RESUMO
Selective digestive decontamination (SDD) is a prophylactic strategy aimed at preventing or eradicating bacterial overgrowth in the intestinal flora that precedes the development of most infections in the Intensive Care Unit. SDD prevents serious infections, reduces mortality, is cost-effective, has no adverse effects, and its short- or long-term use is not associated with any significant increase in antimicrobial resistance. SDD is one of the most widely evaluated interventions in critically ill patients, yet its use is not widespread. The present article offers a narrative review of the most relevant evidence and an update of the pathophysiological concepts of infection control supporting the use of SDD.
Assuntos
Antibacterianos , Infecções Bacterianas , Humanos , Antibacterianos/uso terapêutico , Descontaminação , Trato Gastrointestinal/microbiologia , Infecções Bacterianas/tratamento farmacológico , Controle de InfecçõesRESUMO
La descontaminación digestiva selectiva (DDS) es una estrategia profiláctica cuyo objetivo es prevenir o erradicar el sobrecrecimiento bacteriano en la flora intestinal que precede al desarrollo de la mayoría de las infecciones en la UCI. La DDS previene infecciones graves, reduce la mortalidad, es coste-efectiva, no tiene efectos adversos, y su uso a corto o largo plazo no muestra un aumento significativo de la resistencia antimicrobiana. La DDS es una de las intervenciones más evaluadas en pacientes críticos, a pesar de lo cual su uso no se ha generalizado. El objetivo de este artículo es presentar una revisión narrativa de la evidencia más relevante y una actualización de los conceptos fisiopatológicos de control de la infección en los que se fundamenta el uso de la DDS. (AU)
Selective digestive decontamination (SDD) is a prophylactic strategy aimed at preventing or eradicating the bacterial overgrowth in the intestinal flora that precedes the development of most infections in the ICU. SDD prevents serious infections, reduces mortality, is cost-effective, has no adverse effects, and its short- or long-term use does not show a significant increase in antimicrobial resistance.SDD is one of the most evaluated interventions in critically ill patients, yet its use is not widespread. The aim of this article is to present a narrative review of the most relevant evidence and an update of the pathophysiological concepts of infection control supporting the use of SDD. (AU)
