation of the autoconversion process.

8.
Chaos ; 31(12): 123128, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34972351

RESUMO

Many frameworks exist to infer cause and effect relations in complex nonlinear systems, but a complete theory is lacking. A new framework is presented that is fully nonlinear, provides a complete information theoretic disentanglement of causal processes, allows for nonlinear interactions between causes, identifies the causal strength of missing or unknown processes, and can analyze systems that cannot be represented on directed acyclic graphs. The basic building blocks are information theoretic measures such as (conditional) mutual information and a new concept called certainty that monotonically increases with the information available about the target process. The framework is presented in detail and compared with other existing frameworks, and the treatment of confounders is discussed. While there are systems with structures that the framework cannot disentangle, it is argued that any causal framework that is based on integrated quantities will miss out potentially important information of the underlying probability density functions. The framework is tested on several highly simplified stochastic processes to demonstrate how blocking and gateways are handled and on the chaotic Lorentz 1963 system. We show that the framework provides information on the local dynamics but also reveals information on the larger scale structure of the underlying attractor. Furthermore, by applying it to real observations related to the El-Nino-Southern-Oscillation system, we demonstrate its power and advantage over other methodologies.


Assuntos
Causalidade , Processos Estocásticos
9.
Q J R Meteorol Soc ; 145(723): 2335-2365, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31598012

RESUMO

Particle filters contain the promise of fully nonlinear data assimilation. They have been applied in numerous science areas, including the geosciences, but their application to high-dimensional geoscience systems has been limited due to their inefficiency in high-dimensional systems in standard settings. However, huge progress has been made, and this limitation is disappearing fast due to recent developments in proposal densities, the use of ideas from (optimal) transportation, the use of localization and intelligent adaptive resampling strategies. Furthermore, powerful hybrids between particle filters and ensemble Kalman filters and variational methods have been developed. We present a state-of-the-art discussion of present efforts of developing particle filters for high-dimensional nonlinear geoscience state-estimation problems, with an emphasis on atmospheric and oceanic applications, including many new ideas, derivations and unifications, highlighting hidden connections, including pseudo-code, and generating a valuable tool and guide for the community. Initial experiments show that particle filters can be competitive with present-day methods for numerical weather prediction, suggesting that they will become mainstream soon.

10.
Physiol Meas ; 40(6): 064002, 2019 07 03.
Artigo em Inglês | MEDLINE | ID: mdl-31071684

RESUMO

OBJECTIVE: In fetal diagnosis the myriad and diversity of heart rate variability (HRV) indices prevents a comparable routine evaluation of disturbances in fetal development and well-being. The work aims at the extraction of a small set of HRV key indices that could help to establish a universal, overarching tool to screen for any disturbance. APPROACH: HRV indices were organized in categories of short-term (prefix s) and long-term (prefix l) amplitude fluctuations (AMP), complexity (COMP), and patterns (PATTERN) and common representatives for each category were extracted. This procedure was done with respect to the diagnostic value in the evaluation of the maturation age throughout the second and complete third trimester of pregnancy as well as to potential differences associated with maternal life-style factors (physical exercise, smoking), nutrient intervention (docosahexaenoic acid (DHA) supplementation), and complications of pregnancy (gestational diabetes mellitus (GDM), intra-uterine growth restriction (IUGR)). MAIN RESULTS: We found a comprehensive minimal set that includes [lAMP: short term variation (STV), initially introduced in cardiotocography, sAMP: heart rate increase across one interbeat interval of phase rectified averaged signal - acceleration capacity (ACst1), lCOMP: scale 4 multi-scale entropy (MSE4), PATTERN: skewness] for the maturation age prediction, and partly overlapping [lAMP: STV, sAMP: ACst1, sCOMP: Lempel Ziv complexity (LZC)] for the discrimination of the deviations. SIGNIFICANCE: The minimal set of category-based HRV representatives allows for a screening of fetal development and well-being. These results are an important step towards a universal and comparable diagnostic tool for the early identification of developmental disturbances. Novelty & Significance Fetal development and its disturbances have been reported to be associated with a multiplicity of HRV indices. Furthermore, these HRV indices change with maturation. We propose the abstraction of HRV categories defined by short- and long-term fluctuation amplitude, complexity, and pattern indices that cover all relevant aspects of maturational age, behavioral influences and a series of pathological disturbances. The study data are provided by multiple centers. Our approach is an important step towards the goal of a standardized diagnostic tool for early identification of fetal developmental disturbances with respect to the reduction of serious complications in the later life.


Assuntos
Biomarcadores/metabolismo , Desenvolvimento Fetal/fisiologia , Frequência Cardíaca Fetal/fisiologia , Área Sob a Curva , Feminino , Idade Gestacional , Humanos , Modelos Lineares , Gravidez
11.
Q J R Meteorol Soc ; 144(711): 305-316, 2018 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29937591

RESUMO

Synchronization based state estimation tries to synchronize a model with the true evolution of a system via the observations. In practice, an extra term is added to the model equations which hampers growth of instabilities transversal to the synchronization manifold. Therefore, there is a very close connection between synchronization and data assimilation. Recently, synchronization with time-delayed observations has been proposed, in which observations at future times are used to help synchronize a system that does not synchronize using only present observations, with remarkable successes. Unfortunately, these schemes are limited to small-dimensional problems. In this article, we lift that restriction by proposing an ensemble-based synchronization scheme. Tests were performed using the Lorenz'96 model for 20-, 100- and 1000-dimension systems. Results show global synchronization errors stabilizing at values of at least an order of magnitude lower than the observation errors, suggesting that the scheme is a promising tool to steer model states to the truth. While this framework is not a complete data assimilation method, we develop this methodology as a potential choice for a proposal density in a more comprehensive data assimilation method, like a fully nonlinear particle filter.

12.
IEEE J Biomed Health Inform ; 22(2): 495-502, 2018 03.
Artigo em Inglês | MEDLINE | ID: mdl-28092581

RESUMO

We present a new approach of integrated maximum current density (IMCD) for the noninvasive detection of myocardial infarction (MI) using magnetocardiography (MCG) data acquired from a superconducting quantum interference device (SQUID) system. In this paper, we investigated the relationship of the maximum current density (MCD) in the current density map and the underlying equivalent current dipole (ECD) based on a novel method of reconstructing the ECD in the extremum circle of the magnetic field map. The performance of IMCD and the integrated ECD (IECD) approaches were also evaluated by using 61-channel MCG data from 39 healthy subjects and 102 patients with ST elevation myocardial infarction (STEMI). Statistical analysis of the healthy and STEMI groups demonstrate that the IMCD approach obtains sensitivity and specificity up to 91.2% and 84.6%, somewhat higher than that of IECD, respectively. The results indicate that IMCD provides spatiotemporal information regarding cardiac electrical activity during ventricular repolarization. This approach may be helpful to diagnose MI in clinic application. The physical concept of the approach is also explained in this paper.


Assuntos
Magnetocardiografia/métodos , Infarto do Miocárdio/diagnóstico , Processamento de Sinais Assistido por Computador , Bases de Dados Factuais , Humanos
13.
Q J R Meteorol Soc ; 144(717): 2650-2665, 2018 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30774157

RESUMO

Data assimilation is often performed in a perfect-model scenario, where only errors in initial conditions and observations are considered. Errors in model equations are increasingly being included, but typically using rather adhoc approximations with limited understanding of how these approximations affect the solution and how these approximations interfere with approximations inherent in finite-size ensembles. We provide the first systematic evaluation of the influence of approximations to model errors within a time window of weak-constraint ensemble smoothers. In particular, we study the effects of prescribing temporal correlations in the model errors incorrectly in a Kalman smoother, and in interaction with finite-ensemble-size effects in an ensemble Kalman smoother. For the Kalman smoother we find that an incorrect correlation time-scale for additive model errors can have substantial negative effects on the solutions, and we find that overestimating of the correlation time-scale leads to worse results than underestimating. In the ensemble Kalman smoother case, the resulting ensemble-based space-time gain can be written as the true gain multiplied by two factors, a linear factor containing the errors due to both time-correlation errors and finite ensemble effects, and a nonlinear factor related to the inverse part of the gain. Assuming that both errors are relatively small, we are able to disentangle the contributions from the different approximations. The analysis mean is affected by the time-correlation errors, but also substantially by finite-ensemble effects, which was unexpected. The analysis covariance is affected by both time-correlation errors and an in-breeding term. This first thorough analysis of the influence of time-correlation errors and finite-ensemble-size errors on weak-constraint ensemble smoothers will aid further development of these methods and help to make them robust for e.g. numerical weather prediction.

14.
Q J R Meteorol Soc ; 144(713): 1310-1320, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31031422

RESUMO

A method is presented for estimating the error covariance of the errors in the model equations in observation space. Estimating model errors in this systematic way opens up the possibility to use data assimilation for systematic model improvement at the level of the model equations, which would be a huge step forward. This model error covariance is perhaps the hardest covariance matrix to estimate. It represents how the missing physics and errors in parametrizations manifest themselves at the scales the model can resolve. A new element is that we use an efficient particle filter to avoid the need to estimate the error covariance of the state as well, which most other data assimilation methods do require. Starting from a reasonable first estimate, the method generates new estimates iteratively during the data assimilation run, and the method is shown to converge to the correct model error matrix. We also investigate the influence of the accuracy of the observation error covariance on the estimation of the model error covariance and show that, when the observation errors are known, the model error covariance can be estimated well, but, as expected and perhaps unavoidably, the diagonal elements are estimated too low when the observation errors are estimated too high, and vice versa.

15.
PLoS One ; 12(11): e0186871, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29121090

RESUMO

Motorsport has developed into a professional international competition. However, limited research is available on the perceptual and cognitive skills of racing drivers. By means of a racing simulator, we compared the driving performance of seven racing drivers with ten non-racing drivers. Participants were tasked to drive the fastest possible lap time. Additionally, both groups completed a choice reaction time task and a tracking task. Results from the simulator showed faster lap times, higher steering activity, and a more optimal racing line for the racing drivers than for the non-racing drivers. The non-racing drivers' gaze behavior corresponded to the tangent point model, whereas racing drivers showed a more variable gaze behavior combined with larger head rotations while cornering. Results from the choice reaction time task and tracking task showed no statistically significant difference between the two groups. Our results are consistent with the current consensus in sports sciences in that task-specific differences exist between experts and novices while there are no major differences in general cognitive and motor abilities.


Assuntos
Condução de Veículo , Simulação por Computador , Movimentos Oculares/fisiologia , Esportes , Movimentos da Cabeça , Humanos , Masculino , Atividade Motora , Tempo de Reação
16.
Space Weather ; 15(11): 1490-1510, 2017 11.
Artigo em Inglês | MEDLINE | ID: mdl-29398983

RESUMO

Data assimilation (DA) is used extensively in numerical weather prediction (NWP) to improve forecast skill. Indeed, improvements in forecast skill in NWP models over the past 30 years have directly coincided with improvements in DA schemes. At present, due to data availability and technical challenges, DA is underused in space weather applications, particularly for solar wind prediction. This paper investigates the potential of advanced DA methods currently used in operational NWP centers to improve solar wind prediction. To develop the technical capability, as well as quantify the potential benefit, twin experiments are conducted to assess the performance of the Local Ensemble Transform Kalman Filter (LETKF) in the solar wind model ENLIL. Boundary conditions are provided by the Wang-Sheeley-Arge coronal model and synthetic observations of density, temperature, and momentum generated every 4.5 h at 0.6 AU. While in situ spacecraft observations are unlikely to be routinely available at 0.6 AU, these techniques can be applied to remote sensing of the solar wind, such as with Heliospheric Imagers or interplanetary scintillation. The LETKF can be seen to improve the state at the observation location and advect that improvement toward the Earth, leading to an improvement in forecast skill in near-Earth space for both the observed and unobserved variables. However, sharp gradients caused by the analysis of a single observation in space resulted in artificial wavelike structures being advected toward Earth. This paper is the first attempt to apply DA to solar wind prediction and provides the first in-depth analysis of the challenges and potential solutions.

17.
Rev. bras. crescimento desenvolv. hum ; 26(2): 162-173, 2016. graf, tab
Artigo em Inglês | LILACS | ID: lil-797807

RESUMO

INTRODUCTION: Fetal heart rate and its variability during the course of gestation have been extensively researched. The overall reduction in heart rate and increase in fetal HRV is associated with fetal growth and the increase in neural integration. The increased complexity of the demands on the cardiovascular system leads to more variation in the temporal course of the heart rate which has been shown to be reflected in measures of complexity. The aim of this work was to investigate novel complexity measures with respect to their ability to quantify changes over gestational age in individual fetuses consistently and in a stable manner. METHODS: We examined 215 fetal magnetocardiograms (FMCG), each of 5 min duration, in 11 fetuses during the second and third trimesters (at least 10 data sets per fetus). From the FMCG we determined the fetal RR beat durations. For each 5 min time-series of RR intervals we then calculated Shannon entropy, high spectral entropy, high spectral Detrended Fluctuation Analysis, spectral Multi-Taper Method as well as the standard deviation and two commonly used complexity measures: Approximate Entropy and Sample Entropy. For each subject and HRV measure, we performed regression analysis with respect to gestational age. The coefficient of determination R² was used to estimate 'goodness-of-fit', the slope of the regression indicated the strength of the individual dependency on gestational age. RESULTS: We found that the new complexity measures do not outperform ApEn. CONCLUSION: This study has now rejected the hypothesis that the spectral complexity measures outperform those applied previously.


INTRODUÇÃO: A freqüência cardíaca fetal e da sua variabilidade durante o curso da gestação têm sido extensivamente pesquisada. A redução global da frequência cardíaca e aumento da VFC fetal está associada com o crescimento fetal e aumento da integração neural. O aumento da complexidade das exigências sobre o sistema cardiovascular conduz a uma maior variação no decurso temporal da frequência cardíaca o que foi mostrado para reflectir-se medidas de complexidade. O objetivo deste trabalho foi investigar medidas de complexidade novos em relação à sua capacidade de quantificar as mudanças ao longo da idade gestacional em fetos individuais de forma consistente e de forma estável. MÉTODO: Foram examinados 215 magnetocardiograms fetais (FMCG), cada um dos 5 min de duração, em 11 fetos durante o segundo e terceiro trimestres (pelo menos 10 conjuntos de dados por feto). A partir do grande consumo determinamos as durações RR batimento fetais. Para cada série temporal 5 min dos intervalos RR então calculada Shannon entropia, alta entropia espectral, alta espectral Destendenciada Análise Flutuação, espectral Multi-Taper Método, bem como o desvio padrão e duas medidas de complexidade comumente utilizados: aproximado Entropia e Amostra Entropia. Para cada medida assunto e HRV, foi realizada análise de regressão em relação à idade gestacional. O coeficiente de determinação R² foi usada para estimar a "o bem-of-fit", a inclinação da regressão indicou a força do indivíduo dependência da idade gestacional. RESULTADOS: Verificou-se que as novas medidas de complexidade não superar ApEn. CONCLUSÃO: Este estudo agora rejeitou a hipótese de que as medidas de complexidade espectrais superar os aplicados anteriormente.


Assuntos
Humanos , Masculino , Feminino , Sistema Cardiovascular , Entropia , Desenvolvimento Fetal , Feto , Idade Gestacional , Frequência Cardíaca Fetal , Gravidez
18.
Physiol Meas ; 36(11): 2369-78, 2015 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-26489779

RESUMO

With the objective of evaluating the functional maturation age and developmental disturbances we have previously introduced the fetal autonomic brain age score (fABAS) using 30 min fetal magnetocardiographic recordings (fMCG, Jena). The score is based on heart rate pattern indices that are related to universal principles of developmental biology. The present work aims at the validation of the fABAS methodology on 5 min recordings from an independent database (fMCG, Bochum).We found high agreement of fABAS obtained from Jena normal fetuses (5 min subsets, n = 364) and Bochum recordings (n = 322, normal fetuses). fABAS of 48 recordings from fetuses with intra-uterine growth restriction (IUGR, Bochum) was reduced in most of the cases, a result consistent with IUGR fetuses from Jena previously reported. fABAS calculated from 5 min snapshots only partly covers the accuracy when compared to fABAS from 30 min recordings. More precise diagnosis requires longer recordings.fABAS obtained from fMCG recordings is a strong candidate for standardized assessment of functional maturation age and developmental disturbances. Even 5 min recordings seem to be valuable for screening for maturation problems.


Assuntos
Envelhecimento/fisiologia , Sistema Nervoso Autônomo/fisiologia , Encéfalo/fisiologia , Feto/fisiologia , Magnetocardiografia , Humanos , Fatores de Tempo
19.
Physiol Meas ; 36(4): 643-57, 2015 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-25798889

RESUMO

Traditional measures of heart rate variability (HRV) in the time or frequency domain (e.g. standard deviation of normal-to-normal intervals, SDNN, or the high frequency component of spectral analysis, HF) may be used to track vagal and sympathetic modulation directed to the sinus node. In this study, we assess the ability of symbolic analysis to monitor cardiac autonomic regulation during two autonomic challenges (phenylephrine and nitroprusside; low and high dose of atropine). To assess the effect of the coarse graining procedure, symbolic series obtained from four different transformations over the original series and the series of successive differences of the original values. The analysis focused on patterns of length 3 and exploited a redundancy reduction strategy to group patterns into a small number of families. It turns out that each symbolic series created by the four transformations still contained sufficient dynamical features to quantify differences of cardiovascular changes during the pharmacological challenges. The symbolic series created by transformations of the beat-to-beat interview, i.e RR interval series, showed that patterns without variations (0V) appear more often during a high dose of atropine compared to rest or to a low dose of atropine. Furthermore, patterns with two unlike variations (2UV) appear more often during a low dose of atropine and less often during a high dose of atropine. Differences of nitroprusside and phenylephrine could also be assessed by patterns with these variations. In conclusion, the changes of cardiovascular regulation during pharmacological challenges can be assessed by the analysis of symbolic dynamics derived from the RR interval series independently of the specific symbolic transformation.


Assuntos
Sistema Nervoso Autônomo/fisiologia , Frequência Cardíaca/fisiologia , Coração/fisiologia , Atropina/farmacologia , Sistema Nervoso Autônomo/efeitos dos fármacos , Relação Dose-Resposta a Droga , Eletrocardiografia , Coração/efeitos dos fármacos , Frequência Cardíaca/efeitos dos fármacos , Humanos , Modelos Cardiovasculares , Nitroprussiato/farmacologia , Parassimpatolíticos/farmacologia , Fenilefrina/farmacologia , Descanso , Processamento de Sinais Assistido por Computador , Vasoconstritores/farmacologia , Vasodilatadores/farmacologia
20.
Front Physiol ; 6: 71, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25806002

RESUMO

Two diverse complexity metrics quantifying time irreversibility and local prediction, in connection with a surrogate data approach, were utilized to detect nonlinear dynamics in short heart period (HP) variability series recorded in fetuses, as a function of the gestational period, and in healthy humans, as a function of the magnitude of the orthostatic challenge. The metrics indicated the presence of two distinct types of nonlinear HP dynamics characterized by diverse ranges of time scales. These findings stress the need to render more specific the analysis of nonlinear components of HP dynamics by accounting for different temporal scales.

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