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1.
Rev Mal Respir ; 2024 Aug 19.
Artigo em Francês | MEDLINE | ID: mdl-39164130

RESUMO

INTRODUCTION: In a prevalence and opinion survey on smoking, this work focused on a strategy favoring tobacco-free areas at hospital entrances. METHODS: Outreach to the public occupying outdoor spaces led to immediate collection of responses over the course of 13 actions carried out in November 2022, a tobacco-free month. RESULTS: Thirty-two percent of the persons interrogated were smokers, 38% among patients, 26% among professionals and 18% among nursing students. A majority expressed support for smoke-free building entrances, which were viewed by half of the smokers as an encouragement to quit or cut down on their consumption. However, a quarter of participants anticipated difficulties, particularly the "heaviest" smokers. In the psychiatry sector, 54% were smokers, and they were relatively unfavorable to the initiative. As for non-smokers, most voiced discomfort regarding the smell of tobacco, the infiltration of smoke in indoor spaces, passive smoking, a negative image of the hospital, and the detrimental ecological impact. CONCLUSIONS: The tobacco-free hospital entrance initiative is relevant and of benefit to hospitals. In order to succeed, it must involve all stakeholders, whether they are users or professionals, in a concerted attempt to optimize assistance to smokers wishing to quit, by applying an educational and synergistic approach at all levels.

4.
J Clin Med ; 13(2)2024 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-38256665

RESUMO

Depressive symptoms are a customary finding in hospitalized patients, particularly those who are undergoing long hospitalizations, underwent major surgical procedures or suffer from high levels of multimorbidity and frailty. The patients included in this case series shared high degrees of frailty-complexity and were evaluated within the ordinary consultation and liaison psychiatry service of the University Hospital in Pisa, Italy, from September 2021 to June 2023. Patients were administered at least one follow-up evaluation after a week and before discharge. To relate this case series to the extant literature, a comprehensive systematic review of vortioxetine safety and efficacy was performed. None of the six patients included developed serious safety issues, but one patient complained of mild-to-moderate nausea for some days after the vortioxetine introduction. Five out of six patients exhibited at least a slight clinical benefit as measured by the clinical global impression scale. Of the 858 entries screened via Scopus and Medline/PubMed, a total of 134 papers were included in our review. The present case series provides preliminary evidence for vortioxetine's safety in this healthcare domain. The literature reviewed in this paper seems to endorse a promising safety profile and a very peculiar efficacy niche for vortioxetine in consultation and liaison psychiatry.

5.
Gen Hosp Psychiatry ; 86: 50-55, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38070241

RESUMO

BACKGROUND: There is currently an increasing recognition of and focus on structural and institutional racism and its impacts on health disparities. In psychiatry and mental health, research has focused on racial and ethnic disparities in the availability and utilization of mental health services, care in emergency departments, and inpatient psychiatric services. Little is known about disparities in care on general hospital psychiatry consultation-liaison (CL) services. METHODS: In this exploratory study, we conducted a retrospective chart review using electronic health record (EHR) data of all adults (≥ 18 years of age) admitted to inpatient medical or surgical floors at an urban academic medical center for whom a psychiatric consultation was requested during the study period. We examined differences by race and ethnicity in: rates of consultation requests; use of legal holds, constant observation, restraints; follow-up by the CL service; and ultimate disposition. RESULTS: The service received 310 unique consults during the study period. Compared to hospital-wide numbers, Black-identifying patients were over-represented in our sample (11.9% vs 6.6%), while Latinx patients were underrepresented (6.1% vs 9.8%). Of the clinical and outcome variables collected, there were higher odds of being placed on a legal hold both prior to (OR 2.6) and after the consult question (OR 2.98) and in the odds of having a one-to-one observer prior to (OR 2.47) and after (OR 2.9) the initial consult visit for Black-identifying patients, when adjusting for confounders. There were no other measurable differences in care or outcomes by racial or ethnic categories. CONCLUSION: Black-identifying patients may be more likely to receive psychiatric consultation and be placed on legal holds because of a combination of chronic adverse social determinants of health and race-based bias. Conversely, Latinx patients may be less likely to receive psychiatric consultation because of language barriers among other factors. The lack of disparities identified in other domains may be encouraging, but larger studies are needed. Further research is also needed to identify causality and interventions that could help close the gap in care and outcomes for racial and ethnic minorities.


Assuntos
Centros Médicos Acadêmicos , Etnicidade , Adulto , Humanos , Estudos Retrospectivos , Hospitais , Encaminhamento e Consulta
6.
An. Fac. Med. (Perú) ; 84(4)dic. 2023.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1533594

RESUMO

Introducción. En los últimos 10 a 20 años, la psiquiatría de emergencia ha experimentado un progreso constante en cuanto a la prestación de servicios altamente especializados y enfocados en el paciente. Este aumento global refleja desafíos en accesibilidad y calidad de atención. En el contexto peruano, la legislación de salud mental y múltiples directrices clínicas orientan la prestación de servicios, no obstante, la insuficiencia de datos representa una barrera significativa para la toma de decisiones informadas. Objetivo. Examinar y reportar las características sociodemográficas y clínicas de los pacientes evaluados en la Unidad de Psiquiatría de Emergencia del Hospital Nacional Guillermo Almenara Irigoyen (HNGAI), de Lima, Perú, y analizar la naturaleza de los cuadros sintomatológicos y sindrómicos. Métodos. Estudio descriptivo, transversal. Se estudiaron las interconsultas recibidas por la Unidad de Psiquiatría de Emergencia del HNGAI, entre julio y diciembre del 2022. Se aplicó un análisis factorial de los síntomas. Resultados. En 1037 pacientes vistos en interconsulta, la edad promedio fue 41,15 ± 23,52 años. El 65,2 % fueron mujeres. La tasa de derivación fue de 1,18 %. Los trastornos más frecuentes fueron los del humor (27,8 %); los síntomas más frecuentes fueron el afecto ansioso (47,3 %), insomnio (38,8 %) y ánimo depresivo (32,6 %). Con respecto al tratamiento, el más usado fueron los antipsicóticos (50,4 %). El análisis factorial exploratorio de los síntomas mostró siete factores o componentes sindrómicos importantes: psicótico, delirium, depresivo-suicida, obsesivo-compulsivo, negativo, apático, ansioso. Conclusión. El paciente típico de esta muestra fue mujer al inicio de su cuarta década de vida. Los trastornos del humor y los síntomas ansiosos fueron los más comunes. El análisis factorial exploratorio mostró la presencia de siete síndromes. Es necesario incrementar la recopilación sistemática de datos e inversión en investigación en psiquiatría de emergencia, todo con la finalidad de mejorar la atención que se brinda a estos pacientes.


Introduction. In the last 10 to 20 years, emergency psychiatry has undergone consistent progress in providing highly specialized and patient-focused services. This global advancement reflects challenges in accessibility and quality of care. In the Peruvian context, mental health legislation and various clinical guidelines guide service provision; however, the lack of data constitutes a significant barrier to informed decision-making. Objective. The objective of this study was to examine and report the sociodemographic and clinical characteristics of patients evaluated at the Emergency Psychiatry Unit of the National Guillermo Almenara Irigoyen Hospital (HNGAI) in Lima, Peru, and analyze the nature of the symptomatic and syndromic profiles present. Methods. This was a descriptive, cross-sectional study. Interconsultations received by the Emergency Psychiatry Unit of HNGAI between July and December 2022 were analyzed. A factorial analysis of symptoms was conducted. Results. Out of a total of 1037 patients seen in interconsultation, the mean age was 41.15 ± 23.52 years. 65.2% of the patients were female. The referral rate was 1.18%. Mood disorders (27.8%) were the most frequent diagnoses, with anxious affect (47.3%), insomnia (38.8%), and depressive mood (32.6%) being the most common symptoms. Antipsychotics (50.4%) were the most used treatment modality. Exploratory factor analysis of symptoms revealed the presence of seven important syndromic factors: psychotic, delirium, depressive-suicidal, obsessive-compulsive, negative, apathetic, and anxious. Conclusion. The typical patient in this sample was a female in the early forties. Mood disorders and anxious symptoms were the most prevalent. Exploratory factor analysis identified the presence of seven syndromes. There is a need to increase systematic data collection and investment in emergency psychiatry research to enhance the care provided to these patients.

7.
J Am Acad Psychiatry Law ; 51(4): 542-550, 2023 Dec 08.
Artigo em Inglês | MEDLINE | ID: mdl-37788863

RESUMO

As racial influences on forensic outcomes are identified in every aspect of practice, scholars are exploring methods to disentangle race from its historical, economic, and attitudinal antecedents. Because jurisdictions vary in these influences, definitions and data may differ among them, creating inconsistencies in analysis and policy. This retrospective database review compared differences in racial outcomes among 200 pretrial defendants, 160 Black and 40 White, exploring a wide range of socioeconomic, clinical, and forensic influences before, during, and after hospitalization. Because of the tight relationship of socioeconomic factors and race, investigators hypothesized that it would be difficult to distinguish racial influences alone. Using a confirmatory approach to data collection and a statistical analysis based in logistic regression, only differences in referral for psychological testing were identified. Application of this method based on local demographics and culture may prove useful for institutions interested in evaluating racial influences on forensic outcomes.


Assuntos
Psiquiatria Legal , Transtornos Mentais , Humanos , Psiquiatria Legal/métodos , Competência Mental/psicologia , Transtornos Mentais/psicologia , Estudos Retrospectivos , Testes Psicológicos
8.
Front Psychiatry ; 14: 1166191, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37599892

RESUMO

Introduction: General hospital emergency departments (GHEDs) are notoriously overcrowded. This is caused, in part, by ineffective referrals, that is to say referrals that do not require medical examination or other interventions in the context of a general hospital. This study aims to investigate the contribution of psychiatric referrals to this issue, to identify potential determinants of these referrals and offer means to reduce them. Materials and methods: Retrospective data were collected from psychiatric admission files within a GHED of a tertiary-care city hospital over a 1 year period. Two experienced clinicians separately reviewed each file to determine rationale of referrals according to predetermined criteria. Results: A total of 2,136 visits included a psychiatric examination, 900 (42.1%) were determined "effective," and 1,227 (57.4%) were deemed "potentially ineffective." The leading causes for potentially ineffective referrals to a GHED were psychiatric illness exacerbation (43.4%), and suicidal ideations (22%). Most referrals (66.9%) were initiated by the patient or their family, and not by a primary care physician or psychiatrist. Conclusion: More than half of the psychiatric referrals did not necessarily require the services of a general hospital, and may be more suitable for referral to a dedicated psychiatric facility. Ineffective referrals to the GHED pose a burden on general hospital resources, and may be less effective for the psychiatric patients. This calls for clear guidelines for the provision of optimal emergency treatment for mental-health patients.

9.
Psychiatry Res ; 326: 115328, 2023 08.
Artigo em Inglês | MEDLINE | ID: mdl-37429173

RESUMO

INTRODUCTION: We developed and tested a Bayesian network(BN) model to predict ECT remission for depression, with non-response as a secondary outcome. METHODS: We performed a systematic literature search on clinically available predictors. We combined these predictors with variables from a dataset of clinical ECT trajectories (performed in the University Medical Center Utrecht) to create priors and train the BN. Temporal validation was performed in an independent sample. RESULTS: The systematic literature search yielded three meta-analyses, which provided prior knowledge on outcome predictors. The clinical dataset consisted of 248 treatment trajectories in the training set and 44 trajectories in the test set at the same medical center. The AUC for the primary outcome remission estimated on an independent validation set was 0.686 (95%CI 0.513-0.859) (AUC values of 0.505 - 0.763 observed in 5-fold cross validation of the model within the train set). Accuracy 0.73 (balanced accuracy 0.67), sensitivity 0.55, specificity 0.79, after temporal validation in the independent sample. Prior literature information marginally reduced CI width. DISCUSSION: A BN model comprised of prior knowledge and clinical data can predict remission of depression after ECT with reasonable performance. This approach can be used to make outcome predictions in psychiatry, and offers a methodological framework to weigh additional information, such as patient characteristics, symptoms and biomarkers. In time, it may be used to improve shared decision-making in clinical practice.


Assuntos
Eletroconvulsoterapia , Humanos , Depressão/terapia , Teorema de Bayes , Prognóstico , Biomarcadores , Resultado do Tratamento
11.
Ind Psychiatry J ; 31(2): 354-358, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36419681

RESUMO

Background: Mental illnesses are becoming a major health issue across the world. The availability of inpatient facilities for mentally ill patients is very much limited in developing countries such as India. Aim: This study was aimed to explore the pattern of psychiatric admissions at a general hospital psychiatry unit (GHPU) in South India. Methodology: The study was conducted at a multispecialty tertiary care hospital in South India. A retrospective, chart-based study design was adopted to achieve the objectives. All inpatient case records available from the department of psychiatry, the medical records department, and the electronic hospital information system of the institute were reviewed between April 2006 and March 2016. Results: A total of 3082 patients were admitted as psychiatry inpatients during the 10-year study period, representing an average of 308.2 admissions per calendar year. The majority of inpatients were male (n = 1824; 59.2%). Concerning diagnostic categories, mood disorders were accounted for 33.6% of admissions, followed by psychotic disorders (26.4%) and substance use disorders (19.3%), respectively. The median length of hospital stay was 14 days (range 0-163 days). A statistically significant seasonality pattern was noticed for mood disorders (December to February) and anxiety and neurotic disorders (August to October). Conclusion: It is obvious that treatment-seeking attitude among individuals with mental illnesses is increasing and the awareness regarding treatment aspects is also increasing among the general public. Hence, there is a need to improve the existing resources to facilitate intensive management for better treatment outcomes and this, in turn, will enhance the quality of life of mentally ill individuals.

12.
Front Psychiatry ; 13: 959399, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36311528

RESUMO

Introduction: Conducted under the auspices of the Italian Society of Consultation Liaison Psychiatry (SIPC) the aim of this study was to describe the characteristics of Consultation Liaison Psychiatry (CLP) activity in Italy (SIPC-2-2018) over the past 20 years by comparing with data from the first Italian nation-wide study (SIPC-1-1998). Methods: We collected data on CLP visits of 3,943 patients from 10 Italian hospitals over a period of 1 year. Data were compared with those from the SIPC-1 1998 study (4,183 participants). Patients were assessed with the same ad hoc 60-item Patient Registration Form recording information from five different areas: Sociodemographic, hospitalization-related, consultation-related, interventions and outcome. Results: Compared with participants from the previous study, SIPC-2-2018 participants were significantly older (d = 0.54) and hospitalized for a longer duration (d = 0.20). The current study detected an increase in the proportion of referrals from surgical wards and for individuals affected by onco-hematologic diseases. Depressive disorders still represented the most frequent psychiatric diagnosis, followed by adjustment and stress disorders and delirium/dementia. Also, CLP psychiatrists prescribed more often antidepressants (Φ = 0.13), antipsychotics (Φ = 0.09), mood stabilizers (Φ = 0.24), and less often benzodiazepines (Φ = 0.07). Conclusion: CLP workload has increased considerably in the past 20 years in Italy, with changes in patient demographic and clinical characteristics. A trend toward increase in medication-based patient management was observed. These findings suggest that the psychiatric needs of patients admitted to the general hospital are more frequently addressed by referring physicians, although Italian CLP services still deserve better organization and autonomy.

13.
J Am Acad Psychiatry Law ; 50(4): 533-540, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-36223939

RESUMO

The rate of civil commitment in Oregon fell from 53.2/100,000 in 1972 to 9.2/100,000 in 2020. The paper discusses this decline in civil commitment as related to statutory and case law changes and complex interactions including bed availability at Oregon State Hospital (OSH). The latter was in turn influenced by the significant increase in the last decade of hospitalization at OSH of competence to stand trial evaluation and restoration (CST) patients. Multnomah County, which contains the city of Portland, was responsible for the largest number of investigations and commitments and led the state in using a 14-day diversion alternative to commitment. This analysis may serve as a model for other states to engage in similar longitudinal research to shed light on the functioning of their involuntary commitment statutes.


Assuntos
Internação Involuntária , Transtornos Mentais , Humanos , Internação Compulsória de Doente Mental , Oregon , Comportamento Perigoso , Hospitais Estaduais
15.
J Am Acad Psychiatry Law ; 50(3): 427-433, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35798392

RESUMO

Referrals for competency restoration increased in the past decade, with the majority of incompetent to stand trial (IST) patients having schizophrenia; 25 percent of schizophrenia patients are treatment resistant. Clozapine is superior to other antipsychotics for treatment resistance but remains underutilized, particularly in forensic settings. Despite the impact of treatment resistance on the legal system, the literature on clozapine for IST patients is limited to two papers comprising 26 patients. A retrospective chart review was conducted of all IST admissions to a California hospital for 2014 to -2018, examining clinical and forensic outcomes in those newly started on clozapine and discharged. There were 191 new clozapine starts among IST patients, 92.7 percent of whom were diagnosed with schizophrenia or another psychosis. Over 90 percent were discharged on clozapine, and 36.1 percent were discharged on clozapine as trial competent; moreover, this cohort also had the shortest length of stay. This analysis indicates that most IST patients needing clozapine can be successfully treated, with a substantial proportion restored to trial competency. These data and earlier studies reinforce the concept that forensic programs have a medical duty to offer IST patients with severe mental illness a clozapine trial when indications exist for its use.

16.
J Am Acad Psychiatry Law ; 50(3): 388-395, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35793905

RESUMO

Most competence restoration occurs in secure inpatient settings. As states struggle with strained resources and seek to best utilize restoration services, factors such as charge severity and violence risk remain key considerations in determining the appropriate setting for an individual's competence restoration. This study offers a quantitative analysis of aggressive behavior during inpatient restoration efforts and whether criminal charge severity correlates with inpatient aggression. Results of this study indicate that a substantial minority of defendants engaged in aggressive behavior and required restraint during the initial months of their hospitalizations. Most of those engaged in few episodes of aggression and required few episodes of restraint. Rates of aggression and restraint were higher in individuals with lower severity charges compared with those with higher severity charges. Courts and evaluators may have selected for a more disordered group of defendants with lower severity charges.


Assuntos
Transtornos Mentais , Humanos , Psiquiatria Legal/métodos , Competência Mental , Hospitalização , Agressão
17.
J Am Acad Psychiatry Law ; 50(3): 434-439, 2022 09.
Artigo em Inglês | MEDLINE | ID: mdl-35710129

RESUMO

Forensic mental health services provide care for many people of minority ethnicity whose over-representation in these areas is a result of complex structural inequities in society. The need for cross-cultural understanding has long been advocated in forensic practice. Guidance on the integration of culture into forensic assessment has been well described, but little has been written about cultural responsiveness in forensic rehabilitation and recovery-based services. Cultural responsiveness is commonly expressed as a strategic goal for forensic providers, but there is little reported evidence of how to address and measure the effectiveness of cultural responsiveness initiatives. Equity of outcome by ethnicity should be the aim of forensic services, and this requires systematic measurement. Cultural safety, rather than cultural competence, has been promoted as the patient experience services should strive for. A measurement-based care framework can provide tools to evaluate service responses systematically and iteratively to address the challenges in achieving delivery of culturally safe forensic services.


Assuntos
Competência Cultural , Serviços de Saúde Mental , Humanos , Medicina Legal , Grupos Minoritários , Etnicidade
18.
J Acad Consult Liaison Psychiatry ; 63(3): 225-233, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34695618

RESUMO

BACKGROUND: Some patients engage in self-harm behaviors while in the emergency department, both suicidal and nonsuicidal self-harm. Little is known about what motivates these behaviors. This gap in the empirical literature limits efforts to develop early identification and risk mitigation strategies. OBJECTIVE: To describe methods and motivations when patients self-harm in the emergency department. METHOD: Authors reviewed self-harm incident reports and medical records from two urban academic emergency departments. Event timing and self-harm methods were extracted. Authors performed a qualitative content analysis of self-harm narratives to examine the question, "Which factors motivate patients to engage in deliberate (nonaccidental) self-harm in the emergency department?" RESULTS: The sample included 184 self-harm incidents involving 118 unique patients. A wide variety of self-harm methods were present in the data. Suicidal intent was present in a minority of incidents. Other motives included psychosis, intoxication, aggression, managing distress, communication, and manipulation. CONCLUSIONS: Self-harm behaviors in the emergency department encompassed a variety of methods and motivations. These findings suggest risk mitigation strategies that emphasize suicide screening, reducing environmental hazards, and increasing observation are unlikely to achieve the goal of zero harm. Strategies focusing on engagement may create more fruitful opportunities to improve patient safety.


Assuntos
Comportamento Autodestrutivo , Prevenção do Suicídio , Serviço Hospitalar de Emergência , Humanos , Comportamento Autodestrutivo/diagnóstico , Comportamento Autodestrutivo/epidemiologia , Ideação Suicida , Tentativa de Suicídio/prevenção & controle
19.
Front Psychiatry ; 12: 748224, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34912252

RESUMO

Objective: This study aimed to describe the provision of consultation-liaison psychiatry (CLP, also known as liaison psychiatry) services in acute hospitals in Ireland, and to measure it against recommended resourcing levels. Methods: This is a survey of all acute hospitals in Ireland with Emergency Departments, via an electronic survey sent by email and followed up by telephone calls for missing data. Data were collected on service configuration, activity, and resourcing. Data were collected from CLP or proxy services at all acute hospitals with an Emergency Department in Ireland (n = 29). This study measured staffing and activity levels where available. Results: None of the services met the minimum criteria set out by either national or international guidance per 500 bed general hospital. Conclusions: CLP is a relatively new specialty in Ireland, but there are clear international guidelines about the staffing levels required to run these services safely and effectively. In Ireland, despite clear national guidance on staffing levels, no services are staffed to the levels suggested as the minimum. It is likely that patients in Ireland's acute hospitals have worse outcomes, and hospitals have unnecessary costs, due to this lack. This is the first study of CLP provision in Ireland and demonstrates the resource constraints under which most services work and the heterogeneity of services nationally.

20.
BMC Psychiatry ; 21(1): 182, 2021 04 07.
Artigo em Inglês | MEDLINE | ID: mdl-33827497

RESUMO

BACKGROUND: Access to psychiatric care is critical for patients discharged from hospital psychiatric units to ensure continuity of care. When face-to-face follow-up is unavailable or undesirable, telepsychiatry becomes a promising alternative. This study aimed to investigate hospital- and county-level characteristics associated with telepsychiatry adoption. METHODS: Cross-sectional national data of 3475 acute care hospitals were derived from the 2017 American Hospital Association Annual Survey. Generalized linear regression models were used to identify characteristics associated with telepsychiatry adoption. RESULTS: About one-sixth (548 [15.8%]) of hospitals reported having telepsychiatry with a wide variation across states. Rural noncore hospitals were less likely to adopt telepsychiatry (8.3%) than hospitals in rural micropolitan (13.6%) and urban counties (19.4%). Hospitals with both outpatient and inpatient psychiatric care services (marginal difference [95% CI]: 16.0% [12.1% to 19.9%]) and hospitals only with outpatient psychiatric services (6.5% [3.7% to 9.4%]) were more likely to have telepsychiatry than hospitals with neither psychiatric services. Federal hospitals (48.9% [32.5 to 65.3%]), system-affiliated hospitals (3.9% [1.2% to 6.6%]), hospitals with larger bed size (Quartile IV vs. I: 6.2% [0.7% to 11.6%]), and hospitals with greater ratio of Medicaid inpatient days to total inpatient days (Quartile IV vs. I: 4.9% [0.3% to 9.4%]) were more likely to have telepsychiatry than their counterparts. Private non-profit hospitals (- 6.9% [- 11.7% to - 2.0%]) and hospitals in counties designated as whole mental health professional shortage areas (- 6.6% [- 12.7% to - 0.5%]) were less likely to have telepsychiatry. CONCLUSIONS: Prior to the Covid-19 pandemic, telepsychiatry adoption in US hospitals was low with substantial variations by urban and rural status and by state in 2017. This raises concerns about access to psychiatric services and continuity of care for patients discharged from hospitals.


Assuntos
COVID-19 , Telemedicina , Estudos Transversais , Hospitais , Humanos , Pandemias , SARS-CoV-2 , Estados Unidos
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