Synergistic effects of covalently coupled eosin-Y with Ben-graphitic carbon nitride framework for improved photocatalytic activity in solar light-driven Biginelli product generation and NADH regeneration.

Elevated global pollution level is the prime reason that contributes to the onset of various harmful health diseases. The products of Biginelli reaction are enormously used in the pharmaceutical industry as they have antiviral, antibacterial, and calcium channel modulation abilities. This work reports a novel eosin Y sensitized boron graphitic carbon nitride (EY-Ben-g-C3N4) as a photocatalyst that efficiently produced 3,4-dihydropyrimidine-2-(1H)-one by the Biginelli reaction of benzaldehyde, urea, and methyl acetoacetate. The photocatalyst EY-Ben-g-C3N4 showed a successful generation of 3,4-dihydropyrimidine-2-(1H)-one (Biginelli product) in good yield via photocatalysis which is an eco-friendly method and has facile operational process. In addition to the production of Biginelli products, the photocatalyst also showed a remarkable NADH regeneration of 81.18%. The incorporation of g-C3N4 with boron helps increase the surface area and the incorporation of eosin Y which is an inexpensive and non-toxic dye, and in Ben-g-C3N4, enhanced the light-harvesting capacity of the photocatalyst. The production of 3,4-dihydropyrimidine-2-(1H)-one and NADH by the EY-Ben-g-C3N4 photocatalyst is attributed to the requisite band gap, high molar absorbance, low rate of charge recombination, and increased capacity of the photocatalyst to harvest solar light energy.

Effect of Trehalose Supplementation in Egg-Yolk-Free Extender on Conventional Parameters and Gene Expression Related to Reactive Oxygen Species, Apoptosis, and Motility of Frozen Dog Spermatozoa.

The present study was conducted to evaluate the effects of trehalose supplementation in egg-yolk (EY)-free tris extender on dog spermatozoa. Pooled spermatozoa were diluted with extender 1 (EY-free tris extender supplemented with 0, 10, 15, 20, or 30 mM trehalose) and cooled (2 × 108 sperm/mL) for 1 hour at 4°C. After that, extender 2 (extender 1 containing 1 M glycerol) was added (v:v) to the diluted sperm, loaded in 0.5-mL straws (1 × 108 sperm/mL), and incubated at 4°C for 30 minutes. The sperm straws were frozen over liquid nitrogen (LN2) vapor for 20 minutes and then plunged directly into LN2. After thawing at 37°C for 25 seconds, sperm progressive motility (CASA), viability (SYBR-14/PI), apoptosis (Annexin V/PI), and reactive oxygen species (ROS; H2DCFDA/PI) were evaluated. Thereafter, the optimal concentrations of trehalose were selected, and the gene expression of BAX, BCL2, NOX5, SMOX, OGG1, and ROMO1 was evaluated after freeze-thawing. Supplementation with 20 and 30 mM trehalose significantly increased sperm progressive motility and viability compared to the control. However, trehalose had no significant effect on sperm ROS or phosphatidylserine translocation index. There were minor numerical increases and decreases in gene expression when the selected optimal concentrations of trehalose (20 and 30 mM) were compared to the control. However, there were no significant differences. We conclude that the addition of trehalose (20 and 30 mM) in EY-free extender could improve sperm motility and viability without significant effects on ROS, apoptosis, or gene expression.

Enhanced Yeast One-Hybrid Assays to Study Protein-DNA Interactions.

The specificity in gene regulation is controlled by interactions between transcription factors (TFs) and genomic DNA regions such as promoters and enhancers. Enhanced yeast one-hybrid (eY1H) assays are among the methods used for high-throughput detection of transcription factor-DNA interactions. Here, we describe the procedure for screening interactions between DNA regions of interest ("DNA-baits") and an array of transcription factors ("TF-preys"), after DNA-bait and TF-prey yeast strains have been generated. Using a high-density array robotic platform, this method can be used to screen interactions between multiple DNA regions and >1000 TFs within a single experiment.

Fabrication of spherical porous pAg2O-nWO3/Ag/GNS heterostructure with enhanced photocatalytic activity through plasmonic S-scheme mechanism and its complementing biological interest.

The synthesis and characterization of Ag2OWO3/Ag/GNS heterostructure with desired modifications has been elucidated in the contemporary study. The fabrication involves a simple hydrothermal method for the configuration of fascinating heterostructures intended to photo-catalytically degrade Eosin Yellow (EY) dye. The toxic dye molecules were converted into non-toxic molecular intermediates, also the elimination of heavy metals from industrial wastewater, being trapped in the pores of heterostructure. The pn junction photocatalyst with plasmonic resonance of Ag for abolition of electron and hole coupling, enhances the photo-response where the catalyst abides S-Scheme mechanism. The work functions of active photocatalysts as calculated for Ag2O is 6.61eV and WO3 is 6.04eV. Furthermore, the Ag2OWO3/Ag/GNS photocatalysts recovery and reuse in several trials without any noticeable loss of photocatalytic activity, complimented the recyclability of the heterostructure. To ensure the safety of the environment on heterostructure being released, toxicity analysis were carried out. These Ag2OWO3/Ag/GNS heterostructures had optimistic result on cytotoxicity assay, and on Musmusculus skin melanoma cells (B16-F10), with anti-microbial/fungal properties. Thereby, the contemporary experiment upholds efficient photocatalysis and ropes multiple errands on biological applications.

Methyl jasmonate stimulates the synthesis and accumulation of asperosaponin VI in the roots of Dipsacus asper / 药学学报

We investigated the effect of methyl jasmonate (MeJA) on the content of asperosaponin VI and the expression of genes involved in its synthesis. Dipsacus aspero seedlings were treated with MeJA at different concentrations of 50, 100, 150, 200 and 300 μmol·L-1, and leaves and roots were sampled following treatment for 1, 3 and 5 days. The content of asperosaponin VI and superoxide anion in the roots, malondialdehyde (MDA) content in leaves and superoxide dismutase were determined. The results show that 150 μmol·L-1 MeJA significantly increased the accumulation of asperosaponin VI in roots. The content of asperosaponin VI was greatest after treatment for 3 days, and was 2.16 times higher than the control. After MeJA treatment, SOD activity decreased and MDA content increased in leaves. Moreover, superoxide anion content in roots increased. The expression of squalene epoxidase (DaSE1) and geranyl diphosphate synthase (DaGPS), key enzymes in the synthesis of asperosaponin VI, were up-regulated compared with the control group. These results indicate that an optimal concentration of 150 μmol·L-1 MeJA increases the accumulation of asperosaponin VI by up-regulating the expression of key enzymes involved in the synthesis of asperosaponin VI, which facilitates resistance to adversity stress stimulated by MeJA.

Optimization of process parameters of 3D printed clozapine dispersive tablets and establishment of personalized dose model / 药学学报

This study aims to establish the design space of the key processes for drop-on-powder 3D printing based on design of experiment (DoE). By utilizing Minitab, an experimental scheme with three factors, two levels and three center points was designed to analyze the factors that significantly affected the tablet quality attributes. Furthermore, the factor interactions were analyzed using Minitab. subsequently, the computer aided drafting (CAD) software was used to adjust the model volume with fixed radius/height ratio (r/h = 1.25) and establish a linear regression equation between model volume and dose. As a result, the drug dose could be controlled in a flexible manner. The finally determined process parameters were: ink-jet level is 12, layer thickness is 150 μm, and the X-axis printing head speed of 635 mm·s-1. Regression equation between drug content (y) and model volume (x) was y = 0.062 x - 0.582 7 (R2 = 0.999 9) showing good linear relationship. This indicated that robust and feasible process parameters were obtained through DoE, and the preparation of personalized-dose tablets was realized with good reproducibility.

Clinical Observation of Roxadustat in the Treatment of Chronic Kidney Disease Combined with Renal Anemia / 中国药房

OBJECTIVE：To observe the efficacy and safet y of roxadustat in the treatment of chronic kidney disease （CKD） combined with renal anemia. METHODS ：The data of 80 inpatients with CKD combined with renal anemia treated in the nephrology department of the First Affiliated Hospital of Anhui University of Science and Technology during Nov. 2019 to Dec. 2020 were analyzed retrospectively. They were divided into observation group （40 case）and control group （40 case）according to different treatment methods. Control group was given Human erythropoieti n for injection subcutaneously ，100-150 IU/kg every week，3 times a week. Observation group were given Roxadu- stat capsules orally ，100 mg each time for dialysis patients with a bodyweight of 45-＜60 kg，70 mg each time for non- 717060193@qq.com dialysis patients ，3 times a week ；120 mg each time for dialysis patients with bodyweight ≥60 kg and 100 mg each time for non-dialysis patients ，3 times a week. After 4 weeks of treatment ，the dosage of the two groups w as adjusted according to the level of hemoglobin （Hb）. Treatment course of 2 groups were 12 weeks. The levels of anemia indexes （Hb，red blood cell count （RBC），hematocrit（Hct）），iron metabolism indexes （serum iron （Fe），ferritin（Fer），total iron-binding capacity （TIBC），tranfeerrin saturation （TSAT）），lipid metabolism indexes （total cholesterol （TC），triglycerides（TG），high-density lipoprotein （HDL），low-density lipoprotein （LDL））and inflammation index（C-reactive protein （CRP））were detected in 2 groups before treatment and after 12 weeks of treatment. The levels of Hb were observed in high-level CRP subgroup and low-level CRP subgroup ；the occurrence of ADR was recorded in 2 groups during treatment. RESULTS ：Before treatment ，there was no statistical significance in the anemia indexes ，iron metabolism indexes ，lipid metabolism indexes or inflammation index between 2 groups（P＞0.05）. After treatment ，the levels of Hb ，RBC and Hct in 2 groups and the levels of TIBC and HDL in observation group were significantly higher than before treatment. The levels of Fe ，Fer and TSAT in 2 groups and the levels of TC and LDL in observation group were significantly lower than before treatment ；the levels of Hb ，RBC，Hct，TIBC and HDL in observation group were significantly higher than before control group ，while the level of TC was significantly lower than control group （P＜0.05）. The incidence of high reactivity in observation group was significantly higher than control group ，while the incidence of low reactivity was significantly lower than control group （P＜0.05）. There was no statistical significance in the levels of CRP between 2 groups before and after treatment （P＞0.05）. Subgroup comparison results showed that there was no statistical significance in the level of Hb between high-level CRP subgroup and low-level CRP subgroup of 2 groups before treatment （P＞0.05）. After treatment ，the level of Hb in high-level CRP subgroup of observation group was significantly higher than that of high-level CRP subgroup of control group （P＜0.05）. The total incidence of ADR in observation group was significantly lower than control group （P＜0.05），and no severe ADR was observed in 2 groups. CONCLUSIONS ： Roxadustat can effectively improve anemia in CKD patients with renal anemia ，and curative effect is less affected by inflammatory state，and it has good short-term safety.

Management of preseptal and orbital cellulitis for the primary care physician.

Preseptal cellulitis and postseptal (orbital) cellulitis represent a spectrum of orbital infections which a primary care provider and ophthalmologist may see during practice. Most often these conditions occur through spread from the sinuses, though there are a variety of other inciting factors. These conditions can both present with erythema and edema, but a complete and thorough exam can help a practitioner differentiate the two. Patients should be treated with targeting the most common pathogens and followed very closely by their providers. This article will discuss the anatomy, pathogenesis, risk factors, diagnosis, management and prognosis of preseptal and orbital cellulitis.

First report of antioxidant abeo-labdane type diterpenoid from intertidal red seaweed Gracilaria salicornia with 5-lipoxygenase inhibitory potential.

Phytochemical investigation on the biologically active compounds of seaweed Gracilaria salicornia {(C. Agardh) E.Y. Dawson} (family Gracilariaceae) guided to the separation of a previously unreported abeo-labdane class of diterpenoid. The compound was characterized as methyl-16(13→14)-abeo-7-labdene-(12-oxo) carboxylate by extensive spectroscopic experiments, and comparison with the related compounds. The studied compound registered significantly greater activities against pro-inflammatory 5-lipoxygenase (IC50 0.86 mg/mL) than that exhibited by non-steroidal anti-inflammatory agent ibuprofen (IC50 0.92 mg/mL, P < 0.05). Likewise, this compound exhibited comparable radical quenching (1, 1-diphenyl-2-picryl-hydrazil) activity (IC50 0.66 mg/mL) as standard antioxidant agent α-tocopherol (IC50 0.62 mg/mL).

[Prediction of the effectiveness of the therapy of LUTS/BPH by Serenoa repens extracts].

INTRODUCTION: For the treatment of LUTS/BPH is used a wide range of drugs that patients have to take for a long time. Therefore, it is important to develop methods for predicting long-term results of therapy. The purpose of this work is to evaluate the possibility to predict long-term results of drug therapy of LUTS/BPH using mathematical modeling on the example of treatment with Serenoa repens extract (ESR - Permixon). MATERIALS AND METHODS: For prediction using the methods of predictive analytics of the therapeutic ESR effect in the long term, materials from the open study "Clinical and biological long-term tolerance of a lipidosterolic extract of Serenoa repens (Permixon) in patients with symptomatic benign prostatic hypertrophy" (No. P0048 95 GP 401) were used. The study took place in 1995-1999 in 3 Moscow medical centers: Research Institute of Urology of the Ministry of Health of the Russian Federation, Urological Clinic of the Moscow Medical Academy named after Sechenov and the urology department of Moscow Clinical Hospital No 60. The study included 155 patients aged 52 to 87 years (65.3) who received the drug in 320 mg capsules per day for two years. The target indicators of the prognosis identified key clinical parameters: a decrease IPSS of>25% or>3 points and an increase in Qmax>25% at 12 and 24 months of treatment. When evaluating the results, a binary approach was used: improvement achieved (1), not achieved (0). RESULTS: Using the methods of predictive analytics, mathematical models were built to predict the long-term results of treatment according to the most significant 7 initial criterias (predictors): IPSS; Qmax; average urine flow rate; urination volume, urination time, residual urine volume, prostate volume. For each target field and time interval, mathematical models were built using ensembles from 7 selected machine learning algorithms with the best predictive qualities: BNet; C5.0; SVM; KNN; NNet; CHAID; C&RT. Verification of models on internal randomized samples showed their high prognostic properties: sensitivity 82.4-99.0; specificity 75.0-96.1; AUC 0,864-0,965. CONCLUSION: The potential for effective prediction by the methods of predictive analytics and data mining of the separated results of drug therapy of LUTS / BPH according to the main clinical criteria was demonstrated. It is necessary to continue training and testing the model with the inclusion of new clinical observations in the data set. This approach is applicable to the creation of similar models for predicting the effect of other drugs.

Characterization of paralogous uncx transcription factor encoding genes in zebrafish.

The paired-type homeodomain transcription factor Uncx is involved in multiple processes of embryogenesis in vertebrates. Reasoning that zebrafish genes uncx4.1 and uncx are orthologs of mouse Uncx, we studied their genomic environment and developmental expression. Evolutionary analyses indicate the zebrafish uncx genes as being paralogs deriving from teleost-specific whole-genome duplication. Whole-mount in situ mRNA hybridization of uncx transcripts in zebrafish embryos reveals novel expression domains, confirms those previously known, and suggests sub-functionalization of paralogs. Using genetic mutants and pharmacological inhibitors, we investigate the role of signaling pathways on the expression of zebrafish uncx genes in developing somites. In identifying putative functional role(s) of zebrafish uncx genes, we hypothesized that they encode transcription factors that coordinate growth and innervation of somitic muscles.

Zebrafish Transcription Factor ORFeome for Gene Discovery and Regulatory Network Elucidation.

The completion of the zebrafish genome sequence and advances in miniaturization and multiplexing were essential to the creation of techniques such as RNA-seq, ChIP-seq, and high-throughput behavioral and chemical screens. Multiplexing was also instrumental in the recent enhancement of the classic yeast one-hybrid interaction techniques to provide unprecedented discovery capabilities for protein-DNA interactions. Unfortunately its use for zebrafish research is currently hampered by the lack of an open reading frame (ORF) clone collection. As a first step toward a complete collection, we describe a small library of transcriptional regulatory proteins comprising 142 ORFs and its potential applications.

Time resolution dependence of information measures for spiking neurons: scaling and universality.

The mutual information between stimulus and spike-train response is commonly used to monitor neural coding efficiency, but neuronal computation broadly conceived requires more refined and targeted information measures of input-output joint processes. A first step toward that larger goal is to develop information measures for individual output processes, including information generation (entropy rate), stored information (statistical complexity), predictable information (excess entropy), and active information accumulation (bound information rate). We calculate these for spike trains generated by a variety of noise-driven integrate-and-fire neurons as a function of time resolution and for alternating renewal processes. We show that their time-resolution dependence reveals coarse-grained structural properties of interspike interval statistics; e.g., τ-entropy rates that diverge less quickly than the firing rate indicated by interspike interval correlations. We also find evidence that the excess entropy and regularized statistical complexity of different types of integrate-and-fire neurons are universal in the continuous-time limit in the sense that they do not depend on mechanism details. This suggests a surprising simplicity in the spike trains generated by these model neurons. Interestingly, neurons with gamma-distributed ISIs and neurons whose spike trains are alternating renewal processes do not fall into the same universality class. These results lead to two conclusions. First, the dependence of information measures on time resolution reveals mechanistic details about spike train generation. Second, information measures can be used as model selection tools for analyzing spike train processes.

Wurtzite-derived ternary I-III-O2 semiconductors.

Ternary zincblende-derived I-III-VI2 chalcogenide and II-IV-V2 pnictide semiconductors have been widely studied and some have been put to practical use. In contrast to the extensive research on these semiconductors, previous studies into ternary I-III-O2 oxide semiconductors with a wurtzite-derived ß-NaFeO2 structure are limited. Wurtzite-derived ß-LiGaO2 and ß-AgGaO2 form alloys with ZnO and the band gap of ZnO can be controlled to include the visible and ultraviolet regions. ß-CuGaO2, which has a direct band gap of 1.47 eV, has been proposed for use as a light absorber in thin film solar cells. These ternary oxides may thus allow new applications for oxide semiconductors. However, information about wurtzite-derived ternary I-III-O2 semiconductors is still limited. In this paper we review previous studies on ß-LiGaO2, ß-AgGaO2 and ß-CuGaO2 to determine guiding principles for the development of wurtzite-derived I-III-O2 semiconductors.

E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila.

Transcriptional activation of Notch signaling targets requires the formation of a ternary complex that involves the intracellular domain of the Notch receptor (NICD), DNA-binding protein Suppressor of Hairless [Su(H), RPBJ in mammals] and coactivator Mastermind (Mam). Here, we report that E(y)1/TAF9, a component of the transcription factor TFIID complex, interacts specifically with the NICD-Su(H)-Mam complex to facilitate the transcriptional output of Notch signaling. We identified E(y)1/TAF9 in a large-scale in vivo RNA interference (RNAi) screen for genes that are involved in a Notch-dependent mitotic-to-endocycle transition in Drosophila follicle cells. Knockdown of e(y)1/TAF9 displayed Notch-mutant-like phenotypes and defects in target gene and activity reporter expression in both the follicle cells and wing imaginal discs. Epistatic analyses in these two tissues indicated that E(y)1/TAF9 functions downstream of Notch cleavage. Biochemical studies in S2 cells demonstrated that E(y)1/TAF9 physically interacts with the transcriptional effectors of Notch signaling Su(H) and NICD. Taken together, our data suggest that the association of the NICD-Su(H)-Mastermind complex with E(y)1/TAF9 in response to Notch activation recruits the transcription initiation complex to induce Notch target genes, coupling Notch signaling with the transcription machinery.

De Emil Kraepelin a Sigmund Freud y Henri Ey: fracturas, candiles y penumbras de la Posmodernidad / From Emil Kraepelin to Sigmund Freud and Henri Ey: fractures, candlelights and shadows of Postmodernism

El presente trabajo intenta recorrer la evolución del pensamiento psiquiátrico desde el Siglo XIX hasta el XXI, através de tres de sus más importantes representantes. Emil Kraepelin fue un positivista que quiso encontrar un método de exploración que le permitiera relacionar la clínica y la evolución con la alteración subyacente Sigmund Freud introduce y formaliza el estudio de la subjetividad en la medicina de su tiempo, lo cual lo distancia enormemente de la corriente positivista entonces predominante. Henri Ey, va más allá de ambos, porque sin proponer una síntesis ecléctica, desarrolla un nuevo concepto de la enfermedad mental que no excluye ni la subjetividad ni el funcionamiento cerebral: la teoría órganodinámica, basada en el modelo desarrollado por Jackson en Inglaterra, a su vez inspirado en la ideas de Darwin sobre la evolución del Sistema Nervioso Central. De esta exploración es posibleencontrar puntos de encuentro y aproximación entre las ideas de Ey y lo que hoy se denomina el pensamientoposmoderno, el cual también puede servir de nicho conceptual a las actuales neurociencias.

This paper aims to explore the evolution of psychiatric thought between the 19th and the 21st. centuries by examining the work of three of its most important representatives. Emil Kraepelin was a positivist who worked to find a screening method that would allow a relevant connection between clinical course and the underlying disorder. Sigmund Freud introduced and formalized the study of subjectivity in the medicine of his time which distanced him greatly from the then prevailing Positivism. Henri Ey, goes beyond Kraepelin and Freud as, without proposing an eclectic synthesis, develops a new concept of mental illness which does not exclude subjectivity and brain function; he calls it, organodynamic theory, based on the model developed by Jackson in England, and in turn inspired by Darwin’s ideas about the evolution of the Central Nervous System. A common ground is detected between Ey’s approach and what is now called postmodern thought, which can also serve as a conceptual niche for the current neurosciences.

Henry Ey, Jackson e as ideias obsessivas / Henri Ey, Jackson and obsessive ideas / Henry Ey, Jackson et les idées obsédantes / Henry Ey, Jackson y las ideas obsesivas

O artigo destaca a importante contribuição do professor de psiquiatria Henry Ey aos estudos sobre John Hughlings Jackson. Analisa historicamente uma interface pouco conhecida de Jackson com a psiquiatria: o diálogo sobre as "ideias obsessivas" que figura nas páginas da revista Brain, entre 1894 e 1895. Discute as razões históricas que podem explicar a não influência de Jackson na psiquiatria britânica, em contraste com a ampla difusão de suas posições no campo da neurologia.

This article highlights the important contribution of the French psychiatrist Henry Ey, to studies on John Hughlings Jackson. It historically analyzes a little-known text that presents an interface between Jackson and psychiatry, namely: Dialogue on "Obsessive Ideas." This article appeared in the journal Brain, between 1894 and 1895. The author discusses historical reasons that might explain Jackson's lack of influence on British psychiatry, in contrast to the considerable spread of his ideas on neurology.

L'article souligne l'importante contribution du professeur de psychiatrie Henry Ey aux études de John Hughlings Jackson. Il analyse de façon historique une interface peu connue entre Jackson et la psychiatrie: le dialogue sur les "idées obsédantes" publié dans la revue Brain entre 1894 et 1895. Cet article discute d'ailleurs les raisons historiques qui pourraient expliquer le manque d'influence de Jackson sur la psychiatrie britannique qui contraste avec la large diffusion de ses positions en neurologie.

El artículo destaca la importante contribución del profesor de psiquiatria Henry Ey a los estúdios sobre John Hughlings Jackson. Se analisa históricamente uma interfaz poço conocida de Jackson com la psiquiatria: el diálogo acerca de las "ideas obsesivas" que figura en las páginas de la revista Brain, entre 1894 y 1895. Se discute las razones históricas que pueden explicar la ausencia de influencia de Jackson em la psiquiatria britânica, lo que contrasta con la amplia difusión de sus posiciones en la neurologia.

Henry Ey, Jackson e as ideias obsessivas / Henri Ey, Jackson and obsessive ideas / Henry Ey, Jackson et les idées obsédantes / Henry Ey, Jackson y las ideas obsesivas

O artigo destaca a importante contribuição do professor de psiquiatria Henry Ey aos estudos sobre John Hughlings Jackson. Analisa historicamente uma interface pouco conhecida de Jackson com a psiquiatria: o diálogo sobre as "ideias obsessivas" que figura nas páginas da revista Brain, entre 1894 e 1895. Discute as razões históricas que podem explicar a não influência de Jackson na psiquiatria britânica, em contraste com a ampla difusão de suas posições no campo da neurologia.(AU)

This article highlights the important contribution of the French psychiatrist Henry Ey, to studies on John Hughlings Jackson. It historically analyzes a little-known text that presents an interface between Jackson and psychiatry, namely: Dialogue on "Obsessive Ideas." This article appeared in the journal Brain, between 1894 and 1895. The author discusses historical reasons that might explain Jackson's lack of influence on British psychiatry, in contrast to the considerable spread of his ideas on neurology.(AU)

L'article souligne l'importante contribution du professeur de psychiatrie Henry Ey aux études de John Hughlings Jackson. Il analyse de façon historique une interface peu connue entre Jackson et la psychiatrie: le dialogue sur les "idées obsédantes" publié dans la revue Brain entre 1894 et 1895. Cet article discute d'ailleurs les raisons historiques qui pourraient expliquer le manque d'influence de Jackson sur la psychiatrie britannique qui contraste avec la large diffusion de ses positions en neurologie.(AU)

El artículo destaca la importante contribución del profesor de psiquiatria Henry Ey a los estúdios sobre John Hughlings Jackson. Se analisa históricamente uma interfaz poço conocida de Jackson com la psiquiatria: el diálogo acerca de las "ideas obsesivas" que figura en las páginas de la revista Brain, entre 1894 y 1895. Se discute las razones históricas que pueden explicar la ausencia de influencia de Jackson em la psiquiatria britânica, lo que contrasta con la amplia difusión de sus posiciones en la neurologia.(AU)