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1.
Eur J Epidemiol ; 19(10): 915-21, 2004.
Artigo em Inglês | MEDLINE | ID: mdl-15575349

RESUMO

BACKGROUND: Endothelial cell dysfunction may be related to an increase in cellular oxidative stress. Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis. METHODS: We measured serum carotenoids, alpha-tocopherol and Vitamin C concentrations in 379 subjects sampled from the general population. High-sensitive C-reactive protein (CRP), fibrinogen (Fbg) and leukocytes were measured as markers of inflammation. Furthermore, soluble intercellular adhesion molecule-1 (sICAM-1) and flow-mediated vasodilation (FMD; n= 165) were measured as markers of endothelial function. Relationships between serum carotenoids and vitamins and markers of endothelial function and inflammation were analysed after adjustment for confounding. RESULTS: In the total study group, lutein and lycopene were inversely related to sICAM-1 with regression-coefficients of -0.38+/-0.19 (p = 0.04) and -0.16+/-0.08 (p = 0.04) per 1 micromol/l, respectively. beta-Carotene was inverse related to leukocytes (-0.23+/-0.07; p = 0.007) and CRP (-1.09+/-0.30; p = 0.0003) per 1 micromol/l. Vitamin C was inverse related to CRP (-0.01+/-0.005; p = 0.04) per 1 micromol/l, whereas alpha-tocopherol was positively related to CRP (0.03+/-0.01; p = 0.02) per 1 micro/l. Zeaxanthin was inversely related to FMD (31.2+/-15.3; p = 0.04) per 1 micromol/l. CONCLUSION: The inverse relations between carotenoids, Vitamin C and sICAM-1, CRP and leukocytes may help to explain the possible protective effect of carotenoids and Vitamin C on atherosclerosis through an influence on inflammatory processes and endothelial function.


Assuntos
Carotenoides/sangue , Endotélio Vascular/fisiopatologia , beta Caroteno/análogos & derivados , Adulto , Ácido Ascórbico/sangue , Biomarcadores/sangue , Proteína C-Reativa/análise , Estudos Transversais , Criptoxantinas , Feminino , Fibrinogênio/análise , Humanos , Molécula 1 de Adesão Intercelular/sangue , Licopeno , Masculino , Pessoa de Meia-Idade , Fumar/sangue , Vasodilatação/fisiologia , Xantofilas , alfa-Tocoferol/sangue , beta Caroteno/sangue
2.
J Nutr ; 133(3): 720-6, 2003 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-12612143

RESUMO

Excessive consumption of energy and fat increases the risk for obesity. Snacks containing sucrose polyesters (SPE) as a dietary fat replacer are on the market in the United States. SPE products have been shown to lower concentrations of serum carotenoids in short-term studies. Experimental studies on the longer-term effects on health of decreased carotenoid concentrations are lacking. A 1-y randomized, double-blind, placebo-controlled parallel trial was performed. Subjects (n = 380) with a habitual low or high fruit and vegetable intake were assigned to the treatments (0, 7, 10 or 17 g/d SPE). SPE was given in the form of spreads, chips or both. The groups were compared for serum carotenoids, vitamins and markers of oxidative damage, eye health, cardiovascular health and immune status. After 1 y, serum lipid-adjusted carotenoids showed the largest decrease in the SPE chips and spread group (17 g/d) compared with the control group [alpha-carotene 33%; beta-carotene 31%, lycopene 24%, beta-cryptoxanthin 18%, lutein 18% (all P < 0.001) and zeaxanthin 13% (P < 0.05)]. Consumption of SPE spread (10 g/d SPE) decreased carotenoid concentrations by 11-29% (all P < 0.05). SPE chips (7 g/d SPE) decreased zeaxanthin (11%), beta-carotene (12%) and alpha-carotene (21%; all P < 0.05). Serum lipid adjusted alpha-tocopherol decreased significantly by 6-8% (all P < 0.001) in all SPE groups. No negative effects were observed on markers of oxidation, eye health, cardiovascular health or immune status. This study shows that decreases in serum carotenoid concentrations do not affect possible markers of disease risk.


Assuntos
Carotenoides/sangue , Gorduras Insaturadas na Dieta/efeitos adversos , Ácidos Graxos/efeitos adversos , Nível de Saúde , Sacarose/análogos & derivados , Sacarose/efeitos adversos , beta Caroteno/análogos & derivados , Adolescente , Adulto , Idoso , Peso Corporal , Doenças Cardiovasculares/diagnóstico , Gorduras Insaturadas na Dieta/administração & dosagem , Método Duplo-Cego , Endotélio Vascular/fisiologia , Oftalmopatias/diagnóstico , Ácidos Graxos/administração & dosagem , Feminino , Humanos , Imunidade , Peroxidação de Lipídeos , Lipídeos/sangue , Macula Lutea/anatomia & histologia , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Placebos , Fatores de Risco , Sacarose/administração & dosagem , Xantofilas , Zeaxantinas , alfa-Tocoferol/sangue , beta Caroteno/sangue
3.
Arch Ophthalmol ; 120(12): 1732-7, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12470150

RESUMO

OBJECTIVE: To investigate whether nutritional factors and possible risk factors for cataract influence the lens optical density (LOD). DESIGN: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for lutein, zeaxanthin, vitamin C, alpha-tocopherol, and cholesterol levels. Adipose tissue (n = 187) was analyzed for lutein level. The LOD and the macular pigment optical density (MPOD) were measured by spectral fundus reflectance. RESULTS: The mean +/- SD LOD at 420 nm was 0.52 +/- 0.17. It showed a significant association with age (beta =.008, P<001) and MPOD (beta = -.096, P =.02). For subjects 50 years and younger (mean +/- SD LOD, 0.45 +/- 0.11), we found only a single significant beta coefficient, for age (beta =.006, P<.001). For subjects older than 50 years (mean +/- SD LOD, 0.68 +/- 0.16), we found significant beta coefficients for age (beta =.011, P<.001) and MPOD (beta = -.240, P =.005). Controlling for age, we found no associations between LOD and other possible risk factors for age-related cataract or serum or adipose tissue concentrations of carotenoids, vitamin C, and alpha-tocopherol. CONCLUSIONS: Macular pigment is composed of lutein and zeaxanthin, the only carotenoids found in human lenses. The inverse relationship between LOD and MPOD suggests that lutein and zeaxanthin may retard aging of the lens.


Assuntos
Envelhecimento/fisiologia , Catarata/metabolismo , Cristalino/fisiologia , Estado Nutricional/fisiologia , beta Caroteno/análogos & derivados , Tecido Adiposo/metabolismo , Adolescente , Adulto , Idoso , Ácido Ascórbico/sangue , Catarata/epidemiologia , Colesterol/sangue , Estudos Transversais , Feminino , Humanos , Luteína/sangue , Masculino , Pessoa de Meia-Idade , Pigmentos da Retina/metabolismo , Fatores de Risco , Xantofilas , Zeaxantinas , alfa-Tocoferol/sangue , beta Caroteno/sangue
4.
Am J Clin Nutr ; 76(3): 595-603, 2002 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-12198005

RESUMO

BACKGROUND: Macular pigment (MP), concentrated in the central area of the retina, contains the carotenoids lutein and zeaxanthin. A low MP density could be a risk factor for age-related macular degeneration. Little information is available regarding MP density in relation to serum lutein and zeaxanthin and adipose lutein concentrations in a general population. OBJECTIVE: The objective was to investigate the associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein, taking into account potential confounders in a population. DESIGN: Volunteers (n = 376) aged 18-75 y were recruited. In a cross-sectional design, serum (n = 376) and adipose tissue (n = 187) were analyzed for carotenoids, and MP density was measured by spectral fundus reflectance. RESULTS: Mean MP density in the total study group was 0.33 +/- 0.15. MP density was 13% higher in men than in women (P < 0.05). Serum and blood concentrations of alpha-tocopherol, vitamin C, and all carotenoids except lycopene were significantly higher in women. Adipose lutein concentrations were also significantly higher in women than in men. Regression models showed a positive significant association between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations in men after adjustment for age, but no relation in women. In men, serum lutein remained significantly associated with MP density after adjustment for age, total cholesterol, body mass index, and smoking. CONCLUSION: The associations between MP density and serum lutein, serum zeaxanthin, and adipose lutein concentrations are stronger in men than in women.


Assuntos
Tecido Adiposo/química , Luteína/análise , Luteína/sangue , Macula Lutea/química , Pigmentos da Retina/análise , beta Caroteno/sangue , Adolescente , Adulto , Idoso , Ácido Ascórbico/sangue , Índice de Massa Corporal , Carotenoides/sangue , Colesterol/sangue , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Feminino , Humanos , Licopeno , Masculino , Pessoa de Meia-Idade , Análise de Regressão , Caracteres Sexuais , Fumar , Xantofilas , Zeaxantinas , alfa-Tocoferol/sangue , beta Caroteno/análogos & derivados
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