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Objective: To understand the combination use and rationality of Chinese patent drugs containing Salvia Miltiorrhiza or its active ingredients and western medicines to provide reference for regulating prescriptions and improving rational drug use level. Methods: The prescriptions of outpatients in our hospital during January 2016 and December 2016 were collected by a retrospective study method, and the ones with the combination use of Chinese patent drugs containing Salvia Miltiorrhiza or its active ingredients and western medicines were analyzed. The rationality of the combination use was analyzed in aspects of physicochemical properties, phar-macological effects, pharmacodynamics and pharmacokinetics. Results: Totally 257 730 prescriptions were examined selectively, and among them, 8 894 were with the combination use of western medicines and Chinese patent medicines containing Salvia Miltiorrhiza or its active ingredients including 1 213 irrational prescriptions (13. 64% ). The irrational prescriptions showed such problems as antago-nism in pharmacologic action causing decreased efficacy (510, 42. 04% ), overlaying in pharmacological effects causing increased effi-cacy (492, 40. 56% ), precipitation because of physical and chemical reactions and chemical taboos (299, 24. 65% ) and reduced bioavailability and affected efficacy due to complex reactions (174, 14. 34% ). Conclusion: The combination use of western medicines and Chinese patent medicines containing Salvia Miltiorrhiza or its active ingredients should be careful to avoid irrational problems. When they are auditing prescriptions and monitoring medication, clinical pharmacists should strengthen intervention of the combination use of Chinese patent medicines and western medicines reasonably combining with physical and chemical properties of medicines, phar-macological effects, pharmacodynamics and other characteristics.
RESUMO
OBJECTIVE:To investigate the application of vitamins in parenteral nutrition (PN) prescription,and to provide reference for rational use of vitamins in PN. METHODS:Usingparenteral nutritionintravenous nutritionprescription analy-sisrational drug useanalysis of medical orderas keywords,the literatures about the rationality analysis of PN prescriptions were retrieved from CNKI and Wanfang database during 2006-2015,and the utilization of vitamin included in literatures were ana-lyzed and summarized. RESULTS:A total of 34 literatures were included. There were 158874 prescriptions,among which vitamin was used in 145400 prescriptions (91.52%). 12 or 13 kinds of vitamin were used in 73508 prescriptions (46.27%);over-dose drug use was found in 53388 prescriptions(33.60%),and vitamin was not completely added into 18504 prescriptions(11.65%);no vitamin was added into 1663 prescriptions (1.05%). The proportion of the prescriptions including 12 or 13 kinds of vitamin was the highest in northern China (52.00%). 12 or 13 kinds of vitamin were added into the prescriptions and the author believed that the proportion of excessive use of vitamin,incomplete addition of water-soluble vitamin and fat-soluble vitamin in class three grade A hospitals were all lower than hospitals below class three grade A. The prescriptions including 12 or 13 kinds of necessary vi-tamin were adopted in oncology department(97.72%),internal medicine department(86.62%),intensive care unit(77.99%)and surgery department(52.83%). CONCLUSIONS:The standardized use of vitamin PN prescriptions occupies low proportion in Chi-na. It is necessary to enhance the conception that multiple recommended vitamins should be added into PN.
RESUMO
OBJECTIVE:To provide reference for rational use of polycystic ovary syndrome(PCOS)drugs. METHODS:The utilization of PCOS drugs in our hospital during Jan.-Dec. 2013 were analyzed in respects of consumption sum,DDDs,sorting and so on. The rationality of prescription was analyzed according to guidelines and drug package inserts and so on. RESULTS:There were 1 551 prescriptions,involving 76 kinds of drugs,and their total consumption sum was 181 072.90 yuan. Main types of drugs were hormone related drugs (accounting for 81.37% of prescription frequency,73.51% of consumption sum) and Chinese patent medicine (accounting for 15.41% of prescription frequency,19.43% of consumption sum). Top 5 hormone drugs in the list of DDDs were Ethinylestradiol and Cyproterone acetate tablets,Metformin hydrochloride enteric-coated tablets,Progesterone soft cap-sule,Dydrogesterone tablets and Progesterone soft capsules. Top 5 Chinese patent medicines in the list of DDDs were Kuntai cap-sule,Yougui capsule,Huanshao capsule,Jiawei xiaoyao capsule and Nvjin capsule. Single drug accounted for 72.08% in prescrip-tion. The proportion of irrational drug use was 1.69%. CONCLUSIONS:The application of drug in patients with PCOS is reason-able generally. Some prescriptions are unreasonable,mainly manifesting as incomplete clinical diagnosis,irrational usage and dos-age. Pharmacists should strengthen prescription verification and intervention.
RESUMO
Objective:To investigate the situation of narcotic drug use in the out-patient department of our hospital to provide reference for the rational use of drugs.Method:By collecting all the prescriptions of the out-patient department of our hospital in 2007,the designations,dosages,dosage form,usage,synptoms and section offices of the narcotic drug were statistically analyzed.Result:Top 3 of the prescriptions amounts in the out-patient department were morphine sulfate sustained-Relrase tablets,pethidine hydrochloride injection and oxycodone hydrochloride sustained-release tablets. Top 3 of the prescriptions amounts in DUI were fentanyl citrate injecton,bucinnazine hydrochlooride injection and morphine hydrochloride injection.Conclusion:The narcotic drug used in the out-patient clinic of our hospital is rational on the whole,and the doctors and pharmacists should pay much attention to the use and management of narcotic drug.
