Harnessing placebo: Lessons from psychedelic science.

The randomized controlled trial (RCT) research design assumes that a drug's "specific" effect can be isolated, added, and subtracted from the "nonspecific" effect of context and person. While RCTs are helpful in assessing the added benefit of a novel drug, they tend to obscure the curative potential of extra-pharmacological variables, known as "the placebo effect." Ample empirical evidence suggests that person/context-dependent physical, social, and cultural variables not only add to, but also shape drug effects, making them worth harnessing for patient benefits. Nevertheless, utilizing placebo effects in medicine is challenging due to conceptual and normative obstacles. In this article, we propose a new framework inspired by the field of psychedelic science and its employment of the "set and setting" concept. This framework acknowledges that drug and nondrug factors have an interactive and synergistic relationship. From it, we suggest ways to reintegrate nondrug variables into the biomedical toolbox, to ethically harness the placebo effect for improved clinical care.

Revisiting Multifactor Models of Dyslexia: Do They Fit Empirical Data and What Are Their Implications for Intervention?

Developmental dyslexia can be viewed as the result of the effects of single deficits or multiple deficits. This study presents a test of the applicability of a multifactor-interactive model (MFi-M) with a preliminary set of five variables corresponding to different neuropsychological functions involved in the reading process. The model has been tested on a sample of 55 school-age children with developmental dyslexia. The results show that the data fit a model in which each variable contributes to the reading ability in a non-additive but rather interactive way. These findings constitute a preliminary validation of the plausibility of the MFi-M, and encourage further research to add relevant factors and specify their relative weights. It is further discussed how subtype-based intervention approaches can be a suitable and advantageous framework for clinical intervention in a MFi-M perspective.

The Interactive Model of L2 Listening Processing in Chinese Bilinguals: A Multiple Mediation Analysis.

Second language (L2) listening is a common challenge for language learners. It remains largely unknown how bilinguals process L2 listening. The literature has suggested an interactive model of L2 listening processing. However, few studies have examined the model from an experimental approach. The current study tried to provide empirical evidence for the interactive model of L2 listening processing in bilinguals by exploring the relationships among English spoken word segmentation (SWS), cognitive inhibition, cognitive flexibility, and L2 listening proficiency. The results showed positive associations among SWS, cognitive inhibition, cognitive flexibility, and L2 listening proficiency. Mediation analysis suggested that SWS might have a positive influence on L2 listening proficiency both directly and indirectly through cognitive inhibition and cognitive flexibility, respectively. These results imply that both bottom-up (reflected at SWS) and top-down (reflected at cognitive inhibition and flexibility) processes are engaged in bilinguals' L2 listening processing.

Missing links: The functional unification of language and memory (L∪M).

The field of neurocognition is currently undergoing a significant change of perspective. Traditional neurocognitive models evolved into an integrative and dynamic vision of cognitive functioning. Dynamic integration assumes an interaction between cognitive domains traditionally considered to be distinct. Language and declarative memory are regarded as separate functions supported by different neural systems. However, they also share anatomical structures (notably, the inferior frontal gyrus, the supplementary motor area, the superior and middle temporal gyrus, and the hippocampal complex) and cognitive processes (such as semantic and working memory) that merge to endorse our quintessential daily lives. We propose a new model, "L∪M" (i.e., Language/union/Memory), that considers these two functions interactively. We fractionated language and declarative memory into three fundamental dimensions or systems ("Receiver-Transmitter", "Controller-Manager" and "Transformer-Associative" Systems), that communicate reciprocally. We formalized their interactions at the brain level with a connectivity-based approach. This new taxonomy overcomes the modular view of cognitive functioning and reconciles functional specialization with plasticity in neurological disorders.

An Interactive Model among Potential Human Risk Factors: 331 Cases of Coal Mine Roof Accidents in China.

In order to explore optimal strategies for managing potential human risk factors, this paper developed an interactive model among potential human risk factors based on the development processes of accidents. This model was divided into four stages, i.e., risk latency stage, risk accumulation stage, risk explosion stage and risk residue stage. Based on this model, this paper analyzed risk management procedures and relevant personal's responsibility in each stage, and then probed into the interactive mechanism among human risk factors in three aspects, i.e., knowledge, information and communication. The validity and feasibility of the model was validated by analyzing a coal mine roof accident in China. In addition, the contribution of different functional levels' personnel in risk evolution was discussed. It showed that this model can effectively reveal the interactive mechanism of potential human risk factors, and can thus give significant insights into the development of risk management theories and practices. It also proves that the contribution of different functional levels' personnel in the model is different. This can further help practitioners design enhanced Behavioral-Based Safety (BBS) intervention approaches which can have a more sustainable and persistent impact on corporate personnel's safety behavior. Specific recommendations and suggestions are provided fundamentally for future BBS practices in the coal mine industry.

A Location-Based Interactive Model of Internet of Things and Cloud (IoT-Cloud) for Mobile Cloud Computing Applications.

This paper presents a location-based interactive model of Internet of Things (IoT) and cloud integration (IoT-cloud) for mobile cloud computing applications, in comparison with the periodic sensing model. In the latter, sensing collections are performed without awareness of sensing demands. Sensors are required to report their sensing data periodically regardless of whether or not there are demands for their sensing services. This leads to unnecessary energy loss due to redundant transmission. In the proposed model, IoT-cloud provides sensing services on demand based on interest and location of mobile users. By taking advantages of the cloud as a coordinator, sensing scheduling of sensors is controlled by the cloud, which knows when and where mobile users request for sensing services. Therefore, when there is no demand, sensors are put into an inactive mode to save energy. Through extensive analysis and experimental results, we show that the location-based model achieves a significant improvement in terms of network lifetime compared to the periodic model.

An Efficient Interactive Model for On-Demand Sensing-As-A-Servicesof Sensor-Cloud.

This paper proposes an efficient interactive model for the sensor-cloud to enable the sensor-cloud to efficiently provide on-demand sensing services for multiple applications with different requirements at the same time. The interactive model is designed for both the cloud and sensor nodes to optimize the resource consumption of physical sensors, as well as the bandwidth consumption of sensing traffic. In the model, the sensor-cloud plays a key role in aggregating application requests to minimize the workloads required for constrained physical nodes while guaranteeing that the requirements of all applications are satisfied. Physical sensor nodes perform their sensing under the guidance of the sensor-cloud. Based on the interactions with the sensor-cloud, physical sensor nodes adapt their scheduling accordingly to minimize their energy consumption. Comprehensive experimental results show that our proposed system achieves a significant improvement in terms of the energy consumption of physical sensors, the bandwidth consumption from the sink node to the sensor-cloud, the packet delivery latency, reliability and scalability, compared to current approaches. Based on the obtained results, we discuss the economical benefits and how the proposed system enables a win-win model in the sensor-cloud.

Digital dissection - using contrast-enhanced computed tomography scanning to elucidate hard- and soft-tissue anatomy in the Common Buzzard Buteo buteo.

Gross dissection has a long history as a tool for the study of human or animal soft- and hard-tissue anatomy. However, apart from being a time-consuming and invasive method, dissection is often unsuitable for very small specimens and often cannot capture spatial relationships of the individual soft-tissue structures. The handful of comprehensive studies on avian anatomy using traditional dissection techniques focus nearly exclusively on domestic birds, whereas raptorial birds, and in particular their cranial soft tissues, are essentially absent from the literature. Here, we digitally dissect, identify, and document the soft-tissue anatomy of the Common Buzzard (Buteo buteo) in detail, using the new approach of contrast-enhanced computed tomography using Lugol's iodine. The architecture of different muscle systems (adductor, depressor, ocular, hyoid, neck musculature), neurovascular, and other soft-tissue structures is three-dimensionally visualised and described in unprecedented detail. The three-dimensional model is further presented as an interactive PDF to facilitate the dissemination and accessibility of anatomical data. Due to the digital nature of the data derived from the computed tomography scanning and segmentation processes, these methods hold the potential for further computational analyses beyond descriptive and illustrative proposes.

Application of the interactive model in the context of individualism and collectivism / Aplicação do modelo interativo no contexto do individualismo e coletivismo

The objective of the present study was to apply the Interactive Model methodology to the Individualism-Collectivism:Horizontal and Vertical Models to better understand the last model. The sample consisted of 271 individuals and theIdiocentric-Allocentric Athlete Profile Inventory was used. Multiple analyses of variance revealed that when theconstructs become polarized, as in the Idiocentric supremacy, greater are the individual needs for differentiation fromothers, success and achievement. As the constructs get balanced, the individuals tend to present more egalitarian attitudes,and allocentric individuals seek benefits for the group, submission and hierarchy. In conclusion, one can infer that as thefields of idiocentrism and allocentrism become more distant from the bisector, the vertical dominion increases(hierarchy), while a greater proximity with the bisector favors the horizontal dominion (equality). These areas don’treflect the predominance or not of one construct over the other anymore. (AU)

O objetivo deste estudo foi aplicar a metodologia do Modelo Interativo no modelo do Individualismo-Coletivismo:Horizontal e Vertical para melhor entender este último modelo. A amostra foi composta por 271 indivíduos e foi utilizadoo Inventário de Perfil Idiocêntrico-Alocêntrico para Atletas. Múltiplas análises de variância revelaram que quando osconstrutos tornam-se polarizados, como na supremacia idiocêntrica, mais os indivíduos necessitam dieferenciar-se dosdemais, buscando sucesso e realização. Quando os construtos tornam-se equilibrados, os indivíduos tendem a apresentaratitudes igualitárias e os indivíduos alocêntricos buscam o benefício do grupo, submisão e hierarquia. Em conclusão,pode-se inferir que quando os campos do idiocentrismo e alocentrismo tornam-se mais distantes da bissetriz, o domíniovertical aumenta (hierarquia) e a maior proximidade da bissetriz favorece o domínio horizontal (igualdade). Essesdomínios não mais refletem a predominância ou não de um construto sobre o outro. (AU)

Application of the interactive model in the context of individualism and collectivism / Aplicação do modelo interativo no contexto do individualismo e coletivismo

The objective of the present study was to apply the Interactive Model methodology to the Individualism-Collectivism:Horizontal and Vertical Models to better understand the last model. The sample consisted of 271 individuals and theIdiocentric-Allocentric Athlete Profile Inventory was used. Multiple analyses of variance revealed that when theconstructs become polarized, as in the Idiocentric supremacy, greater are the individual needs for differentiation fromothers, success and achievement. As the constructs get balanced, the individuals tend to present more egalitarian attitudes,and allocentric individuals seek benefits for the group, submission and hierarchy. In conclusion, one can infer that as thefields of idiocentrism and allocentrism become more distant from the bisector, the vertical dominion increases(hierarchy), while a greater proximity with the bisector favors the horizontal dominion (equality). These areas don’treflect the predominance or not of one construct over the other anymore.

O objetivo deste estudo foi aplicar a metodologia do Modelo Interativo no modelo do Individualismo-Coletivismo:Horizontal e Vertical para melhor entender este último modelo. A amostra foi composta por 271 indivíduos e foi utilizadoo Inventário de Perfil Idiocêntrico-Alocêntrico para Atletas. Múltiplas análises de variância revelaram que quando osconstrutos tornam-se polarizados, como na supremacia idiocêntrica, mais os indivíduos necessitam dieferenciar-se dosdemais, buscando sucesso e realização. Quando os construtos tornam-se equilibrados, os indivíduos tendem a apresentaratitudes igualitárias e os indivíduos alocêntricos buscam o benefício do grupo, submisão e hierarquia. Em conclusão,pode-se inferir que quando os campos do idiocentrismo e alocentrismo tornam-se mais distantes da bissetriz, o domíniovertical aumenta (hierarquia) e a maior proximidade da bissetriz favorece o domínio horizontal (igualdade). Essesdomínios não mais refletem a predominância ou não de um construto sobre o outro.

O perfil psicológico de atletas baseado na teoria do individualismo e do coletivismo / The athletes psychological profile based on individualism and collectivism theory / El perfil psicológico de atletas basado em la teoria del individualismo y del colectivismo

O objetivo deste trabalho foi avaliar o perfil psicológico de atletas, classificados em grupos tipológicos segundo a teoria do Individualismo-Coletivismo. O Modelo Interativo foi utilizado como metodologia para a classificação das atletas em grupos tipológicos. Participaram do estudo 274 atletas universitários. Foram utilizados os inventários Perfil I-A, IFEGA e o IMEGA. Análises descritivas e inferenciais (Manova) foram realizadas. Os resultados demonstraram que o grupo Heteroidiocêntrico orienta-se para as metas pessoais, buscam a auto-realização, poder e fama. Os Heteroalocêntricos tendem a ser mais sensíveis ao contexto social e prestam mais atenção às necessidades dos outros e os Isocêntricos apresentam traços tanto do idiocentrismo quanto do alocentrismo, o que resulta em atitudes igualitárias. Conclui-se que todos os grupos apresentam perfis ideais, os quais podem se adequar melhor para determinadas modalidades esportivas, em situações específicas do jogo e em diferentes posições em quadra.(AU)

The Athlete’s Psychological Profile Based on Individualism and Collectivism TheoryThe purpose of this study was to evaluate the athlete’s psychological profile classified in typological groups based on Individualism-Collectivism theory. The Interactive Model’s methodology was used to classify the athletes in typological groups. The sample was composed by 274 athletes. It were used Perfil I-A, IFEGA and IMEGA inventories. Descriptive and inferential analyses (Manova) were performed. The results showed that the Heteroidiocentric group is self oriented, searching for self-realization, power and fame. The Heteroalocentric group tends to be more sensitive to social context and pay more attention to the needs of others and the Isocentrics showed both Idiocentric and Alocentric traits, which results in egalitarian attitudes. In conclusion, all groups have ideal profiles that can be better adjusted in specific sports, in specific situations during the game and in to different play positions.(AU)

El Perfil Psicológico de Atletas basado em la Teoria del Individualismo Y del ColectivismoEL objetivo de este trabajo fue evaluar el perfil psicológico de atletas, clasificados en grupos tipológicos según la teoria del Individualismo-Colectivismo. El Modelo Interactivo fue utilizado como metodologia para la clasificación de las atletas en grupos tipológicos. Participaron del estudio 274 atletas universitários. Fueron utilizados los inventários Perfil I-A, IFEGA y el IMEGA. Análisis descriptivas y diferenciales (Manova) fueron realizadas. Los resultados demostraron que el grupo Heteroidiocêntrico se orienta para las metas personales, buscan la auto-realización, poder y fama. Los Heteroalocêntricos tienden a ser mas sensibles al contexto social y prestan mas atención a lasnecesidades de los otros y los Isocêntricos presentan trazos tanto del idiocentrismo cuanto del alocentrismo, lo que resulta en actitudes igualitárias.Se Concluye que todos los grupos presentan perfiles ideales, los cuales puedenadecuarse mejor para determinados desportes, en situaciones específicas de juego y en diferentes posiciones en cuadra.(AU)

The psychological synthesis evaluated by the interactive model / A síntese psicológica avaliada pelo modelo interativo

The purpose of this article was to elaborate a model to evaluate the synthesis process resulting from the interaction which is established between opposing constructs, like gender schemas. In social psychology, the existence of opposites is possible to be detecting in contemporary theories, such as individualism versus collectivism and masculinity versus femininity. In all these themes, opposites assume both an oppositional and complementary attitude, but little relevance has been given to the process of synthesis. The Interactive Model was elaborated in an attempt to mathematically express the synthesis process and open up the possibility of studying human personality from a new perspective - the Psychological Synthesis.

O propósito deste estudo foi elaborar um modelo para avaliar o processo de síntese resultante da interação que se estabelece entre constructos com naturezas opostas, como os esquemas de gênero. Em psicologia social, a existência dos opostos pode ser detectada em teorias contemporâneas, tais como: individualismo versus coletivismo e masculinidade versus feminilidade. Em todos estes temas, os opostos assumem tanto uma postura de oposição quanto uma postura complementar, mas pouca relevância tem sido dada ao processo de síntese. O Modelo Interativo foi elaborado na tentativa de expressar matematicamente este processo de síntese, e abre a possibilidade de se estudar a personalidade a partir de uma nova perspectiva - a Síntese Psicológica.

The psychological synthesis evaluated by the interactive model / A síntese psicológica avaliada pelo modelo interativo

The purpose of this article was to elaborate a model to evaluate the synthesis process resulting from the interaction which is established between opposing constructs, like gender schemas. In social psychology, the existence of opposites is possible to be detecting in contemporary theories, such as individualism versus collectivism and masculinity versus femininity. In all these themes, opposites assume both an oppositional and complementary attitude, but little relevance has been given to the process of synthesis. The Interactive Model was elaborated in an attempt to mathematically express the synthesis process and open up the possibility of studying human personality from a new perspective - the Psychological Synthesis.(AU)

O propósito deste estudo foi elaborar um modelo para avaliar o processo de síntese resultante da interação que se estabelece entre constructos com naturezas opostas, como os esquemas de gênero. Em psicologia social, a existência dos opostos pode ser detectada em teorias contemporâneas, tais como: individualismo versus coletivismo e masculinidade versus feminilidade. Em todos estes temas, os opostos assumem tanto uma postura de oposição quanto uma postura complementar, mas pouca relevância tem sido dada ao processo de síntese. O Modelo Interativo foi elaborado na tentativa de expressar matematicamente este processo de síntese, e abre a possibilidade de se estudar a personalidade a partir de uma nova perspectiva - a Síntese Psicológica.(AU)