Assuntos
Pressão Sanguínea/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Extratos Vegetais/farmacologia , Desempenho Psicomotor/efeitos dos fármacos , Adulto , Método Duplo-Cego , Medicamentos de Ervas Chinesas/efeitos adversos , Etanol/sangue , Etanol/farmacologia , Feminino , Frequência Cardíaca/efeitos dos fármacos , Humanos , Masculino , Medição da Dor , Projetos PilotoRESUMO
Dantrolene plasma concentrations and renal clearance calculations in a patient undergoing major surgery are reported. The family history was positive for malignant hyperthermia. Following oral pretreatment the plasma concentrations in this patient were not noticeably different from values obtained in a study in awake volunteers and which were thought to be effective. This is the first report of dantrolene measurements made during anaesthesia and in the post-operative period.
Assuntos
Dantroleno/metabolismo , Hipertermia Maligna/tratamento farmacológico , Administração Oral , Anestesia , Creatinina/urina , Dantroleno/uso terapêutico , Feminino , Humanos , Pessoa de Meia-IdadeRESUMO
A reversed-phase high-performance liquid chromatographic method for the determination of the skeletal muscle relaxant baclofen in human plasma and urine is described. Cation-exchange extraction, precolumn derivatization with o-phthaldialdehyde, and on-column concentration precede fluorimetric detection (excitation at 340 nm, emission at 460 nm). The precision of the assay was always better than 6%. Recoveries of standards added to plasma and urine were 92% and 93%, respectively. With a sample size of 0.5 ml, a detection limit of a few nanograms, and the possibility of analysing up to four samples per hour, this method is suitable for pharmacokinetic studies. An example is presented.
Assuntos
Baclofeno/análise , Adulto , Baclofeno/sangue , Baclofeno/urina , Cromatografia Líquida de Alta Pressão , Cromatografia por Troca Iônica , Feminino , Humanos , Cinética , o-FtalaldeídoRESUMO
A reversed-phase high-performance liquid chromatographic method is described for the simultaneous determination of the skeletal muscle relaxant dantrolene and its metabolites, 5-hydroxydantrolene and nitro-reduced acetylated dantrolene (F-490), in plasma and urine of man and dog. The substances are detected spectrophotometrically at 375 nm. The detection limits are 0.02 mg/l. A preliminary extraction step into a choloroform-butanol mixture is required for the plasma samples. The method is suitable for pharmacokinetic studies of dantrolene.
Assuntos
Dantroleno/análogos & derivados , Dantroleno/análise , Animais , Cromatografia Líquida de Alta Pressão , Dantroleno/sangue , Dantroleno/urina , Cães , Humanos , MasculinoRESUMO
Plasma concentration-time curves are described for the intravenous infusion and portal vein infusion of the quaternary ammonium compound thiazinamium methylsulfate to dogs. Comparison of areas under the curve indicate that hepatic first-pass elimination occurred on the order of 25--50%.
