Trastornos del espectro autista, trastornos por déficit de atención hiperactividad y desregulación emocional: enmascaramiento y abordaje / Autistic spectrum disorders, attention deficit disorders, hyperactivity and emotional dysregulation: masking and approach

Resumen Los Trastornos del Espectro Autista (TEA) y los Tras tornos por Déficit de Atención Hiperactividad (TDAH) son Trastornos del Neurodesarrollo (TN) que coexisten frecuentemente y que tienen factores etiológicos, bio lógicos, clínicos en común. La comorbilidad de ambos TN se asocia a un retraso en el diagnóstico del TEA o un diagnóstico que nunca llegan a recibir y es frecuente el desarrollo de alteraciones perceptivas, emocionales, cognitivas y conductuales relacionadas con la Desregu lación Emocional (DE). Cuando ambos TN no son diag nosticados en infancia, frecuentemente reciben diag nósticos equivocados en edades más tardías, siendo el más frecuente el Trastorno Límite de Personalidad (TLP). Se analiza la presentación clínica de la asociación del TEA y el TDAH, la asociación con DE, diferenciación del TLP y evaluación e intervención. La comorbilidad TEA, TDAH, DE, es un trastorno más severo, asociado a poli farmacología y a ingresos hospi talarios.

Abstract Autism Spectrum Disorders (ASD) and Attention Defi cit Hyperactivity Disorders (ADHD) are Neurodevelop mental Disorders (ND) that frequently coexist together and have etiological, biological, and clinical factors in common. The comorbidity of both neurodevelopmental disorders is associated with a delay or lack of ASD di agnosis and the development of perceptual, emotional, cognitive and behavioral alterations related to Emotional Dysregulation (ED) is common. When both TN are not diagnosed in childhood, they frequently receive wrong diagnoses at later ages, the most frequent being Border line Personality Disorder (BPD). The clinical presentation of the association of ASD and ADHD, the association with ED, differentiation of BPD, and evaluation and intervention are here analyzed. The comorbidity ASD, ADHD, ED is a more severe disorder associated to polypharmacology and hospital admissions.

Problematização sobre o Transtorno Disruptivo da Desregulação do Humor / Problematization about Disruptive Mood Dysregulation Disorder / Problématisation du Trouble Disruptif avec Dysrégulation émotionnelle / Problematización del Trastorno de Desregulación Disruptiva del Estado de Ánimo

Este artigo se propõe a delinear, historicamente, o diagnóstico clínico do Transtorno Disruptivo da Desregulação do Humor (TDDH). Com base no método genealógico, essa categoria diagnóstica é desnaturalizada e recontextualizada em sua origem. Analisa-se o conceito de desregulação do humor a partir da escala CBCL (Childhood Behaviour Checklist), sua identificação como um transtorno bipolar da infância, posterior transformação no diagnóstico de TDDH e subsequente crítica deste, com a proposta de englobar os sintomas de desregulação do humor na infância, no diagnóstico de transtorno opositor-desafiante. Como alternativa, o artigo sugere que o humor irritadiço na infância é um estado afetivo primário, constituindo-se, assim, em uma predisposição orgânica primária. Já a regulação emocional é uma construção adaptativa, que se modela ao longo da vida, gerando apresentações subjetivas diversas.

Resumos This article historically outlines the clinical diagnosis of disruptive mood dysregulation disorder (DMDD). Based on the genealogical method, this diagnostic category is denaturalized and recontextualized in its origin. The concept of mood dysregulation is analyzed from the Childhood Behavior Checklist scale (CBCL), its identification as a childhood bipolar disorder, subsequent transformation in the diagnosis of DMDD and subsequent criticism of it, with the proposal of encompassing the symptoms of mood dysregulation humor in childhood into the diagnosis of oppositional defiant disorder. As an alternative, the article suggests that irritable mood in childhood is a primary affective state, thus, constituting a primary organic predisposition. Emotional regulation, on the other hand, is an adaptive construction, which is modeled throughout life, generating diverse subjective presentations.

Cet article retrace l'historique du diagnostic clinique du trouble disruptif avec dysrégulation émotionnelle (TDDE). Basée sur la méthode généalogique, cette catégorie diagnostique est dénaturalisée et recontextualisée dans ses origines. Le concept de dysrégulation émotionnelle est analysé à partir de l'échelle CBCL (Childhood Behavior Checklist), de son identification en tant que trouble bipolaire de l'enfance, de sa transformation ultérieure en diagnostic de TDDE et de sa critique ultérieure, avec la proposition d'inclure les symptômes de dysrégulation émotionnelle dans l'enfance dans le diagnostic du trouble oppositionnel avec provocation. Comme alternative, l'article suggère que l'humeur irritable dans l'enfance est un état affectif primaire, constituant ainsi une prédisposition organique primaire. La régulation émotionnelle, quant à elle, est une construction adaptative qui est modelée tout au long de la vie, générant diverses présentations subjectives.

Este artículo describe historicamente el diagnóstico clínico del trastorno de desregulación disruptiva del estado de ánimo (TDDEA). Con base en el método genealógico, esta categoria diagnostica se desnaturaliza y recontextualiza en su origen. Se analiza el concepto de desregulación del estado de ánimo a partir de la escala CBCL (Childhood Behavior Checklist), su identificación como trastorno bipolar pediátrico, posterior transformación en el diagnóstico de TDDEA y posterior crítica al mismo, con la propuesta de englobar los síntomas de desregulación del estado de ánimo en el diagnóstico de trastorno negativista desafiante. Como alternativa, se sugiere que el estado de ánimo de irritabilidad en la infancia es un estado afectivo primario, constituyendo una predisposición orgánica primaria. La regulación emocional, por su parte, es una construcción adaptativa, que se modela a lo largo de la vida, generando diversas presentaciones subjetivas.

Non-suicidal self-injury in young adults with and without borderline personality disorder: the role of emotion dysregulation and negative urgency / Autolesión no suicida en adultos jóvenes con y sin trastorno límite de la personalidad: el papel de la desregulación emocional y la urgencia negativa

La Autolesión No Suicida (ANS) se define como un dolor auto-infligido que se utiliza como un mecanismo para aliviar la angustia psicoló-gica. Aunque ANS es común en el trastorno límite de la personalidad (TLP), también es un problema creciente en estudiantes universitarios. Si bien la desregulación emocional y la urgencia negativa están asociadas con ANS, poco se sabe sobre las dimensiones específicas que predicen la moti-vación (funciones) y la frecuencia de las autolesiones. Se exploró la relación entre la desregulación emocional, la urgencia negativa, y ANS en 86 adultos jóvenes, divididos en tres grupos: estudiantes universitarios con ANS, pa-cientes TLP con ANS y un grupo de control sano sin ANS. Realizamos análisis de regresión múltiple para predecir las funciones y frecuencia de ANS. La no aceptación de las emociones, una dimensión especifica de la desregulación emocional, predijo de manera única las funciones intraperso-nales de ANS, pero no las funciones interpersonales. Por último, la falta de estrategias de regulación emocional predijo la frecuencia de ANS solo en individuos con una alta urgencia negativa, es decir, individuos que tienden a actuar impulsivamente cuando experimentan emociones negativas, pero no en aquellos con una baja urgencia negativa. Los hallazgos resaltan las moti-vaciones subyacentes a la autolesión y revelan facetas de la desregulación emocional relevantes para el tratamiento de ANS.(AU)

Non-suicidal self-injury (NSSI) is defined as self-inflicted pain, and it is used as a mechanism to alleviate psychological distress. Although NSSI is prevalent in Borderline Personality Disorder (BPD), it is also an increasing concern among college student populations. While emotion dysregulation and negative urgency are associated with NSSI, little is known about which dimensions specifically predict the motivations (NSSI-functions) and frequency of self-harm. The current study explored the rela-tionship between emotion dysregulation, negative urgency, and NSSI in 86 young adults, divided into three groups: college students with NSSI, BPD patients with NSSI, and a healthy control group without NSSI. We con-ducted multiple regression analyses to predicted NSSI-functions and NSSI-frequency. Non-acceptance of emotions, a specific dimension of emotion dysregulation, uniquely predicted intrapersonal NSSI-functions (e.g., regu-lating distressing emotions), but not interpersonal NSSI-functions (e.g., communicating distress). Lastly, poor emotion regulation strategies pre-dicted NSSI-frequency only in individuals with high negative urgency, that is, individuals who tend to act impulsively when experiencing negative emotions, but not in those with low negative urgency. Findings shed light on the underlying motivations for engaging in self-injury, and they reveal facets of emotion dysregulation relevant for NSSI treatment.(AU)

DERSR-B. A Brief Scale for Detection of Emotional Dysregulation Risk / DERSR-B. Una Escala Breve para la Detección del Riesgo de Desregulación Emocional

Abstract Emotional dysregulation (ED) is related to problems in understanding, perceiving, and regulating emotions. The aim is to find the psychometric properties of an instrument that measures ED and classifies the high/low ED group membership with the least possible error. For statistical purposes (factor analysis), two independent samples of males and females (n1 = 476) and (n2 = 562) were obtained, with ages sample 1 (15 -19 years; M= 15.8; SD=0.71) and sample 2 (15-19 years; M=15.6; SD= 0.69). Three factors were formed by sex, males with 14 items and females with 13 items, each loading on a single factor (total α=0.71 - 0.78 ɷ =0.67- 0.79 females; α= 0.70 - 0.79 ɷ=0.73 - 0.75 males) and good fit indices. In sum, a validated cut version instrument (DERSR-B), a risk screening instrument, was obtained.

Resumen La desregulación emocional (DE) se relaciona con problemas para comprender, percibir y regular las emociones. Determinar las propiedades psicométricas de un instrumento que mide DE y que clasifica con el menor error posible la pertenencia de grupo alto/bajo de DE se propuso como el objetivo de este estudio. Para propósitos estadísticos (análisis factoriales) se obtuvieron dos muestras independientes de hombres y mujeres (n1 = 476) y (n2 = 562) respectivamente, con edades para muestra 1 (15-19 años; M= 15.8; DE= 0.71) y muestra 2 (15-19 años; M=15.6; DE= 0.69). Se obtuvieron tres factores por sexo, hombres con 14 ítems y mujeres con 13 ítems cada uno cargando en un solo, un único factor (total α =0.71 - 0.78 ɷ =0.67- 0.79 mujeres; α=0.70 - 0.79 ɷ=0.73-0.75 hombres) y con índices de ajuste aceptables. Se obtuvo un instrumento válido en versión corta de detección rápida de riesgo de Desregulación Emocional (DERSR-B).

Altered cortical thickness and emotional dysregulation in adolescents with borderline personality disorder.

Background: Emotional dysregulation is a core feature of borderline personality disorder (BPD). Previous studies have reported that abnormal grey matter volume is associated with the limbic-cortical circuit and default mode network (DMN) in patients with BPD. However, alterations of cortical thickness in adolescents with BPD have not been well evaluated.Objective: The aim of this study was to assess cortical thickness and its association with emotional dysregulation in adolescents with BPD.Method: This prospective study enrolled 52 adolescents with BPD and 39 age- and sex-matched healthy controls (HCs). Assessments included brain magnetic resonance imaging (MRI) acquisition with structural and resting-state functional MRI data, and clinical assessment for emotional dysregulation using the Difficulties in Emotion Regulation Scale (DERS). Cortical thickness and seed-based functional connectivity were analysed with FreeSurfer 7.2 software. Correlation analysis between cortical thickness and the scores from emotional assessment was performed with Spearman analysis.Results: Compared to HCs, there was altered cortical thickness in the DMN and limbic-cortical circuit in adolescents with BPD (Monte Carlo correction, all p < .05). These regions with altered cortical thickness were significantly associated with emotional dysregulation (all p < .05). There were also alterations of functional connectivity, i.e. with increased connectivity of the right prefrontal cortex with bilateral occipital lobes, or with the limbic system, and with decreased connectivity among the DMN regions (voxel p < .001, cluster p < .05, family-wise error corrected).Conclusions: Our results suggest that the altered cortical thickness and altered functional connectivity in the limbic-cortical circuit and DMN may be involved in emotional dysregulation in adolescents with BPD.

Emotional dysregulation is a core feature of borderline personality disorder, but the underlying neural correlates are not well known.There was altered cortical thickness and functional connectivity in the DMN and limbic­cortical circuit in adolescents with borderline personality disorder.Altered cortical thickness was associated with emotional dysregulation in adolescents with borderline personality disorder.

Associations between trauma and substance use among healthcare workers and public safety personnel during the SARS-CoV-2 (COVID-19) pandemic: the mediating roles of dissociation and emotion dysregulation.

BACKGROUND: Given the highly stressful environment surrounding the SARS-CoV-2 pandemic, healthcare workers (HCW) and public safety personnel (PSP) are at an elevated risk for adverse psychological outcomes, including posttraumatic stress disorder (PTSD) and alcohol/substance use problems. As such, the study aimed to identify associations between PTSD severity, related dissociation and emotion dysregulation symptoms, and alcohol/substance use problems among HCWs and PSP. METHODS: A subset of data (N = 498; HCWs = 299; PSP = 199) was extracted from a larger study examining psychological variables among Canadian HCWs and PSP during the pandemic. Structural equation modelling assessed associations between PTSD symptoms and alcohol/substance use-related problems with dissociation and emotion dysregulation as mediators. RESULTS: Among HCWs, dissociation fully mediated the relation between PTSD and alcohol-related problems (indirect effect ß = .133, p = .03) and emotion dysregulation partially mediated the relation between PTSD and substance-related problems (indirect effect ß = .151, p = .046). In PSP, emotion dysregulation fully mediated the relation between PTSD and alcohol-related problems (indirect effects ß = .184, p = .005). For substance-related problems among PSP, neither emotion dysregulation nor dissociation (ps >.05) had any effects. CONCLUSION: To our knowledge, this is the first study examining associations between PTSD severity and alcohol/substance use-related problems via mediating impacts of emotion dysregulation and dissociation among HCWs and PSP during the SARS-CoV-2 pandemic. These findings highlight dissociation and emotion dysregulation as important therapeutic targets for structured interventions aimed at reducing the burden of PTSD and/or SUD among Canadian HCWs or PSP suffering from the adverse mental health impacts of the SARS-CoV-2 pandemic.

Among healthcare workers, dissociation mediated relation between posttraumatic stress disorder (PTSD) severity and alcohol-related problems and emotion dysregulation mediated relation between PTSD severity and substance-related problems.Among public safety personnel, emotion dysregulation mediated relation between PTSD severity and alcohol-related problems. Neither dissociation nor emotion dysregulation mediated relation between PTSD severity and substance-related problems.Results underscore dissociation and emotion dysregulation as potential key therapeutic targets for intervention for healthcare workers and public safety personnel struggling with PTSD and comorbid alcohol/substance use-related problems.

Facets of emotion dysregulation differentially predict depression and PTSD symptom severity following traumatic injury.

Background: Emotion dysregulation is a hallmark characteristic of psychopathology following trauma. Yet, emotion dysregulation is multifaceted, and little is known about which aspects of emotion dysregulation predict depression and posttraumatic stress disorder (PTSD) symptom severity following traumatic injury.Objective: The aim of this longitudinal study was to evaluate how facets of dysregulation differentially predicted the severity of PTSD symptom clusters and depressive symptoms six months after a traumatic injury requiring medical treatment.Methods: Traumatically injured adults (N = 99) presenting to a Level 1 trauma centre completed a measure of emotion dysregulation 2 weeks post-injury, and PTSD and depression were assessed at 2-weeks and 6 months later.Results: Using stepwise regressions controlling for baseline symptoms, age, gender, race, and injury severity, results showed baseline emotion dysregulation significantly predicted the four symptom clusters of PTSD 6 months post-injury. Notably, hyperarousal symptoms and negative alterations in mood and cognition were predicted by a lack of clarity. On the other hand, depressive symptoms were significantly predicted by difficulty accessing emotion regulation strategies.Conclusion: Results highlight that specific facets of emotion dysregulation predict PTSD and depression symptom severity differentially after injury. Indeed, lack of emotional clarity appears to predict PTSD symptomatology, suggesting a potential mechanism driving worsening symptoms. Lack of clarity could also be detrimental to engagement in PTSD treatment. Conversely, lack of regulation strategies may represent a sense of helplessness in managing depression after trauma. As such, future research should elucidate whether interventions targeting aspects of emotion dysregulation based on symptom presentations are useful in treating PTSD and depression following injury.

Specific facets of emotion dysregulation are differentially associated with PTSD symptom clusters and depression symptom severity after injury.Findings suggest that targeting lack of emotional clarity may be critical for patients with prominent hyperarousal and trauma-related changes in mood and cognitions (i.e. two PTSD symptom clusters).Patients with depressive symptoms following trauma may especially benefit from the development of emotion regulation strategies.

Immune dysregulation and pathophysiology of alcohol consumption and alcoholic liver disease.

Alcoholic liver disease (ALD) is a clinical-pathologic entity caused by the chronic excessive consumption of alcohol. The disease includes a broad spectrum of anomalies at the cellular and tissual level that can cause acute-on-chronic (alcoholic hepatitis) or chronic (fibrosis, cirrhosis, hepatocellular cancer) injury, having a great impact on morbidity and mortality worldwide. Alcohol is metabolized mainly in the liver. During alcohol metabolism, toxic metabolites, such as acetaldehyde and oxygen reactive species, are produced. At the intestinal level, alcohol consumption can cause dysbiosis and alter intestinal permeability, promoting the translocation of bacterial products and causing the production of inflammatory cytokines in the liver, perpetuating local inflammation during the progression of ALD. Different study groups have reported systemic inflammatory response disturbances, but reports containing a compendium of the cytokines and cells involved in the pathophysiology of the disease, from the early stages, are difficult to find. In the present review article, the role of the inflammatory mediators involved in ALD progression are described, from risky patterns of alcohol consumption to advanced stages of the disease, with the aim of understanding the involvement of immune dysregulation in the pathophysiology of ALD.

Revisión de revisiones sobre la eficacia de los tratamientos psicológicos para adolescentes con trastorno de la personalidad límite / Review of reviews on the efficacy of psychological treatments for adolescents with borderline personality disorder

La literatura científica señala que es importante llevar a cabo una intervención psicológica temprana en el trastorno de la personalidad límite (TPL)debido a que en la adolescencia es cuando se observa un mayor auge de los síntomas graves. Sin embargo, existe poca literatura científica sobrequé tratamientos psicológicos son más eficaces para esta población. El objetivo de este trabajo es realizar una revisión de revisiones sobre losdatos de eficacia de los tratamientos psicológicos para adolescentes con rasgos o diagnóstico de TPL o desregulación emocional. Se seleccionaron revisiones que evaluaran la eficacia de tratamientos psicológicos en adolescentes (entre 12 y 19 años) con esta problemática. Se realizó unabúsqueda de literatura científica en diversas bases de datos (Web of Science, PsycInfo, Pubmed, Dialnet) y se incluyeron un total de 5 revisiones.Resultados: La Terapia Dialéctica Comportamental para adolescentes (DBT-A) y la Terapia Basada en la Mentalización para adolescentes (MBT-A)han demostrado su eficacia para reducir la ideación suicida, los síntomas de TPL, los niveles de ansiedad y depresión, así como mejorar la adaptación social y la calidad de vida después de la intervención. Sin embargo, algunas revisiones sugieren que la MBT-A podría no ser tan efectiva debidoa las altas tasas de abandonos. Las intervenciones psicológicas con más evidencia consiguen reducir los síntomas más graves y mejorar la calidadde vida de los adolescentes con este problema. Es fundamental intervenir lo antes posible, lo que ayudará a prevenir el desarrollo y cronicidad deun trastorno grave y difícil de tratar. (AU)

The scientific literature indicatesthat it is important to carry out early psychological intervention in borderline personality disorder (BPD) due to the fact that adolescence is when agreater upsurge of the most severe symptoms is observed. However, there is little scientific literature on which psychological treatments are mosteffective for this population. The aim of this paper is to conduct a review of reviews on the efficacy data of psychological treatments for adolescentswith traits or diagnosis of BPD or emotional dysregulation. We selected reviews that evaluated the efficacy of psychological treatments in adolescents (between 12 and 19 years old) with this problem. A search of scientific literature was carried out in various databases (Web of Science,PsycInfo, Pubmed, Dialnet) and a total of 5 reviews were included. Dialectical Behavior Therapy for Adolescents (DBT-A) and Mentalization-BasedTherapy for Adolescents (MBT-A) have demonstrated efficacy in reducing suicidal ideation, BPD symptoms, anxiety and depression levels, as wellas improving social adjustment and quality of life after the intervention. However, some reviews suggest that MBT-A may not be as effective due tohigh dropout rates. Psychological interventions with more evidence achieve to reduce the most severe symptoms and improve the quality of life ofadolescents with this problem. It is essential to intervene as early as possible, which will help prevent the development and chronicity of a severeand difficult-to-treat disorder. (AU)

Social Expectancy Increases Skin Conductance Response in Mobile Instant Messaging Users / La Expectativa Social Incrementa la Respuesta Electrodérmica en Usuarios de Mensajería Instantánea Móvil

Background: Society is witnessing two parallel phenomena: an increase in the number of mobile phone users worldwide and a growing concern about problematic smartphone use. Leading explanatory models suggest that social reward may explain some problematic smartphone use. Given that experimental evidence about the impact of social variables on problematic smartphone use is scarce, the impact of social expectancy on emotional arousal measured with skin conductance response (SCR) was analysed during instant messaging. Method: A sample of 86 undergraduate students were randomly assigned to two groups. Experimental group participants were instructed to send a social expectation-generating message to their more active contacts in their preferred social network. After experiencing a virtual reality distraction environment, participants’ SCR was measured when they were allowed to use the smartphone and when it was withdrawn. Results: Participants in the experimental group showed a higher SCR response than the control group. Peaks analysis also showed that peak amplitude was higher in experimental participants when their smartphones were used and withdrawn. Experimental participants also showed a longer half recovery time when using the smartphone. Conclusions: Social expectancy is a critical variable in understanding problematic smartphone use and it should be considered in clinical contexts.(AU)

Antecedentes: La sociedad está presenciando dos fenómenos paralelos: el incremento mundial de usuarios de teléfonos móviles y una preocupación creciente por el uso problemático de estos dispositivos. Los modelos teóricos explicativos sugieren que la recompensa social podría explicar parte del uso problemático del teléfono móvil. Dado que la evidencia experimental sobre el impacto que lo social tiene en este fenómeno es limitada, el impacto de la expectativa social sobre el arousalemocional fue analizada mientras se usó mensajería instantánea. Método: Una muestra de 86 estudiantes se asignó aleatoriamente a dos grupos. Los participantes del grupo experimental enviaron un mensaje generador de expectativa social a sus contactos más activos usando su red social preferida. Tras un periodo de distracción, a respuesta electrodérmica de la piel se midió al usar y retirar el móvil. Resultados: El grupo experimental mostró mayores niveles de arousal. El análisis de picos muestra una mayor amplitud en el grupo experimental cuando se usó y se retiró el móvil. Un tiempo de recuperación medio más largo se observó en el grupo experimental al usar el móvil. Conclusiones: La expectativa social es una variable crítica para conceptualizar el uso problemático del móvil y debería considerarse en contextos clínicos.(AU)

Enfermedades autoinmunes asociadas a inmunodeficiencias primarias / Autoimmune diseases associated with primary immunodeficiencies

Introducción: Las enfermedades y manifestaciones autoinmunes ocupan el segundo lugar de las enfermedades por inmunodeficiencia primaria, después de las infecciones. Objetivo: Determinar el comportamiento de las enfermedades autoinmunes en los pacientes con inmunodeficiencias primarias. Métodos: Se realizó estudio de caso control en el servicio de Alergia e Inmunología de Bayamo, Granma entre los años 2013 y 2022. El grupo de estudio fue de 38 pacientes con diagnóstico de inmunodeficiencia primaria y el grupo control de 76 pacientes sin compromiso del sistema inmune. Se empleó el programa estadístico SPSS 25, las frecuencias absolutas y relativas, odds ratio y Chi cuadrado. Resultados: Las manifestaciones sugerentes de autoinmunidad en los pacientes con inmunodeficiencias primarias fue 39,47 % y en los controles 3,95 %, OR = 15,869 y p= 0,000. Las más frecuentes fueron: dolor monoarticular en 6 pacientes (33,33 %); poliartralgia, dermatitis y alopecia en 3 casos (16,67 %) cada uno; dolor en la columna vertebral y nódulos subcutáneos, un paciente (5,56 %) cada uno. Las enfermedades autoinmunes asociadas a inmunodeficiencias primarias fueron: enfermedad celiaca (30,71 %), vitíligo (23,07 %), fibromialgia (15,38 %), eritema nodoso, la gastritis eosinofílica, anemia perniciosa y vasculitis con 7,69 % cada uno. Conclusiones: Las manifestaciones y enfermedades autoinmunes prevalecieron en pacientes con inmunodeficiencias primarias; en ambos casos fueron más frecuentes en los pacientes mayores de 18 años de edad. Las inmunodeficiencias más frecuentemente asociadas a los trastornos autoinmunes fueron las deficiencias predominantemente de anticuerpos y los defectos desregulatorios.

Introduction: Autoimmune diseases are in second place, after infections to suspect primary immunodeficiency diseases. Objective: To determine the behavior of autoimmune diseases in patients with primary immunodeficiencies. Methods: A case control study was carried out in the allergy and immunology service of Bayamo, Granma between 2013 and 2022. The universe was studied as a whole, the study group with 38 patients diagnosed with primary immunodeficiency and the control group with 76 patients without immune system compromise. The SPSS 25 statistical program, absolute and relative frequencies, odds ratio and chi-square were used. Results: The manifestations suggestive of autoimmunity in patients with PID was 39.47% and in controls 3.95%, OR = 15.869 and p = 0.000 and the most frequent were: monoarticular pain in 6 patients (33.33%), polyarthralgia, dermatitis and alopecia with 3 cases (16.67%) each one, pain in dorsal spine and subcutaneous nodule, one patient (5.56%) each one. Immune diseases associated with PID were: celiac disease (30.71%), vitiligo (23.07%), fibromyalgia (15.38%), erythema nodosum, eosinophilic gastritis, pernicious anemia and vasculitis with 7.69% each. Conclusions: Autoimmune manifestations and diseases prevailed in patients with PID, in both cases were more frequent in patients older than 18 years. The immunodeficiencies most frequently associated with autoimmune disorders were those of antibodies and those with some dysregulation component.

Desregulación emocional y nivel de riesgo por consumo de sustancias psicoactivas en universitarios colombianos / Emotional dysregulation and risk level for consumption of psychoactive substances in Colombian university students

Resumen El consumo de sustancias psicoactivas [SPA] es un problema de salud pública, y constituye uno de los principales factores de riesgo para la salud. Se ha observado que el consumo de SPA está mediado por diferentes variables, una de ellas es la desregulación emocional, y se requiere mayor investigación del comportamiento de esta variable y su relación con los niveles de riesgo asociado al consumo. El objetivo del presente estudio fue determinar si existen diferencias en la desregulación emocional según el nivel de riesgo asociado al consumo de sustancias en una muestra de universitarios. Para tal efecto se adelantó un estudio descriptivo por comparación de grupos con una muestra de 721 estudiantes. Los resultados indicaron altas prevalencias de consumo de SPA; diferencias en los puntajes de desregulación emocional según el nivel de riesgo para tranquilizantes y cocaína, y que, a nivel general, aquellos universitarios con menor nivel de riesgo son quienes presentan menores puntajes de desregulación emocional, lo que sugiere que la desregulación emocional es una variable predictora de un mayor nivel de riesgo asociado al consumo de SPA.

Abstract The use of psychoactive substances is a public health problem, and it is one of the main health risk factors. It has been observed that the use of drugs is mediated by different variables, one of them is the emotional dysregulation, and more research is required on the behavior of this variable and its relationship with the levels of risk in the consumption. The aim of this study was to determine whether there are differences in emotional dysregulation according to the level of risk associated with substance use in a sample of 721 university students. For this purpose, a descriptive study was carried out by comparing groups. The results indicated high prevalence of PAS consumption, differences in emotional dysregulation scores according to the risk level for tranquilizer pills and cocaine. In general, the students with a lower risk level are those who present lower emotional dysregulation scores, suggesting that emotional dysregulation is a predictor variable of a higher level of risk associated with PAS consumption.

Does emotional dysregulation mediate the relationship between disability and depressive symptoms in older people? / ¿La desregulación emocional media la relación entre la discapacidad y los síntomas depresivos en las personas mayores?

Background: Emotion dysregulation has been consistently linked to psychopathology, and the relationship between disability and depressive symptomatology in old age is well-known. Objective: To examine the mediational role of emotional dysregulation in the relationship between perceived disability and depressive symptomatology in older adults. Methods: Two hundred eighty-three participants, aged 60–96 years (M±SD=74.22±8.69; 62.9% women; 29.0% with long-term care support [LTC-S] and 71.0% community residents without LTC-S), were assessed with the Geriatric Depression Scale-8 (GDS-8), the World Health Organization Disability Assessment Schedule-2 (WHODAS-2), and the Difficulties in Emotion Regulation Scale-16 (DERS-16). Results: A mediation model was established, which revealed: (1) a moderate association between WHODAS-2 and GDS-8 (β=0.20; p<.001); (2) DERS-16 partially and weakly mediated the relationship between WHODAS-2 and GDS-8 (β=0.003; p<.01). The model explained 31.9% of the variance of depressive symptoms. An inconsistent mediation model was obtained in the LTC-S group. Conclusions: Globally, our findings indicate that disability has an indirect relationship with depressive symptomatology through emotional dysregulation (except for those in the LTC-S). Accordingly, we present suggestions for the treatment of depressive symptoms and for the inclusion of other emotion regulation variables in the study of the disability-depressive symptom link in future studies with older people in the LTC-S. (AU)

Antecedentes: La desregulación de las emociones se ha relacionado sistemáticamente con la psicopatología, y es bien conocida la relación entre la discapacidad y la sintomatología depresiva en la edad avanzada. Objetivo: Examinar el papel mediador de la desregulación emocional en la relación entre la discapacidad percibida y la sintomatología depresiva en los adultos mayores. Materiales y métodos: Doscientos ochenta y tres participantes, entre 60-96 años de edad (M±DE=74,22±8,69; 62,9% mujeres; 29% con apoyo de cuidados de larga duración [A-CLD] y 71% residentes en la comunidad sin A-CLD), fueron evaluados con la Geriatric Depression Scale-8 (GDS-8), el World Health Organization Disability Assessment Schedule-2 (WHODAS-2) y la Difficulties in Emotion Regulation Scale-16 (DERS-16). Resultados: Se estableció un modelo de mediación que reveló: (1) una asociación moderada entre el WHODAS-2 y el GDS-8 (β=0,20; p<0,001); (2) el DERS-16 medió parcial y ligeramente la relación entre el WHODAS-2 y el GDS-8 (β=0,003; p<0,01). El modelo explicó el 31,9% de la varianza de los síntomas depresivos. Se ha obtenido un modelo de mediación inconsistente en el grupo A-CLD. Conclusiones: Globalmente, nuestros hallazgos indican que la discapacidad tiene una relación indirecta con la sintomatología depresiva a través de la desregulación emocional. En consecuencia, presentamos sugerencias para el tratamiento de los síntomas depresivos y para la inclusión de otras variables de regulación de las emociones en el estudio del vínculo discapacidad-síntomas depresivos en futuros estudios con personas mayores en el A-CLD. (AU)

Does emotional dysregulation mediate the relationship between disability and depressive symptoms in older people?

BACKGROUND: Emotion dysregulation has been consistently linked to psychopathology, and the relationship between disability and depressive symptomatology in old age is well-known. OBJECTIVE: To examine the mediational role of emotional dysregulation in the relationship between perceived disability and depressive symptomatology in older adults. METHODS: Two hundred eighty-three participants, aged 60-96 years (M±SD=74.22±8.69; 62.9% women; 29.0% with long-term care support [LTC-S] and 71.0% community residents without LTC-S), were assessed with the Geriatric Depression Scale-8 (GDS-8), the World Health Organization Disability Assessment Schedule-2 (WHODAS-2), and the Difficulties in Emotion Regulation Scale-16 (DERS-16). RESULTS: A mediation model was established, which revealed: (1) a moderate association between WHODAS-2 and GDS-8 (ß=0.20; p<.001); (2) DERS-16 partially and weakly mediated the relationship between WHODAS-2 and GDS-8 (ß=0.003; p<.01). The model explained 31.9% of the variance of depressive symptoms. An inconsistent mediation model was obtained in the LTC-S group. CONCLUSIONS: Globally, our findings indicate that disability has an indirect relationship with depressive symptomatology through emotional dysregulation (except for those in the LTC-S). Accordingly, we present suggestions for the treatment of depressive symptoms and for the inclusion of other emotion regulation variables in the study of the disability-depressive symptom link in future studies with older people in the LTC-S.

Análisis factorial confirmatorio de la Escala de Dificultades en la Regulación Emocional Estado en una muestra argentina / Confirmatory Factor Analysis of State Difficulties in Emotion Regulation Scale in an Argentine Sample

Resumen La desregulación emocional es un constructo multidimensional determinado por formas poco adaptativas de responder frente a las emociones. Las personas adultas emergentes (i.e., entre 18 y 25/30 años de edad), particularmente universitarias, son vulnerables a involucrarse en comportamientos riesgosos en contextos emocionales. La Escala de Dificultades en la Regulación Emocional Estado (S-DERS) resulta adecuada para medir dimensiones de desregulación emocional momentánea en esta población; sin embargo, no se conocen estudios confirmatorios de su estructura factorial ni estudios de adaptación al idioma español. El objetivo del presente estudio fue examinar las propiedades psicométricas de la S-DERS. Se evaluaron 178 adultos emergentes universitarios argentinos (18-28 años; 53.9% mujeres; Medad= 22.03; DE ±2.06). Se analizó la estructura y la consistencia interna del modelo original (S-DERS; cuatro factores: aceptación, conciencia, claridad y modulación) y un modelo alternativo (S-DERS-R; 3 factores) sin el factor claridad. Ambos modelos presentaron un ajuste satisfactorio de su estructura factorial y valores aceptables de consistencia interna, a excepción de la subescala claridad. Mayormente, para las subescalas aceptación y modulación y puntajes totales de ambos modelos, se obtuvieron evidencias de validez convergente con dos escalas de desregulación emocional rasgo concurrente con una escala de afecto positivo y negativo y predictiva con una medida de activación emocional. Los resultados muestran propiedades psicométricas adecuadas. S-DERS-R, que prescinde del factor claridad, mejora el ajuste y mantiene valores de consistencia interna aceptables respecto a S-DERS. Se espera que este instrumento sea útil en estudios transversales y longitudinales de la desregulación emocional estado en universitarios.

Abstract: Emotion dysregulation is a multidimensional construct determined by maladaptive ways of responding to emotions. Emerging adults (i.e., aged from 18 to 25/30), particularly college students, are vulnerable to involvement in risky behaviors under emotions. The State Difficulties in Emotion Regulation Scale (S-DERS) became suitable to measure facets of momentary emotion dysregulation in this population; however, there are no confirmatory studies or studies of adaptation to the Spanish language. The aim of this study was to examine psychometric properties of S-DERS. A sample of 178 Argentine emerging college-age adults was evaluated (18-28 years old; 53.9% women; Mage= 22.03; DE ± 2.06). Internal structure and consistency of the original model (i.e., S-DERS; four factors: Nonacceptance, Awareness, Clarity, Modulation) and an alternative model without Clarity (i.e., S-DERS-R; three factors) was analyzed. Both models presented a factor structure with satisfactory fit and acceptable values of internal consistency, with the exception of the Clarity subscale. Mainly to Nonacceptance and Modulation subscales, we observed evidence of convergent validity with two-trait emotion dysregulation scales, concurrent validity with a positive and negative affect scale, and predictive validity with an emotion arousal measure. Results show suitable sychometric properties. The S-DERS-R model (i.e., without Clarity factor) improves the model fit and maintains acceptable internal consistency values with respect to the S-DERS model. This instrument is expected to be useful in cross-sectional and longitudinal studies of state emotion dysregulation in college students.

Emotional Dysregulation in Adults from 10 World Societies: An Epidemiological Latent Class Analysis of the Adult-Self-Report

AbstractBackground/Objective: Emotional dysregulation (ED) is a dimensional psychological domain, previously operationalized by instruments of the Achenbach System of Empirically Based Assessment (ASEBA) for children and adolescents; however, its cross-cultural and bottom-up characteristics among adult populations are still unknown. Method: We examined scores obtained on the Adult Self-Report (ASR) by 9,238 18- to 59-year-olds from 10 societies that differed in social, economic, geographic, and other characteristics. A Latent Class Analysis was performed on the data from each society. Results: In each society, a dysregulated class (DYS) was identified, which was characterized by elevated scores on most ASR syndromes. The mean prevalence of DYS was 9.2% (6.1-12.7%). The best models ranged from three to five latent classes in the different societies. Conclusions: Although the number of identified classes and the prevalence of ED varied across societies, a DYS class was found in each society, suggesting the need to adopt a dimensional view of psychopathology and a cross cultural perspective also in adult populations.

ReportResumenAntecedentes/Objetivo: La desregulación emocional (DE) es un ámbito dimensional en Psicología, previamente operacionalizado por los instrumentos del Achenbach System of Empirically Based Assessment (ASEBA) para niños y adolescentes; sin embargo, aún se desconocen sus características interculturales y su enfoque ascendente en su aplicación a la población adulta. Método: Examinamos las puntuaciones obtenidas en el Adult Self-Report (ASR) por 9.238 personas de 18 a 59 años pertenecientes a diez sociedades que diferían en cuanto a sus características sociales, económicas, geográficas y de otro tipo. Se realizó un análisis de clases latentes con los datos de cada sociedad. Resultados: En cada sociedad se identificó una clase desregulada (DES), que se caracterizaba por pun-tuaciones elevadas en la mayoría de los síndromes ASR. La prevalencia media de DES fue del 9,2% (6,1-12,7%). Los mejores modelos oscilaron entre tres y cinco clases latentes en las diferentes sociedades. Conclusiones: Aunque el número de clases identificadas y la prevalencia de DE variaron entre las diversas sociedades, se encontró una clase DES en cada sociedad, lo que sugiere la necesidad de adoptar una visión dimensional de la psi-copatología y una perspectiva intercultural también en las poblaciones adultas.

Silencing LncRNA-DANCR attenuates inflammation and DSS-induced endothelial injury through miR-125b-5p / Silenciar LncRNA-DANCR atenúa la inflamación y la lesión endotelial inducida por DSS a través de miR-125b-5p

Background: LncRNA-DANCR is involved in inflammation and acts as a major contributor to colon cancer. The effects and mechanism of LncRNA-DANCR were first investigated in a DSS-induced colitis model in vivo and vitro. Material and methods: Sprague-Dawley rats were given DSS to induce the colitis model. TNF-α, IL-1β, IL-6 levels and expression of intestinal adhesion proteins ZO-1 and MUC2 in colon tissues and DSS-induced NCM460 cells were measured using corresponding kits. A hematoxylin and eosin (H&E) staining assay was performed to evaluate colon tissue pathology conditions. Protein expression levels in DSS-induced NCM460 cells were evaluated by Western blotting, and cell apoptosis was detected using a TUNEL assay. Gene levels in DSS-induced NCM460 cells were evaluated by PCR. The StarBase online tool was used to predict the LncRNA-DANCR target. The LncRNA-DANCR target was verified using a luciferase reporter assay. Results: LncRNA-DANCR was up-regulated in DSS-induced groups of rats. TNF-α, IL-1β and IL-6 expression was significantly increased in DSS-induced groups of rats and cells. Zo-1 and MUC2 expression levels were decreased in DSS-induced groups of rats. Silencing LncRNA-DANCR reduced inflammation, cell apoptosis and up-regulated ZO-1, MUC2 and Claudin-1 in DSS-induced cells. MiR-125b-5p was the downstream LncRNA-DANCR target. All LncRNA-DANCR effects in the colitis model were reversed by the miR-125b-5p inhibitor. Conclusion: LncRNA-DANCR/miR-125b-5p, which may act as a regulatory axis in inflammation, apoptosis and barrier function dysregulation, can provide an essential reference for the development of new drugs in colitis treatment.(AU)

Antecedentes: LncRNA-DANCR está involucrado en la inflamación y es uno de los mayores contribuyentes al cáncer de colon. Los efectos y el mecanismo de LncRNA-DANCR se investigaron por primera vez en el modelo de colitis inducido por DSS in vivo e in vitro. Material y métodos: Las ratas Sprague-Dawley recibieron DSS para inducir el modelo de colitis. Se midieron el nivel de TNF-α, IL-1, IL-6 y la expresión de proteínas de adhesión intestinal ZO-1 y MUC2 en los tejidos del colon y las células NCM460 inducidas por DSS utilizando los kits correspondientes. Se realizó un ensayo de tinción de hematoxilina y eosina (HE) para la evaluación de las condiciones patológicas del tejido del colon. El nivel de expresión de proteína en las células NCM460 inducidas por DSS se evaluó a través de Western blotting y se detectó apoptosis celular mediante el uso de un ensayo de TUNEL. El nivel genético en las células NCM460 inducidas por DSS se evaluó mediante un ensayo de PCR. La base estelar en línea se aplicó para predecir el objetivo de LncRNA-DANCR. El objetivo de LncRNA-DANCR fue verificado a través del ensayo Luciferase Reporter. Resultados: LncRNA-DANCR fue regulado en grupos inducidos por DSS en ratas. La expresión de TNF-α, IL-1 e IL-6 se incrementó significativamente en grupos inducidos por DSS en ratas y células. El nivel de expresión de Zo-1 y MUC2 disminuyó en los grupos inducidos por DSS en ratas. Silenciar LncRNA-DANCR redujo la inflamación, la apoptosis celular y el ZO-1, MUC2 y Claudin-1 regulados en células inducidas por DSS. MiR-125b-5p era el siguiente objetivo de lncRNA-DANCR. Todos los efectos de LncRNA-DANCR en el modelo de colitis fueron revertidos por el inhibidor miR-125b-5p. Conclusión: El LncRNA-DANCR/miR-125b-5p, que puede ser un eje regulador en la inflamación, la apoptosis y la desregulación de la función de barrera, puede proporcionar una referencia vital para el desarrollo de nuevos fármacos en el tratamiento de la colitis.(AU)

Tratamiento de la desregulación emocional en hospitales del área metropolitana de Buenos Aires: una encuesta a profesionales / Treatment of emotional dysregulation in hospitals of the metropolitan area of Buenos Aires: a survey to practitioners

Resumen El proceso de regulación emocional está siendo foco de gran cantidad de investigaciones en la actualidad. Se estima que se encuentra asociada al desarrollo y mantenimiento del 75 % de los trastornos mentales del Manual Diagnóstico y Estadístico de los Trastornos Mentales (DSM, por sus siglas en inglés). En esta línea se han estado estudiando en los últimos años, a nivel global, protocolos transdiagnósticos que tienen, como foco de tratamiento, dicho proceso. El objetivo de este estudio consistió en explorar la familiaridad de los profesionales de la salud mental, de hospitales públicos del área metropolitana de Buenos Aires, con el constructo de la desregulación emocional y los protocolos diseñados para el tratamiento de pacientes con dichas características. A su vez, se buscó conocer el grado de acercamiento de los profesionales clínicos a las investigaciones sobre psicoterapias. A estos fines, se diseñó un cuestionario con 40 preguntas de respuestas abiertas y opción múltiple que fue completado por 75 profesionales (psicólogos y psiquiatras) de hospitales públicos del área metropolitana de Buenos Aires. La mayoría reportó conocer el constructo de desregulación emocional, pero al pedirles que conceptualicen un caso diseñado para este estudio muy pocos utilizaron el constructo. En cuanto a los protocolos transdiagnósticos diseñados para intervenir en la desregulación emocional, son muy poco implementados. Por su parte, menos de la mitad reportó haber leído investigaciones empíricas. Los cursos elegidos para continuar la formación son en su mayoría psicoanalíticos y la participación en congresos internacionales es escasa. Se propone la necesidad de fomentar el uso de intervenciones basadas en evidencia en hospitales públicos y la divulgación de protocolos transdiagnósticos con evidencia para la desregulación emocional.

Abstract A substantial amount of evidence regarding comorbidity among mental disorders has been accumulated during the last years. Moreover, it has been identified that there is a great variability within nosological categories. These limitations of categorical systems lead to the development of the transdiagnostic paradigm which contemplates the existence of underlying processes common to different diagnoses. The process of emotional regulation is currently the focus of many investigations. It is estimated that it is associated with the development and maintenance of 75 % of DSM mental disorders. Emotional dysregulation is being studied particularly as a common factor in depression and anxiety, the two most prevalent disorders in Argentina. Related to this, transdiagnostic protocols aiming this process have been studied in the last years at a global level. The Unified Protocol has been developed by Barlow from a transdiagnostic perspective aiming to offer an evidence-based intervention that could be faithfully used in heterogeneous groups. It was created for emotional disorders with a specific focus on emotional dysregulation, contemplating comorbidity and heterogeneity. This makes the Unified Protocol a proper and valid intervention for the most prevalent disorders in Argentina. The objective of this study was to explore the familiarity of mental health practitioners, of public hospitals in the metropolitan area of ​​Buenos Aires, with the emotional dysregulation construct and protocols designed for the treatment of patients with these characteristics. Moreover, the degree in which clinicians approach psychotherapy research was evaluated. For this purpose, a cross-sectional descriptive study was carried on. A questionnaire was designed with 40 questions (25 with closed answer and 15 with short open answer) that investigated five thematic areas: demographic characteristics, therapeutic approach, knowledge about the emotional dysregulation construct and treatment protocols, knowledge about the transdiagnostic paradigm and approach to empirical research. The questionnaire was completed by 75 practitioners (psychologists and psychiatrists) from public hospitals of the metropolitan area of Buenos Aires. After analyzing the results, it can be said that the most prominent theoretical framework from which practitioners work in public hospitals is psychoanalysis. The most prevalent diagnoses are anxiety and depression and comorbidity is frequent (M = 2.23, SD = .707). When studying the familiarity to the construct of emotional dysregulation, it was observed that even though most of them reported knowing the emotional dysregulation construct (89.3 %), when asked to conceptualize a person with intense and long-lasting emotional distress and difficulty in controlling their behavior and recognizing their emotions, very few mentioned difficulties in the regulation of emotions (13.51 %). Individual format treatment was the most chosen by psychologists for patients with these characteristics (69 %). Psychiatrists reported pharmacotherapy as the most chosen treatment (87.5 %). Group format is not frequently used. In regards to transdiagnostic protocols designed to intervene in emotional dysregulation, they are very poorly implemented. Dialectical Behavioral Therapy was reported to be known by 80 % of the sample, but used by 33.9 %, while the Unified Protocol was referred to be known by 34.7 % and used by 7.69 % of them. On the other hand, the gap between clinical practice and research seems to be wide. Less than half of the practitioners reported reading empirical research (44 %). And the transdiagnostic paradigm is known by 46.7 % of practitioners. When asked to mention the most influential authors in their practice, Freud and Lacan (classical psychoanalytic authors) were mentioned by the majority. The courses chosen to continue their training are mostly psychoanalytic and participation in international congresses is low (10.45 %). These results show the need to look for ways to encourage the use of evidence-based interventions in public hospitals and specifically the dissemination of transdiagnostic protocols with evidence for emotional dysregulation, being emotional disorders the most prevalent.

Perceived Child Difficultness, Emotion Dysregulation, and Emotion-Related Parenting among Chinese Parents.

This study investigated the integrative effects of parents' perceptions of child difficultness and parental emotion dysregulation on emotion-related parenting among a group of Chinese parents of school-age children. One hundred and fifty parent-child dyads (121 biological mothers and 29 biological fathers as primary caregivers; Mage = 39.22 years) from urban Beijing, China participated in the study. Parents reported on their own emotion dysregulation and their children's difficultness, as well as their emotion socialization practices. Children (Mage = 8.54 years; ranged from 6 to 12 years) reported on their parents' use of psychological control strategies. Main and interactive effects were tested using path analysis. Results indicated that parents' perceived child difficultness was negatively associated with supportive reactions to children's expression of negative emotions, and parental emotion dysregulation was positively associated with unsupportive reactions. When parents perceived their children to be difficult and also reported emotion regulation difficulties of their own, they showed the highest levels of psychological control (child reports). These findings suggest differential effects of parent cognition and emotion on supportive and unsupportive reactions to children's negative emotions. Both cognition and emotion play important roles in relation to parents' use of psychological control.

En este estudio se investigaron los efectos integradores de la dificultad de los niños percibida por los padres y la desregulación emocional parental en la crianza relacionada con las emociones entre un grupo de padres chinos de niños en edad escolar. En el estudio participaron ciento cincuenta díadas de padres e hijos (121 madres biológicas y 29 padres biológicos como cuidadores principales; edad promedio = 39.22 años) del área urbana de Beijing, China. Los padres informaron su propia desregulación emocional y la dificultad de sus hijos, así como sus prácticas de socialización emocional. Los niños (edad promedio = 8.54 años; de entre 6 y 12 años) informaron sobre el uso de estrategias de control psicológico de sus padres. Los efectos principales e interactivos se evaluaron usando el análisis de ruta. Los resultados indicaron que la dificultad de los niños percibida por los padres estuvo asociada negativamente con reacciones de apoyo a la expresión de emociones negativas de los niños, y la desregulación emocional parental estuvo asociada positivamente con reacciones de falta de apoyo. Cuando los padres percibieron que sus hijos eran difíciles y también informaron dificultades propias de regulación emocional, demostraron niveles más altos de control psicológico (informes de los niños). Estos resultados sugieren efectos diferenciales de cognición y emoción de los padres en las reacciones de apoyo y de falta de apoyo a las emociones negativas de los niños. Tanto la cognición como la emoción cumplen funciones importantes en relación con el uso del control psicológico de los padres.

Silencing LncRNA-DANCR attenuates inflammation and DSS-induced endothelial injury through miR-125b-5p.

BACKGROUND: LncRNA-DANCR is involved in inflammation and acts as a major contributor to colon cancer. The effects and mechanism of LncRNA-DANCR were first investigated in a DSS-induced colitis model in vivo and vitro. MATERIAL AND METHODS: Sprague-Dawley rats were given DSS to induce the colitis model. TNF-α, IL-1ß, IL-6 levels and expression of intestinal adhesion proteins ZO-1 and MUC2 in colon tissues and DSS-induced NCM460 cells were measured using corresponding kits. A hematoxylin and eosin (H&E) staining assay was performed to evaluate colon tissue pathology conditions. Protein expression levels in DSS-induced NCM460 cells were evaluated by Western blotting, and cell apoptosis was detected using a TUNEL assay. Gene levels in DSS-induced NCM460 cells were evaluated by PCR. The StarBase online tool was used to predict the LncRNA-DANCR target. The LncRNA-DANCR target was verified using a luciferase reporter assay. RESULTS: LncRNA-DANCR was up-regulated in DSS-induced groups of rats. TNF-α, IL-1ß and IL-6 expression was significantly increased in DSS-induced groups of rats and cells. Zo-1 and MUC2 expression levels were decreased in DSS-induced groups of rats. Silencing LncRNA-DANCR reduced inflammation, cell apoptosis and up-regulated ZO-1, MUC2 and Claudin-1 in DSS-induced cells. MiR-125b-5p was the downstream LncRNA-DANCR target. All LncRNA-DANCR effects in the colitis model were reversed by the miR-125b-5p inhibitor. CONCLUSION: LncRNA-DANCR/miR-125b-5p, which may act as a regulatory axis in inflammation, apoptosis and barrier function dysregulation, can provide an essential reference for the development of new drugs in colitis treatment.