RESUMO
The main clinical signs of three dogs with Zollinger-Ellison syndrome were vomiting, diarrhoea, poor appetite and weight loss. The diagnosis was confirmed by histological examination and by gastrin immunocytochemistry. Gastrin was extracted from pancreatic tumours of two dogs. Gastrin-component III predominated in one dog while gastrin-component II and gastrin-component III were demonstrated in almost equal amounts in the other dog. In one dog serum gastrin concentration was high. Postmortem examination revealed pancreatic tumours in all three dogs and metastases in the regional lymph nodes and liver in two. The pancreatic tumours contained three patterns of growth: solid, trabecular and acinar. Electron microscopy of liver metastases showed cells with secretory granules. In all three dogs there was an erosive oesophagitis and thick gastric mucosa caused mainly by glandular proliferation. Two dogs had erosions and ulcers in the duodenum, one also in the first part of the jejunum. Villous atrophy and cellular infiltration of the duodenal mucosa were found in all dogs.
Assuntos
Doenças do Cão/patologia , Síndrome de Zollinger-Ellison/veterinária , Adenoma de Células das Ilhotas Pancreáticas/patologia , Adenoma de Células das Ilhotas Pancreáticas/veterinária , Animais , Doenças do Cão/metabolismo , Cães , Esôfago/patologia , Feminino , Gastrinas/metabolismo , Intestinos/patologia , Masculino , Neoplasias Pancreáticas/veterinária , Estômago/patologia , Síndrome de Zollinger-Ellison/metabolismo , Síndrome de Zollinger-Ellison/patologiaRESUMO
Esophageal carcinomas in two cats are described. The main clinical sign was regurgitation of food and fluids. Radiographic examination revealed severe esophageal abnormalities in both cats. In the second cat, the radiographic appearance of the esophagus together with the esophagoscopic findings provided a presumptive diagnosis of neoplasia. Histologic examination in both cats revealed squamous cell carcinoma with metastases.
Assuntos
Carcinoma de Células Escamosas/veterinária , Doenças do Gato/diagnóstico , Neoplasias Esofágicas/veterinária , Animais , Carcinoma de Células Escamosas/diagnóstico , Carcinoma de Células Escamosas/patologia , Doenças do Gato/patologia , Gatos , Neoplasias Esofágicas/diagnóstico , Neoplasias Esofágicas/patologia , MasculinoRESUMO
Case reports of a paraesophageal hiatal hernia in a French bulldog and an invagination of the stomach into the esophagus in a cheetah are presented. In both cases there was an enlarged hiatus and in the cheetah the hiatus was clearly bounded by a muscular loop. Treatment consisted of surgical narrowing of the hiatus. The pathophysiology of hiatal hernia is discussed with reference to experimental studies in dogs.
