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1.
Sci Rep ; 14(1): 14976, 2024 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-38951646

RESUMO

Software-defined networking (SDN) is a pioneering network paradigm that strategically decouples the control plane from the data and management planes, thereby streamlining network administration. SDN's centralized network management makes configuring access control list (ACL) policies easier, which is important as these policies frequently change due to network application needs and topology modifications. Consequently, this action may trigger modifications at the SDN controller. In response, the controller performs computational tasks to generate updated flow rules in accordance with modified ACL policies and installs flow rules at the data plane. Existing research has investigated reactive flow rules installation that changes in ACL policies result in packet violations and network inefficiencies. Network management becomes difficult due to deleting inconsistent flow rules and computing new flow rules per modified ACL policies. The proposed solution efficiently handles ACL policy change phenomena by automatically detecting ACL policy change and accordingly detecting and deleting inconsistent flow rules along with the caching at the controller and adding new flow rules at the data plane. A comprehensive analysis of both proactive and reactive mechanisms in SDN is carried out to achieve this. To facilitate the evaluation of these mechanisms, the ACL policies are modeled using a 5-tuple structure comprising Source, Destination, Protocol, Ports, and Action. The resulting policies are then translated into a policy implementation file and transmitted to the controller. Subsequently, the controller utilizes the network topology and the ACL policies to calculate the necessary flow rules and caches these flow rules in hash table in addition to installing them at the switches. The proposed solution is simulated in Mininet Emulator using a set of ACL policies, hosts, and switches. The results are presented by varying the ACL policy at different time instances, inter-packet delay and flow timeout value. The simulation results show that the reactive flow rule installation performs better than the proactive mechanism with respect to network throughput, packet violations, successful packet delivery, normalized overhead, policy change detection time and end-to-end delay. The proposed solution, designed to be directly used on SDN controllers that support the Pyretic language, provides a flexible and efficient approach for flow rule installation. The proposed mechanism can be employed to facilitate network administrators in implementing ACL policies. It may also be integrated with network monitoring and debugging tools to analyze the effectiveness of the policy change mechanism.

2.
Heliyon ; 10(9): e30058, 2024 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-38707407

RESUMO

A concept has been proposed for an installation designed to store excess electricity periodically occurring on the grid. Excess electricity will be used for straw pyrolysis. The main pyrolysis product, gas, will be used to generate electricity using a combustion generator to feed back power into the grid during periods of shortage. The resulting biochar from the pyrolysis can be introduced into the soil to improve soil quality and play a significant role in carbon sequestration. The system uses an electrically heated reactor with a screw conveyor. To preliminarily assess the feasibility of this system, experiments were carried out using wheat straw at temperatures of 300, 400, 500, 600, and 700 °C for the pyrolysis reactor. The resulting gas-to-feedstock mass ratio ranged from 29.04 % at 300 °C to 52.7 % at 700 °C reactor temperature, the biochar mass yield ratio to feedstock varied from 39.41 % to 27.36 % (at 700 °C), and the pyrolysis liquid ranged from 31.55 % to 27.36 % (at 700 °C). The pyrolytic liquid contained a high water content relative to its mass, reaching up to 95.2 % at 700 °C, rendering it less suitable as an energy feedstock. At a reactor temperature of 700 °C, the energy value of the gas produced from the feedstock was twice that of the electricity used for the pyrolysis process. These results suggest the feasibility and operation of the proposed installation.

3.
Sensors (Basel) ; 23(24)2023 Dec 18.
Artigo em Inglês | MEDLINE | ID: mdl-38139755

RESUMO

Efficient deep-water offshore wind power installation platforms with a pressurized self-elevating mat are a new type of equipment used for installing offshore wind turbines. However, the unstable internal pressure of the pressurized self-elevating mat can cause serious harm to the platform. This paper studies the pneumatic control system of the self-elevating mat to improve the precision of its pressure control. According to the pneumatic control system structure of the self-elevating mat, the pneumatic model of the self-elevating mat is established, and a conventional PID controller and fuzzy PID controller are designed and established. It can be seen via Simulink simulation that the fuzzy PID controller has a smaller adjustment time and overshoot, but its anti-interference ability is relatively weak. The membership degree and fuzzy rules of the fuzzy PID controller are optimized using a neural network algorithm, and a fuzzy neural network PID controller based on BP neural network optimization is proposed. The simulation results show that the overshoot of the optimized controller is reduced by 9.71% and the stability time is reduced by 68.9% compared with the fuzzy PID. Finally, the experiment verifies that the fuzzy neural network PID controller has a faster response speed and smaller overshoot, which improves the pressure control accuracy and robustness of the self-elevating mat and provides a scientific basis for the engineering applications of the self-elevating mat.

4.
Mol Cell Pediatr ; 10(1): 18, 2023 Nov 28.
Artigo em Inglês | MEDLINE | ID: mdl-38012334

RESUMO

BACKGROUND: The kidneys of preterm and low birth weight babies reflect vulnerability, since several noxae can evoke the termination of nephron formation. This again leads to oligonephropathy with severe consequences for health in the later life. While the clinical parameters have been intensely investigated, only little is known about the initial traces left by the noxae. For the fetal human kidney, solely the lack of basophilic S-shaped bodies and the reduction in width of the nephrogenic zone were registered. It is not known in how far also the involved progenitor cells, the earlier nephron stages, the collecting duct (CD) ampullae, and the local interstitium are collaterally harmed. AIM: The interstitium at the forming nephron is heterogeneously structured. Thereby, it fulfills quite different mastering and integrative tasks. Since data dealing with the installation of a nephron is not available, the microanatomical features were recorded. RESULTS: The microscopic specimens show that the installation of the transient stages of nephron anlage is not synchronized. Instead, it is controlled within a nephrogenic compartment of the nephrogenic zone. It starts near the renal capsule by positioning the nephrogenic niche so that the nephrogenic progenitor cells face the epithelial progenitor cell at the tip of a CD ampulla. Then, the induced nephrogenic progenitor cells assimilate in the pretubular aggregate. While its medial part remains opposite the head of the CD ampulla, at its proximal end, the primitive renal vesicle is formed. Only a part of it separates to stick to the section border between the head and conus of the CD ampulla. This marks the link with the future connecting tubule at the distal pole of the extending renal vesicle. Meanwhile, the proximal pole is mounted next to the connecting tubule of an earlier developed nephron. The resulting two-point mounting serves a common elongation of the conus at the CD ampulla and the medial aspect of the comma-shaped body. In the S-shaped body, it supports to defoliate the arising glomerulus and to link it with the perforating radiate artery at its deep lateral aspect. CONCLUSIONS: The investigation depicts that the installation is an interactive process between the stages of nephron anlage and its structural neighbors. A special meaning has the interjacent interstitium. It is vital for the positioning, shaping, and physiological integration. Due to its special location, this is mainly exposed to noxae.

5.
Behav Sci (Basel) ; 13(10)2023 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-37887508

RESUMO

In this practice-based case study, we investigate the subjective aesthetic and affective responses to a shift from 2D stereo-based modelling to 3D object-based Dolby Atmos in an audio installation artwork. Dolby Atmos is an infinite object-based audio format released in 2012 but only recently incorporated into more public-facing formats. Our analysis focuses on the artist Sadia Sadia's 30-channel audio installation 'Notes to an Unknown Lover', based on her book of free verse poetry of the same title, which was rebuilt and reformatted in a Dolby Atmos specified studio. We examine what effect altered spatiality with an infinite number of 'placements' has on the psychoacoustic and neuroaesthetic response to the text. The effectiveness of three-dimensional (3D) object-based audio is interrogated against more traditional stereo and two-dimensional (2D) formats regarding the expression and communication of emotion and what effect altered spatiality with an infinite number of placements has on the psychoacoustic and neuroaesthetic response to the text. We provide a unique examination of the consequences of a shift from 2D to wholly encompassing object-based audio in a text-based artist's audio installation work. These findings may also have promising applications for health and well-being issues.

6.
Materials (Basel) ; 16(19)2023 Oct 06.
Artigo em Inglês | MEDLINE | ID: mdl-37834721

RESUMO

BACKGROUND: Although many works focus on increasing the energy efficiency of buildings, there are still a number of problems that need to be solved, such as reducing heat losses at the window-to-wall interface, especially since the requirements for saving energy used for heating/cooling rooms are constantly increasing. This paper analyses the impact of the material parameters of the external wall and the window installation in the insulation layer on the size of thermal bridges around the window. PURPOSE: The aim of the work is to demonstrate the benefits resulting from the correct installation of the window, the appropriate location of the window in relation to the face of the external wall, as well as the correct selection of construction materials. METHODOLOGY: In order to show the improvement in the energy efficiency of buildings, an analysis of the heating/cooling energy consumption was carried out for the selected buildings. The thermal and humidity analyses were carried out using TRISCO program, while the economic analysis was performed using the Audytor OZC program. RESULTS: It was found that the proposed system of window installation in the thermal insulation layer reduced the annual heating demand by at least 10% on average. CONCLUSIONS: It has been shown that the method of window installation and the type of the wall structural materials are interrelated and therefore should be considered simultaneously. Their proper selection allows for a reduction in the amount of energy needed for heating and cooling buildings, and thus a reduction of heating/cooling costs, as well as limiting greenhouse gas emissions.

7.
Sensors (Basel) ; 23(15)2023 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-37571532

RESUMO

Infrared thermography (IRT) is a technique used to diagnose Photovoltaic (PV) installations to detect sub-optimal conditions. The increase of PV installations in smart cities has generated the search for technology that improves the use of IRT, which requires irradiance conditions to be greater than 700 W/m2, making it impossible to use at times when irradiance goes under that value. This project presents an IoT platform working on artificial intelligence (AI) which automatically detects hot spots in PV modules by analyzing the temperature differentials between modules exposed to irradiances greater than 300 W/m2. For this purpose, two AI (Deep learning and machine learning) were trained and tested in a real PV installation where hot spots were induced. The system was able to detect hot spots with a sensitivity of 0.995 and an accuracy of 0.923 under dirty, short-circuited, and partially shaded conditions. This project differs from others because it proposes an alternative to facilitate the implementation of diagnostics with IRT and evaluates the real temperatures of PV modules, which represents a potential economic saving for PV installation managers and inspectors.

8.
Front Psychol ; 14: 1192689, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37529312

RESUMO

Installation art, with its immersive and participatory character, has been argued to require the use and awareness of the body, which potentially constitute key parts of the artwork's experience and appreciation. Heightened body awareness is even argued to be a key to particularly profound emotional or even transformative states, which have been frequently ascribed to this genre. However, the body in the experience of installation art has rarely been empirically considered. To address this gap, we investigated the body's role in the experience of Tomás Saraceno's in orbit installation. Based on a list of self-report items created from a review of the theoretical literature, we-for the first time-captured (quantitatively and qualitatively): what kind of subjective bodily experiences visitors (N = 230) reported, how these items grouped into clusters (using network science), and how these relate to emotion, art appraisal, and transformative outcomes. Network analysis of the items determined four communities related to "interoception," "presence," "disturbance," and "proprioception." Proprioception (e.g., awareness of balance/movement/weight) turned out to be a significant determinant of art appreciation in our study, and, together with "disturbing" body experiences (feeling awkward/watched/chills), coincided with transformation. We also assessed individual differences in body awareness yet did not find that these moderate those relationships. We suggest future research on installation art based on a more unified assessment of the role of the body in embodied-enactive aesthetics and its relation to the intensity and impact of art experience in general.

9.
Traffic Inj Prev ; 24(7): 625-631, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37477419

RESUMO

BACKGROUND: Child restraint systems (CRSs) significantly reduce risk of crash-related injury, however installation and use errors undermine their benefits. The National Highway Traffic Safety Administration (NHTSA) created the Ease of Use (EOU) rating system to help guide consumers and incentivize manufacturers to improve their products. The EOU rating system assigns one to five stars to four CRS features and overall. Our study assessed the relationship between EOU ratings and CRS installation and use errors documented in seat checks conducted by child passenger safety technicians (CPSTs). METHODS: We performed a secondary analysis of data from Safe Kids Illinois seat check records from 2015 through 2019 and EOU ratings from 2008 to 2020. Five types of errors were documented by CPSTs. Study authors (JYL and MLM) used a tiered system to match seat check model numbers to EOU ratings. We calculated chi-square statistics and performed logistic regression analyses to assess for EOU as a predictor of relevant CRS errors (e.g., tether errors for forward-facing CRSs). RESULTS: Our analyses included 2132 seat check observations, of which 217 (10.2%) were exact, 244 (10.5%) were probable, and 1671 (78.4%) were near matches via sorting and web search. Errors were most common for seat belts (70.7%) and least common for recline angle (36.9%). Star ratings for instructions, vehicle installation, and labels were associated with recline angle and seat belt errors. Star ratings for instructions, labels, and securing child were associated with harness errors. CRSs with 4-star and 5-star ratings had lower odds of errors for recline angle (Odds Ratio (OR) 0.62; 95% Confidence Interval (CI): 0.43, 0.89 and OR 0.31; 95% CI: 0.17, 0.56) lower anchors (OR 0.59; 95% CI 0.40, 0.89 and OR 0.38; 95% CI: 0.21, 0.68), and harness (OR 0.56; 95% CI: 0.40, 0.76 and OR 0.19; 95% CI: 0.10, 0.35) when compared with 1 and 2-star CRSs. CONCLUSIONS: This study provides evidence in support of NHTSA's EOU ratings as predictors of some CRS installation and use errors among caregivers who obtain seat checks. A higher star rating may be helpful for caregivers when choosing a CRS that will yield lower installation errors.


Assuntos
Sistemas de Proteção para Crianças , Criança , Humanos , Acidentes de Trânsito , Cintos de Segurança , Illinois , Probabilidade
10.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi ; 40(3): 508-514, 2023 Jun 25.
Artigo em Chinês | MEDLINE | ID: mdl-37380390

RESUMO

The surgical installation accuracy of the components in unicompartmental knee arthroplasty (UKA) is an important factor affecting the joint function and the implant life. Taking the ratio of the medial-lateral position of the femoral component relative to the tibial insert (a/A) as a parameter, and considering nine installation conditions of the femoral component, this study established the musculoskeletal multibody dynamics models of UKA to simulate the patients' walking gait, and investigated the influences of the medial-lateral installation positions of the femoral component in UKA on the contact force, joint motion and ligament force of the knee joint. The results showed that, with the increase of a/A ratio, the medial contact force of the UKA implant was decreased and the lateral contact force of the cartilage was increased; the varus rotation, external rotation and posterior translation of the knee joint were increased; and the anterior cruciate ligament force, posterior cruciate ligament force and medial collateral ligament force were decreased. The medial-lateral installation positions of the femoral component in UKA had little effect on knee flexion-extension movement and lateral collateral ligament force. When the a/A ratio was less than or equalled to 0.375, the femoral component collided with the tibia. In order to prevent the overload on the medial implant and lateral cartilage, the excessive ligament force, and the collision between the femoral component and the tibia, it is suggested that the a/A ratio should be controlled within the range of 0.427-0.688 when the femoral component is installed in UKA. This study provides a reference for the accurate installation of the femoral component in UKA.


Assuntos
Artroplastia do Joelho , Prótese do Joelho , Humanos , Articulação do Joelho/cirurgia , Marcha , Rotação
11.
Poult Sci ; 102(8): 102799, 2023 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-37315427

RESUMO

Passive radio frequency identification (RFID) can advance poultry behavior research by enabling automated, individualized, longitudinal, in situ, and noninvasive monitoring; these features can usefully extend traditional approaches to animal behavior monitoring. Furthermore, since the technology can provide insight into the visiting patterns of tagged animals at functional resources (e.g., feeders), it can be used to investigate individuals' welfare, social position, and decision-making. However, the lack of guidelines that would facilitate implementing an RFID system for such investigations, describing it, and establishing its validity undermines this technology's potential for advancing poultry science. This paper aims to fill this gap by 1) providing a nontechnical overview of how RFID functions; 2) providing an overview of the practical applications of RFID technology in poultry sciences; 3) suggesting a roadmap for implementing an RFID system in poultry behavior research; 4) reviewing how validation studies of RFID systems have been done in farm animal behavior research, with a focus on terminologies and procedures for quantifying reliability and validity; and 5) suggesting a way to report on an RFID system deployed for animal behavior monitoring. This guideline is aimed mainly at animal scientists, RFID component manufacturers, and system integrators who wish to deploy RFID system as an automated tool for monitoring poultry behavior for research purposes. For such a particular application, it can complement indications in classic general standards (e.g., ISO/IEC 18000-63) and provide ideas for setting up, testing, and validating an RFID system and a standard for reporting on its adequacy and technical aspects.


Assuntos
Dispositivo de Identificação por Radiofrequência , Animais , Dispositivo de Identificação por Radiofrequência/métodos , Aves Domésticas , Reprodutibilidade dos Testes , Galinhas , Comportamento Animal
12.
Data Brief ; 48: 109147, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-37128590

RESUMO

We present a new hydrological dataset collected during a field campaign in the Saigon-Dong Nai estuary system, Vietnam. These data include water level and water temperature measurements at five locations along the Saigon river and 2 locations along the Dong Nai river as well as discharge measurements from four 24-hour Acoustic Doppler Current Profiler (ADCP) campaigns at 2 locations in the Saigon river and 1 location in the Dong Nai river. Additionally, water level was barometrically compensated using air pressure measurements. Data were sampled between October 21st, 2022 and December 16th, 2022 and are provided in three processing stages namely, direct measurements as provided by the sensors (raw), barometricaly compensated measurements (pre-processed) and corrected measurements (post-processed). Even though of short duration (about 2 months), this dataset provides water level measurements at unprecedented spatial and temporal resolution in a region where data is scarce and not freely available. The synchronous logging of multiple water level sensors along river provides an opportunity to study profiles of water surface slope and upstream tidal propagation. Furthermore, the concurrent discharge measurements can be used to calibrate hydrological and/or hydraulic models of this estuary system. Additionally, the spatial resolution of this dataset is similar to the prospective measurements that the novel Surface Water and Ocean Topography (SWOT) satellite will provide. Thus, it enables the study of synthetic SWOT measurements to evaluate the future potential of the SWOT satellite over this estuary system.

13.
Sensors (Basel) ; 23(9)2023 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-37177589

RESUMO

With the development of industrial automation, articulated robots have gradually replaced labor in the field of bolt installation. Although the installation efficiency has been improved, installation defects may still occur. Bolt installation defects can considerably affect the mechanical properties of structures and even lead to safety accidents. Therefore, in order to ensure the success rate of bolt assembly, an efficient and timely detection method of incorrect or missing assembly is needed. At present, the automatic detection of bolt installation defects mainly depends on a single type of sensor, which is prone to mis-inspection. Visual sensors can identify the incorrect or missing installation of bolts, but it cannot detect torque defects. Torque sensors can only be judged according to the torque and angel information, but cannot accurately identify the incorrect or missing installation of bolts. To solve this problem, a detection method of bolt installation defects based on multiple sensors is proposed. The trained YOLO (You Only Look Once) v3 network is used to judge the images collected by the visual sensor, and the recognition rate of visual detection is up to 99.75%, and the average confidence of the output is 0.947. The detection speed is 48 FPS, which meets the real-time requirement. At the same time, torque and angle sensors are used to judge the torque defects and whether bolts have slipped. Combined with the multi-sensor judgment results, this method can effectively identify defects such as missing bolts and sliding teeth. Finally, this paper carried out experiments to identify bolt installation defects such as incorrect, missing torque defects, and bolt slips. At this time, the traditional detection method based on a single type of sensor cannot be effectively identified, and the detection method based on multiple sensors can be accurately identified.

14.
Polymers (Basel) ; 15(7)2023 Apr 06.
Artigo em Inglês | MEDLINE | ID: mdl-37050422

RESUMO

Medulloblastoma is a life-threatening disease with poor therapeutic outcomes. In chemotherapy, low drug accumulation has been a cause of these outcomes. Such inadequate response to treatments has been associated with low drug accumulation, particularly with a limited cellular uptake of drugs. Recently, the conjugation of drugs to ligand molecules with high affinity to tumor cells has attracted much attention for enhancing drug internalization into target cells. Moreover, combining tumor-targeting ligands with nano-scaled drug carriers can potentially improve drug loading capacity and the versatility of the delivery. Herein, we focused on the possibility of targeting CD276/B7-H3, which is highly expressed on the medulloblastoma cell membrane, as a strategy for enhancing the cellular uptake of ligand-installed nanocarriers. Thus, anti-CD276 antibodies were conjugated on the surface of model nanocarriers based on polyion complex micelles (PIC/m) via click chemistry. The results showed that the anti-CD276 antibody-installed PIC/m improved intracellular delivery into CD276-expressing medulloblastoma cells in a CD276-dependent manner. Moreover, increasing the number of antibodies on the surface of micelles improved the cellular uptake efficiency. These observations indicate the potential of anti-CD276 antibody-installed nanocarriers for promoting drug delivery in medulloblastoma.

15.
Soins Gerontol ; 28(160): 10-16, 2023.
Artigo em Francês | MEDLINE | ID: mdl-36870758

RESUMO

Liberal geriatrics is not developed in France. However, given the aging of the population and the benefits of specialized care for elderly patients, the increase in this activity could be beneficial. For a liberal activity in geriatrics to be established, it would be necessary to better define the role of the geriatrician in the follow-up of patients, to inform during the studies of this possibility of exercise and that a real adapted nomenclature be put in place.


Assuntos
Geriatria , Idoso , Humanos , Envelhecimento , Geriatras , Prática Privada , França
16.
Micromachines (Basel) ; 14(3)2023 Mar 21.
Artigo em Inglês | MEDLINE | ID: mdl-36985104

RESUMO

As an important deterministic error of the inertial measurement unit (IMU), the installation error has a serious impact on the navigation accuracy of the strapdown inertial navigation system (SINS). The impact becomes more severe in a highly dynamic application environment. This paper proposes a new IMU calibration model based on polar decomposition. Using the new model, the installation error is decomposed into a nonorthogonal error and a misalignment error. The compensation of the IMU calibration model is decomposed into two steps. First, the nonorthogonal error is compensated, and then the misalignment error is compensated. Based on the proposed IMU calibration model, we used a three-axis turntable to calibrate three sets of strapdown inertial navigation systems (SINS). The experimental results show that the misalignment errors are larger than the nonorthogonal errors. Based on the experimental results, this paper proposes a new method to simplify the installation error. This simplified method defines the installation error matrix as an antisymmetric matrix composed of three misalignment errors. The navigation errors caused by the proposed simplified calibration model are compared with the navigation errors caused by the traditional simplified calibration model. The 48-h navigation experiment results show that the proposed simplified calibration model is superior to the traditional simplified calibration model in attitude accuracy, velocity accuracy, and position accuracy.

17.
Environ Monit Assess ; 195(2): 320, 2023 Jan 23.
Artigo em Inglês | MEDLINE | ID: mdl-36689091

RESUMO

Sustainable management of the US Army installations is critical for military training and readiness of forces. However, monitoring military training-induced vegetation cover disturbances using remote sensing data is challenging due to the lack of methodology for optimizing the selection of spectral variables or predictors and spatial modeling methods. This study aimed to propose and demonstrate a methodological solution for this purpose. The study was conducted in the Fort Riley installation in which three training areas were selected to map and monitor the training-induced vegetation cover loss. Sentinel-2 images and field observations of percentage vegetation cover (PVC) were combined at a spatial resolution of 10 m by 10 m to map PVC and its dynamics by comparison of two predictor selection methods and five spatial modeling algorithms based on a total of 304 spectral variables from the images before and after the training. Results showed that overall, the correlation-based predictor selection method reduced the relative root mean square error (RRMSE) of PVC predictions by 4.44% than the random forest (RF)-based predictor selection. Machine learning methods including RF, neural network, and support vector machine overall reduced the RRMSE of PVC predictions by 42.83% compared with multiple linear regression and k-nearest neighbors. Combining correlation-based predictor selection and RF modeling, coupled with leave one out cross validation, provided the greatest potential of increasing the accuracy of monitoring the vegetation cover loss. The findings provided useful implications to develop a near real-time system of monitoring military training-induced vegetation cover loss.


Assuntos
Militares , Tecnologia de Sensoriamento Remoto , Humanos , Tecnologia de Sensoriamento Remoto/métodos , Monitoramento Ambiental/métodos , Imagens de Satélites , Algoritmos
18.
ChemMedChem ; 18(5): e202200651, 2023 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-36585386

RESUMO

Innovations in synthetic chemistry have a profound impact on the drug discovery process, and will always be a necessary driver of drug development. As a result, it is of significance to develop novel simple and effective synthetic installation of medicinal modules to promote drug discovery. Herein, we have developed a NaClO-mediated cross installation of indoles and azoles, both of which are frequently encountered in drugs and natural products. This effective toolbox provides a convenient synthetic route to access a library of N-linked 2-(azol-1-yl) indole derivatives, and can be used for late-stage modification of drugs, natural products and peptides. Moreover, biological screening of the library has revealed that several adducts showed promising anticancer activities against A549 and NCI-H1975 cells, which give us a hit for anticancer drug discovery.


Assuntos
Azóis , Produtos Biológicos , Indóis , Descoberta de Drogas
19.
Proc Nutr Soc ; 82(1): 80-90, 2023 02.
Artigo em Inglês | MEDLINE | ID: mdl-36524548

RESUMO

Changing consumer behaviour has potential benefits for health, the economy and the environment. Change is possible, and behavioural change has been the purpose of much research; nevertheless we can still observe limited success, as in the case of food in public policies or individual diets. One reason is that models driving behavioural change interventions tend to neglect some important contextual factors. The three layers of components that channel behaviour ('installations' in the material, embodied and social realms) are described here and how this channelling can be hacked, modified and leveraged to foster behavioural change. Installations scaffold and control individual and collective behaviour at each step of the behavioural path with their three-layered and partly redundant structure. This redundancy makes the channelling resilient enough to train novices and to guide and repair behaviour. The three layers, physical affordances, embodied competences and social regulation are described in detail. To change eating behaviour, installations must be adapted at all steps of behaviour, from procurement to storage, preparation, meal and disposal. This adaptation can be done through the various layers in an opportunistic way, according to the agency of those who endeavour to change behaviour (e.g. budget, time, political power, etc.) Finally the steps necessary to design behavioural change interventions leveraging installations are listed.


Assuntos
Comportamento do Consumidor , Dieta , Humanos , Comportamento Alimentar
20.
Ann Work Expo Health ; 67(2): 228-240, 2023 02 13.
Artigo em Inglês | MEDLINE | ID: mdl-36269106

RESUMO

OBJECTIVES: Work on offshore petroleum installations may cause exposure to benzene. Benzene is a carcinogenic agent, and exposure among workers should be as low as reasonably practicable. We aimed to assess short-term (less than 60 min) benzene exposure from the most frequent work tasks on offshore installations on the Norwegian continental shelf and identify determinants of exposure. In addition, we aimed to assess the time trend in task-based benzene measurements from 2002 to 2018. METHODS: The study included 763 task-based measurements with a sampling duration of less than 60 min, collected on 28 offshore installations from 2002 to 2018. The measurements were categorized into 10 different tasks. Multilevel mixed-effect Tobit regression models were developed for two tasks: sampling and disassembling/assembling equipment. Benzene source, season, indoors or outdoors, design of process area, year of production start, sampling method, and work operation were considered as potential determinants for benzene exposure in the models. RESULTS: The overall geometric mean (GM) benzene exposure was 0.02 ppm (95% confidence intervals 95%(CI: 0.01-0.04). The pipeline inspection gauge (PIG) operation task was associated with the highest exposure, with a GM of 0.33 ppm, followed by work on flotation cells, disassembling/assembling, and sampling, with GMs of 0.16, 0.04, and 0.01 ppm, respectively. Significant determinants for the disassembling/assembling task were work operation (changing or recertifying valves, changing or cleaning filters, and breaking pipes) and benzene source. For sampling, the benzene source was a significant determinant. Overall, the task-based benzene exposure declined annually by 10.2% (CI 95%: -17.4 to -2.4%) from 2002 to 2018. CONCLUSIONS: The PIG operation task was associated with the highest exposure out of the ten tasks, followed by work on flotation cells and when performing disassembling/assembling of equipment. The exposure was associated with the type of benzene source that was worked on. Despite the decline in task-based exposure in 2002-2018, technical measures should still be considered in order to reduce the exposure.


Assuntos
Exposição Ocupacional , Petróleo , Benzeno/análise , Exposição Ocupacional/análise , Carcinógenos , Noruega
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