Assuntos
Doenças dos Cavalos/diagnóstico , Hidrocefalia/veterinária , Imageamento por Ressonância Magnética/veterinária , Animais , Animais Recém-Nascidos , Autopsia/veterinária , Encéfalo/patologia , Diagnóstico Diferencial , Feminino , Doenças dos Cavalos/diagnóstico por imagem , Cavalos , Hidrocefalia/diagnóstico , Hidrocefalia/diagnóstico por imagem , Hipóxia-Isquemia Encefálica/diagnóstico , Hipóxia-Isquemia Encefálica/veterinária , Exame Neurológico/veterinária , Crânio/diagnóstico por imagem , Crânio/patologia , Tomografia Computadorizada por Raios X/veterináriaRESUMO
OBJECTIVES: Investigation of the efficacy of zonisamide as an add-on therapy in dogs with refractory epilepsy. METHODS: Thirteen dogs fulfilled the inclusion criteria of poor seizure control despite adequate serum levels of phenobarbital, potassium bromide or both. One further dog was treated with zonisamide as monotherapy because of severe blood dyscrasia due to phenobarbital treatment. Various seizure parameters were evaluated retrospectively for a four month period without zonisamide and prospectively for the same time period under zonisamide add-on therapy. The study time period was extended by up to 17 months to evaluate long-term outcome. RESULTS: Data of 11 dogs could be evaluated: nine of them were responders. The median reduction of seizure frequency of all dogs on zonisamide add-on therapy was 70 per cent (range 14 to 100 per cent). Only transient central nervous system side effects were reported. No further increase of liver enzymes occurred. In three of the responder dogs, seizure control subsided after individual time periods (between 69 days and seven months). CLINICAL SIGNIFICANCE: In dogs with refractory epilepsy, zonisamide may have a beneficial effect on seizure control. In three responder dogs, seizure activity relapsed possibly because of an induction of tolerance. Limiting factors are the high costs.
Assuntos
Anticonvulsivantes/uso terapêutico , Doenças do Cão/tratamento farmacológico , Epilepsia/veterinária , Isoxazóis/uso terapêutico , Administração Oral , Animais , Anticonvulsivantes/administração & dosagem , Doenças do Cão/patologia , Cães , Epilepsia/tratamento farmacológico , Isoxazóis/administração & dosagem , Estudos Prospectivos , Resultado do Tratamento , ZonisamidaRESUMO
A case of chronic inflammatory demyelinating polyradiculoneuropathy in a Magyar Vizsla dame, 7 months of age, is described. The neurological deficits such as movement disorders, hyporeflexia and muscle atrophy, were limited to the front legs. The hypertrophied cervico-thoracal nerve roots could be shown by magnetic resonance imaging. The diagnosis was additionally based on clinical findings, the relapsing course, the good response to therapy with prednisolone, the results of electrodiagnostic workup and muscle and nerve biopsy.
