A novel strategy for the quantify of emerging isomeric pollutants belonging to the dihydroxybenzene family for environmental sample monitoring by amperometric detection.

This study introduces an innovative approach for quantifying isomeric pollutants utilizing an amperometric sensor. The determination of the isomers hydroquinone and catechol is based on the use of a glassy carbon electrode modified with Cu@PtPd/C nanoparticles (Cu@PtPd/C/GCE) in core-shell form, showing significant electrocatalytic activity in the oxidation of the later compounds. The determination was carried out at two different potentials: one at which where only hydroquinone is oxidized, and another in which where both hydroquinone and catechol are oxidized. Using these potentials, two calibration curves were built, one for the quantification of hydroquinone and the other for both isomers. Subsequently, the quantification of catechol was performed using a strategy based on the calculation of a difference using the information collected in the first step. The experiments using hydrogen peroxide as a redox probe demonstrate a clear synergistic effect in the catalytic reduction of hydrogen peroxide at -0.100 V, when Pt, Pd and Cu are incorporated into the core-shell nanostructure. The best performance was achieved with Cu@PtPd/C/GCE 1.00 mg mL-1. For the selected sensor, the analytical parameters are very competitive compared to similar devices reported in recent years for hydroquinone and catechol, with comparable linearity ranges of 0.010-0.200 mmol L-1 (hydroquinone) and 0.005-0.500 mmol L-1 (catechol), low limits of detection (LODs) of 14.0 nmol L-1 (S/N = 3.3) and 1.75 nmol L-1 (S/N = 3.3) for hydroquinone and catechol. The resulting sensor platform has been successfully applied for the quantification of hydroquinone and catechol in river and tap water and could be a promising candidate for environmental monitoring and drinking water safety.

Iron-Reduced Graphene Oxide Core-Shell Micromotors Designed for Magnetic Guidance and Photothermal Therapy under Second Near-Infrared Light.

Core-shell micro/nanomotors have garnered significant interest in biomedicine owing to their versatile task-performing capabilities. However, their effectiveness for photothermal therapy (PTT) still faces challenges because of their poor tumor accumulation, lower light-to-heat conversion, and due to the limited penetration of near-infrared (NIR) light. In this study, we present a novel core-shell micromotor that combines magnetic and photothermal properties. It is synthesized via the template-assisted electrodeposition of iron (Fe) and reduced graphene oxide (rGO) on a microtubular pore-shaped membrane. The resulting Fe-rGO micromotor consists of a core of oval-shaped zero-valent iron nanoparticles with large magnetization. At the same time, the outer layer has a uniform reduced graphene oxide (rGO) topography. Combined, these Fe-rGO core-shell micromotors respond to magnetic forces and near-infrared (NIR) light (1064 nm), achieving a remarkable photothermal conversion efficiency of 78% at a concentration of 434 µg mL-1. They can also carry doxorubicin (DOX) and rapidly release it upon NIR irradiation. Additionally, preliminary results regarding the biocompatibility of these micromotors through in vitro tests on a 3D breast cancer model demonstrate low cytotoxicity and strong accumulation. These promising results suggest that such Fe-rGO core-shell micromotors could hold great potential for combined photothermal therapy.

Magnetic properties of Fe-doped NiO nanoparticles.

Undoped and Fe-doped NiO nanoparticles were successfully synthesized using a lyophilization method and systematically characterized through magnetization techniques over a wide temperature range, with varying intensity and frequency of the applied magnetic fields. The Ni1-xFexO nanoparticles can be described by a core-shell model, which reveals that Fe doping enhances exchange interactions in correlation with nanoparticle size reduction. The nanoparticles exhibit a superparamagnetic blocking transition, primarily attributed to their cores, at temperatures ranging from above room temperature to low temperatures, depending on the Fe-doping level and sample synthesis temperature. The nanoparticle shells also exhibit a transition at low temperatures, in this case to a cluster-glass-like state, caused by the dipolar magnetic interactions between the net magnetic moments of the clusters. Their freezing temperature shifts to higher temperatures as the Fe-doping level increases. The existence of an exchange bias interaction was observed, thus validating the core-shell model proposed.

Unveiling the Role of Donor Impurity Position on the Electronic Properties in Strained Type I and Type II Core/Shell Quantum Dots under Magnetic Field.

In this theoretical investigation, we delve into the significant effects of donor impurity position within core/shell quantum dot structures: type I (CdTe/ZnS) and type II (CdTe/CdS). The donor impurity's precise location within both the core and the shell regions is explored to unveil its profound influence on the electronic properties of these nanostructures. Our study investigates the diamagnetic susceptibility and binding energy of the donor impurity while considering the presence of an external magnetic field. Moreover, the lattice mismatch-induced strain between the core and shell materials is carefully examined as it profoundly influences the electronic structure of the quantum dot system. Through detailed calculations, we analyze the strain effects on the conduction and valence bands, as well as the electron and hole energy spectrum within the core/shell quantum dots. The results highlight the significance of donor impurity position as a key factor in shaping the behaviors of impurity binding energy and diamagnetic susceptibility. Furthermore, our findings shed light on the potential for tuning the electronic properties of core/shell quantum dots through precise impurity positioning and strain engineering.

Bi-coloured enhanced luminescence imaging by targeted switch on/off laser MEF coupling for synthetic biosensing of nanostructured human serum albumin.

In this communication luminescent bioconjugated human serum albumin nanostructures (HSA NPs) with tiny ultraluminescent gold core-shell silica nanoparticles (Au@SiO2-Fl) were designed with enhanced bi-coloured luminescence properties. The HSA NPs were obtained from Human Serum Albumin free (HSA free) through the desolvation method, and Au@SiO2-Fl, through modified Turkevich and Störber methods. In this manner, porous HSA Nanostructures of 150.0-200 nm and Au@SiO2-Fl 45.0 nm final diameters were obtained. Both methodologies and structures were conjugated to obtain modified Nanocomposites based on tiny gold cores of 15 nm surrounded with well spatial Nanostructured architectures of HSA (d15 Au@SiO2-Fl-HSA) that generated variable nanopatterns depending on the modified methodology of synthesis applied within colloidal dispersions. Therefore, three methodologies of non-covalent conjugation were developed. In optimal conditions, through Transmission Electronic Microscopy (TEM), well resolved multilayered nano-architectures with a size 190.0-200 nm in average with variable contrast depending of the focused nanomaterial within the nanocomposite were shown. Optimized nanoarchitecture was based on a template tiny gold core-shell surrounded by nanostructured HSA NPs (d15 Au@SiO2-Fl-HSA). In this manner, the NanoImaging generated by laser fluorescence microscopy permitted to record improved optical properties and functionalities, such as: (i) enhanced ultraluminescent d15 Au@SiO2-Fl-HSA composites in comparison to individual components based on Metal Enhanced Fluorescence (MEF); (ii) diminished photobleaching; (iii) higher dispersibility; (iv) higher resolution of single bright nano-emitters of 210.0 nm sizes; and (v) enhanced bi-coloured Bio-MEF coupling with potential non-classical light delivery towards other non-optical active biostructures for varied applications. The characterization of these nanocomposites allowed the comparison, evaluation and discussion focused on new properties generated and functionalities based on the incorporation of different types of tuneable materials. In this context, the biocompatibility, Cargo confined spaces, protein-based materials, optical transparent could be highlighted, as well as optical active materials. Thus, the potential applications of nanotechnology to both nanomedicine and nano-pharmaceutics were discussed.

One-Pot Synthesis of CdTe/ZnS Quantum Dots and their Physico-Chemical Characterization.

A known property of quantum dots (QDs) is their characteristic luminescence, which would make it possible to detect different types of cancers after being functionalized with some type of biological molecule. For this reason, in the present investigation a methodological analysis of the physicochemical characteristics of the CdTe/ZnS core/shell QDs was carried out, using techniques such as Optical Absorbance Spectroscopy (UV-Vis), Molecular Fluorescence, Fourier Transform Infrared Spectroscopy (FT-IR), Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), Transmission Electron Microscopy (TEM) and Zeta Potential that allowed to verify the photoluminescent effectiveness of these semiconductor nanocrystals as an alternative to conventional techniques currently used for the detection of specific cancers smaller than 1 cm. The study consisted of theoretically determining the bandgap energy, the size of the nanocrystals and the molar absorptivity from the wavelength value for the maximum intensity of the excitonic peak. It was also possible to verify the maximum intensity for each sample and thus evaluate its photoluminescent response, as well as it was possible to determine the charge distribution, the hydrodynamic size and the surface composition of each quantum dot. The results obtained correspond to what has been reported in the literature, which makes them good candidates for the detection of cancer in precancerous stages.

Solution Blow-Spun Poly (Ethylene Oxide)-Polysulfone Bicomponent Fibers-Characterization of Morphology, Structure, and Properties.

Solution blow spinning was used to prepare nonwoven bicomponent fibers constituted by poly (ethylene oxide)-Polysulfone (PEO-PSF). As a new material, deep characterization was carried out to have a database to understand final performance regarding its multiple functions as a potential material for biomedical applications. The morphology was studied by field emission scanning electron and transmission electron microscopy and optical profilometry. Structural characterization was carried out by Fourier transform infrared spectroscopy and thermal degradation by thermogravimetric analysis. Additionally, wettability and mechanical behavior were studied by contact angle measurements and tensile tests, respectively. The bicomponent material was constituted of fibers with a structure mainly described by a core-shell structure, where the PSF phase is located at the center of the fibers, and the PEO phase is mainly located at the outer parts of the fibers, leading to a kind of shell wall. The study of possible interactions between different phases revealed them to be lacking, pointing to the presence of an interface core/shell more than an interphase. The morphology and roughness of the bicomponent material improved its wettability when glycerol was tested. Indeed, its mechanical properties were enhanced due to the PSF core provided as reinforcement material.

Core-shell chitosan/Porphyridium-exopolysaccharide microgels: Synthesis, properties, and biological evaluation.

Advanced materials used in the biomedicine field comprises a diverse group of organic molecules, including polymers, polysaccharides, and proteins. A significant trend in this area is the design of new micro/nano gels whose small size, physical stability, biocompatibility, and bioactivity could lead to new applications. Herein a new synthesis route is described to obtain core-shell microgels based on chitosan and Porphyridium exopolysaccharides (EPS) crosslinked with sodium tripolyphosphate (TPP). First, the synthesis of EPS-chitosan gels through ionic interactions was explored, leading to the formation of unstable gels. Alternatively, the use of TTP as crosslinker agent led to stable core-shell structures. The influence of reaction temperature, sonication time, and exopolysaccharide concentration, pH and TPP concentration were determined as a function of particle size and polydispersity index (PDI). The obtained EPS-chitosan gels were characterized by TEM, TGA, and FTIR; followed by the assessment of protein load capacity, stability upon freezing, cytotoxicity, and mucoadhesivity. Experimentation revealed that the core-shell particles size ranges 100-300 nm, have a 52 % loading capacity for BSA and a < 90 % mucoadhesivity, and no toxic effects in mammalian cell cultures. The potential application of the obtained microgels in the biomedical field is discussed.

Optical Properties in a ZnS/CdS/ZnS Core/Shell/Shell Spherical Quantum Dot: Electric and Magnetic Field and Donor Impurity Effects.

A theoretical analysis of optical properties in a ZnS/CdS/ZnS core/shell/shell spherical quantum dot was carried out within the effective mass approximation. The corresponding Schrödinger equation was solved using the finite element method via the 2D axis-symmetric module of COMSOL-Multiphysics software. Calculations included variations of internal dot radius, the application of electric and magnetic fields (both oriented along z-direction), as well as the presence of on-center donor impurity. Reported optical properties are the absorption and relative refractive index change coefficients. These quantities are related to transitions between the ground and first excited states, with linearly polarized incident radiation along the z-axis. It is found that transition energy decreases with the growth of internal radius, thus causing the red-shift of resonant peaks. The same happens when the external magnetic field increases. When the strength of applied electric field is increased, the opposite effect is observed, since there is a blue-shift of resonances. However, dipole matrix moments decrease drastically with the increase of the electric field, leading to a reduction in amplitude of optical responses. At the moment impurity effects are activated, a decrease in the value of the energies is noted, significantly affecting the ground state, which is more evident for small internal radius. This is reflected in an increase in transition energies.

Engineering Gold Shelled Nanomagnets for Pre-Setting the Operating Temperature for Magnetic Hyperthermia.

This study investigated the fabrication of spherical gold shelled maghemite nanoparticles for use in magnetic hyperthermia (MHT) assays. A maghemite core (14 ± 3 nm) was used to fabricate two samples with different gold thicknesses, which presented gold (g)/maghemite (m) content ratios of 0.0376 and 0.0752. The samples were tested in MHT assays (temperature versus time) with varying frequencies (100-650 kHz) and field amplitudes (9-25 mT). The asymptotic temperatures (T∞) of the aqueous suspensions (40 mg Fe/mL) were found to be in the range of 59-77 °C (naked maghemite), 44-58 °C (g/m=0.0376) and 33-51 °C (g/m=0.0752). The MHT data revealed that T∞ could be successful controlled using the gold thickness and cover the range for cell apoptosis, thereby providing a new strategy for the safe use of MHT in practice. The highest SAR (specific absorption rate) value was achieved (75 kW/kg) using the thinner gold shell layer (334 kHz, 17 mT) and was roughly twenty times bigger than the best SAR value that has been reported for similar structures. Moreover, the time that was required to achieve T∞ could be modeled by changing the thermal conductivity of the shell layer and/or the shape/size of the structure. The MHT assays were pioneeringly modeled using a derived equation that was analytically identical to the Box-Lucas method (which was reported as phenomenological).

Blue Titania: The Outcome of Defects, Crystalline-Disordered Core-Shell Structure, and Hydrophilicity Change.

In this research, changes in several characteristics of partially reduced titania were studied. The reduction process used made it possible to gradually observe changes in the material depending on the amount of reducing agent used. We used NaBH4 to impregnate commercial TiO2 with isopropyl alcohol. Impregnated TiO2 nanoparticles were dried and thermally treated in a nitrogen flow to obtain blue titania samples. Thorough spectroscopic characterization showed that oxygen atoms from hydroxyl groups, as well as from the surface, and the lattice of TiO2 was consumed. This caused changes in the surface and even in the bulk of TiO2 when the amount of reducing agent used was increased. Structural, optical, superficial, and textural characteristics were studied using XRD, Raman, DRS UV-Vis-NIR, Mid-DRIFT, XPS, and nitrogen adsorption/desorption isotherms. A photocatalytic test of the degradation of methylene blue dye was performed. Among different effects on the mentioned characteristics, we found evidence of changes in the surface properties of the blue titania samples and their probable effect on the photocatalytic properties. The reduction process implied a preponderant decrease in the surface hydrophilicity of the reduced samples, an effect shown for the first time in this type of material.

Drug Delivery from Stimuli-Responsive Poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/Chitosan Core/Shell Nanohydrogels.

The synthesis of stimulus-responsive poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide)/chitosan core/shell nanohydrogels made by batch emulsion polymerization in the presence of chitosan (CS) micelles is reported. The ratio of monomers required to obtain copolymers with a volume phase transition temperature (TVPT) in the range of the temperatures observed in the human body in response to an infection (38 to 40 °C) was estimated with the Fox equation. The conversion was determined by gravimetry; mean particle size, size distribution, and thermal response were measured by quasi-elastic light scattering (QLS). The core/shell structure was confirmed by TEM, and FTIR showed the presence of N-isopropyl acrilamide (NIPA), N-isopropyl methacrylamide (NIPMA), and CS in the nanohydrogels. The nanohydrogels were loaded with the drug doxycycline hyclate, and their release kinetic profile was determined at pH = 2.0 and 7.4 at their volume phase transition temperatures (TVPT). A higher amount of drug was released at acidic pH. Some mathematical models described in the literature were used to fit the experimental drug release data.

Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy.

Superparamagnetic iron oxide nanoparticles (SPIONs) have some limitations in the physiological environment, however, a modification on their surface, such as a core-shell structure with gold (SPIONs@Au), can enhance their applicability. In this study, SPIONs were synthesized by the chemical coprecipitation method, stabilized by sodium citrate, and followed by the gold-coating process. SPIONs@Au were functionalized with EGF-α-lipoic acid and chlorin e6 (Ce6)-cysteamine complexes, composing a Theranostic Nanoprobe (TP). The outcomes showed that the SPIONs@Au had changed in color to red and had an absorption band centered at 530 nm. The coating was verified in the TEM micrographs in bright and dark fields by EDS mapping, which indicated the presence of Au and Fe. The Ce6-cysteamine complex had a resonant band at 670 nm that enabled the diagnosis of biological samples using fluorescence analysis. In the measure of TNBC cell uptake, the maximum value of TP fluorescence intensity was obtained within 4 h of internalization. At 2 h, the incorporation of the TP in the cytoplasm as well as in the nuclei was observed, suggesting that it could be employed as a diagnostic marker. The PTT results showed significant percentages of apoptosis in the TNBC cell line, which confirms the efficacy of the TP.

Polymeric nanocapsules: A review on design and production methods for pharmaceutical purpose.

Polymeric nanocapsules have extensive application potential in medical, biological, and pharmaceutical fields, and, therefore, much research has been dedicated to their production. Indeed, production protocols and the materials used are decisive for obtaining the desired nanocapsules characteristics and biological performance. In addition to that, several technological strategies have been developed in the last decade to improve processing techniques and form more valuable nanocapsules. This review provides a guide to current methods for developing polymeric nanocapsules, reporting aspects to be considered when choosing appropriate materials, and discussing different ways to produce nanocapsules for superior performances.

Au@Ag Core@Shell Nanoparticles Synthesized with Rumex hymenosepalus as Antimicrobial Agent.

In this work, we used a sequential method of synthesis for gold-silver bimetallic nanoparticles with core@shell structure (Au@AgNPs). Rumex hymenosepalus root extract (Rh), which presents high content in catechins and stilbenes, was used as reductor agent in nanoparticles synthesis. Size distribution obtained by Transmission Electron Microscopy (TEM) gives a mean diameter of 36 ± 11 nm for Au@AgNPs, 24 ± 4 nm for gold nanoparticles (AuNPs), and 13 ± 3 nm for silver nanoparticles (AgNPs). The geometrical shapes of NPs were principally quasi-spherical. The thickness of the silver shell over AuNPs is around 6 nm and covered by active biomolecules onto the surface. Nanoparticles characterization included high angle annular dark field images (HAADF) recorded with a scanning transmission electron microscope (STEM), Energy-Dispersive X-ray Spectroscopy (EDS), X-Ray Diffraction (XRD), UV-Vis Spectroscopy, Zeta Potential, and Dynamic Light Scattering (DLS). Fourier Transform Infrared Spectrometer (FTIR), and X-ray Photoelectron Spectroscopy (XPS) show that nanoparticles are stabilized by extract molecules. A growth kinetics study was performed using the Gompertz model for microorganisms exposed to nanomaterials. The results indicate that AgNPs and Au@AgNPs affect the lag phase and growth rate of Escherichia coli and Candida albicans in a dose-dependent manner, with a better response for Au@AgNPs.

Magnetic Simulations of Core-Shell Ferromagnetic Bi-Magnetic Nanoparticles: The Influence of Antiferromagnetic Interfacial Exchange.

Magnetic properties of ferromagnetic nanostructures were studied by atomistic simulations following Monte Carlo and Landau-Lifshitz-Gilbert approaches. First, we investigated the influence of particle size and shape on the temperature dependence of magnetization for single cobalt and gadolinium nanoparticles and also in bi-magnetic Co@Gd core-shell nanoparticles with different sizes. The Landau-Lifshitz-Gilbert approach was subsequently applied for inspecting the magnetic hysteresis behavior of 2 and 4 nm Co@Gd core-shell nanoparticles with negative, positive, and zero values of interfacial magnetic exchange. We were able to demonstrate the influence of finite-size effect on the dependence of the Curie temperature of Co and Gd nanoparticles. In the Co@Gd core-shell framework, it was possible to handle the critical temperature of the hybrid system by adjusting the Co core size. In addition, we found an improvement in the coercive field values for a negative interfacial exchange energy and for a different core size, suggesting an exchange spring behavior, while positive and zero values of interfacial exchange constant showed no strong influence on the hysteresis behavior.

A simple, sensitive and efficient electrochemical platform based on carbon paste electrode modified with Fe3O4@MIP and graphene oxide for folic acid determination in different matrices.

A new biomimetic sensor selective to folic acid based on a carbon paste modified with graphene oxide and Fe3O4 nanoparticles coated with molecularly imprinted polymer in the core@shell format (Fe3O4@MIPs) was obtained using the polyol method. The sensing phase was synthesized in a simple way and characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and Brunauer-Emmett-Teller (BET) surface area. In the binding experiments the selective material showed a high adsorption capacity (Q) of 30.4 mg g-1 for MMIP, while the Q value for MNIP (magnetic non-imprinted polymer) was 15.3 mg g-1 both of them following the Langmuir model to the adsorption procedure. After their efficiency was proven, these materials were used as modifiers in the electrochemical sensor (Fe3O4@MIP-GO/CPE). Under optimized conditions using the square-wave adsorptive voltammetry, the proposed sensor exhibited excellent response with a concentration linear range between 2.5 and 48 µmol L-1 and limit of detection of 0.65 µmol L-1 (S/σ = 3). The advantages obtained with the proposed method were high robustness, selectivity, and low cost being these characteristics due to the MIP; highly sensibility due to the high superficial area being the contribution of the magnetite in the core of material; and experimentally versatile since was possible carry out numerous reproductible analysis only make the renovation of the paste electrode surface by simple polishing. The sensor was applied successfully in pharmaceutical formulation and river water samples with recoveries percentages near 100%.

Synthesis of mussel-inspired polydopamine-gallium nanoparticles for biomedical applications.

Aim: To established a simple, controlled and reproducible method to synthesize gallium (Ga)-coated polydopamine (PDA) nanoparticles (NPs). Materials & methods: PDA NPs were synthesized in alkali medium with posterior Ga shell formation due to ion chelation on the NP surface. Results: The obtained results with energy-dispersive x-ray spectroscopy confirmed the incorporation of Ga on the PDA NP surface. The cytotoxicity of Ga-coated PDA NPs was evaluated in vitro at different concentrations in contact with human adipose-derived stem cells. Further cell analysis also demonstrated the benefit of Ga-coated PDA NPs, which increased the cell proliferation rate compared with noncoated PDA NPs. Conclusion: This study indicated that Ga could work as an appropriate shell for PDA NPs, inducing cell proliferation at the analyzed concentrations.

Mesoporous molecularly imprinted polymer core@shell hybrid silica nanoparticles as adsorbent in microextraction by packed sorbent for multiresidue determination of pesticides in apple juice.

In this work, we report the synthesis of a mesoporous molecularly imprinted polymer on the surface of silica nanoparticles (core@mMIP) to be applied as adsorbent in microextraction by packed sorbent (MEPS) for selective determination of pesticides in apple juice. The core@mMIP was properly characterized, showing good adhesion of the polymer to the silica core. The best extraction conditions were: 200 µL of ultrapure water as washing solvent, 150 µL of acetonitrile as eluent, 100 µL of sample at pH 2.5, five draw-eject cycles and 8 mg of adsorbent. Thereby, recoveries of 96.12 ± 1.05%, 76.88 ± 6.18% and 76.18 ± 5.57% were obtained for pyriproxyfen (PPX), deltamethrin (DTM) and etofenprox (ETF), respectively. After validation, the method presented linearity in the range of 0.02-10 µg mL-1 (r > 0.99), limit of detection of 0.005 µg mL-1, satisfactory selectivity, and proper precision and accuracy. The method was successfully applied real samples of processed and fresh apple juice.

Well Defined Poly(Methyl Methacrylate)-Fe3O4/Poly(Vinyl Pivalate) Core-Shell Superparamagnetic Nanoparticles: Design and Evaluation of In Vitro Cytotoxicity Activity Against Cancer Cells.

The objective of this work is to develop and characterize polymeric nanoparticles with core-shell morphology through miniemulsion polymerization combined with seeded emulsion polymerization, aiming at the application in the treatment of vascular tumors via intravascular embolization. The synthesis of the core-shell nanocomposites was divided into two main steps: (i) Formation of the core structure, consisting of poly(methyl methacrylate)/magnetic oxide coated with oleic acid (OM-OA) via miniemulsion and (ii) shell structure produced through seeded emulsion polymerization of vinyl pivalate. Nanocomposites containing about 8 wt.% of OM-OA showed high colloidal stability, mean diameter of 216.8 nm, spherical morphology, saturation magnetization (Ms) of 4.65 emu·g-1 (57.41 emu·g-1 of Fe3O4), preserved superparamagnetic behavior and glass transition temperature (Tg) of 111.8 °C. TEM micrographs confirmed the obtaining of uniformly dispersed magnetic nanoparticles in the PMMA and that the core-shell structure was obtained by seeded emulsion with Ms of 1.35 emu·g-1 (56.25 emu·g-1 of Fe3O4) and Tg of 114.7 °C. In vitro cytotoxicity assays against murine tumor of melanoma (B16F10) and human Keratinocytes (HaCaT) cell lines were carried out showing that the core-shell magnetic polymeric materials (a core, consisting of poly(methyl methacrylate)/Fe3O4 and, a shell, formed by poly(vinyl pivalate)) presented high cell viabilities for both murine melanoma tumor cell lines, B16F10, and human keratinocyte cells, HaCaT.