RESUMO
We report a rare case of an ovarian mucinous cystadenoma in which there were peculiar neuroendocrine micronests composed of gastrin-immunoreactive cells. There was no clinical evidence of hypergastrinemia. The mucinous component of the neoplasm was represented by columnar cells mostly expressing a gastric phenotype with MUC5AC and claudin 18 positivity, which was consistent with the presence of interspersed gastrin cells. The tumoral stroma displayed areas of luteinization with cells intensely positive for α-inhibin, MART-1 and calretinin.
Assuntos
Cistadenoma Mucinoso/patologia , Células Neuroendócrinas/patologia , Neoplasias Ovarianas/patologia , Biomarcadores Tumorais/análise , Cistadenoma Mucinoso/metabolismo , Feminino , Gastrinas/biossíntese , Humanos , Hiperplasia , Imuno-Histoquímica , Pessoa de Meia-Idade , Células Neuroendócrinas/metabolismo , Neoplasias Ovarianas/metabolismoRESUMO
53 male Wistar rats were divided into three groups, i.e. experimental ulcer group, saline control group and normal control group. The antral tissues were prepared for immunohistochemical staining at 4th, 10th, 14th, 21st and 28th days after operation. Sternberger's PAP method was used to demonstrate the gastrin cells (G cells) and somatostatin cells (D cells)in the antral mucosa in order to observe their changes during experimental gastric ulcer. The morphological relationships of G cells and D cells were examined by simultaneous double immunostaining method.The results indicated that the G cells count as well as D cells count in the antral mucosa was increased (P
