[Analysis on mechanism of toxicity reduction through compatibility of Aconiti Lateralis Radix Praeparata-Glycyrrhizae Radix et Rhizoma from in vitro component changes,in vivo metabolism and biological effects antagonism].

Aconiti Lateralis Radix Praeparata and Glycyrrhizae Radix et Rhizoma is a representative acid-alkali drug pair,commonly used in clinical application of traditional Chinese medicine( TCM). Its unique compatibility connotation fully embodied the wisdom of ancient people in drug use. In order to more comprehensively and deeply understand the scientific connotation of the compatibility of the two drugs,pharmacy workers have studied the mechanism of reducing toxicity and enhancing efficacy through their compatibility from the perspectives of chemistry,pharmacology and toxicology. On the basis of combing the previous research work,this paper interpreted the unique compatibility connotation from the three-level system of reducing the content of toxic components in vitro by hydrolysis,lipid exchange and formation of associations,the active constituents of Glycyrrhizae Radix et Rhizoma affecting the metabolism of toxic components and direct antagonism of the toxic effects of aconite in vivo. The existing problems and controversies of the modern mechanism of their compatibility were also proposed,providing a reference for further in-depth studies.

Biological Antagonism Inspired Detoxification: Removal of Toxic Elements by Porous Polymer Networks.

Water contamination by toxic heavy elements is becoming an urgent problem in environmental science and separation technologies. However, the design of sophisticated absorbents with high stability and outstanding removal efficacy for ion coadsorption is still a technical challenge. Herein, inspired by biological Hg/Se antagonism detoxification, we have designed the first porous polymer network (PPN) for the concurrent removal of Hg/Se species in aqueous solutions. Remarkably, the MoS42- functionalized PPN-150-MoS4 exhibits a rapid and highly efficient simultaneous removal of toxic anions (SeO42- and SeO32-) and metals (Hg2+). The high thiophilicity of Hg2+ leads to 99.9% removal within minutes. More importantly, selenite and selenate, typically known for being difficult to remove from aqueous environments, can be removed by PPN-150-MoS4, exhibiting >99% removal within minutes when in the presence of Hg2+. At the same time, the removal efficiency for Se(IV) and Se(VI) oxoanions in the absence of Hg2+ is very low, reaching only 14% removal. Overall, PPN-150-MoS4 exhibits one of the highest adsorption capacities toward SeO32- (124 mg/g), making it a promising and cheap sorbent material for water remediation applications. This work provides a fresh route for detoxification and remediation strategies that aim to regulate the presence of toxic ions in nature. The material herein shall guide the state-of-the-art design of efficient water treatment techniques through a combination of biological antagonism and materials chemistry.

Analysis on mechanism of toxicity reduction through compatibility of Aconiti Lateralis Radix Praeparata-Glycyrrhizae Radix et Rhizoma from in vitro component changes,in vivo metabolism and biological effects antagonism / 中国中药杂志

Aconiti Lateralis Radix Praeparata and Glycyrrhizae Radix et Rhizoma is a representative acid-alkali drug pair,commonly used in clinical application of traditional Chinese medicine( TCM). Its unique compatibility connotation fully embodied the wisdom of ancient people in drug use. In order to more comprehensively and deeply understand the scientific connotation of the compatibility of the two drugs,pharmacy workers have studied the mechanism of reducing toxicity and enhancing efficacy through their compatibility from the perspectives of chemistry,pharmacology and toxicology. On the basis of combing the previous research work,this paper interpreted the unique compatibility connotation from the three-level system of reducing the content of toxic components in vitro by hydrolysis,lipid exchange and formation of associations,the active constituents of Glycyrrhizae Radix et Rhizoma affecting the metabolism of toxic components and direct antagonism of the toxic effects of aconite in vivo. The existing problems and controversies of the modern mechanism of their compatibility were also proposed,providing a reference for further in-depth studies.

STUDIES ON ANTAGONISTIC INTERACTION OF HUMAN SKIN NORMAL FLORA AND COMMON PATHOGENIC BACTERIA / 微生物学通报

Biological antagonism was found to be only one aspeet When we Study the interactions among the microbial populations in and on the human beings. We examined the following strains of the resident flora isolated from the human healthy skin, including propionibacterium acnes (A14-1), Staphylococcus epidermidis (F65), and a number of the common dermal pathogenic micro-organisms such as staphylococcus aurcns. Ps. acruginosa snd E. coli, for their antagonistic interactions in vitro. The following results were obtained, they revealed obvious antagonism After 48h of contact in vitro antagonistic interaction to appear, and after 72h antagonism displayed obviously. On the other hand, P. acnes (A14-1) and S. epidermidis (F65) showed no antagonisim, they behaved commesaly, such commensality seemed to be important for the autoperification of the human normal skin surfaces resulting in dermal microeubiosis of the human beings.We examined the members of the transient microbial flora of the healthy human skin Lactobacterium (ad3), Bifidobacterium (Bf1) and some common pathogenic bacteria in antagonistic experiments in vitro, and discovered that they showed micropopulations appeared to be of great value to the maintenance of good health to their host.