Dynamic evaluation of liver fibrosis to assess hepatocellular carcinoma risk in patients with chronic hepatitis B receiving nucleoside analogs treatment

ABSTRACT Despite good hepatitis B virus (HBV) inhibition by nucleoside analogs (NAs), cases of hepatocellular carcinoma (HCC) still occur. This study proposed a non-invasive predictive model to assess HCC risk in patients with chronic hepatitis B (CHB) receiving NAs treatment. Data were obtained from a hospital-based retrospective cohort registered on the Platform of Medical Data Science Academy of Chongqing Medical University, from 2013 to 2019. A total of 501 patients under NAs treatment had their FIB-4 index updated semiannually by recalculation based on laboratory values. Patients were divided into three groups based on FIB-4 index values: < 1.45, 1.45-3.25, and ≥ 3.25. Subsequently, HCC incidence was reassessed every six months using Kaplan-Meier curves based on the updated FIB-4 index. The median follow-up time of CHB patients after receiving NAs treatment was 2.5 years. HCC incidences with FIB-4 index < 1.45, 1.45-3.25, and ≥ 3.25 were 1.18%, 1.32%, and 9.09%, respectively. Dynamic assessment showed that the percentage of patients with FIB-4 index < 1.45 significantly increased semiannually (P < 0.001), and of patients with FIB-4 index ≥ 3.25 significantly decreased (P < 0.001). HCC incidence was the highest among patients with FIB-4 index ≥ 3.25. The FIB-4 index effectively predicted HCC incidence, and its dynamic assessment could be used for regular surveillance to implement early intervention and reduce HCC risk.

Vaginal leiomyoma: Advantages of clinical sonovaginography and ultrasound dynamic evaluation of uterine cervix-related lesions.

Evaluation of vaginal leiomyoma by dynamic transvaginal ultrasound improves the diagnosis, with the impact on surgical planning, and surgical outcomes. Sonovaginography using three-dimensional ultrasound allows the assessment of spatial relationship between the cervix and the tumor.

La evaluación dinámica y las potencialidades para el aprendizaje: recorrido conceptual y perspectivas de desarrollo / Dynanic assesment and learning potential: concetual overview and development perspectives

El presente trabajo se desprende del Proyecto de Tesis Doctoral: "Posibilidades y límites en el aprendizaje: el WISC-IV desde la evaluación dinámica", que se encuadra en la perspectiva de la Evaluación Dinámica (ED) de las capacidades intelectuales en función de reconocer las potencialidades de los sujetos con dificultades de aprendizaje y las intervenciones más apropiadas para potenciarlas. En este artículo se plantean los fundamentos teóricos y los principales modelos de la ED, y se desarrolla una categorización de los estudios en función de los aspectos metodológicos. Por último, se examinan las ventajas de este enfoque y las críticas que recibe, reconociendo que se ha difundido ampliamente en las últimas décadas y que numerosos estudios han puesto de manifiesto su validez y utilidad, en particular para abordar las problemáticas en el aprendizaje.

This work stems from the doctoral thesis project "Possibilities and limits on learning: the WISC-IV in the dynamic assessment perspective". It adopts the framework of Dynamic Assessment of intellectual ability to recognize the potential of subjects with learning difficulties and the most appropriate interventions to maximize that potential. This article sets out to review the theoretical bases and the main models of Dynamic Assessment. Studies in this field are categorized in terms of methodological aspects. Finally, the advantages of this approach and the criticism it has received are reviewed, acknowledging the fact that it has gained growing prestige over the last few decades, and a large number of studies have proved its validity and usefulness, in particular to approach learning difficulties.