Revolutionizing orthopedics: a comprehensive review of robot-assisted surgery, clinical outcomes, and the future of patient care.

Robotic-assisted orthopedic surgery (RAOS) is revolutionizing the field, offering the potential for increased accuracy and precision and improved patient outcomes. This comprehensive review explores the historical perspective, current robotic systems, advantages and limitations, clinical outcomes, patient satisfaction, future developments, and innovation in RAOS. Based on systematic reviews, meta-analyses, and recent studies, this article highlights the most significant findings and compares RAOS to conventional techniques. As robotic-assisted surgery continues to evolve, clinicians and researchers must stay informed and adapt their practices to provide optimal patient care. Evidence from published studies corroborates these claims, highlighting superior component positioning, decreased incidence of complications, and heightened patient satisfaction. However, challenges such as costs, learning curves, and technical issues must be resolved to fully capitalize on these advantages.

Correlations between 3D preoperative planning and postoperative reduction in the osteosynthesis of distal humeral fractures.

BACKGROUND: Three-dimensional preoperative planning has been applied to the osteosynthesis of distal humerus fractures. The present study investigated the correlations between 3D preoperative planning and postoperative reduction for the osteosynthesis of distal humerus fractures using 3D parameters. METHODS: Twenty-three elbows of 23 distal humerus fracture patients who underwent osteosynthesis with three-dimensional preoperative planning were evaluated. 3D images of the distal humerus were created after taking preoperative CT scans of the injured elbow. Fracture reduction, implant selection, and placement simulations were performed based on 3D images. Postoperative CT images were taken 1 month after surgery. Correlations were evaluated with preoperative plans and postoperative 3D images. The longitudinal axis and coordinates of the humerus were defined on the 3D images. The coronal angle (CA) was defined as the angle formed by the long axis and the line connecting the medial and lateral margins of the trochlea of the humerus on a coronal plane image. The sagittal angle (SA) was defined as the angle formed by the long axis and the line connecting the top of the lateral epicondyle and the center of the humeral capitellum on a sagittal plane image. The axial angle (AA) was defined as the angle between the sagittal plane and the line connecting the medial and lateral margins behind the trochlea of the humerus. The intraclass correlation coefficients (ICC) of each measurement value were assessed between preoperative planning and postoperative images. RESULTS: Preoperative planning and postoperative measurement values were CA: 85.6 ± 5.9°/85.8 ± 5.9°, SA: 140.9 ± 8.5°/139.4 ± 7.9°, and AA: 84.0 ± 3.1°/82.6 ± 4.9°, respectively. ICCs were CA: 0.75 (P < 0.01), SA: 0.78 (P < 0.01), and AA: 0.34 (P < 0.05), respectively. CONCLUSIONS: The 3D preoperative planning of distal humeral fractures achieved the good correlations of coronal and sagittal angles, but the relatively poor correlation of the axial angle. This may be attributed to an inability to assess the rotation angle during surgery. We propose the measurement indices shown in the present study as a three-dimensional evaluation index for distal humerus fractures. TRIAL REGISTRATION: Registered as NCT04349319 at ClinicalTrials.gov.

Femur reconstruction in 3D ultrasound for orthopedic surgery planning.

PURPOSE: Derotation varisation osteotomy of the proximal femur in pediatric patients usually relies on 2-dimensional X-ray imaging, as CT and MRI still are disadvantageous when applied in small children either due to a high radiation exposure or the need of anesthesia. This work presents a radiation-free non-invasive tool to 3D-reconstruct the femur surface and measure relevant angles for orthopedic diagnosis and surgery planning from 3D ultrasound scans instead. METHODS: Multiple tracked ultrasound recordings are segmented, registered and reconstructed to a 3D femur model allowing for manual measurements of caput-collum-diaphyseal (CCD) and femoral anteversion (FA) angles. Novel contributions include the design of a dedicated phantom model to mimic the application ex vivo, an iterative registration scheme to overcome movements of a relative tracker only attached to the skin, and a technique to obtain the angle measurements. RESULTS: We obtained sub-millimetric surface reconstruction accuracy from 3D ultrasound on a custom 3D-printed phantom model. On a pre-clinical pediatric patient cohort, angular measurement errors were [Formula: see text] and eventually [Formula: see text] for CCD and FA angles, respectively, both within the clinically acceptable range. To obtain these results, multiple refinements of the acquisition protocol were necessary, ultimately reaching success rates of up to 67% for achieving sufficient surface coverage and femur reconstructions that allow for geometric measurements. CONCLUSION: Given sufficient surface coverage of the femur, clinically acceptable characterization of femoral anatomy is feasible from non-invasive 3D ultrasound. The acquisition protocol requires leg repositioning, which can be overcome using the presented algorithm. In the future, improvements of the image processing pipeline and more extensive surface reconstruction error assessments could enable more personalized orthopedic surgery planning using cutting templates.

Robot-assisted percutaneous pars-pedicle screw fixation for treating Hangman's fracture.

BACKGROUND: This study aimed to evaluate the safety and efficacy of robot-assisted percutaneous pars-pedicle screw fixation surgery for treating Hangman's fracture. METHODS: The study involved 33 patients with Hangman's fracture who underwent robot-assisted fixation surgery using cannulated pars-pedicle screws through a percutaneous approach. The primary parameter evaluated was the accuracy of the screws according to the Gertzbein-Robbins scale, using postoperative CT images. Secondary parameters included the duration of surgery, intraoperative blood loss, postoperative hospital stay, and neurovascular injury. RESULTS: A total of 60 pars-pedicle screws were placed in 33 patients. Based on the Levine and Edwards classification, the patients included 12 cases of type I, 15 cases of type II, five cases of type IIa, and one atypical case. The average operative time was 92.4 ± 37.4 min, and the average blood loss was 22.4 ± 17.9 ml. Fifty-five of 60 screws were successfully placed within the bone. No screw-related neurovascular injury was observed, and satisfactory reduction was achieved in all cases. CONCLUSION: Robot-assisted percutaneous pars-pedicle screw fixation is a safe and feasible method for treating Hangman's fracture. TRIAL REGISTRATION: The study was retrospectively registered and approved by our center's institutional review board.

Does acetabular robotic-assisted total hip arthroplasty with femoral navigation improve clinical outcomes at 1-year post-operative? A case-matched propensity score study comparing 98 robotic-assisted versus 98 manual implantation hip arthroplasties.

INTRODUCTION: Despite the optimization of implant positioning, the clinical benefit of the use of robotic assistance during THA remains uncertain. In this case-control study (robotic versus manual technique) we made a retrospective short-term comparison of: (1) the functional results, (2) the complications, (3) and the influence of radiological symmetrization of the hips on the functional result. HYPOTHESIS: The use of a robotic arm improved the functional results of a THA. MATERIALS AND METHOD: A retrospective case-control study was performed, including patients with unilateral hip osteoarthritis who underwent a robotic arm-assisted THA (THA-R). The controls (THA-C) were matched according to age, sex, body mass index and surgical approach. The Harris (HHS), Oxford (OHS) and Forgotten Joint (FJS) scores were collected preoperatively and 1 year postoperatively. At each review, complications were categorized into minor events, revision surgery with and without implant change. Radiographic analysis was performed on weight-bearing images of the pelvis 3 months postoperatively. The objective of the surgery was symmetrization of the THA in the contralateral healthy hip. For each measured parameter of the hip joint center of rotation (COR), global offset (GO) and articular leg length discrepancy (aLLD), the difference between the two sides corresponding to the delta symmetrization was compared. RESULTS: Ninety-eight patients were included in the THA-R group and matched to 98 controls in the THA-C group. At 1 year postoperatively, the FJS and OHS scores were statistically higher in the THA-R group, respectively 82.1±22.3 [8.3; 100] and 40.8±8.8 [6; 48] vs. 71.2±27.8 [0; 100] and 38.1±9.7 [12; 48] in the THA-C group (p=0.004 and p=0.043). There was no difference in HHS (THA-R: 85.9±15.8 [31; 100] vs. THA-C: 85.8±13.3 [49-100] (p=0.962)). The implant revision rate at 1 year was significantly higher in the THA-C group (0% vs. 5.1% (p=0.025)). There was no difference in the reoperation without component exchange despite 3 dislocations (3.1%) in the THA-R group (5 (5.1%) vs. 9 (9.2%) (p=0.273)). The rate of abarticular pathologies (ilio-psoas irritation and greater trochanteric bursitis) was higher in the THA-C group (10 (10.8%) vs. 2 (2%) (p=0.016). Robotic acetabular assistance allowed a significantly better restitution of the horizontal position (THA-R: 1mm±4.8 [-11.7; 12.6] vs. THA-C: 4.1mm±7 [-29.6; 28] (p=0.0005)) and vertical COR (THA-R: 0.5mm±3.1 [-6; 8.3] vs. THA-C: 2mm±4.1 [-6; 14.6] (p=0.0068)). Navigated assistance of the femur did not significantly optimize the restitution of the Global Offset (THA-R: +2mm±6.4 [-16.4; 27.6] vs. THA-C: +0.5mm±7 .7 [-34; 30.2] (p=0.145)), or lower limb length (THA-R: +1.1mm±5 [-8.2; 13.5] vs. THA-C: +0.3mm±6 [-14.1; 22.5] (p=0.344). The FJS was statistically correlated with the restoration of the symmetry of the COR and the aLLD. A post-hoc power analysis confirmed sufficient potency (1-ß=0.85). CONCLUSION: Robotic acetabular assistance combined with femoral navigation improves clinical outcomes of THAs with fewer short-term complications. The precision of the positioning of the implants, optimized by the computer-assisted surgery system, is correlated with the missed joint score. LEVEL OF EVIDENCE: III, retrospective case-control study.

Quantification of manipulation forces needed for robot-assisted reduction of the ankle syndesmosis: an initial cadaveric study.

PURPOSE: Manual surgical manipulation of the tibia and fibula is necessary to properly align and reduce the space in ankle fractures involving sprain of the distal tibiofibular syndesmosis. However, manual reduction is highly variable and can result in malreduction in about half of the cases. Therefore, we are developing an image-guided robotic assistant to improve reduction accuracy. The purpose of this study is to quantify the forces associated with reduction of the ankle syndesmosis to define the requirements for our robot design. METHODS: Using a cadaveric specimen, we designed a fixture jig to fix the tibia securely on the operating table. We also designed a custom fibula grasping plate to which a force-torque measuring device is attached. The surgeon manually reduced the fibula utilizing this construct while translational and rotational forces along with displacement were being measured. This was first performed on an intact ankle without ligament injury and after the syndesmosis ligaments were cut. RESULTS: Six manipulation techniques were performed on the three principal directions of reduction at the cadaveric ankle. The results demonstrated the maximum force applied to the lateral direction to be 96.0 N with maximum displacement of 8.5 mm, applied to the anterior-posterior direction to be 71.6 N with maximum displacement of 10.7 mm, and the maximum torque applied to external-internal rotation to be 2.5 Nm with maximum rotation of 24.6°. CONCLUSIONS: The specific forces needed to perform the distal tibiofibular syndesmosis manipulation are not well understood. This study quantified these manipulation forces needed along with their displacement for accurate reduction of ankle syndesmosis. This is a necessary first step to help us define the design requirements of our robotic assistance from the aspects of forces and displacements.

USE OF COMPUTER NAVIGATION IN TOTAL HIP ARTHROPLASTY (LITERATURE REVIEW).

OBJECTIVE: The aim: Analyze the accuracy and ease of use of various computer navigations in total hip arthroplasty. PATIENTS AND METHODS: Materials and methods: Data from about 50 literature sources for the last two decades have been analysed. CONCLUSION: Conclusions: Analyzing the accuracy and ease of use of various computer navigations in total hip arthroplasty, we offer two the most promising for further study and improvement systems: a semi-active navigation system and augmented reality system in total hip arthroplasty.

A novel intraoperative method to project osteotomy lines for accurate resection of primary bone sarcomas.

Background: Accurate reproduction of a preoperative plan is critical in wide resection of bone sarcomas. Recent advances in computer navigation and 3D-custom jigs have increased resection accuracy, although with certain practical drawbacks. Methods: We developed a novel "projector method" that projects the preoperative osteotomy lines onto the bone. A sawbone study was conducted to evaluate accuracy in reproducing preoperative resection plans. An additional cadaver experiment was conducted to evaluate feasibility in a more realistic operating room setting. Results: Based on the results of experiments conducted on sawbones, the proposed light projector method was more accurate at depicting desired osteotomy lines than a traditional manual method, reducing the corner deviation from 2.53 mm to 0.35 mm, angular deviation from 2.10° to 0.31°, and point deviation from 4.66 mm to 0.48 mm (p < 0.001). Results of the cadaver experiment were consistent with those of sawbone experiments. Conclusions: The new projector method can accurately assist surgeons in visualizing the preoperative plan of osteotomy lines accurately in surgery.

A virtual reality simulator for training the surgical reduction of patient-specific supracondylar humerus fractures.

PURPOSE: Virtual reality has been used as a training platform in medicine, allowing the repetition of a situation/scenario as many times as needed and making it patient-specific prior to an operation. Of special interest is the minimally invasive plate osteosynthesis (MIPO). It represents a novel technique for orthopedic trauma surgery, but requires intensive training to acquire the required skills. In this paper, we propose a virtual reality platform for training the surgical reduction of supracondylar fractures of the humerus using MIPO. The system presents a detailed surgical theater where the surgeon has to place the bone fragments properly. METHODS: Seven experienced users were selected to perform a surgical reduction using our proposal. Two paired humeri were scanned from a dataset obtained from the Complejo Hospitalario de Jaén. A virtual fracture was performed in one side of the pair, using the other as contralateral part. Users have to simulate a reduction for each case and fill out a survey about usability, using a five-option Likert scale. RESULTS: The subjects have obtained excellent scores in both simulations. The users have notably reduced the time employed in the second experiment, being 60% less in average. Subjects have valued the usability (5.0), the intuitiveness (4.6), comfort (4.5), and realism (4.9) in a 1-5 Likert scale. The mean score of the usability survey was 4.66. CONCLUSION: The system has shown a high learning rate, and it is expected that the trainees will reach an expert level after additional runs. By focusing on the movement of bone fragments, specialists acquire motor skills to avoid the malrotation of MIPO-treated fractures. A future study can fulfill the requirements needed to include this training system into the protocol of real surgeries. Therefore, we expect the system to increase the confidence of the trainees as well as to improve their decision making.

Towards markerless computer assisted surgery: Application to total knee arthroplasty.

PURPOSE: A new approach is proposed to localise surgical instruments for Computer Assisted Orthopaedic Surgery (CAOS) that aims at overpassing the limitations of conventional CAOS solutions. This approach relies on both a depth sensor and a 6D pose estimation algorithm. METHODS: The Point-Pair Features (PPF) algorithm was used to estimate the pose of a Patient-Specific Instrument (PSI) for Total Knee Arthroplasty (TKA). Four depth sensors have been compared. Three scores have been computed to assess the performances: The Depth Fitting Error (DFE), the Pose Errors, and the Success Rate. RESULTS: The obtained results demonstrate higher performances for the Microsoft Kinect Azure in terms of DFE. The Occipital Structure core shows better behavior in terms of Pose Errors and Success Rate. CONCLUSION: This comparative study presents the first depth-sensor based solution allowing the intraoperative markerless localization of surgical instruments in orthopedics.

Three-dimensional evaluations of preoperative planning reproducibility for the osteosynthesis of distal radius fractures.

BACKGROUND: Three-dimensional preoperative planning was applied for the osteosynthesis of distal radius fractures. The objective of this study was to evaluate the reproducibility of three-dimensional preoperative planning for the osteosynthesis of distal radius fractures with three-dimensional reference points. METHODS: Sixty-three wrists of 63 distal radius fracture patients who underwent osteosynthesis with three-dimensional preoperative planning were evaluated. After taking preoperative CT scans of the injured wrists, 3D images of the distal radius were created. Fracture reduction, implants choices, and placements simulation were performed based on the 3D images. One month after the surgery, postoperative CT images were taken. The reproducibility was evaluated with preoperative plan and postoperative 3D images. The images were compared with the three-dimensional coordinates of radial styloid process, volar and dorsal edges of sigmoid notch, and the barycentric coordinates of the three reference points. The reproducibility of the preoperative plan was evaluated by the distance of the coordinates between the plan and postoperative images for the reference points. The reproducibility of radial inclination and volar tilt on three-dimensional images were evaluated by intra-class correlation coefficient (ICC). RESULTS: The distances between the preoperative plan and the postoperative reduction for each reference point were (1) 2.1±1.3 mm, (2) 1.9±1.2 mm, and (3) 1.9±1.2 mm, respectively. The distance between the preoperative plan and postoperative reduction for the barycentric coordinate was 1.3±0.8 mm. ICCs were 0.54 and 0.54 for the volar tilt and radial inclination, respectively (P<0.01). CONCLUSIONS: Three-dimensional preoperative planning for the osteosynthesis of distal radius fracture was reproducible with an error of about 2 mm for each reference point and the correlations of reduction shapes were moderate. The analysis method and reference points may be helpful to understand the accuracy of reductions for the three-dimensional preoperative planning in the osteosynthesis of distal radius fractures. TRIAL REGISTRATION: Registered as NCT02909647 at ClinicalTrials.gov.

A 3D printed cast for minimally invasive transfer of distal radius osteotomy: a cadaver study.

PURPOSE: In corrective osteotomy of the distal radius, patient-specific 3D printed surgical guides or optical navigation systems are often used to navigate the surgical saw. The purpose of this cadaver study is to present and evaluate a novel cast-based guiding system to transfer the virtually planned corrective osteotomy of the distal radius. METHODS: We developed a cast-based guiding system composed of a cast featuring two drilling slots as well as an external cutting guide that was used to orient the surgical saw for osteotomy in the preoperatively planned position. The device was tested on five cadaver specimens with different body fat percentages. A repositioning experiment was performed to assess the precision of replacing an arm in the cast. Accuracy and precision of drilling and cutting using the proposed cast-based guiding system were evaluated using the same five cadaver arms. CT imaging was used to quantify the positioning errors in 3D. RESULTS: For normal-weight cadavers, the resulting total translation and rotation repositioning errors were ± 2 mm and ± 2°. Across the five performed surgeries, the median accuracy and Inter Quartile Ranges (IQR) of pre-operatively planned drilling trajectories were 4.3° (IQR = 2.4°) and 3.1 mm (IQR = 4.9 mm). Median rotational and translational errors in transferring the pre-operatively planned osteotomy plane were and 3.9° (IQR = 4.5°) and 2.6 mm (IQR = 4.2 mm), respectively. CONCLUSION: For normal weight arm specimens, navigation of corrective osteotomy via a cast-based guide resulted in transfer errors comparable to those using invasive surgical guides. The promising positioning capabilities justify further investigating whether the method could ultimately be used in a clinical setting, which could especially be of interest when used with less invasive osteosynthesis material.

A New Technique that Combines Navigation-Assisted Lateral Interbody Fusion and Percutaneous Placement of Pedicle Screws in the Lateral Decubitus Position with the Surgeon Using Wearable Smart Glasses: A Small Case Series and Technical Note.

BACKGROUND: We describe a new technique that combines navigation-assisted extreme lateral interbody fusion (NALIF) and percutaneous placement of pedicle screws in the lateral decubitus position with the surgeon using wearable smart glasses. METHODS: We explain our method for nonfluoroscopic NALIF and single-position (SP)- percutaneous pedicle screw (PPS) surgery for patients with degenerative lumbar diseases using wearable smart glasses. The wearable smart glasses provide a semitransparent overlay of the navigation information onto the image seen through the lenses. This technique does not require fluoroscopy during lateral interbody fusion or PPS insertion. It is convenient because it does not require a Jamshidi needle or guidewire when inserting PPSs. RESULTS: Using this method, the surgeon can glance at the 3-dimensional images on the wearable smart glasses while still viewing the operation field. A review of 24 cases yielded an average operation time of 89.5 ± 16.4 minutes and 66.7 ± 67.0 mL of blood loss, without any severe intra- or postoperative complications. CONCLUSIONS: Nonfluoroscopic NALIF and SP-PPS placement surgery is a safe and effective means for implanting cages and PPSs in this minimally invasive approach without compromising the results. Although further investigations are needed, the wearable smart glasses may be a useful surgical aid when performing NALIF and SP-PPS placement in patients with degenerative lumbar diseases.

Influence of multi-angle input of intraoperative fluoroscopic images on the spatial positioning accuracy of the C-arm calibration-based algorithm of a CAOS system.

Intraoperative fluoroscopic images, as one of the most important input data for computer-assisted orthopedic surgery (CAOS) systems, have a significant influence on the positioning accuracy of CAOS system. In this study, we proposed to use multi-angle intraoperative fluoroscopy images as input based on real clinical scenario, and the aim was to analyze the positioning accuracy and the error propagation rules with multi-angle input images compared with traditional two input images. In the experiment, the positioning accuracy of the C-arm calibration-based algorithm was studied, respectively, using two, three, four, five, and six intraoperative fluoroscopic images as input data. Moreover, the error propagation rules of the positioning error were analyzed by the Monte Carlo method. The experiment result showed that increasing the number of multi-angle input fluoroscopic images could reduce the positioning error of CAOS system, which has dropped from 1.01 to 0.61 mm. The Monte Carlo simulation analysis showed that for random input errors subject to normal distribution (µ = 0, σ = 1), the image positioning error dropped from 0.29 to 0.23 mm, and the staff gauge positioning error dropped from 1.36 to 1.19 mm, while the tracking device positioning error dropped from 3.41 to 2.13 mm. In addition, the results showed that image positioning error and staff gauge positioning error were all nonlinear error for the whole system, but tracker device positioning error was a strictly linear error. In conclusion, using multi-angle fluoroscopy images was helpful for clinic, which could improve the positioning accuracy of the CAOS system by nearly 30%. Graphical abstract The experiment process and Monte Carlo analysis of spatial positioning accuracy (A: Setup for the experiment; B: The process of Monte Carlo analysis; C: Results).

Radiation-free methods for navigated screw placement in slipped capital femoral epiphysis surgery.

PURPOSE: For orthopedic procedures, surgeons utilize intra-operative medical images such as fluoroscopy to plan screw placement and accurately position the guide wire with the intended trajectory. The number of fluoroscopic images needed depends on the complexity of the case and skill of the surgeon. Since more fluoroscopic images lead to more exposure and higher radiation dose for both surgeon and patient, a solution that decreases the number of fluoroscopic images would be an improvement in clinical care. METHODS: This article describes and compares three different novel navigation methods and techniques for screw placement using an attachable Inertial Measurement Unit device or a robotic arm. These methods provide projection and visualization of the surgical tool trajectory during the slipped capital femoral epiphysis procedure. RESULTS: These techniques resulted in faster and more efficient preoperative calibration and set up times compared to other intra-operative navigation systems in our phantom study. We conducted an experiment using 120 model bones to measure the accuracy of the methods. CONCLUSION: As conclusion, these approaches have the potential to improve accuracy of surgical tool navigation and decrease the number of required X-ray images without any change in the clinical workflow. The results also show 65% decrease in total error compared to the conventional manual approach.

Design and Evaluation of a Percutaneous Fragment Manipulation Device for Minimally Invasive Fracture Surgery.

Reduction of fractures in the minimally invasive (MI) manner can avoid risks associated with open fracture surgery. The MI approach requires specialized tools called percutaneous fragment manipulation devices (PFMD) to enable surgeons to safely grasp and manipulate fragments. PFMDs developed for long-bone manipulation are not suitable for intra-articular fractures where small bone fragments are involved. With this study, we offer a solution to potentially move the current fracture management practice closer to the use of a MI approach. We investigate the design and testing of a new PFMD design for manual as well as robot-assisted manipulation of small bone fragments. This new PFMD design is simulated using FEA in three loading scenarios (force/torque: 0 N/2.6 Nm, 75.7 N/3.5 N, 147 N/6.8 Nm) assessing structural properties, breaking points, and maximum bending deformations. The PFMD is tested in a laboratory setting on Sawbones models (0 N/2.6 Nm), and on ex-vivo swine samples (F = 80 N ± 8 N, F = 150 ± 15 N). A commercial optical tracking system was used for measuring PFMD deformations under external loading and the results were verified with an electromagnetic tracking system. The average error difference between the tracking systems was 0.5 mm, being within their accuracy limits. Final results from reduction maneuvers performed both manually and with the robot assistance are obtained from 7 human cadavers with reduction forces in the range of (F = 80 N ± 8 N, F = 150 ± 15 N, respectively). The results show that structurally, the system performs as predicted by the simulation results. The PFMD did not break during ex-vivo and cadaveric trials. Simulation, laboratory, and cadaveric tests produced similar results regarding the PFMD bending. Specifically, for forces applied perpendicularly to the axis of the PFMD of 80 N ± 8 N deformations of 2.8, 2.97, and 3.06 mm are measured on the PFMD, while forces of 150 ± 15 N produced deformations of 5.8, 4.44, and 5.19 mm. This study has demonstrated that the proposed PFMD undergoes predictable deformations under typical bone manipulation loads. Testing of the device on human cadavers proved that these deformations do not affect the anatomic reduction quality. The PFMD is, therefore, suitable to reliably achieve and maintain fracture reductions, and to, consequently, allow external fracture fixation.

What is the best hip center location method to compute HKA angle in computer-assisted orthopedic surgery? In silico and in vitro comparison of four methods.

BACKGROUND: In computer-assisted orthopedic surgery, the hip center (HC) can be determined by calculating the center of rotation of the femur in relation to the pelvis. Several methods are available: Gamage, Halvorsen, Pivot or Least-Moving Point (LMP). To our knowledge, no studies have compared these four methods. We therefore conducted in silico and in vitro experiments to assess whether their accuracy and precision in locating the HC and calculating the hip-knee-ankle (HKA) angle were equivalent. HYPOTHESIS: The four methods show similar accuracy and precision. PATIENTS AND METHODS: The in silico experiment assessed the independent influence of four parameters (camera noise, acetabular noise, movement amplitude, and number of circumductions) on accuracy. The accuracy and precision of the four methods and the impact on HKA ankle calculation were assessed in an in vitro study on six cadaver limbs. RESULTS: In the in silico experiment, all differences according to method were significant (p<0.0002). The Pivot method was the most accurate for acetabular and camera noise, number of circumductions, and movement amplitude. With the LMP, Pivot, Gamage and Halvorsen methods, error was respectively 23.07±8.40 (range 2.10-54.67) mm, 1.98±081 (0.15-4.89) mm, 28.18±3.42 (18.57-37.60) mm and 2.84±1.46 (0.11-9.44) mm depending on camera noise, 1.65±0.72 (0.13-4.80) mm, 0.52±0.22 (0.05-1.23) mm, 3.02±0.57 (0.60-4.78) mm and 0.61±0.27 (0.04-1.82) mm depending on movement amplitude, 0.50±0.20 (0.05-1.34) mm, 0.18±0.08 (0.01-0.44) mm, 0.36±0.14 (0.03-0.80) mm and 0.21±0.09 (0.01-0.55) mm depending on number of circumductions, and 11.30±5.77 (0.56-37.87) mm, 2.78±1.47 (0.10-8.77) mm, 88.08±8.85 (60.59-117.79) mm and 24.33±9.82 (1.40-66.17) mm depending on acetabular noise. In the in vitro experiment, differences were non-significant between the Pivot and LMP methods (p>0.98) and between the Gamage and Halvorsen methods (p>0.65). With the LMP, Pivot, Gamage and Halvorsen methods, precision was respectively 8.2±4.6 (3.3-23.6) mm, 7.3±3.6 (3.4-14.1) mm, 33.6±19.1 (4.7-111.4) mm and 35.0±25.0 (4.7-132.5) mm. Accuracy was 13.5±8.2 (3.2-40.7) mm. 12.3±6.4 (3.2-23.6) mm, 47.0±33.3 (6.2-176.6) mm and 40.3±27.8 (6.1-130.3) mm. The LMP and Pivot methods were thus more accurate and more precise than the Gamage and Halvorsen methods. HKA angle error was 1.1±0.9° (0.1-3.7) and 0.9±0.8° (0.0-2.5) with the LMP and Pivot methods, and 3.2±2.7° (0.0-12.7) and 3.8±3.5° (0.0-13.3) with the Gamage and Halvorsen methods. DISCUSSION: The study highlighted differences between the four methods of HC location in computer-assisted surgery; the Pivot method was the most accurate and precise, thus falsifying the study hypothesis. LEVEL OF EVIDENCE: III, prospective comparative in silico and in vitro study.

FCN-based approach for the automatic segmentation of bone surfaces in ultrasound images.

PURPOSE: A new algorithm, based on fully convolutional networks (FCN), is proposed for the automatic localization of the bone interface in ultrasound (US) images. The aim of this paper is to compare and validate this method with (1) a manual segmentation and (2) a state-of-the-art method called confidence in phase symmetry (CPS). METHODS: The dataset used for this study was composed of 1738 US images collected from three volunteers and manually delineated by three experts. The inter- and intra-observer variabilities of this manual delineation were assessed. Images having annotations with an inter-observer variability higher than a confidence threshold were rejected, resulting in 1287 images. Both FCN-based and CPS approaches were studied and compared to the average inter-observer segmentation according to six criteria: recall, precision, F1 score, accuracy, specificity and root-mean-square error (RMSE). RESULTS: The intra- and inter-observer variabilities were inferior to 1 mm for 90% of manual annotations. The RMSE was 1.32 ± 3.70  mm and 5.00 ± 7.70 mm for, respectively, the FCN-based approach and the CPS algorithm. The mean recall, precision, F1 score, accuracy and specificity were, respectively, 62%, 64%, 57%, 80% and 83% for the FCN-based approach and 66%, 34%, 41%, 52% and 43% for the CPS algorithm. CONCLUSION: The FCN-based approach outperforms the CPS algorithm, and the obtained RMSE is similar to the manual segmentation uncertainty.

Augmented Reality Based Navigation for Computer Assisted Hip Resurfacing: A Proof of Concept Study.

Implantation accuracy has a great impact on the outcomes of hip resurfacing such as recovery of hip function. Computer assisted orthopedic surgery has demonstrated clear advantages for the patients, with improved placement accuracy and fewer outliers, but the intrusiveness, cost, and added complexity have limited its widespread adoption. To provide seamless computer assistance with improved immersion and a more natural surgical workflow, we propose an augmented-reality (AR) based navigation system for hip resurfacing. The operative femur is registered by processing depth information from the surgical site with a commercial depth camera. By coupling depth data with robotic assistance, obstacles that may obstruct the femur can be tracked and avoided automatically to reduce the chance of disruption to the surgical workflow. Using the registration result and the pre-operative plan, intra-operative surgical guidance is provided through a commercial AR headset so that the user can perform the operation without additional physical guides. To assess the accuracy of the navigation system, experiments of guide hole drilling were performed on femur phantoms. The position and orientation of the drilled holes were compared with the pre-operative plan, and the mean errors were found to be approximately 2 mm and 2°, results which are in line with commercial computer assisted orthopedic systems today.

Stem cell therapy in bilateral osteonecrosis: computer-assisted surgery versus conventional fluoroscopic technique on the contralateral side.

PURPOSE: Surgical management of osteonecrosis with core decompression with stem cell therapy is a new procedure. The technique is performed with fluoroscopic guidance. This study attempts to determine if computer-navigated technique can improve the procedure. METHODS: Thirty consecutive patients with bilateral symptomatic osteonecrosis without collapse were included in this study during the year 2011. A prospective, randomized, and controlled study was conducted on 60 hips (bilateral osteonecrosis) using conventional fluoroscopy technique on one side and computer-based navigation on the contralateral side. Bone marrow aspirated from the two iliac crests was mixed before concentration. Each side received the same volume of concentrated bone marrow and the same number of cells 110,000 ± 27,000 cells (counted as CFU-F). RESULTS: Computer navigation achieved better parallelism to the ideal position of the trocar, with better trocar placement as regards to tip-to-subchondral distance and ideal centre position within the osteonecrosis for injection of stem cells. Using computer navigation took fewer attempts to position the trocar, used less fluoroscopy time, and decreased the radiation exposure as compared with surgery performed with conventional fluoroscopy. At the most recent follow-up (6 years), increasing the precision with computer navigation resulted in less collapse (7 versus 1) and better volume of repair (13.4 versus 8.2 cm3) for hips treated with the computer-assisted technique. CONCLUSIONS: The findings of this study suggest that computer navigation may be safely used in a basic procedure for injection of stem cells.