Daily dataset of precipitation and temperature in the Department of Cauca, Colombia.

This study used the geostatistical Kriging methodology to reduce the spatial scale of a host of daily meteorological variables in the Department of Cauca (Colombia), namely, total precipitation and maximum, minimum, and average temperature. The objective was to supply a high-resolution database from 01/01/2015 to 31/12/2021 in order to support the climate component in a project led by the National Institute of Health (INS) named "Spatial Stratification of dengue based on the identification of risk factors: a pilot study in the Department of Cauca". The scaling process was applied to available databases from satellite information and reanalysis sources, specifically, CHIRPS (Climate Hazards Group InfraRed Precipitation with Station Data), ERA5-Land (European Centre for Medium-Range Weather Forecasts), and MSWX (Multi-Source Weather). The 0.1° resolution offered by both the MSWX and ERA5-Land databases and the 0.05° resolution found in CHIRPS, was successfully reduced to a scale of 0.01° across all variables. Statistical metrics such as Root Mean Squared Error (RMSE), Mean Absolute Error (MAE), Person Correlation Coefficient (r), and Mean Bias Error (MBE) were used to select the database that best estimated each variable. As a result, it was determined that the scaled ERA5-Land database yielded the best performance for precipitation and minimum daily temperature. On the other hand, the scaled MSWX database showed the best behavior for the other two variables of maximum temperature and daily average temperature. Additionally, using the scaled meteorological databases improved the performance of the regression models implemented by the INS for constructing a dengue early warning system.

Implications of the prevalence of Ascaris sp. in the funerary context of a Late Antique population (5th-7th c.) in Granada (Spain).

OBJECTIVE: To evaluate the prevalence of gastro-intestinal parasites in human remains from Late Antiquity (5th - 7th c.) Granada (Spain). MATERIALS: The study included pelvic and cranial control samples from 17 skeletons from the archaeological sites of Los Mondragones (n = 13) and Rafael Guillén (n = 4). METHODS: In the paleoparasitological study, soil samples from pelvic area and cranium were analyzed using the rehydration, homogenization, and micro-sieving method and visualization under brightfield microscopy. RESULTS: Ascaris sp. eggs were detected in pelvic samples from seven individuals. CONCLUSIONS: These findings may indicate that this parasite was endemic. Its detection frequency is one of the highest reported at group level in an osteological series from Late Antiquity. SIGNIFICANCE: The prevalence of Ascaris sp. associated with skeletal remains has implications for assessing the lifestyle and health of populations in southern Spain during the Late Antique period. LIMITATIONS: The number of individuals is small and taphonomic processes could have limited paleoparasitological findings SUGGESTIONS FOR FURTHER RESEARCH: Future interdisciplinary studies of this type are warranted in larger osteological series to improve knowledge of parasitosis in the past.

Personalized embryo transfer guided by endometrial receptivity analysis: a systematic review with meta-analysis.

STUDY QUESTION: Does a personalized embryo transfer (pET) guided by tests for endometrial receptivity (TER) increase the effectiveness of ART procedures? SUMMARY ANSWER: The use of TER-guided pET is not supported by current published evidence in women without repeated implantation failure (RIF), while in women with RIF more research is needed to assess a potential benefit. WHAT IS KNOWN ALREADY: Implantation rates are still far from ideal, especially in some patients that have RIF with good-quality embryos. As a potential solution, a wide range of diverse TER use different sets of genes to identify displacements of the window of implantation to adjust the individual length of progesterone exposure in a pET. STUDY DESIGN, SIZE, DURATION: A systematic review with meta-analysis was performed. Search terms included endometrial receptivity analysis, ERA, personalized embryo transfer. CENTRAL, PubMed, Embase, reference lists, clinical trials registers, and conference proceedings (search date October 2022) were searched, with no language restrictions. PARTICIPANTS/MATERIALS, SETTING, METHODS: Randomized controlled trials (RCTs) and cohort studies comparing a pET guided by TER vs standard embryo transfer (sET) in different subgroups that undergo ART were identified. We also investigated pET in non-receptive-TER vs sET in receptive-TER, and pET in a specific population vs sET in a general population. Risk of bias (RoB) was assessed with the Cochrane tool and ROBINS-I. Only those with low/moderate RoB underwent meta-analysis. The GRADE approach was used to evaluate the certainty of evidence (CoE). MAIN RESULTS AND THE ROLE OF CHANCE: We screened 2136 studies and included 35 (85% used ERA and 15% used other TER). Two studies were RCTs comparing endometrial receptivity analysis (ERA)-guided pET vs sET in women with no history of RIF. In women without RIF, no important differences (moderate-CoE) were found in live birth rates and clinical pregnancy rates (CPR). We also performed a meta-analysis of four cohort studies that were adjusted for confounding. In agreement with the RCTs, no benefits were found in women without RIF. However, in women with RIF, low CoE suggests that pET might improve the CPR (OR 2.50, 95% CI 1.42-4.40). LIMITATIONS, REASONS FOR CAUTION: We found few studies with low RoB. Only two RCTs in women without RIF were published, and none in women with RIF. Furthermore, the heterogeneity observed in populations, interventions, co-interventions, outcomes, comparisons, and procedures limited the pooling of many of the included studies. WIDER IMPLICATIONS OF THE FINDINGS: In the population of women without RIF, in agreement with previously published reviews, pET did not prove to be more effective than sET and, therefore, it precludes the routine use of this strategy in this population until more evidence is available. However, more research is advisable in women with RIF as low-certainty evidence from observational studies adjusted for confounders suggests that the CPR might be higher with pET guided by TER in this population. Although this review presents the best available evidence, it is still insufficient to change current policies. STUDY FUNDING/COMPETING INTEREST(S): No specific funding was obtained for this study. There are no conflicts of interest to declare. REGISTRATION NUMBER: PROSPERO CRD42022299827.

Risk evaluation and prioritization of contaminants of emerging concern and other organic micropollutants in two river basins of central Argentina.

A research gap exists in baseline concentrations of organic micropollutants in South American rivers. Identification of areas with different degrees of contamination and risk to the inhabitant biota is needed to improve management of freshwater resources. Here we inform the incidence and ecological risk assessment (ERA) of current used pesticides (CUPs), pharmaceutical and personal care products (PPCPs) and cyanotoxins (CTX) measured in two river basins from central Argentina (South America). Risk Quotients approach was used for ERA differentiating wet and dry seasons. High risk was associated to CUPs in both basins (45 % and 30 % of sites from Suquía and Ctalamochita rivers, respectively), mostly in the basins extremes. Main contributors to risk in water were insecticides and herbicides in Suquía river and insecticides and fungicides in Ctalamochita river. In Suquía river sediments, a very high risk was observed in the lower basin, mainly from AMPA contribution. Additionally, 36 % of the sites showed very high risk of PCPPs in Suquía river water, with the highest risk downstream the wastewater treatment plant of Córdoba city. Main contribution was from a psychiatric drug and analgesics. In sediments medium risk was observed at the same places with antibiotics and psychiatrics as main contributors. Few data of PPCPs are available in the Ctalamochita river. The risk in water was low, with one site (downstream Santa Rosa de Calamuchita town) presenting moderated risk caused by an antibiotic. CTX represented in general medium risk in San Roque reservoir, with San Antonio river mouth and the dam exit showing high risk during the wet season. The main contributor was microcystin-LR. Priority chemicals for monitoring or further management include two CUPs, two PPCPs, and one CTX, demonstrating a significant input of pollutants to water ecosystems from different sources and the need to include organic micropollutants in current and future monitoring.

Appraisal on the role of passive sampling for more integrative frameworks on the environmental risk assessment of contaminants.

Over time multiple lines of research have been integrated as important components of evidence for assessing the ecological quality status of water bodies within the framework of Environmental Risk Assessment (ERA) approaches. One of the most used integrative approaches is the triad which combines, based on the weight-of-evidence, three lines of research, the chemical (to identify what is causing the effect), the ecological (to identify the effects at the ecosystem level) and the ecotoxicological (to ascertain the causes of ecological damage), with the agreement between the different lines of risk evidence increasing the confidence in the management decisions. Although the triad approach has proven greatly strategic in ERA processes, new assessment (and monitoring) integrative and effective tools are most welcome. In this regard, the present study is an appraisal on the boost that passive sampling, by allowing to increase information reliability, can give within each of the triad lines of evidence, for more integrative ERA frameworks. In parallel to this appraisal, examples of works that used passive samplers within the triad are presented providing support for the use of these devices in a complementary form to generate holistic information for ERA and ease the process of decision-making.

G-SAIP: Graphical Sequence Alignment Through Parallel Programming in the Post-Genomic Era.

A common task in bioinformatics is to compare DNA sequences to identify similarities between organisms at the sequence level. An approach to such comparison is the dot-plots, a 2-dimensional graphical representation to analyze DNA or protein alignments. Dot-plots alignment software existed before the sequencing revolution, and now there is an ongoing limitation when dealing with large-size sequences, resulting in very long execution times. High-Performance Computing (HPC) techniques have been successfully used in many applications to reduce computing times, but so far, very few applications for graphical sequence alignment using HPC have been reported. Here, we present G-SAIP (Graphical Sequence Alignment in Parallel), a software capable of spawning multiple distributed processes on CPUs, over a supercomputing infrastructure to speed up the execution time for dot-plot generation up to 1.68× compared with other current fastest tools, improve the efficiency for comparative structural genomic analysis, phylogenetics because the benefits of pairwise alignments for comparison between genomes, repetitive structure identification, and assembly quality checking.

Current and Future Climate Extremes Over Latin America and Caribbean: Assessing Earth System Models from High Resolution Model Intercomparison Project (HighResMIP).

Extreme temperature and precipitation events are the primary triggers of hazards, such as heat waves, droughts, floods, and landslides, with localized impacts. In this sense, the finer grids of Earth System models (ESMs) could play an essential role in better estimating extreme climate events. The performance of High Resolution Model Intercomparison Project (HighResMIP) models is evaluated using the Expert Team on Climate Change Detection and Indices (ETCCDI) over the 1981-2014 period and future changes (2021-2050) under Shared Socioeconomic Pathway SSP5-8.5, over ten regions in Latin America and the Caribbean. The impact of increasing the horizontal resolution in estimating extreme climate variability on a regional scale is first compared against reference gridded datasets, including reanalysis, satellite, and merging products. We used three different groups based on the resolution of the model's grid (sg): (i) low (0.8° ≤ sg ≤ 1.87°), (ii) intermediate (0.5° ≤ sg ≤ 0.7°), and (iii) high (0.23° ≥ sg ≤ 0.35°). Our analysis indicates that there was no clear evidence to support the posit that increasing horizontal resolution improves model performance. The ECMWF-IFS family of models appears to be a plausible choice to represent climate extremes, followed by the ensemble mean of HighResMIP in their intermediate resolution. For future climate, the projections indicate a consensus of temperature and precipitation climate extremes increase across most of the ten regions. Despite the uncertainties presented in this study, climate models have been and will continue to be an important tool for assessing risk in the face of extreme events. Supplementary Information: The online version contains supplementary material available at 10.1007/s41748-022-00337-7.

Nutritional assessment of servicemen in relation to area of duty and feeding habits: a Pakistani prospective

Abstract The present study was carried out to determine incidence of overweight and obesity in Pakistani servicemen with reference to their area of duty, feeding habits and also to identify risk factors. Accordingly, 2,501 servicemen selected from all over Pakistan using multiple stage stratified sampling protocol. Nutrition assessment performed using body mass index (BMI), waist to hip ratio (WHR) and dietary assessment using food frequency questionnaire. Collected data was analyzed using the SPSS version 25. Regression was used to find risk factors of obesity and WHR. Results indicated that about 1/4th of servicemen were smokers. Approximately, 1/5th of them were overweight and about one quarter were eating fruits and vegetables for 3 days/ week and 4 days/week, respectively. Only 1/3rd of them were physically active for at least 40 minutes per day. Age and fruits intake were significantly predicting BMI with a direct relation and vegetable intake was negatively correlated to BMI of the servicemen. Age and rank were significant predictors of WHR while, physical activity was negatively correlated to WHR. It is concluded and suggested from our study that there is a need to modify eating patterns and habits as well as improving physical activity on daily basis for healthy and long life of the servicemen.

Resumo

Prevenção do suicídio: esquecimento do ser e era da técnica / Suicide prevention: forgetfulness of being and technical era / Prevención del suicidio: olvido del ser y la era de la técnica

Martin Heidegger, em sua ontologia, destaca uma característica específica da atualidade que atravessa o comportamento humano, na filosofia, na ciência ou no senso comum: o esquecimento do ser. O filósofo diferencia a época atual das demais épocas históricas. O horizonte histórico contemporâneo se desvela por meio do desafio e da exploração, da tentativa de controle e domínio dos acontecimentos, ao modo da disponibilidade e em função da produtividade. O filósofo esclarece que todo esse desenraizamento do homem atual está atrelado ao esquecimento daquilo que é o mais essencial, qual seja, a existência. A questão que norteia este estudo é apurar, por meio das referências de Heidegger e dos estudos sobre suicídio, o quanto a interpretação da morte voluntária nos dias atuais está atravessada por tal esquecimento. Pretendemos investigar o quanto as ações de prevenção desenvolvidas pela suicidologia se encontram atravessadas por tal esquecimento do ser do homem e, dessa forma, acabam por estabelecer relações entre ser e ente em uma consequente redução ao ente como invariante e atemporal. O caminho para investigar a questão iniciará por abordar, em maiores detalhes, a analítica existencial, a questão da técnica e o movimento de esquecimento do ser apontados por Heidegger a fim de problematizar as perspectivas científicas atuais sobre o suicídio em sua prevenção para, então, estabelecer uma compreensão fenomenológica e existencial sobre o referido fenômeno.(AU)

Martin Heidegger, in his ontology, highlights a specific characteristic of the present moment that crosses human behavior, in philosophy, science, or common sense: the forgetfulness of being. The philosopher differentiates the current age from other historical ages. The contemporary historical horizon is unveiled by the challenge and the exploration, from the attempt to control and dominate events, to the mode of standing reserve and in terms of productivity. The philosopher clarifies that all this uprooting of the current man is linked to the forgetfulness of what is the most essential, namely, the existence itself. The question that guides this study is to investigate, via Heidegger's references and studies on suicide, to what extent the interpretation of voluntary death today is crossed by such forgetfulness. We intend to investigate to what extent the prevention actions developed by suicidology are crossed by such forgetfulness of the human's being and, in this way, they end up establishing relationships between being and entity in a consequent reduction to entity as an invariant and timeless. The path to investigate the issue will start by addressing, in greater detail, the existential analytics, the question concerning technique and the movement of forgetting the being pointed out by Heidegger to problematize the current scientific perspectives on suicide and its prevention to, then, propose a phenomenological and existential understanding about the referred phenomenon.(AU)

Martin Heidegger en su ontología destaca una característica específica del presente que atraviesa el comportamiento humano, ya sea en la filosofía, la ciencia o el sentido común: el olvido del ser. El filósofo diferencia la época actual de otras épocas históricas. El horizonte histórico contemporáneo se devela el desafío y la exploración, el intento de controlar y dominar los eventos, en la modalidad de disponibilidad y en términos de productividad. Y así aclara que todo este desarraigo del hombre actual está involucrado en el olvido de lo más esencial, que es la existencia misma. A partir de las referencias a Heidegger y de los estudios sobre el suicidio, este estudio busca saber hasta qué punto la interpretación de la muerte voluntaria hoy está atravesada por este olvido. Pretendemos investigar en qué medida las acciones de prevención desarrolladas por la suicidología se encuentran atravesadas por el olvido del ser del hombre y, de esta manera, terminan por establecer relaciones entre el ser y el ente, en una consecuente reducción al ente como invariante y atemporal. Para investigar el tema se abordará inicialmente, con mayor detalle, la analítica existencial, la cuestión de la técnica y el movimiento del olvido del ser señalado por Heidegger para problematizar las perspectivas científicas actuales sobre el suicidio y su prevención y, luego, proponer una comprensión fenomenológica y existencial sobre el referido fenómeno.(AU)

Feasibility of climate reanalysis data as a proxy for onsite weather measurements in outdoor thermal comfort surveys.

Outdoor thermal comfort (OTC) surveys require synchronous monitoring of meteorological variables for direct comparisons against subjective thermal perception. The Universal Thermal Climate Index (UTCI) is a feasible index as it integrates meteorological conditions as a single value irrespective of urban morphological attributes or biological sex, age and body mass. ERA5-HEAT (Human thErmAl comforT) is a downloadable reanalysis dataset providing hourly grids of UTCI climate records at 0.25° × 0.25° spatial resolution from 1979 to present. We here evaluate for the first time whether it is possible to use ERA5-HEAT data as a proxy for the UTCI measured onsite during OTC surveys. A dataset comprising 1640 survey responses gathered over 14 OTC campaigns in Curitiba, Brazil (25°26'S, 49°16'W) was analysed. We assessed the bias obtained between the Dynamic Thermal Sensation, an index derived from the UTCI, and the thermal sensation reported by survey participants by considering locally measured meteorological variables and ERA5-HEAT reanalysis data. As ERA5-HEAT data are given on an hourly basis, prediction bias can be greatly reduced when accounting for survey responses close to the hour. In terms of seasons, the fall and winter seasons have diminished mean bias, though with larger spread than in summer. In terms of UTCI stress categories, prediction bias is lower for the thermal comfort range. When comparing reanalysis data against WMO station data as proxy candidates for survey field data, the former presented lower bias, less spread in terms of standard deviation and higher correlation to in situ data.

Tecnologia e precarização da saúde do trabalhador: uma coexistência na era digital / Tecnology and worker's health precariousness: a coexistence in the digital age

Resumo: Este artigo versa sobre a correlação entre a precarização da saúde do trabalhador e as novas formas de gestão e controle do trabalho ensejadas pelas inovações tecnológicas das plataformas digitais no Brasil, cuja notoriedade ascendeu na pandemia com o crescimento da "uberização" do trabalho. Um estudo relevante à sociedade brasileira para compreender os impactos socioeconômicos da era digital, a qual se tornou o campo de autoexpansão do sistema financeiro e destrutivo do capital.

Abstract: This article is about the correlation between the worker's health precariousness and the new forms of management and work control, occasioned by technological innovations of digital platforms in Brazil, whose notoriety ascended in the pandemic with the growth of work uberization. A study relevant to Brazilian society to understand the socioeconomic impacts of digital age, in which, it became the self-expanding field of the financial and destructive system of capital.

Long-Term Safety, Tolerability and Survival in Patients with Pulmonary Arterial Hypertension Treated with Macitentan: Results from the SERAPHIN Open-Label Extension.

INTRODUCTION: In SERAPHIN, a long-term, event-driven, double-blind randomised controlled trial in pulmonary arterial hypertension (PAH), macitentan 10 mg significantly reduced the risk of morbidity/mortality compared with placebo. Its open-label extension study (SERAPHIN OL) further assessed long-term safety and tolerability of macitentan 10 mg in PAH patients. METHODS: Patients in SERAPHIN who completed the double-blind treatment period or experienced a morbidity event during the study could enter SERAPHIN OL. Patients received macitentan 10 mg once daily, and safety and survival were assessed until end of treatment (+ 28 days). Two overlapping sets were analysed for safety: (1) all patients in SERAPHIN OL (OL safety set); (2) patients randomised to macitentan 10 mg in SERAPHIN (long-term safety/survival set). Survival was evaluated as an exploratory endpoint in the latter set. RESULTS: Of 742 patients randomised in SERAPHIN, 550 (74.1%) entered SERAPHIN OL (OL safety set); 242 patients were randomised to macitentan 10 mg in SERAPHIN (long-term safety/survival set). Median (min, max) exposure to macitentan 10 mg was 40.1 (0.1, 130.5) months (2074.7 patient-years; OL safety set) and 54.7 (0.1, 141.3) months (1151.0 patient-years; long-term safety/survival set). Safety in both analysis sets was comparable to the known safety profile of macitentan. Kaplan-Meier survival estimates (95% CI) at 1, 5, 7 and 9 years were 95.0% (91.3, 97.1), 73.3% (66.6, 78.9), 62.6% (54.6, 69.6) and 52.7% (43.6, 61.0), respectively (long-term safety/survival set; median follow-up: 5.9 years). CONCLUSIONS: This analysis provides the longest follow-up for safety and survival published to date for any PAH therapy. The safety profile of macitentan 10 mg over this extensive treatment period was in line with that observed in SERAPHIN. As the majority of patients were receiving other PAH therapy at macitentan initiation, our study provides additional insight into the long-term safety of macitentan, including as part of combination therapy. TRIAL REGISTRATION: ClinicalTrials.gov Identifiers: NCT00660179 and NCT00667823.

Tuberculosis: el contrapunto del progreso / Tuberculosis: the counterpoint of progress

Resumen A lo largo de la historia, las enfermedades infecciosas han influido directamente en el desarrollo de la humanidad y en este proceso, la tuberculosis ha tenido un rol protagónico. Esta enfermedad mata más seres humanos que cualquier otra de causa infecciosa y, a pesar de esto, continúa siendo una entidad olvidada y un grave problema de salud pública, sobre todo en las naciones más pobres. La trascendencia de la tuberculosis va más allá del ámbito médico y una visión holística de ella nos permite comprender el grado de desarrollo económico y social de un Estado. Si bien Chile mantenía un programa de control históricamente exitoso, las cifras actuales no son auspiciosas y obligan a analizar el problema desde una mirada multidisciplinaria. Es en este marco que planteamos que el médico clínico, para aportar en el control de la enfermedad, debe poner nuevamente en práctica uno de los principios básicos de la Medicina: la semiología.

Abstract Along history, infectious diseases have had a direct influence in the development of humanity, with tuberculosis showing a leading role. Despite this disease being the main cause of mortality among infectious diseases, it remains neglected and constitutes a serious public health problem, especially among the poorest countries in the world. Tuberculosis greatest importance goes beyond Medicine, and a holistic view of the disease allows us to comprehend the economic and social development of a nation. Despite a historically successful control program in Chile, current figures are not auspicious and force upon us the need to address this problem with a multidisciplinary approach. The medical physician is required to put again into practice the fundamental principle of Medicine, Semiology to contribute to the control of tuberculosis.

Espiritualidad y neoliberalismo: Self en participantes chilenos de la Nueva Era / Espiritualidade e neoliberalismo: o Eu nos participantes chilenos da Nova Era / Spirituality and neoliberalism: Self in Chilean New Age participants / Spiritualité et néolibéralisme: le Soi chez les participants chiliens du Nouvel-Âge

Resumen Hace algunas décadas se observa la masificación en Latinoamérica de las así llamadas "espiritualidades alternativas", como la Nueva Era (New Age). Esta investigación tuvo por propósito explorar el self de los participantes de la Nueva Era en un contexto neoliberal de transformación subjetiva. Para esto, se realizaron entrevistas semiestructuradas de historia de vida a seis practicantes de la Nueva Era del sur de Chile. El análisis de contenido de los relatos de los entrevistados reveló dimensiones en el self de los participantes, tales como: empoderamiento, búsqueda de plenitud, renuencia de las instituciones formales, redención, un terapeuta en las relaciones, las cuales pueden ser conceptuadas desde elementos del neoliberalismo, resultados compatibles con la idea de un emprendedor y consumidor espirituales presentes en esta espiritualidad de culto al self.

Resumo Há algumas décadas, observou-se a massificação na América Latina das chamadas espiritualidades alternativas, como a Era Nueva (Nova Era). O objetivo desta pesquisa foi explorar o Self dos participantes da Nova Era dentro de um contexto neoliberal de transformação subjetiva. Para isso, entrevistas semiestruturadas de história de vida foram conduzidas com seis praticantes da Nova Era no Sul do Chile. A análise de conteúdo das histórias dos entrevistados revelou dimensões no Self dos participantes como: empoderamento, busca de realização, relutância de instituições formais, redenção, terapeuta nas relações, que podem ser conceituadas a partir de elementos do neoliberalismo, resultando compatíveis com a ideia de empreendedor e consumidor espiritual presente nessa espiritualidade de culto a si mesmo.

Abstract In recent decades, Latin America has observed the massification of so-called alternative spiritualities, such as the Nueva Era (New Age). This research sought to explore the Self of New Age participants within a neoliberal context of subjective transformation. Data was collected by semi-structured life history interviews carried out with six New Age practitioners from southern Chile. Content analysis of the interviewees' stories revealed dimensions in the participants' Self, such as: empowerment, search for fulfillment, reluctance of formal institutions, redemption, a therapist in relationships, which can be conceptualized based on neoliberal elements, resulting compatible with the idea of a spiritual entrepreneur and consumer present in this spirituality of self-worship.

Resumé Au cours des dernières décennies, l'Amérique latine a observé la massification des spiritualités dites alternatives, telles que le New Age (Nouvel-Âge). Cette recherche visait à explorer le Soi des participants du New Age dans un contexte néolibéral de transformation subjective. Les données ont été collectées par le biais d'entretiens semi-directifs sur l'histoire de vie de six praticiens du New Age du sud du Chili. L'analyse de contenu des récits des interviewés a révélé des dimensions dans le Soi des participants, telles que : l'autonomisation, la recherche de l'accomplissement, la réticence des institutions formelles, la rédemption, un thérapeute dans les relations, qui peuvent être conceptualisées à partir d'éléments néolibéraux, résultant compatibles avec l'idée d'un entrepreneur et d'un consommateur spirituel présent dans cette spiritualité du culte de soi.

Pesticides Burden in Neotropical Rivers: Costa Rica as a Case Study.

Neotropical ecosystems are highly biodiverse; however, the excessive use of pesticides has polluted freshwaters, with deleterious effects on aquatic biota. This study aims to analyze concentrations of active ingredients (a.i) of pesticides and the risks posed to freshwater Neotropical ecosystems. We compiled information from 1036 superficial water samples taken in Costa Rica between 2009 and 2019. We calculated the detection frequency for 85 a.i. and compared the concentrations with international regulations. The most frequently detected pesticides were diuron, ametryn, pyrimethanil, flutolanil, diazinon, azoxystrobin, buprofezin, and epoxiconazole, with presence in >20% of the samples. We observed 32 pesticides with concentrations that exceeded international regulations, and the ecological risk to aquatic biota (assessed using the multi-substance potentially affected fraction model (msPAF)) revealed that 5% and 13% of the samples from Costa Rica pose a high or moderate acute risk, especially to primary producers and arthropods. Other Neotropical countries are experiencing the same trend with high loads of pesticides and consequent high risk to aquatic ecosystems. This information is highly valuable for authorities dealing with prospective and retrospective risk assessments for regulatory decisions in tropical countries. At the same time, this study highlights the need for systematic pesticide residue monitoring of fresh waters in the Neotropical region.

Factores asociados a la infección y muerte por Covid-19, un análisis ecológico / Factors associated with infection and death from Covid-19, an ecological analysis / Fatores associados à infecção e morte de Covid-19, uma análise ecológica

La pandemia del SARS-CoV-2 y Covid-19 ha sido una amenaza a la vida en todo el planeta. El objetivo del presente estudio fue identificar los factores de riesgo asociados a la infección y mortalidad por Covid-19 a nivel global. Se realizó un análisis ecológico de los factores asociados en 91 países pertenecientes los cinco continentes del planeta. Los datos fueron tomados de la base de datos de acceso libre creada por la organización Our World in Data adscrita a la Universidad de Oxford para tres fechas 30 de junio y 30 de noviembre del año 2020 así como, 4 de junio del 2021. Se analizaron 11 variables predictoras para la infección y muerte por Covid 19 mediante correlación y regresión lineal múltiple en el programa SPSS 25.0. Existió correlación de 7 variables; sin embargo, solo algunas tienen poder explicativo. Los modelos para las tres fechas fueron diferentes. La fracción de adultos mayores de 65 años o más fue la única variable que explica los contagios por país en las tres fechas estudiadas. Las muertes fueron explicadas por el IDH en el mes de junio del año 2020, la proporción de adultos mayores a 65 años en el mes de noviembre del año 2020 y junio del 2021. La fracción de mujeres fumadoras también fue explicativa en junio del. Los hallazgos investigativos corroboran y contradicen investigaciones previas mostrando la heterogeneidad y complejidad en la interacción de los determinantes en salud en el ámbito de la pandemia de Covid-19.

The SARS-CoV-2 and Covid-19 pandemic has been a threat to life across the planet. The objective of this study was to identify the risk factors associated with Covid-19 infection and mortality at a global level. An ecological analysis of the associated factors was carried out in 91 countries belonging to the five continents of the planet. The data were taken from the open access database created by the Our World in Data organization attached to the University of Oxford for three dates June 30 and November 30, 2020 as well as June 4, 2021. They were analyzed 11 predictor variables for Covid 19 infection and death by correlation and multiple linear regression in the SPSS 25.0 program. There was a correlation of 7 variables; however, only some have explanatory power. The models for the three dates were different. The fraction of adults older than 65 years or more was the only variable that explains the infections by country in the three dates studied. The deaths were explained by the HDI in June 2020, the proportion of adults over 65 years in the month of November 2020 and June 2021. The fraction of women smokers was also explanatory in June of. The research findings corroborate and contradict previous research showing the heterogeneity and complexity in the interaction of health determinants in the field of the Covid-19 pandemic.

A pandemia SARS-CoV-2 e Covid-19 tem sido uma ameaça à vida em todo o planeta. O objetivo deste estudo foi identificar os fatores de risco associados à infecção e mortalidade por Covid-19 em nível global. Foi realizada uma análise ecológica dos fatores associados em 91 países pertencentes aos cinco continentes do planeta. Os dados foram retirados do banco de dados de acesso aberto criado pela organização Our World in Data anexada à University of Oxford para três datas 30 de junho e 30 de novembro de 2020, bem como 4 de junho de 2021. Foram analisadas 11 variáveis preditoras para Covid 19 infecção e morte por correlação e regressão linear múltipla no programa SPSS 25.0. Houve uma correlação de 7 variáveis; no entanto, apenas alguns têm poder explicativo. Os modelos para as três datas eram diferentes. A fração de adultos com mais de 65 anos foi a única variável que explica as infecções por país nas três datas estudadas. As mortes foram explicadas pelo IDH em junho de 2020, proporção de adultos com mais de 65 anos no mês de novembro de 2020 e junho de 2021. A fração de mulheres fumantes também foi explicativa em junho de. Os resultados da pesquisa corroboram e contradizem pesquisas anteriores, mostrando a heterogeneidade e complexidade na interação dos determinantes da saúde no campo da pandemia de Covid-19.

Statistical modeling of sea ice concentration in the northwest region of the Antarctic Peninsula.

Sea ice is one of the main components of the cryosphere that modifies the exchange of heat and moisture between the ocean and atmosphere, regulating the global climate. In this sense, it is important to identify the concentration of sea ice in different regions of Antarctica in order to measure the impact of environmental changes on the region's ecosystem. The objective of this study was to evaluate the performance of the multiple linear regression and Box-Jenkins methods for predicting the concentration of sea ice along the northwest coast of the Antarctic Peninsula. Sea ice concentration data from May to November for the period 1979-2018 were extracted from passive remote sensors including a scanning multichannel microwave radiometer, special sensor microwave imager, and special sensor microwave imager/sounder. Meteorological variables from the atmospheric reanalysis model ERA5 of the European Center for Medium-Range Weather Forecasts were used as predictor variables, and the leave-one-out cross-validation technique was used to calibrate and validate the models. It was found that both statistical models have similar performance when analyzing residual analysis results, root mean square error of cross-validation, and final accuracy and residual standard deviation, these responses being related to the regionalization of the study area and to the Box-Jenkins presents strong, homogeneous, and stable correlations in the time series modeled for each pixel.

Personalized Nursing Care in Precision-Medicine Era.

The extensive investment and development of research in molecular biology in the last decades, mainly after the completion of the Human Genome Project, has raised many expectations regarding its impact on Precision-Medicine Era. To meet the new demands for care, it is necessary that the omics sciences be integrated into nursing practice, especially in nursing care. Based on knowledge of structural genomics, it has been improved techniques that enabled the advancement of research related to functional genomics, which together comprising the "omics" sciences including the transcriptomics, proteomics, the epigenomics and metabolomics. The current challenge is to transform this expanded set of information into clinical benefits for patients, through more accurate diagnoses, treatments, and personalized care to the particularities of individuals and communities. For Nursing, the main challenge is the incorporation of the omics sciences in training and professional practice, so that nurses can safely, scientifically, and autonomously empower themselves to provide personalized care to individuals and families based on Precision-Medicine Era. In this paper, a debate on the impacts and challenges for Nursing to incorporate the Precision-Medicine into clinical practice is described.

Macitentan in the treatment of pulmonary arterial hypertension.

Pulmonary arterial hypertension (PAH) is an uncommon but lethal and progressive disease in which prostacyclin, nitric oxide and endothelin-1 pathways are disturbed and contribute to the pathophysiology of this disease. Endothelin receptor antagonists are a class of drugs that have been approved as PAH therapy. Macitentan is a lipophilic, tissue specific, dual receptor antagonist with a higher potency than bosentan and a reduced risk of hepatic injury. Macitentan has shown a reduction in morbidity and mortality due to PAH at long-term follow-up and improvements in hemodynamics, exercise capacity and functional class at the short term. Its main adverse events are nasopharyngitis, bronchitis and an increased risk of anemia. We review the clinical data of macitentan and its use in PAH.

Photon Dissipation as the Origin of Information Encoding in RNA and DNA.

Ultraviolet light incident on organic material can initiate its spontaneous dissipative structuring into chromophores which can catalyze their own replication. This may have been the case for one of the most ancient of all chromophores dissipating the Archean UVC photon flux, the nucleic acids. Oligos of nucleic acids with affinity to particular amino acids which foment UVC photon dissipation would most efficiently catalyze their own reproduction and thus would have been selected through non-equilibrium thermodynamic imperatives which favor dissipation. Indeed, we show here that those amino acids with characteristics most relevant to fomenting UVC photon dissipation are precisely those with greatest chemical affinity to their codons or anticodons. This could provide a thermodynamic basis for the specificity in the amino acid-nucleic acid interaction and an explanation for the accumulation of information in nucleic acids since this information is relevant to the optimization of dissipation of the externally imposed thermodynamic potentials. The accumulation of information in this manner provides a link between evolution and entropy production.