Ethionamide induced blue vision (cyanopsia): Case report.

Ethionamide is part of a group of drugs used in the treatment of drug resistant TB. With the advent of increasing drug resistance in pulmonary TB cases, use of Ethionamide, a second line anti tubercular drug is increasing. Vision changes are rare with ethionamide. Cyanopsia i.e., bluish tinted vision of surroundings with ethionamide is not known in literature. Here, we report a case of DRTB patient who developed cyanopsia soon after introducing ethionamide. Although reversible, ethionamide may sometimes need withdrawal because of significant distress caused to patient.

Comparison of Color and Contrast Sensitivities Between UVCY(Non-Cyanoptic) and Conventional UV-AB IOLs

The non-cyanoptic, yellow colored posterior chamber intraocular lens (UVCY-IOL, HOYA, Japan) was specially designed to reduce the penetration of ultraviolet (UV) and short wave length visible light(400-500 nm) by adding yellow coloring dye(monomethin) for the pervention of aphakic or pseudophakic cyanopsia, and the obtaining closer color sensitivity and contrast sensitivity to the normal phakic eyes. In this study, we implanted both yellow colored IOLs in 16 eyes and conventional clear UV absorbing IOLs in 12 eyes. They were prospectively followed up for 6 months with questionairs asking subjective symptoms and with contrast s~nsitivity test in order to evaluate the color sensitivity and contrast sensitivity. The subjective symptoms of cyanopsia, photophobia, and glare were signi ficantly reduced in the UVCY-IOL group comparing to the conventional UVAB-IOL group. But in few cases of UVCY-IOL implantation(18.8%) were in episode transiently on xanthopsia with some dim state in early postop periods. The contrast sensitivity pattern of UVCY-IOL group was very similar to that of normal phakic group. The decrement of contrast sensitivity was less in UVCY-IOL group than in conventional UVAB-PCL group. The amount of decreased contrast sensitivity of UVCY-IOL group in scotopic condition was similar to that of conventional UVAB-IOL group. The result of this study suggests that yellow colored IOL is effective in decre asing cyanopsia and photophobia and in improving contrast sensitivity after cataract surgery especially in the early postoperative period. And also we recommend patients would receive UVCY-IOL implantations in both eyes if you have cataract on both eyes.