Assuntos
Anticorpos Monoclonais/efeitos adversos , Leucoencefalopatia Multifocal Progressiva/induzido quimicamente , Leucoencefalopatia Multifocal Progressiva/patologia , Esclerose Múltipla/tratamento farmacológico , Esclerose Múltipla/patologia , Adulto , Anticorpos Monoclonais Humanizados , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Imageamento por Ressonância Magnética/normas , Natalizumab , Fatores de Tempo , Resultado do TratamentoRESUMO
An 80-year-old woman with a history of familial primary generalised epilepsy presented to the outpatient clinic with complaints of dizziness, confusion, dullness and feeling of'being worthless'. It turned out that she had been using medication for some time in which the chemical nature of the pharmacologically active ingredient had been changed: methylphenobarbital 60 mg t.i.d. had been replaced by phenobarbital 60 mg t.i.d. The resultant phenobarbital concentration was much higher than the concentration to which she was accustomed. At the same dosage, phenobarbital is more active than methylphenobarbital. When one compound ofa pharmacologically active substance is replaced by a different compound, the dosage should be corrected for both the chemical structure, such as the molecular weight, and the pharmacokinetic properties such as absorption, metabolism and biological availability.
Assuntos
Anticonvulsivantes/efeitos adversos , Anticonvulsivantes/metabolismo , Mefobarbital/metabolismo , Fenobarbital/efeitos adversos , Fenobarbital/metabolismo , Idoso de 80 Anos ou mais , Disponibilidade Biológica , Feminino , Humanos , Absorção Intestinal , Mefobarbital/administração & dosagem , Mefobarbital/efeitos adversosRESUMO
Spinal cord infarction is a rare complication of bacterial meningitis and is, therefore, generally unknown. We describe a patient who developed a flaccid paraparesis 2 weeks after being diagnosed with meningococcal meningitis. The etiology of spinal cord infarction is multifactorial, but vascular mechanisms and coagulation abnormalities play an important role. Epidural hemorrhage and spinal abscess should be considered in the differential diagnosis.