Avaliação histológica da próstata de cães adultos sexualmente intactos / Prostatic histological evaluation in adult not castrated dogs

Avaliou-se histologicamente a próstata de 30 cães adultos e idosos sexualmente intactos que apresentavam ou não sintomatologia clínica de doença prostática, e verificou-se a incidência de possíveis alterações da glândula. Dentre as alterações encontradas, a hiperplasia prostática benigna constituiu o diagnóstico mais comum, 85,6 por cento (n=24), seguida por prostatite crônica, 64,3 por cento (n=18), displasia do epitélio glandular, 42,8 por cento (n=12), atrofia do epitélio glandular, 39,3 por cento (n=11), infiltrado inflamatório focal, 25 por cento (n=7), dilatação glandular focal, 21,4 por cento (n=6), prostatite aguda, 7,1 por cento (n=2), metaplasia escamosa, 3,6 por cento, (n=1), metástase de neoplasia sistêmica, 3,6 por cento (n=1) e abscesso prostático, 3,6 por cento (n=1). Como em muitos casos os cães são assintomáticos, ressalta-se a importância da realização rotineira de exames clínicos específicos, como o toque retal e a ultrassonografia, para o diagnóstico precoce e o tratamento das afecções prostáticas.

The prostates of 30 not castrated old dogs with or without clinical symptoms of prostatic disease were histologically evaluated. It was observed the incidence of possible changes in the gland. Among the changes, benign prostatic hyperplasia (BPH) was the most common diagnosis, accounting for 85.6 percent (n=24), followed by chronic prostatitis, 64.3 percent (n=18), dysplasia of the glandular epithelium, 42.8 percent (n=12), atrophy of the glandular epithelium, 39.3 percent (n=11), focal inflammatory infiltrate, 25 percent (n=7), focal glandular dilation, 21.4 percent (n=6), acute prostatitis, 7.1 percent (n=2), squamous metaplasia, 3.6 percent (n=1), metastasis of systemic neoplasia, 3.6 percent (n=1), and prostatic abscess, 3.6 percent (n=1). Because the lack of symptoms in most of dogs with prostatic changes, the specific clinic exams in routine, as rectal palpation and ultrasonography, are very important to early diagnosis and treatment of dogs with prostatic disease.

Antigenicity of the Male Accessory Sexual Glands I. An Effect of the Homologous Prostatic Extract on the Male Sexual Glands in Rat / 대한비뇨기과학회지

The immunologic properties of the male accessory sexual glands have been the subject of intensive research in the recent years. Hence, the ability of the male accessory sexual gland autoantigens to induce a specific humoral response seems to be fairly well investigated. In contrast, few studies on delayed hypersensitivity and specific tissue damage have been reported. The present work was undertaken to study the immunopathologic effects of the homologous prostatic extract on the male sexual and accessory sexual glands in rat. White rats were immunized with homologous prostatic extract and equal amount of the complete Freund`s adjuvant. Testes, epididymides, prostates and seminal vesicles of the immunized rats were histologically observed. Serum acid phosphatase and fructose of the seminal vesicular fluid were measured in both immunized rats and normal control rats The results were as follows: 1. The level of serum acid phosphatase; The mean value of the immunized rats (1.208+/-0.4 BU/L) was significantly decreased, as compared with that of the normal control rats (1.842+/-0.221 BU/L). 2. The level of fructose of the seminal vesicular fluid; The mean value of the immunized rats (63.1+/-18.1 mg/dl) was significantly decreased, as compared with that of the normal control rats (140.4+/-33.0 mg/dl) 3. Histologic findings of testes, epididymides, prostates and seminal vesicles; The testes and epididymides were not affected in all the immunized rats. The prostates and seminal vesicles showed similarly limited or extensive immunopathologic lesions in all the immunized rats. The lesions were mainly represented by mononuclear cells infiltration and an increase in the fibrous stroma, and flattening, vacuolization, atrophy or desquamation of the epithelial cells. The result indicates that the prostate has strong antigenicity and seems to have antigens which cross-react to seminal vesicular tissue.