[Computed tomography and conventional x-ray diagnosis of interstitial lung diseases]. / Computertomographie und konventionelle Röntgendiagnostik bei interstitiellen Lungenerkrankungen.

One hundred and sixty-four patients with pulmonary fibrosis were examined by CT and by conventional radiological methods. Sixty patients had asbestosis, thirty-nine silicosis, forty sarcoidosis and twenty-five had idiopathic pulmonary fibrosis. CT is superior to conventional radiography in evaluating interstitial pulmonary changes, particularly of the pleura and the lung parenchyma. Areas of fibrosis and of emphysema can be demonstrated without any overlap. In sixty-nine patients there were some findings which could only be demonstrated by CT. In asbestosis, silicosis and sarcoidosis the CT classification of the lung parenchyma which we have suggested produces significantly better correlation with vital capacity than can be achieved from conventional chest films, according to the guide-lines of the I.L.O.

[Computed tomographic studies of fracture healing]. / Computertomographische Untersuchungen der Frakturheilung.

The CT appearances of healing fractures were studied following tibial osteotomy in a dog. Traditional radiological investigations and CT were carried out until healing was complete; CT showed callus on the ninth day, whereas radiographs only showed it after 19 days. After 32 days, callus filled nearly the entire medullary cavity. Similar observations were made in several human situations. CT demonstrates interposed material in the fracture very clearly, even if there is marked callus formation within the fracture.

The influence of molsidomine on myocardial ischemia and ventricular dynamics. An in-vivo study in anesthetized dogs by means of computer tomography.

In six anesthetized dogs with myocardium partially damaged by ischemia (LAD occlusion), the effect of an i.v. bolus injection of 0.05 mg molsidomine/kg body weight followed by a 6-h i.v. infusion of 0.5 micrograms molsidomine/kg/min on the volume of myocardial ischemia, the relative remaining blood flow in the ischemic area, and the dynamics of the left ventricle were examined by means of computer tomography. The extent of the ischemic volume in the group treated with molsidomine was by far lower than in the control group; this difference was significant if one takes into account the individual heart size. The relative remaining blood flow in the ischemic region was not influenced by molsidomine. The reduction of preload and afterload resulted in corresponding changes in left ventricular areas, segments of these areas, the long axis, thickness of myocardium, ejection fraction and stroke volume. Aortic pressure was lowered insignificantly, heart rate remained nearly unchanged. Plasma analyses of molsidomine. SIN 1 and SIN 1C show that the applied dosage was sufficient to reach a constant concentration over the whole period of observation in the dog.

[Results and complications of CT-guided puncture biopsies with a wide-lumen puncture needle]. / Ergebnisse und Komplikationen perkutaner CT-gesteuerter Punktionen mit einer grosslumigen Punktionsnadel.

The results obtained in 187 CT-guided biopsies using a wide lumen needle are described. Biopsies in the thorax, abdomen, retroperitoneum and in the pelvis have been evaluated. A retrospective analysis of the material has shown an accuracy of 97.8% and sensitivity of 95.8%. The total complication rate was 8%. Amongst 120 biopsies in the thorax, 6.6% developed a pneumothorax. Therapeutic drainage was carried out in fifteen patients.

[An extremely malignant uveal melanoma]. / Extremes malignes Uveamelanom.

The authors present an extremely pronounced involvement of the orbita in malignant uveal melanoma with a ten-year course of disease. The results of imaging diagnostics (ultrasound, computed tomography, magnetic resonance tomography) are discussed.

[Diagnosis of lymphomas on the MR tomogram]. / Zur Diagnostik von Lymphomen im MR-Tomogramm.

MR tomography provides images equal to, or superior to, CT of lymph node involvement in the thorax or abdomen. It may be possible to achieve tissue characterisation by means of T1 and T2 images. Chronic inflammatory diseases causing lymph node enlargement, such as sarcoidosis, show characteristic T1 intervals (about 650 msecs), whereas lymphomas show intervals of 900 msecs. Enlarged lymph nodes of low malignancy show lower T2 values (78 to 94 msecs), highly malignant show higher T2 values (83 to 145 msecs). Already we believe MR to be the method of choice in evaluating lymphoma and sarcoidosis.