A Quantitative Framework for Medication Non-Adherence: Integrating Patient Treatment Expectations and Preferences.

Introduction: Medication non-adherence remains a significant challenge in healthcare, impacting treatment outcomes and the overall effectiveness of medical interventions. This article introduces a novel approach to understanding and predicting medication non-adherence by integrating patient beliefs, efficacy expectations, and perceived costs. Existing theoretical models often fall short in quantifying the impact of barrier removal on medication adherence and struggle to address cases where patients consciously choose not to follow prescribed medication regimens. In response to these limitations, this study presents an empirical framework that seeks to provide a quantifiable model for both individual and population-level prediction of non-adherence under different scenarios. Methods: We present an empirical framework that includes a health production function, specifically applied to antihypertensive medications nonadherence. Data collection involved a pilot study that utilized a double-bound contingent-belief (DBCB) questionnaire. Through this questionnaire, participants could express how efficacy and side effects were affected by controlled levels of non-adherence, allowing for the estimation of sensitivity in health outcomes and costs. Results: Parameters derived from the DBCB questionnaire revealed that on average, patients with hypertension anticipated that treatment efficacy was less sensitive to non-adherence than side effects. Our derived health production function suggests that patients may strategically manage adherence to minimize side effects, without compromising efficacy. Patients' inclination to manage medication intake is closely linked to the relative importance they assign to treatment efficacy and side effects. Model outcomes indicate that patients opt for full adherence when efficacy outweighs side effects. Our findings also indicated an association between income and patient expectations regarding the health of antihypertensive medications. Conclusion: Our framework represents a pioneering effort to quantitatively link non-adherence to patient preferences. Preliminary results from our pilot study of patients with hypertension suggest that the framework offers a viable alternative for evaluating the potential impact of interventions on treatment adherence.

Overweight grandsons and grandfathers' starvation exposure.

Much of the increase in the prevalence of overweight and obesity has been in developing countries with a history of famines and malnutrition. This paper is the first to examine overweight among adult grandsons of grandfathers exposed to starvation during developmental ages. I study grandsons born to grandfathers who served in the Union Army during the US Civil War (1861-5) where some grandfathers experienced severe net malnutrition because they suffered a harsh POW experience. I find that male-line but not female-line grandsons of grandfathers who survived a severe captivity during their growing years faced a 21% increase in mean overweight and a 2% increase in mean BMI compared to grandsons of non-POWs. Male-line grandsons descended from grandfathers who experienced a harsh captivity faced a 22%-28% greater risk of dying every year after age 45 relative to grandsons descended from non-POWs, with overweight accounting for 9%-14% of the excess risk.

Respective healthcare system performances taking into account environmental quality: what are the re-rankings for OECD countries?

BACKGROUND: Efficiency analyses have been widely used in the literature to rank countries regarding their health system performances. However, little place has been given to the environmental aspect: two countries with the same characteristics could experience completely different healthcare system outcomes just because they do not face the same environmental quality situation, which is a major determinant of the health of inhabitants. METHODS: Using a stochastic frontier model, this paper analyses the effect of environmental quality on health system outcomes in OECD countries, measured by life expectancy at birth. RESULTS: We show that the healthcare system performance ranking of OECD countries changes significantly, depending on whether the environmental index is taken into account. CONCLUSIONS: These findings, once again, underline the critical importance of the environment when addressing population health issues. In general, our results can be aligned with the messages of the One Health approach literature.

Live and let live: understanding the temporal drivers and spillovers of life expectancy in Europe for public planning.

The European continent has one of the longest life expectancies in the world, but still faces a significant challenge to meet the health targets set by the Sustainable Development Goals of the United Nations for 2030. To improve the understanding of the rationale that guides health outcomes in Europe, this study assesses the direction and magnitude effects of the drivers that contribute to explain life expectancy at birth across 30 European countries for the period 2008-2018 at macro-level. For this purpose, an aggregated health production function is used allowing for spatial effects. The results indicate that an increase in the income level, health expenditure, trade openness, education attainment, or urbanisation might lead to an increase in life expectancy at birth, whereas calories intake or quantity of air pollutants have a negative impact on this health indicator. This implies that health policies should look beyond economic factors and focus also on social and environmental drivers. The results also indicate the existence of significant spillover effects, highlighting the need for coordinated European policies that account for the synergies between countries. Finally, a foresight analysis is conducted to obtain projections for 2030 under different socioeconomic pathways. Results reveal significant differences on longevity projections depending on the adoption, or not, of a more sustainable model of human development and provides valuable insight on the need for anticipatory planning measures to make longer life-spans compatible with the maintenance of the welfare state.

Smog Avoidance Investment While Improving Air Quality: Health Demand or Risk Aversion? Evidence from Cities in China.

Atmospheric pollution control policies have achieved remarkable progress in China since 2013, and the smog protective equipment market has experienced a great boom during the same period. From the perspectives of the health production efficiency hypothesis and the time discount rate hypothesis, this study investigates the relationship between household expenditures on air pollution avoidance and health care, and individuals' self-assessed health based on network survey data from 17 cities in China. Using the treatment effect model to control the potential endogenous selection problems, we explain the paradox of the growing smog avoidance investment coexisting with improving air quality. First, smog avoidance investment and household medical expenditures do not have substitution effects, while the perception of pollution intensity, pollution protection knowledge, and future health preferences significantly promote smog avoidance investment and medical expenditures. Second, air pollution avoidance investment greatly increases the probability that urban residents rate their health as "good" and "very good". The results indicate that the time preference hypothesis can explain the pollution avoidance investment behavior and health demands of Chinese urban residents well. The hidden social welfare loss caused by air pollution may still be underestimated, even though short-term avoidance costs are included in the evaluation of pollution impacts. It is necessary to optimize environmental regulations and policies to consistently improve the ecological environment.

Investigating correlations between illness and defensive behaviour approach: A case of twin cities of Pakistan.

Municipal solid waste (MSW) management has emerged as a major problem for modern societies in recent decades. An optimal waste management system is essential to prevent the pollution burden and associated health related issues. This study carries out an empirical evaluation of the illness caused by inadequate solid waste management in the metropolitan of Rawalpindi-Islamabad. The model is based on utility-maximizing consumer behavior and predicted probability of disease in the household is estimated by employing "seemingly uncorrelated bivariate probit model". Primary data obtained through multistage random sampling that comprises of 849 respondents. The findings show that irregular waste disposal sites in the vicinity of residences cause illness. The key findings indicate that distance from dumpsites and use of contaminated water adversely affect the health outcomes. Furthermore, the results show that respondents were unable to engage in defensive activities due to a lack of awareness. Oft-times, the waste is dumped in illegal sites that is burnt thus causing excessive air and ground water pollution. The results shed light on the respondents' understanding of the negative consequences of excessive waste disposal and study suggests measures that motivate households to engage in defensive activities through effective campaigns and capacity building programmes that ensure sustainable solid waste management.

Does waiting times decrease or increase operational costs in short and long-term? Evidence from Portuguese public hospitals.

The Portuguese National Health System is composed of all public entities offering health services. There has been a successive increase in expenditure in recent years due to various factors that have contributed to a high degree of uncertainty about the evolution of operating costs in Public Business Hospitals. This research's main objective is to study the relationship between operational costs and waiting times as well as costs with healthcare professionals and waiting times in both external consultations and hospital surgeries. Furthermore, we will empirically assess the presence of U-shaped behaviour in both of these two relationships. We have included a sample of 38 hospitals considered in the Portuguese National Health System. We also included, in our analysis, five groups of public business hospitals, according to the Administrative Central Agency of Portugal's Health Service, considering the period between January 2015 and December 2019. To validate the two relationships proposed, the Autoregressive Distributed Lag panel model was used. This study highlights that longer waiting times for external consultation and surgery significantly affect hospital costs and suggest that longer waiting times do not merely increase absence rates. The study also proves that there are long-term effects that last beyond the short-term waiting period.

When can physical distancing be relaxed? A health production function approach for COVID-19 control policy.

BACKGROUND: To assess if physical distancing measures to control the COVID-19 pandemic can be relaxed, one of the key indicators used is the reproduction number R. Many developing countries, however, have limited capacities to estimate R accurately. This study aims to demonstrate how health production function can be used to assess the state of COVID-19 transmission and to determine a risk-based relaxation policy. METHODS: The author employs a simple "bridge" between epidemiological models and production economics to establish the cumulative number of COVID-19 cases as a short-run total product function and to derive the corresponding marginal product, average product, and production elasticity. Three crucial dates defining the states of transmission, labelled red, yellow, and green zones, are determined. Relaxation policy is illogical in the "red zone" and is not recommended in the "yellow zone". In the "green zone", relaxation can be considered. The Bayesian probability of near term's daily cases meeting a policy target is computed. The method is applied to France, Germany, Italy, the UK, and the US, and to Indonesia as an example of application in developing countries. RESULTS: This study uses data from the WHO COVID-19 Dashboard, beginning from the first recording date for each country until February 28, 2021. As of June 30, 2020, France, Germany, Italy, and the UK had arrived at the "green zone" but with a high risk of transmission re-escalations. In the following weeks, their production elasticities were rising, giving a signal of accelerated transmissions. The signal was corroborated by these countries' rising cases, making them leaving the "green zone" in the later months. By February 28, 2021, the UK had returned to the "green zone", France, Germany, and Italy were still in the "yellow zone", while the US reached the "green zone" at a very high number of cases. Despite being in the "red zone", Indonesia relaxed its distancing measures, causing a sharp rise of cases. CONCLUSIONS: Health production function can show the state of COVID-19 transmission. A rising production elasticity gives an early warning of transmission escalations. The elasticity is a useful parameter for risk-based relaxation policy.

Spatio-Temporal Variation of Health Production Efficiency Considering Environmental Pollution in China Based on Modified EBM and Spatial Econometric Model.

In order to strengthen the construction of China's health industry and improve the health of the people, based on the data of 31 provinces and cities in China from 2009 to 2019, the improved EBM model is used to measure the health production efficiency of each region, and Moran index is used to study the Spatio-temporal variation of health production efficiency of each province. Finally, the spatial econometric model is applied to study the influencing factors of the Spatio-temporal variation of health production efficiency. The results show that generally speaking, the average efficiency of 31 provinces and cities is above 0.7, and the average efficiency of some regions is above 1. From the perspective of time variation, the average efficiency value in the eastern region and the middle region increases from 0.816 to 0.882 and from 0.851 to 0.861, respectively. However, the average efficiency value in the western region and northeast region decreases from 0.861 to 0.83 and from 0.864 to 0.805, respectively. From the perspective of spatial distribution, HH agglomeration and LL agglomeration exist in most regions. By comparing Moran scatter plots in 2009 and 2019, it is found that the quadrants of most regions remain unchanged, and LL agglomeration is the main agglomeration type in local space. There is a significant spatial dependence among different regions. From the perspective of spatial empirical results, Pgdp, Med, and Pd have a positive effect on health production efficiency. The direct effect and indirect effect of Pgdp, Med, and Gov all pass the significance test of 1%, indicating that there are spatial spillover effects of the three indicators. Each region should reasonably deal with the spillover effect of surrounding regions, vigorously develop economic activities, carry out cooperation with surrounding regions and apply demonstration effect to accelerate the development of overall health production.

Loucura em território: experimentando produção de saúde com beneficiários do programa “De volta para casa” / Madness in territory: experimenting health production with beneficiaries of the “Back to home” program / Locura en territorio: experimentando producción de salud com beneficiarios del programa “De vuelta a casa” / Folie en territoire: essayer production de santé avec bénéficiaires du programme “Retour à la maison”

Este artigo se propõe a refletir sobre a desinstitucionalização e o Programa de Volta para Casa, incluindo seus impactos na saúde de pessoas longamente institucionalizadas, com base na perspectiva da produção de saúde. Tem como objetivo compreender as estratégias de produção de saúde desenvolvidas por pessoas que viveram longos processos de internação em hospitais psiquiátricos e que agora residem em Serviços Residenciais Terapêuticos localizados no município de Camaragibe/Pernambuco. No que diz respeito à metodologia, foram utilizadas cinco narrativas de homens beneficiários do programa, oriundas do banco de dados de uma pesquisa multicêntrica de caráter nacional sobre o Programa de Volta para Casa. As produções narrativas foram o material e método de análise, na perspectiva de contemplar diferentes fontes e versões do fenômeno. Como resultado, tivemos a construção e análise das possibilidades de produção de saúde a partir de dispositivos como o trabalho, a autonomia, a expressão artística e a cultura.

This paper proposes to reflect about deinstitutionalization and the “Back to Home” Program, as well as their impacts on the health of long institutionalized people, based on the perspective of health production. It is based on discussions about freedom as therapeutic and a new view on health, moving the focus away from the disease and centralizing the subject, their life story and their potential for constant reinvention. The paper aims to understand the strategies of health production developed by people who have lived long processes of hospitalization in psychiatric hospitals and who now reside in Residential Therapeutic Services located in the municipality of Camaragibe (Brazil). Regarding the methodology, five narratives of male beneficiaries of the program were used. Such narratives were taken from the database of a multicenter national research on the “Back to Home” program. The narrative productions were the material and method of analysis, with the aim of contemplating different sources and versions of the phenomenon. As results, we had the construction and analysis of the possibilities of health production from devices such as work, autonomy, artistic expression and culture.

Este artículo se propone reflexionar sobre la desinstitucionalización y el Programa “De Vuelta a Casa”, y sus impactos en la salud de personas largamente institucionalizadas, con base en la perspectiva de la producción de salud. Tiene como objetivo comprender las estrategias de producción de salud desarrolladas por personas que vivieron largos procesos de internación en hospitales psiquiátricos y que ahora residen en Servicios Residenciales Terapéuticos ubicados en el municipio de Camaragibe. En lo que se refiere a la metodología, se utilizaron datos secundarios de una investigación multicéntrica de carácter nacional sobre el Programa de “Vuelta a Casa”, cinco narrativas de hombres beneficiarios del programa. Las produciónes narrativas fueron el material y método de análisis, en la perspectiva de contemplar diferentes fuentes y versiones del fenómeno. Como resultados, tuvimos la construcción y análisis de las posibilidades de producción de salud a partir de dispositivos como el trabajo, la autonomía, la expresión artística y la cultura.

Cet article vise à réfléchir sur la désinstitutionnalisation et le programme Retour à la Maison, y compris ses impacts sur la santé des personnes institutionnalisées depuis longtemps, sur la base de la perspective de la production sanitaire. Il vise à comprendre les stratégies de production de santé développées par des personnes qui ont vécu de longs processus d'hospitalisation dans des hôpitaux psychiatriques et qui résident maintenant dans des services thérapeutiques résidentiels situés dans la municipalité de Camaragibe / Pernambuco. En ce qui concerne la méthodologie, cinq récits des hommes bénéficiaires du programme ont été utilisés, à partir de la base de données d'une recherche nationale multicentrique sur le programme de retour à la maison. Les productions narratives ont constitué le matériau et la méthode d'analyse, en vue d'envisager différentes sources et versions du phénomène. En conséquence, nous avons eu la construction et l'analyse des possibilités de production de santé à partir d'appareils tels que le travail, l'autonomie, l'expression artistique et la culture.

The impact of early-life shocks on adult welfare in Brazil: Questions of measurement and timing.

Recent literature provides evidence that income shocks early in life can have long-run consequences on adult welfare. Rural Brazil frequently suffers from rainfall variations that negatively impact vulnerable households, who often lack the means for coping with these events. This paper evaluates how early-life rainfall shocks influence adult health and socioeconomic outcomes in Brazil. We find evidence that several critical periods can produce long-run consequences. Using rainfall deviations, our two most robust results are that greater rainfall in utero negatively impacts adult incomes (finding that a one standard deviation increase in rainfall causes adult incomes to fall by 7-10 percent) and that greater rainfall in the second and third years of life improve adult health (increasing body mass index by 0.16). However, our results depend crucially on our choices regarding two features. First, our results differ across two common measures of critical periods, which are used to define shocks relative to the timing of one's birth. Second, the way rainfall variation is measured also matters, with use of an extreme weather indicator suggesting heterogeneous effects by gender, with extreme weather negatively impacting women's health (both before and after birth) but positively affecting several men's outcomes (both before and after birth). We find some evidence that mortality selection may drive some of these results. This paper provides further evidence that early-life shocks (from in utero through the third year of life) can cause long-run consequences, but also suggests that more attention should be paid to the specific measurement and timing of rainfall shocks.

Provision of health care services and regional diversity in Germany: insights from a Bayesian health frontier analysis with spatial dependencies.

The German health care system is among the most patient-oriented systems in Europe. Nevertheless, distinct utilisation patterns, access barriers due to socio-economic profiles, and potentials of misallocation of medical resources lead to disparities in the provision of health care services. We analyse how a possible over- and undersupply of services and the utilisation of and the access to the health care system relate to regional variations in the population's well-being. For this purpose, we employ a recent Bayesian stochastic frontier approach that allows for spatial dependence structures. Our results indicate that patient migration plays an important role in contributing to regional differences in the utilisation of the medical infrastructure. As a consequence, policy should take spatial patterns of health care utilisation into account to improve the allocation of medical resources.

A Cost-Benefit Analysis of Hearing Aids, Including the Benefits of Reducing the Symptoms of Dementia.

We carried out a CBA of hearing aids (HAs) in which we estimated the direct utility benefits, and included the indirect utility benefits working through a reduction in dementia symptoms. The benefits methodology involved using QALYs as the outcome measure and then applying the price of a QALY to convert the outcome measure into monetary terms. The price of a QALY was derived from an age specific VSL estimate. The effects of HAs on utility were estimated from a fixed effects regression on a large national panel data set provided by NACC where we used a negative proxy for the QoL. We also used a fixed effects regression for the estimate of the indirect benefits involving HAs reducing dementia symptoms. We found that the total benefits, mainly coming from the direct benefits, were extremely large relative to the costs, with benefit-cost ratios over 30.

Mind the gap: The health advantages that accompany parental marriage vary by maternal nativity.

Using data from the UK Millennium Cohort Study (MCS), we examine whether and how the health benefits of having two biological parents in a continuous marital relationship vary by maternal nativity and ethnicity, comparing UK-born White mothers with: (1) White mothers born in wealthy countries; (2) ethnic minority mothers from South Asia; and (3) ethnic minority mothers born in Africa. Making novel use of classification and regression tree (CART) methods, we examine whether marital status is a uniform marker of economic advantage or better health-related behaviours across the four maternal nativity and ethnic groups. The findings, which indicate that the health-related advantages associated with parental marriage are not uniform across the four nativity and ethnic groups, have implications for future research on family gaps in well-being and the socio-economic determinants of health.

Heat stress management in poultry farms: A comprehensive overview.

Heat stress causes significant economic losses in poultry production, especially in tropical and arid regions of the world. Several studies have investigated the effects of heat stress on the welfare and productivity of poultry. The harmful impacts of heat stress on different poultry types include decreased growth rates, appetites, feed utilization and laying and impaired meat and egg qualities. Recent studies have focused on the deleterious influences of heat stress on bird behaviour, welfare and reproduction. The primary strategies for mitigating heat stress in poultry farms have included feed supplements and management, but the results have not been consistent. This review article discusses the physiological effects of heat stress on poultry health and production and various management and nutritional approaches to cope with it.

The Hispanic health paradox for older Americans: an empirical note.

Previous researchers have found that Hispanic immigrants tend to have better health than could be reasonably explained by their socioeconomic status and other demographic variables. The main objective of this study is to re-investigate the Hispanic health paradox covering the period from 1992 to 2012. Main contributions of the paper include using a data set of older Americans from the Health and Retirement Study. More importantly, we use two new measures of health. Previous research on the paradox had primarily used mortality or morbidity to measure health. In contrast, the HRS includes a measure of self-reported poor health from which we construct a latent health variable. Using both poor health and latent health we find that even among our sample of older Americans that Hispanic Immigrants remain more healthy than could be explained by their socioeconomic status and their other health inputs.

Estimation of a Neonatal Health Production Function for Iran: Secondary Analysis of Iran's Multiple Indicator Demographic and Health Survey 2010.

BACKGROUND: Despite constant decrease in rate of neonatal mortality, the rate is still higher than that of other under-five children. One of the first steps towards reduction of neonatal mortality is to identify its determinants using health production function. The aim of the present study was to estimate neonatal health production function for Iran. METHODS: In this cross-sectional study, Iranian Multiple Indicator Demographic and Health Survey (Ir-MIDHS) 2010 was used. Four categories of socioeconomic, mother, neonatal demographic and healthcare system factors were entered into the Binomial Logistic Regression model to estimate neonate health production function. Households' economic status was constructed using principal component analysis. RESULTS: History of abortion/stillbirth had the highest significant positive impact on odds of neonatal mortality (odds ratio=1.98; 95 % CI=1.55-2.75), indicating that neonates of mothers with such a history had 1.98 times higher chance of death compared to other neonates. Moreover, odds ratio of neonatal death for the poorest quintiles was 1.70 (95 % CI=1.08-2.74), indicating that by moving from the poorest quintile to the richest one, the odds of being alive for neonates increased up to 70%. However, skilled birth attendant decreased the chance of death up to 58% (odds ratio=0.58; 95 % CI=0.36-0.93). CONCLUSION: Considering the most significant inputs of neonatal health production function in Iran, improvement of economic status of households, provision of appropriate care services for mothers, and improvement of delivery care provided by trained personnel, could be priorities for health policymakers to act and reduce neonatal mortality in Iran.

Estimating the monetary benefits of medicare eligibility for reducing the symptoms of dementia.

We adopt a three-component method based on the idea of cost-saving for estimating the monetary benefits of Medicare eligibility for reducing dementia symptoms. The method involves Medicare eligibility lowering dementia symptoms, which reduces the need for dependent living, which in turn lowers caregiving costs. We use the Regression Discontinuity approach to establish a causal link between Medicare eligibility and dementia. The novel aspect of the study comes from using a quality-of-life proxy measure for the utility function to derive the marginal rate of substitution between dementia symptoms reduction and dependent living arrangements.

Health care service provision in Europe and regional diversity: a stochastic metafrontier approach.

■■■: In the last decades, demographic change coupled with new and expensive medical innovations have put most health care systems in developed countries under financial pressure. Therefore, ensuring efficient service provision is essential for a sustainable health care system. This paper investigates the performance of regional health care services in six West European countries between 2005 and 2014. We apply a stochastic metafrontier model to capture the different conditions in the health care systems in the countries within the European Union. By means of this approach, it is possible to detect performance differences in the European health care systems subject to different conditions and technologies relative to the potential technology available. The results indicate that regional deprivation plays a key role for the efficiency of health care provision. Furthermore, a pooled model which assumes a similar technology for all countries cannot sufficiently account for differences between countries. Surprisingly, the Scandinavian regions lag behind other regions with respect to the metafrontier. JEL CLASSIFICATION: C23, D61, I12, I18, R10.