The role of cue salience in prospective memory commission errors in nonperformed nonfocal tasks.

Prospective memory (PM) refers to the ability to remember to execute an intention in the future without having a permanent reminder. These intentions can be performed when they are not relevant or become no-longer needed, the so-called "commission errors". The present study aims to understand the effect of cue salience on PM commission errors with unperformed intentions and on the ongoing task performance-associated costs. Through a between-subjects design, eighty-one participants were assigned to 3 conditions: the no-PM condition, which served as control, and the salient and nonsalient conditions, which were asked to perform a lexical decision task and an incomplete nonfocal prospective memory task (i.e. no PM cues were presented). Subsequently, participants were instructed to no longer execute the prospective intention. In the second phase, a lexical decision task occurred again, including irrelevant PM cues, which should not be answered as such. In the salient condition, cues were salient (i.e. presented in red or blue background). In contrast, in the nonsalient condition, PM cues appeared on a black background, as any other stimuli. In the no-PM control condition, participants only performed an LDT. A commission error occurred when the (irrelevant) intention was performed in this second phase. Results showed that more participants performed a commission error in the presence of salient cues, even when PM intentions became irrelevant. Additionally, when cues were not salient, participants took longer to answer the LDT, as reasoned by the spontaneous retrieval theory. These findings are discussed according to the dual-mechanism account.

Undercompression errors as evidence for conceptual primitives.

The Meaning First Approach offers a model of the relation between thought and language that includes a Generator and a Compressor. The Generator build non-linguistic thought structures and the Compressor is responsible for its articulation through three processes: structure-preserving linearization, lexification, and compression via non-articulation of concepts when licensed. One goal of this paper is to show that a range of phenomena in child language can be explained in a unified way within the Meaning First Approach by the assumption that children differ from adults with respect to compression and, specifically, that they may undercompress in production, an idea that sets a research agenda for the study of language acquisition. We focus on dependencies involving pronouns or gaps in relative clauses and wh-questions, multi-argument verbal concepts, and antonymic concepts involving negation or other opposites. We present extant evidence from the literature that children produce undercompression errors (a type of commission errors) that are predicted by the Meaning First Approach. We also summarize data that children's comprehension ability provides evidence for the Meaning First Approach prediction that decompression should be challenging, when there is no 1-to-1 correspondence.

Neural Signatures of Error Processing in Depressed Adolescents with Comorbid Non-Suicidal Self-Injury (NSSI).

Non-suicidal self-injury (NSSI), as a highly prevalent psychiatric symptom in adolescents and young adults, is defined as the deliberate destruction of body tissue without suicidal intent. Impulsivity and dysfunctional response inhibition have been suggested to play a central role in adolescents' vulnerability to self-harm. To investigate the potentially distinct neurobiology of NSSI, we used a well-established Go/No Go task in which activation of the inferior frontal gyrus (IFG) and dorsal anterior cingulate cortex (dACC) is interpreted as a neural correlate of processing failed response inhibition. Task-based functional magnetic resonance imaging data were obtained from 14 adolescents with a diagnosis of major depression and a history of NSSI (MD-NSSI), 13 depressed adolescents without NSSI (MD-only), and 14 healthy controls (HC). In line with hypotheses of dysfunctional response inhibition, we observed increased rates of commission errors in MD-NSSI along with significantly reduced error-related activations of the dACC and IFG. Intact response inhibition, as reflected by low commission error rates not different from HC, was observed in MD-only, along with increased activation of the error-processing network. Our findings support the hypothesis of a distinct neurobiological signature of NSSI. Further research on biomarkers of NSSI could focus on behavioral and neural correlates of failed response inhibition.

Omission and commission errors underlying AI failures.

In this article we investigate origins of several cases of failure of Artificial Intelligence (AI) systems employing machine learning and deep learning. We focus on omission and commission errors in (a) the inputs to the AI system, (b) the processing logic, and (c) the outputs from the AI system. Our framework yields a set of 28 factors that can be used for reconstructing the path of AI failures and for determining corrective action. Our research helps identify emerging themes of inquiry necessary for developing more robust AI-ML systems. We are hopeful that our work will help strengthen the use of machine-learning AI by enhancing the rates of true positive and true negative judgements from AI systems, and by lowering the probabilities of false positive and false negative judgements.

Dissociating sub-processes of aftereffects of completed intentions and costs to the ongoing task in prospective memory: A mouse-tracking approach.

In the present study, we used mouse tracking to investigate two processes underlying prospective memory (PM) retrieval: First, we aimed to explore to what extent spontaneous retrieval of already completed PM intentions is supported by reflexive-associative and discrepancy-plus-search processes. Second, we aimed to disentangle whether costs to an ongoing task during the pursuit of a PM intention are associated with presumably resource-demanding monitoring processes or with a presumably resource-sparing strategic delay of ongoing-task responses. Our third aim was to explore the interaction of processes underlying costs to the ongoing task and processes of spontaneous retrieval. Our analyses replicated response-time patterns from previous studies indicating aftereffects of completed intentions and costs to ongoing-task performance, as well as increased aftereffects while pursuing a PM intention. Notably, based on our mouse-tracking analyses, we argue that aftereffects of completed intentions are best explained by a reflexive initiation of an already completed intention. If the completed intention is not performed in its entirety (i.e., no commission error), the reflexive initiation of the completed intention is followed by a subsequent movement correction that most likely represents a time-consuming response-verification process. Regarding performance costs in the ongoing task, our analyses suggest that actively pursuing a PM intention most likely leads to a strategic delay of ongoing activities. Lastly, we found that pursuing a novel PM task after intention completion exacerbated orienting responses to all deviant stimuli, exacerbated the readiness to initiate the completed intention reflexively, and substantially prolonged the response-verification process following this reflexive intention retrieval.

Moving forward: Exploring the role of interference on prospective memory deactivation.

Recent prospective memory (PM) studies have shown that an intention may be erroneously executed despite no-longer-needed (i.e., commission errors), especially under demanding ongoing activities. In the current study, we examined whether PM deactivation benefits from a retroactive interference mechanism. For this, we set up a procedure in which participants are first asked to perform a PM task which is critically declared finished afterwards. Next, they encoded a new and dissimilar PM intention to accomplish later (Experiment 1) or performed filler tasks with increased working memory difficulty levels (Experiment 2). Lastly, all participants encountered several (but irrelevant) PM cues. Together, our findings provide evidence that the efficiency of the deactivation process can be modulated by encoding novel and dissimilar PM tasks and by the type of processing after intention completion. These findings are discussed in terms of strategic or spontaneous retrieval processes and linked to a retroactive interference mechanism which helps to overwrite or deteriorate the old-PM task representation.

Effects of a Differential Diagnosis List of Artificial Intelligence on Differential Diagnoses by Physicians: An Exploratory Analysis of Data from a Randomized Controlled Study.

A diagnostic decision support system (DDSS) is expected to reduce diagnostic errors. However, its effect on physicians' diagnostic decisions remains unclear. Our study aimed to assess the prevalence of diagnoses from artificial intelligence (AI) in physicians' differential diagnoses when using AI-driven DDSS that generates a differential diagnosis from the information entered by the patient before the clinical encounter on physicians' differential diagnoses. In this randomized controlled study, an exploratory analysis was performed. Twenty-two physicians were required to generate up to three differential diagnoses per case by reading 16 clinical vignettes. The participants were divided into two groups, an intervention group, and a control group, with and without a differential diagnosis list of AI, respectively. The prevalence of physician diagnosis identical with the differential diagnosis of AI (primary outcome) was significantly higher in the intervention group than in the control group (70.2% vs. 55.1%, p < 0.001). The primary outcome was significantly >10% higher in the intervention group than in the control group, except for attending physicians, and physicians who did not trust AI. This study suggests that at least 15% of physicians' differential diagnoses were affected by the differential diagnosis list in the AI-driven DDSS.

From retrospective to prospective memory research: a framework for investigating the deactivation of intentions.

The definition of episodic memory has evolved into a multifaceted concept that gathered great attention in several research areas in psychology and neuroscience. Prospective memory (PM), or the ability to remember to perform delayed intentions at a later moment in the future, represents one side of this capacity for which that has been a growing interest. In this review, we examined a counterintuitive finding: PM intentions may persist and affect our behaviour despite successful goal attainment and task completion, which in daily life may be as serious as taking medication twice. This review aims to elucidate the existing knowledge and identify some unresolved questions concerning this specific memory failure. Therefore, this review provides an overview of the uprising research dedicated to both PM omission and commission errors, including an analysis of its definitions, of the current theoretical approaches of PM retrieval, and the main procedures used in this field to offer an integrative perspective on this topic. Finally, the last section is devoted to discussing future directions to test the predictions of our suggested theoretical explanations for PM deactivation. This might be an avenue for research that is likely to extend our understanding of episodic memory's usefulness in everyday life.

Efficacy of Artificial-Intelligence-Driven Differential-Diagnosis List on the Diagnostic Accuracy of Physicians: An Open-Label Randomized Controlled Study.

BACKGROUND: The efficacy of artificial intelligence (AI)-driven automated medical-history-taking systems with AI-driven differential-diagnosis lists on physicians' diagnostic accuracy was shown. However, considering the negative effects of AI-driven differential-diagnosis lists such as omission (physicians reject a correct diagnosis suggested by AI) and commission (physicians accept an incorrect diagnosis suggested by AI) errors, the efficacy of AI-driven automated medical-history-taking systems without AI-driven differential-diagnosis lists on physicians' diagnostic accuracy should be evaluated. OBJECTIVE: The present study was conducted to evaluate the efficacy of AI-driven automated medical-history-taking systems with or without AI-driven differential-diagnosis lists on physicians' diagnostic accuracy. METHODS: This randomized controlled study was conducted in January 2021 and included 22 physicians working at a university hospital. Participants were required to read 16 clinical vignettes in which the AI-driven medical history of real patients generated up to three differential diagnoses per case. Participants were divided into two groups: with and without an AI-driven differential-diagnosis list. RESULTS: There was no significant difference in diagnostic accuracy between the two groups (57.4% vs. 56.3%, respectively; p = 0.91). Vignettes that included a correct diagnosis in the AI-generated list showed the greatest positive effect on physicians' diagnostic accuracy (adjusted odds ratio 7.68; 95% CI 4.68-12.58; p < 0.001). In the group with AI-driven differential-diagnosis lists, 15.9% of diagnoses were omission errors and 14.8% were commission errors. CONCLUSIONS: Physicians' diagnostic accuracy using AI-driven automated medical history did not differ between the groups with and without AI-driven differential-diagnosis lists.

Neural signature of error processing in major depression.

The clinical presentation of major depression (MD) is heterogenous and comprises various affective and cognitive symptoms including an increased sensitivity to errors. Various electrophysiological but only few functional magnetic resonance imaging (fMRI) studies investigated neural error processing in MD with inconsistent findings. Thus, reliable evidence regarding neural signatures of error processing in patients with current MD is limited despite its potential relevance as viable neurobiological marker of psychopathology. We therefore investigated a sample of 16 young adult female patients with current MD and 17 healthy controls (HC). During fMRI, we used an established Erikson-flanker Go/NoGo-paradigm and focused on neural alterations during errors of commission. In the absence of significant differences in rates of errors of commission in MD compared to HC, we observed significantly (p < 0.05, FWE-corrected on cluster level) enhanced neural activations of the dorsal anterior cingulate cortex (dACC) and the pre-supplementary motor area (pre-SMA) in MD relative to HC and thus, in brain regions consistently associated to neural error processing and corresponding behavioral adjustments. Considering comparable task performance, in particular similar commission error rates in MD and HC, our results support the evidence regarding an enhanced responsivity of neural error detection mechanisms in MD as a potential neural signature of increased negative feedback sensitivity as one of the core psychopathological features of this disorder.

Deactivation of prospective memory intentions: Examining the role of the stimulus-response link.

Successful prospective remembering involves formation of a stimulus (e.g., bottle of medication and/or place where the bottle is kept)-response (e.g., taking a medication) link. We investigated the role of this link in the deactivation of no-longer-relevant prospective memory intentions, as evidenced by commission error risk. Experiment 1a contrasted two hypotheses of intention deactivation (degree of fulfillment and response frequency) by holding constant the degree of intention fulfillment (e.g., participants responded to one of two target words) while manipulating the number of times the intention was performed. Findings supported the response frequency hypothesis. Experiment 1b employed novel lure trials to examine what "stimulus" participants link the prospective memory response to-target words and/or the salient contextual cue-and compared commission errors to Experiment 1a. Findings suggested the salient context alone does not always function as the stimulus. Collectively these findings, in conjunction with those of Experiment 2 (a within-experiment replication) and a combined analysis, suggest that (a) intention deactivation is facilitated by prior responding (formation/strengthening of stimulus-response links), but additional research is needed to establish the robustness of this effect, and (b) when responding frequently to targets, participants are more likely to bind the response to the context alone than to the target or target/context combination, possibly because they learn to rely on context to predict target occurrence. The latter finding was robust and indicates that deactivation of the appropriate stimulus (target and/or context)-response link may be a critical component of reducing commission errors.

How Does Performing Demanding Activities Influence Prospective Memory? A Systematic Review.

This paper is the first systematic review on the role of ongoing task load in prospective remembering, which was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Forty articles published between 1995 and 2020 were included. They evaluated prospective memory (PM) performance (i.e., the ability to remember to execute a delayed intention) in adult samples aged between 19 and 50 years old when the PM cue appeared under cognitively demanding conditions. The results revealed that people are more likely to fail to remember to perform a delayed intention at the appropriate circumstances or time in the future when their cognitive resources are taxed by demanding ongoing activities. We conclude the review by highlighting that the degree of working memory and executive resources seems to account for some of the discrepant findings and by proposing directions for future research.

Diffusion tensor imaging findings in children with sluggish cognitive tempo comorbid Attention Deficit Hyperactivity Disorder.

Objective: The construct of Sluggish Cognitive Tempo (SCT) is characterized by daydreaming, mental confusion, staring blankly and hypoactivity. Our main goal was to explore neuropsychological differences in Attention Deficit Hyperactivity Disorder-Inattentive presentation (ADHD-IA) groups with and without SCT symptoms compared to healthy controls. After detecting specific neuropsychological differences, we examined white matter microstructure using Diffusion Tensor Imaging (DTI) data obtained from 3.0 Tesla MRI scans of the cases with SCT symptoms comparing to Typically Developing (TD) controls.Method: In this study, we included 24 cases in the ADHD-IA group with SCT symptoms, 57 cases in the ADHD-IA group without SCT symptoms and, 24 children in the TD group. We applied tract-based spatial statistics to the DTI measures for obtaining fractional anisotropy (FA), axial, radial and mean diffusivity (AD, RD, MD) to explore white matter differences for the whole brain.Results: Omission error scores and longer reaction time scores were specifically associated with inattention symptoms. Commission error scores were significantly and specifically related to SCT symptoms. Cases with SCT symptoms presented increased FA in the bilateral anterior and posterior limb of the internal capsule, bilateral cerebral peduncle, and the fornix than TD group.Conclusions: Neurobiological differences in ADHD cases are still relatively unexplored. We suggest that including an assessment for SCT in the neuropsychological and neuroimaging studies of ADHD may provide more consistent results.

When we must forget: the effect of cognitive load on prospective memory commission errors.

Recent studies consistently show that prospective memory (PM) intentions are not always deactivated when no-longer needed and might be erroneously performed upon encountering the once relevant cue - termed PM commission errors. However, empirical evidence on the potential mechanisms that might lead to this kind of memory failure remains mostly unexplored. This study aimed to investigate the influence of the ongoing task demands on PM deactivation of non-performed intentions. Younger adults, except for those in the no-PM condition, were asked to perform a PM task and were then told that the intention was finished. Later, they perform a lexical decision task with some trials containing (irrelevant) PM cues while simultaneously carrying out a counting recall task with two levels of difficulty. The results showed a higher risk of PM commission errors under moderate cognitive load (74%) as compared to the no-load condition (40%). Results also show that commission error risk did not increase in the high-load (54%) compared with the moderate-load condition. Furthermore, comparisons of the ongoign task performance between the no-PM condition and the other conditions with a PM task requirement support that commission errors might arise from a spontaneous PM retrieval. The implications of these findings are discussed within the dual-mechanisms account.

Commission errors with forced response lag.

It is often necessary to retrieve intentions once a certain cue occurs in the environment. However, such prospective memory (PM) tasks can also be erroneously recalled even though they are no longer relevant and may result in commission errors. According to the dual mechanism account, commission errors occur because the intention is spontaneously retrieved, and there is a subsequent failure to suppress the associated action, resulting in erroneous instant execution. In three experiments, we tested whether failed response suppression is a prerequisite for commission errors. We set up a response lag condition in which participants had to delay their response to ongoing task trials for 1 s (Experiment 1) or 2 s (Experiments 2 and 3) and a pause condition in which the delay occurred between ongoing task trials. In both conditions, participants learned about a PM task and were then told that the PM task was cancelled. In addition, a control group with response lag executed the PM task and was subsequently told the task was finished. Later, all participants encountered several irrelevant PM cues. If failed response suppression is a prerequisite for commission errors, commission error rates should be non-existent in the response lag conditions, because participants had designated time to suppress the PM action. However, commission errors occurred at an equal rate in all lag and pause conditions. Due to this contradiction to the dual mechanism account, we suggest that the process for commission error occurrence should be reconsidered. Because commission errors appear not to be caused by failed response suppression, we discuss the idea that erroneous intentions might be formed when encountering the former PM cue and persist over delays between formation and execution.

Are we guilty of errors of omission on the potential role of electronic nicotine delivery systems as less harmful substitutes for combusted tobacco use?

Two of the more controversial tobacco control and regulatory strategies in recent years are the nicotine reduction and tobacco harm reduction (THR) strategies. They have become inextricably intertwined as a successful nicotine reduction policy might only be possible in an environment in which alternative, noncombusted forms of nicotine like electronic nicotine delivery systems (ENDS) are available to address the needs of those who were unable or unwilling to completely give up nicotine. Unfortunately, ENDS have emerged as particularly controversial, in part, because they are the first product to carry reduced risk potential while being broadly appealing to cigarette smokers across demographic groups and subpopulations, and to a much smaller extent nonsmokers including, and most controversial, adolescents. In an effort to better understand some of the reasons that make this a controversial topic, we review some of the relevant history and discuss a broader dilemma that faces practitioners and policy developers of medical and public health interventions, namely, weighing the potential consequences of errors of commission versus omission. Commission errors involve a salient, direct link between an action and associated adverse or unintended consequences while omission errors are typically less salient with a more indirect link between inaction and associated adverse consequences. Decision-making research demonstrates that humans have a bias towards avoidance of commission errors and insensitivity to omission errors. This bias may be contributing to some of the aforementioned difficulties in finding common ground regarding the potential contribution of ENDS to reducing the harm of combusted tobacco use.

Errors on a computer task and subclinical symptoms of attention-deficit/hyperactivity disorder (ADHD).

Previous reports have found increased error rate for children with attention-deficit/hyperactivity disorder (ADHD) on response time (RT) computer tasks. Here we attempt the conceptual replication and extension of two studies that examined error rate in a general population of children (N = 203). Study 1 followed Johnstone and Galletta but considered associations between scores on a dimensional measure of ADHD symptoms (rather than comparing those with or without an ADHD diagnosis) and the frequency of commission and omission errors. Study 2 followed Shiels, Tamm & Epstein and examined post-error adjustment in the same group of children as for Study 1. Study 1 did not replicate previous findings of no increase in errors of commission in those with higher ADHD symptoms (Johnstone & Galletta). Instead, we found that younger children with lower ADHD symptoms were more likely to make commission errors, while omission errors did not vary with age. Study 2 replicated the previous finding of less RT slowing in children with more ADHD symptoms, extending this finding to a general population of children. Namely, as ADHD symptoms increase, RT slowing is less likely, putting children with higher ADHD symptoms at risk of additional errors. Overall, we extend previous ADHD research to typically developing children with ADHD symptoms.

Prevalence of medication errors in primary health care at Bahrain Defence Force Hospital - prescription-based study.

BACKGROUND: One of the important activities that physicians - particularly general practitioners - perform is prescribing. It occurs in most health care facilities and especially in primary health care (PHC) settings. OBJECTIVES: This study aims to determine what types of prescribing errors are made in PHC at Bahrain Defence Force (BDF) Hospital, and how common they are. METHODS: This was a retrospective study of data from PHC at BDF Hospital. The data consisted of 379 prescriptions randomly selected from the pharmacy between March and May 2013, and errors in the prescriptions were classified into five types: major omission, minor omission, commission, integration, and skill-related errors. RESULTS: Of the total prescriptions, 54.4% (N=206) were given to male patients and 45.6% (N=173) to female patients; 24.8% were given to patients under the age of 10 years. On average, there were 2.6 drugs per prescription. In the prescriptions, 8.7% of drugs were prescribed by their generic names, and 28% (N=106) of prescriptions included an antibiotic. Out of the 379 prescriptions, 228 had an error, and 44.3% (N=439) of the 992 prescribed drugs contained errors. The proportions of errors were as follows: 9.9% (N=38) were minor omission errors; 73.6% (N=323) were major omission errors; 9.3% (N=41) were commission errors; and 17.1% (N=75) were skill-related errors. CONCLUSION: This study provides awareness of the presence of prescription errors and frequency of the different types of errors that exist in this hospital. Understanding the different types of errors could help future studies explore the causes of specific errors and develop interventions to reduce them. Further research should be conducted to understand the causes of these errors and demonstrate whether the introduction of electronic prescriptions has an effect on patient outcomes.

Commission errors in delay-execute prospective memory tasks.

Individuals frequently retrieve an intention, but the execution of the task needs to be delayed due to ongoing task demands - so-called delay-execute prospective memory (PM) tasks. We investigated commission errors in the delay-execute paradigm. Participants were told that a PM task is finished (PM task has been executed and is now finished for a final phase) or cancelled (PM task has been cancelled immediately after introduction). We observed commission errors and ongoing task performance in the final phase which included several irrelevant PM cues. In two experiments, we observed significantly more commission errors for cancelled compared to the finished intentions. In Experiment 2, commission errors were eliminated if the final phase required divided attention, regardless of PM task status. In addition, we observed significantly more PM cue interference on the ongoing task in the cancelled compared to the finished group, indicating that the PM task was retrieved in the cancelled group but not in the finished group. As retrieval and execution of the PM task were separated by a delay, the results indicate that commission errors are not always the result of a quick, spontaneous retrieval-execution sequence and may also occur when retrieval and execution are temporally separated.

Laboratory impulsivity and depression in blast-exposed military personnel with post-concussion syndrome.

In military populations, traumatic brain injury (TBI) also holds potential to increase impulsivity and impair mood regulation due to blast injury effects on ventral frontal cortex - to put military personnel at risk for suicide or substance abuse. We assessed a linkage between depression and impaired behavioral inhibition in 117 blast-exposed service members (SM) and veterans with post-concussion syndrome (PCS), where PCS was defined using a Rivermead Postconcussive Symptom Questionnaire (RPQ) modified to clarify whether each symptom worsened compared to pre-blast. Center for Epidemiological Studies-Depression Scale (CES-D) scores, PTSD Checklist 5 (PCL-5) scores, and RPQ raw subscale scores correlated positively with commission and perseverative errors on the continuous performance test II (CPT-II). In contrast, the number of RPQ symptoms ostensibly worsened post-blast did not correlate with impulsive errors on the CPT-II. These data replicate earlier findings that link increased affective symptomatology to impaired behavior inhibition in military TBI populations, but where additional effects on impulsivity from the blast itself remain equivocal.