A methodological study on the identification of ecological security change processes and zoning control strategies -- Based on the perspective of sustainable development.

Ecological security (ES) is a crucial indicator for assessing the sustainable development of a region. Currently, most studies on ES primarily focus on process analysis, and the integration of environmental variability into the development of tailored control strategies for regions with varying ecological quality is overlooked. Therefore, in this study, we identified regional ES change processes, employed an optimized system to calculate the ecological security index (ESI), and identified ecological corridors (ECs) through the Minimum Constrained Resource (MCR) model to determine zoning strategies for typical arid regions, using the Ningxia region in the Yellow River Basin of China as an example. The findings showed that (1) from 2006 to 2020, the ESI values of most regions were between 0.2 and 0.4, with small but consistent increases in the ESI values over the years. (2) The proportion of regions with high ES ratings increased by 9.08 % across all districts and counties, and the center of gravity of ES shifted in a north-south and east-west direction. (3) The ESI exhibited a strong positive spatial correlation, characterized by spatial diffusion and spillover effects in most regions. (4) The ECs were predominantly distributed in a north-south direction, involving a total of 20 districts and counties. Based on the principles of sustainable development, we developed a model for the dynamic identification and zoning control of regional ES, aiming to provide a practical framework for effective ecological restoration and protection measures. Additionally, the strategies and methodologies presented in this study serve as important references for similar regions worldwide to facilitate the zoning control of ES, highlighting the broader significance and applicability of the study.

Revisiting development strategy under climate uncertainty: case study of Malawi.

This paper analyzes the effectiveness of agriculture-led versus non-agriculture-led development strategies under climate-induced economic uncertainty. Utilizing Malawi as a case study, we introduce the application of Stochastic Dominance (SD) analysis, a tool from decision analysis theory, and compare the two strategies in the context of weather/climate-associated economic uncertainty. Our findings suggest that an agriculture-led development strategy consistently surpasses its non-agriculture-led antagonist in poverty and undernourishment outcomes across almost all possible weather/climate scenarios. This underscores that, despite increasing exposure of the entire economy to weather/climate uncertainty, agriculture-led development remains the optimal strategy for Malawi to reduce poverty and undernourishment. The study also endorses the broader use of SD analysis in policy planning studies, promoting its potential to integrate risk and uncertainty into policymaking.

Factors Associated with Inclusion of Japan in Phase I Multiregional Clinical Trials in Oncology.

BACKGROUND: Early inclusion of Japan in the global development program could be a key factor in reducing the drug lag, making participation in phase I multiregional clinical trials (Ph. I MRCTs) an important consideration for oncology drug development in Japan. We aimed to investigate the factors associated with the inclusion of Japan in Ph. I MRCTs in oncology. METHODS: We compared the trial design, target population, type of primary tested drug, trial conduct profile, and sponsor profile for Ph. I MRCTs with or without Japan conducted by the top 20 companies in more than two countries and started between January 1, 2011, and December 31, 2020. RESULTS: One hundred and ninety-seven Ph. I MRCTs included Japan, and 697 did not. Detailed features of the Ph. I MRCTs in oncology were summarized, and several factors (trial design, target population, trial conduct profile, and sponsor profile) associated with inclusion of Japan in the Ph. I MRCTs were identified. CONCLUSIONS: It is important for Japanese subsidiaries within global pharmaceutical companies to closely communicate with the headquarters based on medical practice and unmet needs in Japan to join global development from an early stage. In addition, further efforts to attract emerging biopharmaceutical companies to Japan from the regulatory and/or political perspectives would be needed, thereby preventing drug lag in Japan.

A novel vaccine strategy using quick and easy conversion of bacterial pathogens to unnatural amino acid-auxotrophic suicide derivatives.

We propose a novel strategy for quick and easy preparation of suicide live vaccine candidates against bacterial pathogens. This method requires only the transformation of one or more plasmids carrying genes encoding for two types of biological devices, an unnatural amino acid (uAA) incorporation system and toxin-antitoxin systems in which translation of the antitoxins requires the uAA incorporation. Escherichia coli BL21-AI laboratory strains carrying the plasmids were viable in the presence of the uAA, whereas the free toxins killed these strains after the removal of the uAA. The survival time after uAA removal could be controlled by the choice of the uAA incorporation system and toxin-antitoxin systems. Multilayered toxin-antitoxin systems suppressed escape frequency to less than 1 escape per 109 generations in the best case. This conditional suicide system also worked in Salmonella enterica and E. coli clinical isolates. The S. enterica vaccine strains were attenuated with a >105 fold lethal dose. Serum IgG response and protection against the parental pathogenic strain were confirmed. In addition, the live E. coli vaccine strain was significantly more immunogenic and provided greater protection than a formalin-inactivated vaccine. The live E. coli vaccine was not detected after inoculation, presumably because the uAA is not present in the host animals or the natural environment. These results suggest that this strategy provides a novel way to rapidly produce safe and highly immunogenic live bacterial vaccine candidates. IMPORTANCE: Live vaccines are the oldest vaccines with a history of more than 200 years. Due to their strong immunogenicity, live vaccines are still an important category of vaccines today. However, the development of live vaccines has been challenging due to the difficulties in achieving a balance between safety and immunogenicity. In recent decades, the frequent emergence of various new and old pathogens at risk of causing pandemics has highlighted the need for rapid vaccine development processes. We have pioneered the use of uAAs to control gene expression and to conditionally kill host bacteria as a biological containment system. This report proposes a quick and easy conversion of bacterial pathogens into live vaccine candidates using this containment system. The balance between safety and immunogenicity can be modulated by the selection of the genetic devices used. Moreover, the uAA-auxotrophy can prevent the vaccine from infecting other individuals or establishing the environment.

Harmony with nature: Disentanglement the influence of ecological perception and adaptation on sustainable development and circular economy goals in country.

From the perspective of ecosystem attributes, this research was conducted to explore the impact of people's adaptation and response to their perception of environmental risks on their preference for sustainable development strategies and the realization of a circular economy based on Social Judgment Theory and the Value-Belief-Norm (VBN) theory. To achieve the goal, three substudies were conducted using questionnaire surveys-the first substudy aimed to examine the influence of ecological attributes on environmental risk perception (ERP). The second substudy attempted to understand the intricate connection between ERP and justice, while the third study explored the relationship between justice and SDS (sustainable development strategies) and CEG (realization of a circular economy). The results indicate the following: (1) The first substudy reveals that ecological attributes impact environmental risk perception (ERP), with different environmental values exerting distinct influences. (2) The second substudy suggests that ERP facilitates the realization of social, environmental, and ecological justice, but people's preference for a specific economic growth strategy will affect their tendency to realize justice. (3) The third substudy shows that sustainability strategies (i.e., sustainable production, consumption, and use) mediate the relationship between justice and circular economy goals (CEG). Among the three strategies, sustainable use plays the most significant mediating role. The research outcomes underscore the importance of prioritizing sustainable use in future research in theory and practice.

Increasing orphan drug loss in Japan: Trends and R&D strategy for rare diseases.

Rare disease (RD) patients face significant unmet therapeutic needs worldwide. However, orphan drugs approved in the United States, but not approved or developed in Japan, have increased rapidly with recently increasing US approvals, indicating greater RD drug loss in Japan. US/EU-based startups have become key players in RD drug R&D, significantly contributing to this drug loss trend. They successfully develop drugs in the United States by combining in-licensing with in-house drug discovery. Out-licensing to Japanese companies or large pharma is critical for expansion into Japan, with successes attributed to drug innovation, target indications, and transactional capabilities. These findings highlight the need to foster partnerships with startups and cultivate an ecosystem in Japan that nurtures local startups, to address drug loss and ensure access to promising drugs.

Evaluation and development strategy of urban-rural integration under ecological protection in the Yellow River Basin, China.

The problem of imbalanced urban-rural development in China is becoming increasingly serious. Urban-rural integration (URI) is an inevitable way to narrow the urban-rural gap and promote rural development. The Yellow River Basin (YRB) is an important barrier to China's ecological security and plays a crucial role in promoting ecological protection and in high-quality development strategies. Therefore, this article constructs an evaluation index system for URI from five dimensions: economic integration, social integration, ecological integration, element integration, and spatial integration. The simulated annealing-projection pursuit model and time degree are used to analyze the dynamic urban-rural integration level (URIL) of 373 counties from 2000 to 2019. Building upon this foundation, this study classifies four types of URI zones and proposes development strategies tailored to each zone. The results indicate (1) that the URIL in the YRB continues to increase, and that there has been a significant increase in high-level integration areas since 2010. (2) The URIL exhibits a distinct spatial clustering pattern, characterized by lower levels in the upper reaches, and higher levels in the middle and lower reaches. (3) There exists a spatial disparity between economic development and the ecological environment, and it is particularly noticeable in the lower reaches regions. These results contribute to a better understanding of URI in the YRB and provide a reference for the sustainable development of URI in various regions.

Toward a Long-Term Low Emission Development Strategy: The Case of Energy Transition in Qatar.

The objective of this paper is to present a comprehensive perspective on the development of a long-term low-emission development strategy for Qatar, in line with the Paris Agreement. The methodology used in this paper takes a holistic approach by analyzing national strategies, structures, and mitigation measures from other countries, and synthesizing these with Qatar's unique context in terms of its economy, energy production, and consumption, as well as its energy-related emission profile and characteristics. The findings of this paper identify key considerations and elements that policymakers would need to take into account when developing a long-term low-emission vision for Qatar, with a particular emphasis on its energy sector. The policy implications of this study are significant for policymakers in Qatar, as well as for other countries facing similar challenges in their transition to a sustainable future. This paper contributes to the discourse on energy transition in Qatar and provides insights that can inform the development of potential routes to reduce greenhouse gas emissions in Qatar's energy system. It serves as a foundation for further research and analysis and can contribute to the development of more effective and sustainable policies and strategies for low-emission development in Qatar and beyond.

A roadmap for developing Venezuelan equine encephalitis virus (VEEV) vaccines: Lessons from the past, strategies for the future.

Venezuelan equine encephalitis (VEE) is a zoonotic infectious disease caused by the Venezuelan equine encephalitis virus (VEEV), which can lead to severe central nervous system infections in both humans and animals. At present, the medical community does not possess a viable means of addressing VEE, rendering the prevention of the virus a matter of paramount importance. Regarding the prevention and control of VEEV, the implementation of a vaccination program has been recognized as the most efficient strategy. Nevertheless, there are currently no licensed vaccines or drugs available for human use against VEEV. This imperative has led to a surge of interest in vaccine research, with VEEV being a prime focus for researchers in the field. In this paper, we initially present a comprehensive overview of the current taxonomic classification of VEEV and the cellular infection mechanism of the virus. Subsequently, we provide a detailed introduction of the prominent VEEV vaccine types presently available, including inactivated vaccines, live attenuated vaccines, nucleic acid, and virus-like particle vaccines. Moreover, we emphasize the challenges that current VEEV vaccine development faces and suggest urgent measures that must be taken to overcome these obstacles. Notably, based on our latest research, we propose the feasibility of incorporation codon usage bias strategies to create the novel VEEV vaccine. Finally, we prose several areas that future VEEV vaccine development should focus on. Our objective is to encourage collaboration between the medical and veterinary communities, expedite the translation of existing vaccines from laboratory to clinical applications, while also preparing for future outbreaks of new VEEV variants.

Exploratory Analysis of Drug Lag in New Oncology Drugs Between Japan and the US.

BACKGROUND: Drug lag in Japan has greatly decreased over the past decades; however, new instances of drug lag have appeared along with changes in the circumstances of oncology drug development. We aimed to investigate the factors associated with the approval lag for new oncology drugs between Japan and the United States (US) over the past decade by comparing approval dates and modalities, lead indications, approval types, and phase I strategies for earlier approval in Japan. METHOD: We descriptively evaluated the characteristics of 117 new oncology drugs approved in either Japan or the US from January 1, 2011, to December 31, 2020. RESULTS: Seventy-one drugs were approved in Japan, 112 in the US, five only in Japan, and 46 only in the US. Interestingly, new oncology drugs were predominantly developed by the top 20 pharmaceutical companies in Japan; however, the opposite was true for drugs that were not yet approved in Japan. However, no clear trend was observed in the relationship between drug lag and the studied factors, except for the phase I strategy. There was a numerical but clear trend in which a higher percentage of phase I multiregional clinical trials (MRCTs) in the drug development strategy was observed for drugs with earlier approval in Japan. CONCLUSION: Participation in global drug development during the early stages, such as during phase I MRCTs, is one of the keys to successfully minimizing this new instance of drug lag in Japan.

The Impact of Location-Based Tax Incentives and Carbon Emission Intensity: Evidence from China's Western Development Strategy.

This study seeks to address the question of whether China's Western Development Strategy (WDS) has affected the carbon emission intensity of the regions it covers. There remains a distinct lack of analysis based on the normative causal inference method regarding the impact of this economic development policy on carbon emissions. Our research contributes to the large body of international literature studying the effects of place-based policy and has implications for place-based policies regarding the impact of carbon emissions. It constructs a duopoly model to illustrate the relationship between lower prices of capital (caused by policies such as tax reduction) and carbon emissions. Using county-level data on both sides of the provincial boundary of the WDS from 1998 to 2007, and applying the difference-in-differences method, our results indicate that the WDS has significantly increased carbon emission intensity of the western counties. Our findings also indicate that while the WDS has had no significant positive effect on counties' economic growth, no policy trap effect was found. There is also no evidence suggesting that the economic activities attributable to the WDS have brought any negative externalities of carbon emissions to the counties east of the western provincial border.

Coordinative Management of Soil Resources and Agricultural Farmland Environment for Food Security and Sustainable Development in China.

Major problems in China's pursuit of sustainable agricultural development include inadequate, low-quality soil and water resources, imbalanced regional allocation and unreasonable utilization of resources. In some regions, overexploitation of soil resources and excessive use of chemicals triggered a web of unforeseen consequences, including insufficient use of agricultural resources, agricultural non-point source pollution and land degradation. In the past decade, China has changed its path of agricultural development from an output-oriented one to a modern, sustainable one with agricultural ecological civilization as its goal. First, the government has formulated and improved its laws and regulations on soil resources and the environment. Second, the government has conducted serious actions to ensure food safety and coordinated management of agricultural resources. Third, the government has planned to establish national agricultural high-tech industry demonstration zones based on regional features to strengthen the connection among the government, agri-businesses, scientific community and the farming community. As the next step, the government should improve the system for ecological and environmental regulation and set up a feasible eco-incentive mechanism. At the same time, the scientific community should strengthen the innovation of bottleneck technologies and the development of whole solutions for sustainable management in ecologically fragile regions. This will enhance the alignment between policy mechanisms and technology modes and effectively promote the sustainable development of agriculture in China.

Creative Approach to Development: Leveraging the Sino-African Belt and Road Initiatives to Boost Africa's Cultural and Creative Industries for Africa's Development.

The present study identifies investment in Africa's cultural and creative industries (CCIs) as one of the strategic moves in the right direction for achieving sustainable development across the African continent. Cultural and creative industries (CCIs) offer an alternative approach to development through their wealth creation potential, socioeconomic development, employment opportunities, and promotion of cultural diversity. Nevertheless, CCIs are yet to feature categorically as a development strategy, owing to their many challenges, as indicated by the study. The study submits that partnerships under the Belt and Road Initiatives (BRI) could offer an alternative source of mobilizing support for CCIs, as the BRI is a development framework with robust financing, infrastructure, and human resources development. However, it will require the pragmatic support of policymakers to leverage BRI and boost the expansion of CCIs in Africa.

Local development challenge in lagging-behind areas: insights from new & evolutionary economic geography.

Lagging-behind regions, as an example of the failure of convergence in a country, has attracted the attention of many researchers who are attempting to adopt applicable policies and strategies to overcome the problem of low growth paths. The present study focuses on the policy proposals in the context of new economic geography and evolutionary economic geography for lagging-behind areas. Industrial agglomeration, as an essential element of the new economic geography, has restricted the potential for policy-making in lagging-behind regions. Creating regional advantages, as a policy in evolutionary economic geography, has provided diversified policy options for lagging-behind regions. However, this approach faces multi-level challenges in lagging-behind regions, including the lack of critical mass about low diversity and the gap in the knowledge base between lagging-behind and affluent areas. Therefore, if this policy is to be the basis for creating regional objectives, it should provide a structure for simulating external knowledge links and distinguishing the nature of the various related industries.

Analysis and suggestions on the development trend of drug innovation in China / 中国药科大学学报

@#In order to comprehensivehy evaluate the stage of China in the global drug innovation, to further optimize the environment for drug innovation in China, and to unleash the vitality of drug innovation, this article mainly analyzes through comparison China''s situation of drug innovation in global competition from such perspectives as the current situation of the global drug R&D innovation market, R&D investment, product pipeline, policy support, and development trends, combined with the characteristics of China''s drug innovation development.It can be seen that China''s pharmaceutical innovation is faced with such practical problems as lagging behind some developed countries in terms of innovation development, companies bunching into research and development innovation, sudden research and development rush, and excessive dependence on capital markets for pharmaceutical innovation.Accordingly, this paper puts forward suggestions on continuously improving China''s new drug innovation environment, rationally selecting differentiated competition and new tracks, reasonably formulating drug innovation development strategies, guiding capital to return to innovative research and development, and constructing a "double cycle" strategy for drug innovation.

Amyloid Cascade Hypothesis for the Treatment of Alzheimer's Disease: Progress and Challenges.

The amyloid cascade hypothesis has always been a research focus in the therapeutic field of Alzheimer's disease (AD) since it was put forward. Numerous researchers attempted to find drugs for AD treatment based on this hypothesis. To promote the research of anti-AD drugs development, the current hypothesis and pathogenesis were reviewed with expounding of ß-amyloid generation from its precursor protein and related transformations. Meanwhile, the present drug development strategies aimed at each stage in this hypothesis were also summarized. Several strategies especially immunotherapy showed the optimistic results in clinical trials, but only a small percentage of them eventually succeeded. In this review, we also tried to point out some common problems of drug development in preclinical and clinical studies which might be settled through multidisciplinary cooperation as well as the understanding that reinforces the amyloid cascade hypothesis.

[Development strategy and current situation of Chinese patent medicine for children in China].

This study took the 2020 edition of Chinese Pharmacopoeia(ChP) and the 2018 edition of National Essential Drug List(NEDL) for children as research carriers to systematically analyze the current situation of and problems in the use of Chinese patent medicine for children(CPMC) in China. In view of the problems of imprecise dosage, incomplete safety information, and lack of sui-table varieties, dosage form and specification of CPMC in China, development strategy of CPMC in the future was proposed. It is reco-mmended to carry out systematic post-marketing revaluation studies of CPMC, encourage the development of new varieties or new dosa-ge forms suitable for children, advocate the continuous promotion of real-world studies on children, and expand the information on the use of CPMC with real-world data, so as to lay the foundation for post-marketing revaluation of CPMC and guide the rational use of clini-cal medicines. This study was expected to build a positive policy ecosystem to ensure the supply of CPMC, and promote the high-quality development of CPMC.

Digital transformation, smart technologies, and eco-innovation are paving the way toward sustainable supply chain performance.

The world has limited resources and resource depletion has been a serious concern for many years. To ensure that ecological balance is maintained, the United Nations has developed 17 Sustainable Development Goals (SDGs). This study attempts to meet the 12th SDG of "responsible production and consumption" and provide a guideline to manufacturing organizations in Pakistan. Many scholars have examined the role of different technologies on sustainable performance. However, research using eco-innovation (EI), digital transformation (DT), and smart technologies (ST) is still scarce. The current study develops the conceptual model based on the resource-based view (RBV) and technology, organization, and environment (TOE) theories, and using a simple random sampling technique, valid data from 375 professionals in the manufacturing industry is collected to test the relationship between sustainable development strategy (SDS), EI, DT, ST, and sustainable supply chain performance (SSCP). The results indicate strong positive relationships between SDS, EI, DT, ST, and SSCP. Results indicate that even if organizations are executing SDS and EI, without DT and ST, organizations cannot achieve SSCP. Therefore, it is recommended to the managers that they must apply DT and ST to guarantee their pursuit of achieving sustainable performance and contribution toward SDGs.

[Considerations on Clinical Development and Regulatory of the Oversea License-in 
Anti-tumor Drugs].

With the boom of China's innovative pharmaceutical industry, licensing-in model has gradually become an important research and development model for innovative pharmaceutical companies. The in-licensed drugs at different stages need different research and development (R&D) strategy in China. The pharmaceutical companies take the responsibility to comprehensively collate the oversea clinical data and conduct a detailed analysis of clinical pharmacology, safety, efficacy and ethnic sensitivity. Clinical R&D strategy should be made based on the results of the above data and analysis. We encourage high-quality drugs which fill unmet clinical needs licensed in, and as early as possible, so as to conduct multi-regional clinical trials (MRCTs). The clinical R&D strategy in China is particularly important for the drug's approval. Guidelines published by the National Medical Products Administration (NMPA) and clinical associations should be followed. Communications about clinical R&D strategy with Center of Drug Evaluation (CDE) are encouraged.
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[Current status and development strategy of ISO/TC 249 standards for Chinese materia medica].

The internationalization of traditional Chinese medicine(TCM) is one of the strategic development objectives in China, which has been incorporated into the national strategy as an important part of the Belt and Road Initiative development strategy. As the basis and prerequisite of TCM development, Chinese materia medica(CMM) has a direct impact on the internationalization of TCM. The International Organization for Standardization(ISO) is a global organization composed of national standardization bodies, and the ISO standards impact the world's economy, trade, communication and cooperation. Based on a brief introduction to ISO/Traditional Chinese Medicine Technical Committee(ISO/TC 249), this study elaborates the necessity of establishing ISO standards for CMM and analyzes the current status and challenges faced by the formulation of international standards for CMM. Finally, this study puts forward the development strategy of international standards for CMM. Specifically, efforts should be made to develop top-level design with international market demands as the guidance and improve the quality of standards to accelerate the transformation of domestic high-quality standards into international standards. Moreover, measures should be taken to give full play to the positive role of enterprises in the formulation of standards, vigorously cultivate compound talents for international standardization of TCM, and constantly strengthen international cooperation. The experience and thinking are of guiding significance for the scientific, efficient and reasonable formulation of high-quality ISO standards for CMM in the future.