1.
Int J Pept Protein Res
; 29(3): 318-30, 1987 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3110081
RESUMO
The active sequence Phe7-D-Trp8-Lys9-Thr10 of somatostatin has been cyclized through o-(aminomethyl)phenylacetic acid, a spacer molecule, designed to mimic a Gly-Gly dipeptide containing a cis-constrained peptide bond. The resulting analogue shows no GH-inhibition. A 2D n.m.r. study reveals conformations different from the proposed bio-active one and still sensitive to the medium (solvent).