Sesquiterpenes constituents from fruits of Michelia yunnanensis / 中草药

Objective: To study the chemical constituents from fruits of Michelia yunnanensis. Methods: The chemical constituents were isolated and purified by column chromatographies on silica gel and Sephadex LH-20. Their structures were elucidated on the basis of spectroscopic data. Results: Twelve compounds were isolated from methanol extract of the fruits of M. yunnanensis and the structures were identified as 13-methoxy-11β, 13-dihydrocostunolide (1), lanuginolide (2), tulipinolide (3), lipiferolide (4), costunolide (5), parthenolide (6), 11β, 13-dihydroparthenolide (7), 4α, 5β-epoxy-13-methoxy-11βH-germacra-1 (10)-en-12, 6α-olide (8), cyperusol C (9), aromadendra-4β, 10α-diol (10), 9-oxonerolidol (11), and 11, 13-dehydrocompressanolide (12). Conclusion: Compound 1 is isolated as a new natural product. 1H-NMR and 13C-NMR data of compounds 1 and 2 are reported for the first time. Except compound 6, other compounds are isolated from this plant for the first time.

Two new sesquiterpenoids from leaves of Magnolia grandiflora / 中草药

Objective To study the chemical constituents from the leaves of Magnolia grandiflora. Methods The chemical constituents were isolated and purified by various column chromatographic techniques, including silica gel and Sephadex LH-20, and the structures were identified by spectroscopic analyses. Results Eight sesquiterpenoids were isolated from 70% aq. acetone extract of M. grandiflora and the structures were identified as 12,13-diacetoxy-eudesma-4α,6α,11-triol (1), 12,13-diacetoxy-5αH-guaia-1 (10)-en-4α,6α,11-triol (2), 11,13-dehydrocompressanolide (3), compressanolide (4), α-santonin (5), 1β-hydroxyl-11βH-eudesma-3- en-12,6α-olide (6), β-dictyopterol (7), and 12α-methoxy-germacran-1(10), 4,11(13)-trien-12,6α-acetal (8). Conclusion Compounds 1 and 2 are new compounds named as magnogranol A and B, and compounds 4-8 are isolated from this plant for the first time.