Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook.

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian, introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

Elemene Antitumor Drugs Development Based on "Molecular Compatibility Theory" and Clinical Application: A Retrospective and Prospective Outlook / 中国结合医学杂志

Elemene, derived from Curcuma wenyujin, one of the "8 famous genuine medicinal materials of Zhejiang province," exhibits remarkable antitumor activity. It has gained wide recognition in clinical practice for effectiveness on tumors. Dr. XIE Tian, introduced the innovative concept of "molecular compatibility theory" by combining Chinese medicine principles, specifically the "monarch, minister, assistant, and envoy" theory, with modern biomedical technology. This groundbreaking approach, along with a systematic analysis of Chinese medicine and modern biomedical knowledge, led to the development of elemene nanoliposome formulations. These novel formulations offer numerous advantages, including low toxicity, well-defined composition, synergistic effects on multiple targets, and excellent biocompatibility. Following the principles of the "molecular compatibility theory", further exploration of cancer treatment strategies and methods based on elemene was undertaken. This comprehensive review consolidates the current understanding of elemene's potential antitumor mechanisms, recent clinical investigations, advancements in drug delivery systems, and structural modifications. The ultimate goal of this review is to establish a solid theoretical foundation for researchers, empowering them to develop more effective antitumor drugs based on the principles of "molecular compatibility theory".

The Evolutionary Game Analysis of Low Carbon Production Behaviour of Farmers, Government and Consumers in Food Safety Source Governance.

Whether the quality of agricultural products is safe or not is related to issues of food safety and low carbon production in agriculture. Based on evolutionary game theory, this paper establishes a game model among government, farmers and consumers and analyzes the dynamic evolutionary process and evolutionary stable strategies of the major stakeholders. The results show that: (i) government subsidy coefficient, farmers' penalty coefficient for not producing, consumer trust coefficient and willingness to pay carbon labelled agricultural products premium are positively related to farmers' adoption of low-carbon production behaviour, and fraud penalty coefficient and farmers' cost of adopting low-carbon production technology are negatively related; (ii) farmers' sensitivity to government regulation policies is: fraud penalty coefficient = farmers' cost of adopting low-carbon production technology > government subsidy The sensitivity of farmers to government regulation policies is: fraud penalty coefficient = cost of low-carbon production technology > government subsidy > penalty coefficient for non-production, and the sensitivity of farmers to direct market stimulation is: consumer trust coefficient > coefficient of willingness to pay premium for carbon labelled agricultural products, and the additional benefit coefficient has no significant effect on farmers' decision-making; (iii) In the early stage, the source control of food safety mainly depends on the government's policy intervention. In the later stage, the establishment of carbon label agricultural products market incentive mechanism can achieve long-term stable and effective source control of food safety.

Anti-inflammatory and analgesic activity analysis of Qizhi Weitong Granules based on network pharmacology / 中草药

Objective: The target of anti-inflammatory and analgesic active components of Qizhi Weitong Granules was predicted by network pharmacology method, and the effect of multi-component-multi-target-multi-pathways on TCM-complexation theory was analyzed. Methods: The main chemical constituents of six Chinese medicines in Qizhi Weitong Granules were collected based on the TCMSP Chinese Medicine System Biological Analysis Database and analyzed by LC-MS. The main target of each component was predicted by TCMSP search and Pharmmapper software. The relationship between drug, target and inflammatory pain target was established by DIP database and protein interaction information. In order to elucidate the main mechanism of anti-inflammatory and analgesic effects of Qizhi Weitong Granules, the network of “drug-target-disease” was constructed and the target of anti-inflammatory and analgesic effects of Qizhi Weitong Granules were analyzed by network characteristics. Results: Through the network analysis, a total of 44 inflammatory targets were closely related to Qizhi Weitong Granules, of which 20 were directly targeted, mainly for the action of proteases such as COX-2 and iNOS. The mechanism may be related to the regulation of TNF signaling pathway, NOD-like receptor signaling pathways, VEGF signaling pathways and other signaling pathways closely related to inflammation. Conclusion: The anti-inflammatory and analgesic effects of Qizhi Weitong Granules reflect the multi-component, multi-target and multi-pathway characteristics of traditional Chinese medicine. This study provides a scientific basis for further understanding the anti-inflammatory and analgesic mechanism of Qizhi Weitong Granules and explains the scientificity of the traditional Chinese medicine compatibility theory.

Systems Pharmacology Dissection of Multi-Scale Mechanisms of Action of Huo-Xiang-Zheng-Qi Formula for the Treatment of Gastrointestinal Diseases.

Multi-components Traditional Chinese Medicine (TCM) treats various complex diseases (multi-etiologies and multi-symptoms) via herbs interactions to exert curative efficacy with less adverse effects. However, the ancient Chinese compatibility theory of herbs formula still remains ambiguous. Presently, this combination principle is dissected through a systems pharmacology study on the mechanism of action of a representative TCM formula, Huo-xiang-zheng-qi (HXZQ) prescription, on the treatment of functional dyspepsia (FD), a chronic or recurrent clinical disorder of digestive system, as typical gastrointestinal (GI) diseases which burden human physical and mental health heavily and widely. In approach, a systems pharmacology platform which incorporates the pharmacokinetic and pharmaco-dynamics evaluation, target fishing and network pharmacological analyses is employed. As a result, 132 chemicals and 48 proteins are identified as active compounds and FD-related targets, and the mechanism of HXZQ formula for the treatment of GI diseases is based on its three function modules of anti-inflammation, immune protection and gastrointestinal motility regulation mainly through four, i.e., PIK-AKT, JAK-STAT, Toll-like as well as Calcium signaling pathways. In addition, HXZQ formula conforms to the ancient compatibility rule of "Jun-Chen-Zuo-Shi" due to the different, while cooperative roles that herbs possess, specifically, the direct FD curative effects of GHX (serving as Jun drug), the anti-bacterial efficacy and major accompanying symptoms-reliving bioactivities of ZS and BZ (as Chen), the detoxication and ADME regulation capacities of GC (as Shi), as well as the minor symptoms-treating efficacy of the rest 7 herbs (as Zuo). This work not only provides an insight of the therapeutic mechanism of TCMs on treating GI diseases from a multi-scale perspective, but also may offer an efficient way for drug discovery and development from herbal medicine as complementary drugs.

Examples for Explaining Intentions of Those Famous TCM Combinations for Disease According to Shennong Bencao Jing / 浙江中医药大学学报

Objective] Explain the intentions of those famous TCM combinations for disease according to Shennong Bencao Jing. [Methods] Find out the principles to make up those famous TCM prescriptions based on understanding the efficacy of medicine described in Shennong Bencao Jing, through combining comparing the original documents of each other with the clinical practice of Mr. Xu Xiaodong. The natural medicine such as Gan Dihuang, Baizhu and Chai Hu were used as mediums to relate those famous TCM prescriptions and Shennong Bencao Jing. [Results] The original documents of Shennong Bencao Jing and those famous TCM prescriptions which were related together by natural medicine such as Gan Dihuang, Baizhu and Chai Hu have much in common. For example, Gan Dihuang used in Si Wutang, Huang Tutang etc. according to the effect of promoting blood circulation and removing blood stasis described in Shennong Bencao Jing. Chang Pu used in Changpu Yujintang according to the effect of resuscitation and restoring consciousness described in Shennong Bencao Jing. Baizhu used in Fangji Huangqi Tang, Mahuang Jiazhu Tang of Jinkui Yaolue according to the antiperspirant effect described in Shennong Bencao Jing. Chai Hu used in Xiao Chaihu Tang, Chaihu Shugan San etc. according to the effect of relieving the abdominal discomfort, attacks of chills and fever described in Shennong Bencao Jing. The theory of Shennong Bencao Jing is well applied in clinical teaching and practice by Mr. Xu Xiaodong, bringing students a lot of inspiration. It is possible to explain the principles of making up those famous TCM prescriptions and guide the compatibility of TCM according to Shennong Bencao Jing. [Conclusion] Doctors in the ancient world have inherited and developed the Shennong Bencao Jing theory when filling the prescription; comprehension and application of those famous TCM prescriptions will be more original according to Shennong Bencao Jing. The theory of Shennong Bencao Jing is worth our further study and extension.