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Int J Numer Method Biomed Eng ; 30(2): 180-203, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24023005

RESUMO

We present unconditionally energy-stable second-order time-accurate schemes for diffuse-interface (phase-field) models; in particular, we consider the Cahn-Hilliard equation and a diffuse-interface tumor-growth system consisting of a reactive Cahn-Hilliard equation and a reaction-diffusion equation. The schemes are of the Crank-Nicolson type with a new convex-concave splitting of the free energy and an artificial-diffusivity stabilization. The case of nonconstant mobility is treated using extrapolation. For the tumor-growth system, a semi-implicit treatment of the reactive terms and additional stabilization are discussed. For suitable free energies, all schemes are linear. We present numerical examples that verify the second-order accuracy, unconditional energy-stability, and superiority compared with their first-order accurate variants.


Assuntos
Modelos Teóricos , Neoplasias/metabolismo , Algoritmos , Simulação por Computador , Humanos
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