Assuntos
Imunossupressores/uso terapêutico , Transplante de Rim/imunologia , Proteínas Recombinantes de Fusão , Imunologia de Transplantes , Anticorpos Monoclonais/uso terapêutico , Anticorpos Monoclonais Humanizados , Basiliximab , Ensaios Clínicos como Assunto , Daclizumabe , Quimioterapia Combinada , Sobrevivência de Enxerto , Humanos , Imunoglobulina G/uso terapêutico , Transplante de Rim/mortalidade , Transplante de Rim/fisiologia , Estudos Multicêntricos como Assunto , Sirolimo/uso terapêutico , Taxa de SobrevidaAssuntos
Diabetes Mellitus/epidemiologia , Imunossupressores/uso terapêutico , Transplante de Rim/imunologia , Complicações Pós-Operatórias , Tacrolimo/uso terapêutico , Adulto , Glicemia/metabolismo , Monitoramento de Medicamentos , Feminino , Humanos , Hiperglicemia/epidemiologia , Imunossupressores/efeitos adversos , Imunossupressores/sangue , Masculino , Pessoa de Meia-Idade , Reoperação , Estudos Retrospectivos , Tacrolimo/efeitos adversos , Tacrolimo/sangueAssuntos
Imunossupressores/uso terapêutico , Transplante de Rim/fisiologia , Ácido Micofenólico/análogos & derivados , Adulto , Azatioprina/efeitos adversos , Pressão Sanguínea/efeitos dos fármacos , Ciclosporina/efeitos adversos , Quimioterapia Combinada , Feminino , Seguimentos , Humanos , Transplante de Rim/imunologia , Masculino , Ácido Micofenólico/uso terapêutico , Estudos Retrospectivos , Fatores de Tempo , Falha de TratamentoRESUMO
Intrastromal ring (ISR) implantation is a promising concept in refractive corneal surgery. In theory, it has two main advantages: eccentric corneal surgery and reversibility after ISR explanation. We present our first experimental data on histobiocompatibility after implantation of a 0.2/1.0 mm vaulted polymethylmethacrylate (PMMA) ISR of 7.5 mm diameter with a specially designed "puzzle lock" using a suction-guided stromal channelling device. Ninety-six rabbit eyes were implanted and enucleated after a 24-h to 8-month follow-up to be period and processed for histology (n = 51), scanning electron microscopy (n = 30) and transmission electron microscopy (n = 9). In this study, the histological data are reported. Two main histopathological phases of stromal reaction were observed: (1) up to 3 months: mild inflammation, mostly mononuclear cell reaction with some macrophages; (2) over 3 months: moderate fibrosis surrounding the ISR filling irregularities of the stromal channel. Mild scarring and rare circumscribed vascularization occurred at the sutured peripheral insertion site of the ISR. Persistent epithelial atrophy without erosion or ulceration was regularly observed over the bulging shoulder of the ISR. There was no significant endothelial surgical trauma due to ISR placement. Major complications occurred in 11 cases (11.5%): stromal abscess starting from the incision (n = 8) and massive neovascularization (n = 3). However, the incidence of complications regressed with improved surgical technique. In conclusion, there is good middle-term tolerance of the PMMA ring with a transparent central cornea.