Drying kinetic, thermodynamic and quality analyses of infrared drying of truffle slices.

Kinetic and thermodynamic parameters are the most important part for making a suitable tool for drying agricultural products. Moreover, calculation of the energy required for the drying of product, the properties of the rehydration ratio, the food appearance changes, and the evaluation of the microstructure of food are crucial. Since the thermodynamic properties of truffle slices have not yet been reported, this study aims to establish a mathematical model to describe drying process of agriculture product, evaluate the effective moisture diffusion coefficient (Deff), determining the activation energy (Ea) to elucidate the thermodynamic characteristics, measure color characteristics, and rehydration ratio (RR) during the drying process of truffle slices. Truffle slices were dried in an infrared (IR) dryer at four temperatures of 50-80°C and two thicknesses of 0.5 and 1 cm. The best model to describe the drying process of truffle slices was Midilli et al.'s model. The value of Deff, SEC, and RR were in the range of 3.06 × 10-8 to 2.48 × 10-7 m2/s, 79.68-191.271 kWh/kg, and 5.99-7.49, respectively. The Deff of truffle slices increased with the above-mentioned parameters of the samples. The Ea obtained was 26.62-27.43 kJ/mol. The results indicated that enthalpy and entropy decreased with increasing drying temperature, while Gibbs free energy improved. The enthalpy, entropy, and Gibbs free energy values changed between 24.48-25.28 kJ/mol, -130.47 to -122.63 J/mol °K, and 63.97-70.17 kJ/mol, respectively. In addition, the results of color attributes decreased with increasing temperature, while chroma oppositely increased.

Decontamination of a robot used to reprocess reusable surgical instruments.

BACKGROUND: Using robots to handle medical devices in the decontamination area of the Central Sterile Supply Department (CSSD) can reduce risks and address staff shortages. The gripper design must allow reliable cleaning using standard CSSD procedures to avoid build-up of biofilms and possible cross-contamination between different instrument trays and the gripper's functionality. This study explores the design of the robot's gripper regarding cleanability, aiming to determine whether successful cleaning can be achieved even after prolonged drying for a working shift of 8 h. METHODS: We optimized a gripper for cleanability and used it to assess the spread of different test soils depending on different forms of motion. Subsequently, we analysed the cleanability using sheep's blood as test soil, reprocessing the gripper in different assembly configurations after 4 and 8 h of drying, and measuring residual protein. FINDINGS: Based on our investigations, we documented the spread of contamination depending on the type of motion of the gripper's components. Sheep's blood exhibited the highest dispersion among the test soils, permeating through thin crevices. Importantly, all samples displayed residual protein levels below the warning threshold, irrespective of drying time and gripper disassembly or cleaning position. Cleaning in a device-specific optimized position achieved results comparable to cleaning the disassembled individual components. CONCLUSIONS: These findings indicate that cleaning even after one working shift of 8 h and without the labour-intensive disassembly of the gripper is feasible, supporting the future use of robots to handle contaminated medical devices in the CSSD decontamination area.

Thermo-Hydric Study of Wood-Based Materials under Thermal Comfort Conditions.

This paper tackles the issue of moisture variation in wood-based materials, explicitly focusing on melamine-coated particleboard (hereafter referred to as melamine) and medium-density fiberboard (MDF) used in the third phase of wood industry transformation. The approach involves a comprehensive strategy for predicting moisture content variation, incorporating numerical simulation, experimental testing, and the application of artificial neural network (ANN) technology to enhance accuracy in furniture manufacturing. The developed ANN models are tailored to predict moisture content changes under specific thermal comfort conditions. Remarkably, these models demonstrate high precision, with an average error margin of only 1.40% for 8% moisture content (MC) and 2.85% for 12% MC in melamine, as well as 1.42% for 8% MC and 2.25% for 12% MC in MDF. These levels of precision surpass traditional models, emphasizing this study's novelty and practical relevance to the industrial context. The findings indicate that ANN models adapt to diverse environmental conditions, presenting a robust tool for optimizing moisture management in wood-based materials. This research contributes valuable insights for improving the reliability and efficiency of moisture content predictions in the wood industry.

Validation of a hand hygiene visual feedback system to improve compliance with drying time of alcohol-based hand rub in a neonatal intensive care unit: the Incubator Traffic Light system.

BACKGROUND: Compliance with the recommended 30 s drying time of alcohol-based hand rub (ABHR) is often suboptimal. To increase hand hygiene compliance at a neonatal intensive care unit (NICU), we installed an Incubator Traffic Light (ITL) system which shows 'green light' to open incubator doors after the recommended drying time. AIM: To measure the impact of this visual feedback system on NICU healthcare professionals' compliance with the recommended ABHR drying time. METHODS: Ten traffic light systems were installed on incubators at a NICU, five of which provided visual feedback, and five, serving as a control group, did not provide visual feedback. During a two-month period, the systems measured drying time between the moment of dispensing ABHR and opening the incubator's doors. The drying times of the incubators were compared with and without feedback. FINDINGS: Of the 6422 recorded hand hygiene events, 658 were valid for data analysis. Compliance with correct drying time reached 75% (N = 397/526) for incubators equipped with visual feedback versus 36% (N = 48/132; P < 0.0001) for incubators lacking this feature. CONCLUSION: The ITL improves compliance with the recommended 30 s ABHR drying time in a NICU setting.

Development of a Technology for Protein-Based, Glueless Belevskaya Pastille with Study of the Impact of Probiotic Sourdough Dosage and Technological Parameters on Its Rheological Properties.

The proper functioning of the gastrointestinal tract plays an important role in strengthening the immune system. It is an undeniable fact that lactic acid microorganisms are necessary for the proper functioning of the gastrointestinal tract, the source of which are mainly dairy products. However, there is a problem with the digestibility of lactose; therefore, alternative sources and carriers of probiotics are of particular interest. Due to its dietary and natural properties, protein marshmallow can serve as such a carrier. Therefore, the direction of this study is to identify the dependence of technological factors on the rheological properties of the product and the growth of lactic acid microorganisms in confectionery products enriched with lyophilised strains. According to the results of the study, the following was determined: the optimal technology to produce enriched Belevskaya pastille with a mixture of Lactobacillus acidophilus makes it possible to obtain a product with the necessary rheological properties, utilising a mass drying mode in a dehydrator at 50 °C for 16 h. The strains L. acidophilus M3 and L. acidophilus M4 were the most resistant to a high concentration of bile (40%) in the substrate. Based on the analysis of variance and the obtained regression equations, it was revealed that the growth of lactic acid microorganisms in the product was strongly influenced by the amount of ferment introduced (R² = 0.96). The level of penetration is influenced by factors such as the amount of probiotic starter introduced, the drying time and the interaction of drying time factors on the amount of starter added. The higher the level of penetration, the crumblier the product. The resulting functional product can be characterized as symbiotic since the main raw material of plant origin contains a large amount of fibre, which acts as a prebiotic, and the strain of microorganism, which acts as a probiotic. The data described in the article can be applied in the technological processes of similar products to regulate the structure of the product and vary the dosage of enrichment with probiotic starter cultures.

Low-temperature drying of waste activated sludge enhanced by agricultural biomass towards self-supporting incineration.

A high moisture content of waste activated sludge (WAS) associated with a low calorific value needs to be deeply dried towards self-supporting incineration. On the other hand, thermal energy with low temperature exchanged from treated effluent has great potential for drying sludge. Unfortunately, low-temperature drying of sludge seems to be low in efficiency and long in drying time. For this reason, some agricultural biomass was added into WAS to improve the drying efficiency. The drying performance and sludge properties were analyzed and evaluated with this study. Experimental results demonstrated that wheat straw was the best in enhancing the drying performance. With only 20 % (DS/DS) of crushed wheat straw added, the average drying rate achieved up to 0.20 g water/g DS·min, much higher than 0.13 g water/g DS·min of the raw WAS. The drying time to the targeted moisture content (63 %) (for self-supporting incineration) was shortened to only 12 min, much lower than 21 min of the raw WAS. The analysis revealed that wheat straw could reduce the specific resistance of filtration (SRF) and increase the sludge filterability (X). Also, the sludge rheology, particle size distribution and SEM images could conclude that agricultural biomass played a positive role in skeleton builders, forming a mesh-like structure in sludge flocs. These special channels could obviously improve the transfer capacities of heat and water inside the sludge matrix and thus greatly increase the drying performance of WAS.

Does extended air-drying time improve bond strength of universal adhesives to enamel?

OBJECTIVE: To investigate the effect of extended air-drying time on the microshear bond strength (MSBS) of universal adhesives to enamel. MATERIALS AND METHODS: The distal and mesial specimens from third molars were wet-ground and randomly assigned to three groups according to adhesives tested (n = 60): Clearfil Bond Universal, Gluma Bond Universal, and G-Premio Bond. The adhesives were applied in etch-and-rinse or self-etch modes, followed by air-drying for 5, 15, or 25 s. Composite buildups were constructed and subjected to the MSBS test after 24-h or thermocycling. MSBS results were evaluated using a four-way ANOVA. The thickness of the adhesive layer and the degree of solvent evaporation were further evaluated. RESULTS: At 24-h, MSBS of G-Premio Bond significantly improved with the 25 s air-drying in both of the etching modes when compared to the 5 s air-drying. After thermocycling, the extended air-drying did not produce a significant difference on the MSBS, regardless of the application strategy. Extended air-drying (25 s) evaporated almost all of the volatile part of Gluma Bond Universal and G-Premio Bond. CONCLUSIONS: Extended air-drying times increased solvent evaporation but did not contribute to the bonding effectiveness of the adhesives, regardless of the etching mode. CLINICAL SIGNIFICANCE: Air-drying applications for more than 5 s had no significant effect on enamel bonding performance of universal adhesives.

Instant controlled pressure drop drying: A review on preservation of quality characteristics in fresh produce.

This review describes the efficient Instant controlled pressure drop drying technology. The Détente Instantanée Contôlée (DIC), French for Instant Controlled Pressure-Drop drying, has prodigious potential to cause least variations in the quality characteristics of the final dried product. This review article spotlights the principle of DIC with its effect on vitamins (ascorbic acid), bioactive compounds (carotenoids, polyphenols), physicochemical properties (moisture, rehydration capacity, water holding capacity, color, microstructure texture) and sensory properties of fresh produce. DIC is a thermo-mechanical technique accomplished by treating the fresh produce to saturated steam for less time period, which is carried out by an immediate pressure drop to achieve vacuum. This technique also provides reduced drying time, better volume expansion with larger porosity in the final dried product. It leads to a swift vaporization of the water within fresh produce cells. DIC-treated fresh produce are quickly rehydrated and retains sensory and nutrient quality.

Revealing color change and drying mechanisms of pulsed vacuum steamed Cistanche deserticola through bioactive components, microstructural and starch gelatinization properties.

Cistanche deserticola is a famous herbal medicine and has been used worldwide for its kidney-tonifying and anti-aging values. This study investigated the effects of pulsed vacuum steaming (PVS) on bioactive phenylethanoid glycosides (PhGs), total soluble sugars, polysaccharides, color, drying characteristics, microstructure, and starch gelatinization properties of Cistanche deserticola. PVS pretreatment significantly increased PhGs and soluble sugar content while reduced the polysaccharides content. And increasing the material core temperature to 75 °C at the largest diameter was proposed as the optimal steaming condition and the PhGs content was increased by 1.11 times compared with that by atmospheric steaming. The color of steamed samples changed to oily black due to Maillard reaction. PhGs content was significantly (P < 0.05) positively correlated with total color difference (ΔE). Steaming until the ΔE value of 15.95 could achieve the maximum accumulation of PhGs, corresponding to the highest increasing ratio of echinacoside and acteoside. Starch was completely gelatinized and formed a barrier layer adhering to the cell surface when the material core temperature reached 75 °C at the largest diameter, explaining why after steaming the Cistanche deserticola drying time was prolonged by 85.71 %. The study can provide an innovative steaming technology and optimal process parameters for obtaining high-quality Cistanche deserticola decoction pieces, as well as propose a non-destructive testing method to quickly predict PhGs content based on color parameters during the steaming process.

Cider apple pomace as a source of nutrients: Evaluation of the polyphenolic profile, antioxidant and fiber properties after drying process at different temperatures.

Apple pomace, the by-product of the cider industry, contains a high content of antioxidant compounds and dietary fiber. Drying would allow its preservation for a later use. The aim of this study was to evaluate the effect of the drying temperature on the drying kinetics, antioxidant properties and the fiber characteristics. For this, drying experiments were performed at different temperatures (40-120 °C). The increase in temperature enhanced the drying rate, as was shown by the effective diffusivity and mass transfer coefficient identified by modelling. The influence of temperature was quantified through the activation energy (38.21 kJ/mol). Regarding the retention of antioxidant properties, the best results were found at 80-100 °C while 40-60 °C was the best temperature range for the fiber characteristics. Therefore, 80 °C could be an adequate temperature for drying of cider apple pomace, as it represents a good balance between kinetics, and antioxidant and fiber properties.

Influence of Dentin Surface Roughness, Drying Time, and Primer Application on Self-adhesive Composite-Cement Bond Strength.

PURPOSE: To investigate the effect of roughness and drying time of dentin as well as the number of coats of a self-adhesive composite-cement primer on the bond strength of self-adhesive composite cement. MATERIAL AND METHODS: Sixty human teeth were prepared and assigned to 12 groups (n = 5), according to three experimental factors: 1) dentin surface roughness, rough or fine, as achieved by 250- and 600-grit silicon carbide papers, respectively; 2) dentin wetness based on air-drying time (5 or 10 s); and 3) the self-adhesive composite-cement primer applications (no-coat, 1-coat, and 2-coat). Composite resin blocks were made with hybrid composite resin (M1 GraceFil) and cemented with G-CEM ONE (both GC). Cement-dentin sticks (12) were prepared, and the microtensile bond strength (µTBS) test was performed. Failure modes were observed with a stereomicroscope (40X), and bonding interfaces were evaluated with confocal laser scanning microscopy (CLSM). Statistical analysis was performed using three-way ANOVA and Tukey's post-hoc comparisons test (α = 0.05). RESULTS: Dentin roughness (250-grit > 600-grit, p = 0.000), drying time (5-s drying > 10-s drying, p = 0.000), and primer application (no-coat < 1-coat = 2-coat, p = 0.000) had significant effects on bond strength. These factors also showed significant interactions with each other (p = 0.003). The highest µTBS (31.8 ± 3.1 MPa) was observed in the 1-coat/fine roughness/10-s drying group and the lowest µTBS (13.4 ± 2.7 MPa) in the no-coat/coarse roughness/5-s drying group. CLSM showed higher penetration of cement in the primer-coated groups compared to that in the no-coat groups. CONCLUSION: Bond strength between the self-adhesive composite cement and dentin was higher in the fine-roughness dentin group than in the coarse-roughness dentin group, and in the 5-s drying group compared to the 10-s drying group. Applying a primer to dentin improved bond strength of the self-adhesive composite cement.

Effects of Various Drying Times on the Properties of 3D Printed Orodispersible Films.

Orodispersible films are an innovative dosage form. Their main advantages are the application comfort and the possibility of personalization. This work aimed to evaluate the influence of different drying times on the properties of orodispersible films of various thicknesses, prepared in two different semisolid extrusion 3D printing setups. In the first experiment, drying times were dependent on the overall print time of each batch. In the second setup, the drying time was set equal according to the longest one. The evaluated parameters were films' weight uniformity, thickness, moisture content, surface pH, disintegration time, hardness, and tensile strength. Upon statistical comparison, significant differences in the moisture content were found, subsequently affecting the disintegration time. Moreover, statistically significant differences in films' mechanical properties (hardness, tensile strength) were also described, proving that moisture content simultaneously affects film plasticity and related properties. In conclusion, a mutual comparison of the manufactured orodispersible films showed that the drying time affects their physical and mechanical properties. The in-process drying setup was proved to be sufficient while allowing quicker manufacturing.

A useful quality control using herbal volatiles of Artemisia princeps Pamp. cv. ssajuari (ssajuari-ssuk; Korean mugwort) according to air-drying time by fast gas chromatography with uncoated surface acoustic wave sensor (Electronic zNose).

INTRODUCTION: Korean mugwort has been used as a traditional medicine. Specifically, air-dried Artemisia princeps Pamp. cv. ssajuari (ssajuari-ssuk; Korean mugwort) has been used as moxa in moxibustion therapy. Thus, the evaluation of high quality ssajuari-ssuk containing herbal volatiles is of great interest in clinical therapy and the food industry. OBJECTIVE: The aim of this study is to determine whether fast gas chromatography with uncoated surface acoustic wave (fast GC/SAW) sensor can be a useful technique for performing quality control using herbal volatiles of ssajuari-ssuk air-dried for different times. METHODOLOGY: Fast GC/SAW sensor, called "Electronic zNose", is also a headspace sampling method and is an effective simple analytical method with a second unit analysis providing on-line measurements without the need for pretreatment of the sample. Headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) was employed to confirm the identification of the volatiles and compared to fast GC/SAW sensor. RESULTS: Artemisia princeps Pamp. cv. ssajuari air-dried for 2 years and 4 months (the third year), containing the highest total amount of herbal volatiles, was superior to the others (the first year, the second year, the fourth year) in quality. Moreover, fast GC/SAW sensor shows a high repeatability (relative standard deviation 0.77% âˆ¼ 6.23%), excellent sensitivity (limit of detection value of 0.47 pg/mL), and good linearity (correlation coefficient r2 = 0.997) over the range of nanogram for α-thujone. CONCLUSION: Therefore, the fast GC/SAW sensor can be a useful analytical method for the discrimination and quality control of volatiles of herbal and medicinal plants according to air-drying time, as it provides a simple and second unit analysis.

Comparative Analysis of Thermophysiological Comfort-Related Properties of Elastic Knitted Fabrics for Cycling Sportswear.

This research focused on the investigation of the thermophysiological comfort properties of four selected knitted fabrics of different fiber blend ratios suitable for cycling wear. Comfort-related properties of the fabrics were determined and compared including air permeability, moisture management properties, drying time, thermal conductivity, and water vapor permeability. For those comfort properties of the fabric to be correlated, fabric structural properties, fabric density, fabric weight, and fabric thickness have been considered. Suited fabrics should have good air permeability, thermal conductivity, moisture management properties, and a short drying time. According to the measurement results, the fabric polyamide/elasane (58/42 PA6.6/EL) with good air permeability, thermal conductivity, moisture management properties, and short drying time was more suited for summer cycling clothing. Furthermore, this paper provides a new understanding of considerations that are needed for several end uses involving specific activity levels.

Freeze-Drying of Blueberries: Effects of Carbon Dioxide (CO2) Laser Perforation as Skin Pretreatment to Improve Mass Transfer, Primary Drying Time, and Quality.

Freeze-dried berry fruits are generally consumed as they are, whole and without peeling or cutting, as the conservation of their original shape and appearance is often desired for the final product. However, usually, berries are naturally wrapped by an outer skin that imparts a barrier to vapor flow during freeze-drying, causing berry busting. Photo-sequence, experimental, and theoretical methodologies were applied to evaluate the application of CO2 laser microperforations to blueberry skin. Under the same set of freeze-drying conditions, blueberries with and without perforations were processed. The results showed that the primary drying time was significantly reduced from 17 ± 0.9 h for nontreated berries to 13 ± 2.0 h when nine microperforations per berry fruit were made. Concomitantly, the quality was also significantly improved, as the percentage of nonbusted blueberries at the end of the process increased from an average of 47% to 86%. From a phenomenological perspective, the analysis of the mass transfer resistance of nontreated fruits, in agreement with reported studies, showed a Type II curvature, with a sharp decrease at low time, followed by a linear increase. In contrast, blueberries with nine perforations depicted a Type III regime, with a saturation curvature toward the time axis. It was demonstrated that CO2-laser microperforation has high potential as a skin pretreatment for the freeze-drying of blueberries.

Effect of Process Parameters on the Initial Burst Release of Protein-Loaded Alginate Nanospheres.

The controlled release or delivery of proteins encapsulated in micro/nanospheres is an emerging strategy in regenerative medicine. For this, micro/nanospheres made from alginate have drawn considerable attention for the use as a protein delivery device because of their mild fabrication process, inert nature, non-toxicity and biocompatibility. Though promising, one key issue associated with using alginate micro/nanospheres is the burst release of encapsulated protein at the beginning of the release, which may be responsible for exerting toxic side effects and poor efficiency of the delivery device. To address this issue, this study aimed to investigate the effect of process parameters of fabricating protein-loaded alginate nanospheres on the initial burst release. The alginate nanospheres were prepared via a combination of water-in-oil emulsification and the external gelation method and loaded with bovine serum albumin (BSA) as a model protein. The examined process parameters included alginate concentration, ionic cross-linking time and drying time. Once fabricated, the nanospheres were then subjected to the examination of BSA release, as well as the characterization of their morphology, size, and encapsulation efficiency. Our results revealed that by properly adjusting the process parameters, the initial burst release can be reduced by 13%. Taken together, our study demonstrates that regulating process parameters of fabricating alginate nanospheres is a possible means to reduce the initial burst release.

Effect of Time and Method of Drying on Bond Strength of Tray Adhesives with Vinyl Polysiloxanes.

AIM: To establish an effective combination of drying time and drying method of the tray adhesive so that maximum bond strength can be achieved between impression tray and impression material. MATERIALS AND METHODS: Cylindrical specimens of auto-polymerizing resin and addition silicone impression material were made. A total of 150 specimens were tested. They were divided into two groups Dentsply and GC. Each group was further divided into five subgroups: • Drying with compressed air for half the time as recommended by the manufacturer • Drying with air blower for half the time as recommended by the manufacturer • Open air drying as recommended by the manufacturer • Open air drying for 15 minutes • Open air drying for 1 hour The samples were tested for tensile bond strength using the universal testing machine. The results were subjected to statistical analysis. RESULT: Open air drying as recommended by the manufacturer was better than drying with a blower or compressed air. There was no significant difference between open-air drying for 5 minutes and open-air drying for 15 minutes or 1 hour. CONCLUSION: Open air drying as recommended by the manufacturer, i.e. 5min, showed good bond strength and drying for more than 5mins does not significantly increase bond strength. CLINICAL SIGNIFICANCE: Tray adhesive should not be dried with compressed air or air blower. Tray adhesive should be applied and kept to dry according to the manufacturer's recommended time.

Endoscope reprocessing: Comparison of drying effectiveness and microbial levels with an automated drying and storage cabinet with forced filtered air and a standard storage cabinet.

BACKGROUND: Automated drying may help prevent endoscopically transmitted infections. We aimed to assess the efficacy of an automated drying and storage cabinet compared to a standard storage cabinet in achieving endoscope dryness postreprocessing and in reducing the risk of microbial growth. METHODS: Drying times of bronchoscopes, colonoscopes, and duodenoscopes using 2 drying platforms (an automated drying and storage cabinet vs a standard storage cabinet) were measured using cobalt chloride paper. Drying assessments occurred at: 30 minutes, 1 hour, 2 hours, 3 hours, and 24 hours. A simple linear regression analysis compared rates of microbial growth after inoculation with Pseudomonas aeruginosa following high-level disinfection at: 0, 3 hours, 12 hours, 24 hours, and 48 hours. RESULTS: Using the automated drying and storage cabinet, internal channels were dry at 1 hour and external surfaces at 3 hours in all endoscopes. With the standard storage cabinet, there was residual internal fluid at 24 hours, whereas external surfaces were dry at 24 hours. For bronchoscopes, colonoscopes, and duodenoscopes, the standard cabinet allowed for an average rate of colony forming unit growth of 8.1 × 106 per hour, 8.3 × 106 per hour, and 7.0 × 107 per hour, respectively; the automated cabinet resulted in colony forming unit growth at an average rate of -28.4 per hour (P = .02), -38.5 per hour (P = .01), and -200.2 per hour (P = .02), respectively. CONCLUSIONS: An automated cabinet is advantageous for rapid drying of endoscope surfaces and in reducing the risk of microbial growth postreprocessing.

Preanalytical considerations in therapeutic drug monitoring of immunosuppressants with dried blood spots.

Background Dried blood spots (DBSs) could allow patients to prepare their own samples at home and send them to the laboratory for therapeutic drug monitoring (TDM) of immunosuppressants. The purpose of this review is to provide an overview of the current knowledge about the impact of DBS-related preanalytical factors on TDM of tacrolimus, sirolimus and everolimus. Content Blood spot volume, blood spot inhomogeneity, stability of analytes in DBS and hematocrit (Hct) effects are considered important DBS-related preanalytical factors. In addition, the influence of drying time has recently been identified as a noteworthy preanalytical factor. Tacrolimus is not significantly influenced by these factors. Sirolimus and everolimus are more prone to heat degradation and exhibited variations in recovery which were dependent on Hct and drying time. Summary and outlook DBS-related preanalytical factors can have a significant impact on TDM for immunosuppressants. Tacrolimus is not significantly influenced by the studied preanalytical factors and is a viable candidate for DBS sampling. For sirolimus and everolimus more validation of preanalytical factors is needed. In particular, drying conditions need to be examined further, as current protocols may mask Hct-dependent effects on recovery. Further validation is also necessary for home-based self-sampling of immunosuppressants as the sampling quality is variable.

Microwave-convective drying of food materials: A critical review.

Microwave convective drying (MCD) is gaining increasing interest due to its unique volumetric heating capability and ability to significantly reduce drying time and improve food quality. The main objective of this paper is to discuss, critically analyze and evaluate the recent advances in MCD and suggest the future directions in this field. The main focus of this paper is the mathematical modeling and experimental investigations in microwave convective drying of food materials. Recent developments in mathematical modeling of MCD is discussed and existing experimental setup and their advantages and disadvantages are discussed and analysed. Long drying time is a concern in food industries. Reductions in drying time by applying MCD compared to convection drying are calculated and discussed. It was apparent that the proper integration of mathematical modeling and experimental technique is the best way to maximize the advantages of this drying method. Although a plethora of research is being carried out on this topic, there is still need for research to develop fundamental modeling to optimize the process parameters and scale up this technology for the industrial application. Overall, the review provides an in-depth insight into the latest development of MCD and its mathematical modeling approaches and will hopefully serve to inspire future work in the field.