Analysis of demand and influencing factors for smart senior care among older adults in underdeveloped regions of western China: a case study of Lanzhou.

Introduction: With the rapid development of artificial intelligence and Internet-of-Things technology, internal support systems among families are gradually weakening, which can no longer satisfy the current demands of older adults. In this context, smart senior care has become a new development direction. However, existing studies on the demand for smart senior care are primarily concentrated in economically developed provinces and mega-cities in eastern China; their research results or conclusions may not apply to underdeveloped areas in the Western region. Therefore, our study selects Lanzhou as a representative city in an underdeveloped western region to investigate the demand of older adults for smart senior care and analyze the influencing factors. Methods: This cross-sectional study included 4,815 older adults from Lanzhou, China. A structured questionnaire was designed to investigate the demands of the older adults for smart senior care and analyze thie influencing factors. The Chi-square test was used for single factor analysis of each variable. The logistic regression model included the statistically significant variables to analyze factors influencing older adults' demand for smart senior care. A significance level of p < 0.05 was considered statistically significant. Results: Among the surveyed older adults, 1,625 (33.75%) expressed a demand for smart senior care. The finding indicated that participants' age, level of education, marital status, monthly income, number of children, type of endowment insurance, and knowledge of smart senior care were significantly associated with their demands for smart senior care (p < 0.05). Notably, medical care emerged as the smart senior care service with the highest demand rate (79.45%). Conclusion: In Lanzhou, older adults show a low level of knowledge but a high demand for smart senior care. Their demand is influenced by personal, family, health conditions, senior care security, and other factors. To advance smart senior care, government departments should accelerate the improvement of the laws and regulations on smart senior care while vigorously enhancing the service's publicity to raise knowledge about it. Additionally, the service contents for smart senior care should be expanded to meet the diversified demands of older adults.

[Spatiotemporal Response of Ecosystem Service Value to Land Use Change in the Lanzhou-Xining Urban Agglomeration over the Past 20 Years].

With rapid urbanization and human activities exacerbating threats to the degradation of various ecosystem services in modern urban agglomerations, the exploration of the state of ecological security at the scale of urban agglomerations is of great significance. This study considered the Lanzhou-Xining Urban Agglomeration as the research area, based on the land use data in 2000, 2005, 2010, 2015, and 2020. At the same time, the landscape ecological risk index was introduced. The land use change characteristics of the Lanzhou-Xining Urban Agglomeration were analyzed by using the land use transfer matrix, the value per unit area equivalent factor method, and the bivariate spatial autocorrelation analysis method to elucidate the impacts of the changes in the ecological risk index induced by the land use transition on the value of ecosystem services. This study analyzed the land use change characteristics of the Lanzhou-Xining Urban Agglomeration and elucidated the impacts of changes in the ecological risk index on the value of ecosystem services caused by land use transformation. The results showed that:① During the period from 2000 to 2020, the land use types of the Lanzhou-Xining Urban Agglomeration were mainly dominated by grassland, cropland, and forest land. The construction land area had expanded significantly mainly from cropland and grassland, and the six land use types had strong cross-transformation. The total area of land use change was 6 646.05 km2. ② In terms of spatial changes, the spatial pattern of ecosystem service value in the Lanzhou-Xining Urban Agglomeration had not undergone obvious transformation. However, the regional variability was significant, generally showing the distribution characteristics of high in the northwest and low in the southeast. ③From the perspective of temporal change, the value of ecosystem services in the Lanzhou-Xining Urban Agglomeration showed an upward trend, with the total flow of value increasing from 186.459 billion yuan to 192.156 billion yuan, with a total value-added of 5.697 billion yuan. ④ There was a rising trend in the overall ecological risk index of the Lanzhou-Xining Urban Agglomeration over the past 20 years. Low ecological risk areas and lower ecological risk areas dominated the ecological risk areas. There was a significant positive correlation between the value of ecosystem services and the ecological risk index. This study aimed to reveal the understanding of the impacts of land-use practices on ecosystem service values and ecological risks, to provide important references for regional ecological risk management and land-use policy formulation, and thus to promote the high-quality development of the ecological environment in the Yellow River Basin.

Pollution characteristics, source apportionment, and health risk assessment of PM10 and PM2.5 in rooftop and kerbside environment of Lanzhou, NW China.

To investigate air pollution in the kerbside environment and its associated human health risks, a study was conducted in Lanzhou during December 2018, as well as in April, June, and September 2019. The research aimed to characterize the composition of PM10 and PM2.5, including elements, ions, and carbonaceous components, at both rooftop and kerbside locations. Additionally, source apportionment and health risk assessment were conducted. The results showed that the average mass concentrations of PM10 on the rooftop were 176.01 ± 83.23 µg/m3, and for PM2.5, it was 94.07 ± 64.89 µg/m3. The PM10 and PM2.5 levels at the kerbside are 2.21 times and 1.79 times, respectively, greater than those on the rooftop. Moreover, the concentrations of elements, ions, and carbonaceous components in kerbside PM were higher than those at the rooftop location. Chemical mass closure analysis identified various sources, including organic matter, mineral dust, secondary ions, other ions, elements, and other components. In comparison to rooftop particulate matter (PM), mineral dust makes a more substantial contribution to kerbside PM. Secondary ions show an opposite trend, making a greater contribution to rooftop PM. The contribution of organic components within PM of the same particle size remains relatively consistent. The outcome of the health risk assessment indicates that Co, Cd, and As in PM within the kerbside and rooftop environments do not pose a notable carcinogenic risk. However, Al and Mn do present specific non-carcinogenic risks, particularly in the kerbside environment. Furthermore, children experience elevated non-carcinogenic risk compared to adults. These findings can serve as a scientific foundation for formulating policies within the local health department.

Influence of atmospheric oxidation capacity on atmospheric particulate matters concentration in Lanzhou.

The atmospheric oxidation capacity (AOC) reflects the removal rate of atmospheric pollutants, and this index is typically characterized by the oxidant concentration or total reaction rate. The AOC plays a crucial role in the formation of atmospheric particulate matters and serves as an important indicator for studying changes in the concentration. In this study, we analyse the characteristics of atmospheric oxidants in Lanzhou based on data in the year of 2020 and 2021 retrieved from the Atmospheric Comprehensive Observation Station in Lanzhou. Empirical equations are applied to estimate the impact of atmospheric oxidative properties secondary generation concentrations of atmospheric particulate matters with different particle sizes. The results indicate that the annual average values of Ox were 146 µg/m3 in 2020 and 139 µg/m3 in 2021. The AOC was the highest in summer and lowest in winter. The correlation coefficient between O3 and Ox was significantly higher than that between NO2 and Ox, suggesting that O3 exerted a greater impact on the AOC in Lanzhou. A low AOC (MDA8 O3 ≤ 100 µg/m3) promoted the oxidation process of VOCs and other precursors, leading to the generation of secondary aerosols and subsequent formation of secondary particles. There were negative correlations between Ox and atmospheric particulate matters, secondary inorganic components, sulfur oxidation ratio (SOR) and nitrogen oxidation ratio (NOR), indicating that excessively high levels of Ox could inhibit the conversion rate of SO2 and NO2 into their respective forms to a certain extent.

Fine structure and hypoglycemic effect of a galactoglucan from the bulbs of Lanzhou lily.

The present research aimed to further identify the fine structure, morphology, and thermal behaviors of a galactoglucan BHP-2 derived from Lanzhou lily bulbs through partial acid hydrolysis, methylation, 2D NMR (1H1H COSY, HSQC, and HMBC), scanning electron microscopy (SEM) and thermogravimetric-differential thermal analysis (TG-DTA). Additionally, the study assessed the potential in vitro hypoglycemic effect of BHP-2 by examining its inhibitory effect on α-glucosidase and α-amylase. The results indicated that the main backbone composition of BHP-2 consisted of →4)-α-D-Glcp-(1→, →3)-ß-D-Glcp-(1 â†’ and →6)-ß-D-Galp-(1→, while the side chain composition predominantly featured →4)-α-D-Glcp-(1→, →3,5)-α-L-Araf-(1 â†’ and →3)-ß-D-Galp-(1→, attached to the C-2 and/or C-3 positions of →4)-α-D-Glcp-(1→. Terminal residues consisted of α-D-Glcp-(1 â†’ and ß-L-Araf-(1→. BHP-2 exhibited excellent thermal stability, with a microscopic surface characterized by tightly packed sheets and numerous spiral depressions, which might contribute to its remarkable in vitro hypoglycemic effect. BHP-2 showed competitive inhibition of α-amylase and mixed non-competitive inhibition of α-glucosidase, with respective IC50 values of 0.31 and 0.18 mg/mL, closely resembling to those of acarbose (0.27 and 0.12 mg/mL). These findings suggested that BHP-2 had potential as an additive for glycemic intervention.

Isolation and Identification of Pathogens Causing Blue Mold of Lanzhou Lily during Postharvest Storage and Control of Disease and Mycotoxin Accumulation by Ozone Treatment.

Blue mold (penicilliosis) is a common disease of Lanzhou lily (Lilium davidii var. willmottiae) during postharvest storage, which not only seriously affects the appearance and reduces the quality of lily bulbs, but also leads to the accumulation of mycotoxins in rotten lily tissues, seriously endangering human health. Therefore, it is of great significance to clarify the main isolates causing postharvest blue mold of fresh Lanzhou lily and put forward effective measures to control the disease caused by these pathogens. In this study, pathogens were isolated and purified from the naturally diseased blue-mold tissue of Lanzhou lily, and then morphological and molecular biology techniques were applied to identify the isolates, verify the pathogenicity, determine the disease index and disease incidence, and finally, to analyze the control effect of ozone treatment on the blue mold of lily scale and mycotoxin accumulation. The results indicated that the main isolates causing postharvest blue mold of lily were Talaromyces adpressus, Penicillium gladioli, T. calidominioluteus, and P. polonicum. The pathogenicity test showed that P. gladioli and P. polonicum had a higher disease index than T. calidominioluteus and T. adpressus. Ozone treatment significantly reduced the incidence of disease caused by P. gladioli and P. polonicum, and effectively controlled the accumulation of patulin. This study characterized the main pathogens causing blue mold of postharvest Lanzhou lily during storage, and confirmed ozone application has a significant inhibitory effect on blue mold development and patulin accumulation in Lanzhou lily, which could be helpful in commercially controlling blue mold of postharvest Lanzhou lily during storage.

Ambient carbon monoxide and relative risk of daily hospital outpatient visits for respiratory diseases in Lanzhou, China.

At present, evidence of the associations between carbon monoxide (CO) and respiratory diseases (RD) in Northwest China is limited and controversial. The aim of this study is to evaluate the impact of ambient CO on outpatient visits for RD in Lanzhou, China. The daily amount of outpatient visits for total and cause-specific RD, air pollutant, and weather variables were collected in Lanzhou, China from 1st January 2013 to 31st December 2019. A generalized additive model and distributed lag nonlinear model were used to assess associations between CO and outpatient visits for RD. During the study period, a total of 1,623,361 RD outpatient visits were recorded. For each interquartile range (IQR) (0.77 mg/m3) increase in CO, the relative risk (RR) was 1.163 (95% CI: 1.138, 1.188) for total RD at lag07, 1.153 (95% CI: 1.128,1.179) for upper respiratory tract infection (URTI) at lag07, 1.379 (95% CI: 1.338,1.422) for pneumonia at lag07, 1.029 (95% CI: 0.997,1.062) for chronic obstructive pulmonary disease (COPD) lag04, 1.068 (95% CI: 1.028,1.110) for asthma lag03, and 1.212 (95% CI: 1.178,1.247) for bronchitis lag07, respectively. In the subgroup analyses, the impacts of CO were more pronounced on total RD, pneumonia, COPD, and bronchitis in males than females, while the opposite was true in URTI and asthma. The impact of CO on RD was the strongest for children under 15 years-of-age. We also found significantly stronger effects during cold seasons compared to warm seasons. In addition, we observed a roughly linear exposure-response curve between CO and RD with no threshold effect. This study in Lanzhou revealed a remarkable association between CO level and an elevated risk of total and cause-specific RD outpatient visits, especially for pneumonia.

Ambient carbon monoxide and the risk of cardiovascular disease emergency room visits: a time-series study in Lanzhou, China.

Until now, the epidemiological evidence on the association between short-term exposure to ambient carbon monoxide (CO) and cardiovascular diseases (CVDs) is relatively lacking and controversial. This study aims to examine the relationship between ambient CO and daily emergency room visits (ERVs) for total and cause-specific CVD in Lanzhou, China. A distributed lag nonlinear model was used to examine the association. For every 1 mg/m3 increase in the CO concentration, the relative risks of daily ERVs were 1.041 (95% CI: 1.017, 1.065) for total CVD, 1.065 (95% CI: 1.018, 1.114) for ischemic heart disease (IHD), 1.083 (95% CI: 1.020, 1.149) for heart rhythm disturbances (HRD), 1.062 (95% CI: 1.011, 1.115) for heart failure (HF), and 1.057 (95% CI: 1.017, 1.098) for cerebrovascular diseases (CD). For the two different gender subgroups, the short-term impact of CO on total CVD, IHD, and CD was relatively stronger for the females than for the males, while the opposite was true for HRD and HF. In the age subgroup analyses, the effect of ambient CO on total CVD and IHD appeared to be greater for the age ≥ 65 years group, while the opposite was true for HRD, HF, and CD. The associations for all disease categories were stronger in cold seasons than in warm seasons. We also observed a nearly linear correlation between CO and CVD ERVs. In conclusion, the study showed that exposure to ambient CO may increase the risks of ERVs for total and cause-specific CVD. Besides, CO-ERVs associations may vary by gender and age.

Associations between air pollution and outpatient visits for allergic rhinitis in Lanzhou, China.

There is emerging evidence indicating that short-term exposure to air pollution is associated with the development and occurrence of allergic rhinitis (AR), but limited studies have been conducted in China, and their results were inconsistent. So, quasi-Poisson time series regressions with distributed lag non-linear models (DLNM) were applied to evaluate the lag association between six air pollutants and daily outpatient visits for AR in Lanzhou, China, from January 1, 2014, to December 31, 2019. Stratified analyses were further performed by gender, age, and season. Overall, we found that short-term exposure to air pollutants including PM2.5, PM10, SO2, NO2, O38h, and CO was significantly associated with an increased risk of AR outpatient visits. The strongest associations were observed at a lag of 0-7 days for PM2.5 (relative risk [RR] = 1.035, 95% confidence intervals [CI]: 1.019-1.052), PM10 (RR = 1.006, 95% CI: 1.002-1.011), at a lag of 0-2 days for SO2 (RR = 1.048, 95% CI: 1.017-1.081), NO2 (RR = 1.025, 95% CI: 1.010-1.041), at a lag of 0-6 days for O38h (RR = 1.028, 95% CI: 1.016-1.041), and at a lag of 0-7 days for CO (RR = 1.128, 95% CI: 1.054-1.206). Stratified analyses indicated that males and adults (15-59 years old) appeared to be more sensitive to PM2.5, SO2, NO2, O38h, and CO exposure than females and those in other age groups. The effect of CO exposure was statistically significant in all subgroups. Associations between PM2.5, PM10, NO2, and O38h and AR outpatients were more pronounced in the warm season than in the cold season. The influences of PM2.5, PM10, SO2, NO2, O38h, and CO were found to be significantly relevant to AR-associated outpatient. Different pollutants played different roles for different genders, ages, and seasons.

Enhancing heat stress tolerance in Lanzhou lily (Lilium davidii var. unicolor) with Trichokonins isolated from Trichoderma longibrachiatum SMF2.

Lanzhou lily (Lilium davidii var. unicolor) is a renowned edible crop produced in China and relatively sensitive to high temperature (HT). Trichokonins (TKs) are antimicrobial peptaibols secreted from Trichoderma longibrachiatum strain SMF2. Here, we report that TKs application improves the thermotolerance of Lanzhou lily. The activity of the antioxidant enzyme system (SOD, CAT, and POD), the level of heat-resistance-associated phytohormones (ABA, SA, and JA), the relative water content (RWC), the content of chlorophyll (Chl), and the net photosynthetic rate (P n) were promoted by TKs treatment in Lanzhou lily plants subjected to heat stress (HS). TKs treatment also mitigated cell injury as shown by a lower accumulation of malondialdehyde (MDA) and relative electrolyte leakage (REL) under HS conditions. RNA-seq data analysis showed that more than 4.5 times differentially expressed genes (DEGs) responded to TKs treatment under HS compared to non-HS, and TKs treatment reduced protein folding and enhanced cellular repair function under HS conditions. The analyses of DEGs involved in hormone (ABA, SA and JA) synthesis and signaling pathways suggested that TKs might improve Lanzhou lily heat tolerance by promoting ABA synthesis and signal transduction. TKs highly induced DEGs of the HSF-HSP pathway under HS, in which HSFA2 accounted for most of the HSF family. Furthermore, TKs treatment resulted in the upregulation of heat-protective genes LzDREB2B, LzHsfA2a, LzMBF1c, LzHsp90, and LzHsp70 involved in HSF-HSP signal pathway after long-term HS. LzHsfA2a-1 likely plays a key role in acquisition of TKs-induced thermotolerance of Lanzhou lily as evidenced by the sustained response to HS, the enhanced response to TKs treatment under long-term HS, and the high sequence similarity to LlHsfA2a which is a key regulator for the improvement of heat tolerance in Lilium longiflorum. Our results reveal the underlying mechanisms of TKs-mediated thermotolerance in Lanzhou lily and highlight an attractive approach to protecting crop plants from damage caused by HS in a global warming future.

How does COVID-19 lockdown affect air quality: Evidence from Lanzhou, a large city in Northwest China.

Coronavirus disease (COVID-19) has disrupted health, economy, and society globally. Thus, many countries, including China, have adopted lockdowns to prevent the epidemic, which has limited human activities while affecting air quality. These affects have received attention from academics, but very few studies have focused on western China, with a lack of comparative studies across lockdown periods. Accordingly, this study examines the effects of lockdowns on air quality and pollution, using the hourly and daily air monitoring data collected from Lanzhou, a large city in Northwest China. The results indicate an overall improvement in air quality during the three lockdowns compared to the average air quality in the recent years, as well as reduced PM2.5, PM10, SO2, NO2, and CO concentrations with different rates and increased O3 concentration. During lockdowns, Lanzhou's "morning peak" of air pollution was alleviated, while the spatial characteristics remained unchanged. Further, ordered multi-classification logistic regression models to explore the mechanisms by which socioeconomic backgrounds and epidemic circumstances influence air quality revealed that the increment in population density significantly aggravated air pollution, while the presence of new cases in Lanzhou, and medium- and high-risk areas in the given district or county both increase the likelihood of air quality improvement in different degrees. These findings contribute to the understanding of the impact of lockdown on air quality, and propose policy suggestions to control air pollution and achieve green development in the post-epidemic era.

Concentrations and light absorption properties of PM2.5 organic and black carbon based on online measurements in Lanzhou, China.

To elucidate the variations in mass concentrations of organic carbon (OC) and black carbon (BC) in PM2.5 and their light absorption characteristics in Lanzhou, we conducted one-year online measurements by using a newly developed total carbon analyzer (TCA08) coupled with an aethalometer (AE33) from July 2018 to July 2019. The mean OC and BC concentrations were 6.4 ± 4.4 and 2.0 ± 1.3 µg/m3, respectively. Clear seasonal variations were observed for both components, with winter having the highest concentrations, followed by autumn, spring, and summer. The diurnal variations of OC and BC concentrations were similar throughout the year, with daily two peaks occurring in the morning and evening, respectively. A relatively low OC/BC ratio (3.3 ± 1.2, n = 345) were observed, indicating that fossil fuel combustion was the primary source of the carbonaceous components. This is further substantiated by relatively low biomass burning contribution (fbiomass: 27.1% ± 11.3%) to BC using aethalometer based measurement though fbiomass value which increased significantly in winter (41.6% ± 5.7%). We estimated a considerable brown carbon (BrC) contribution to the total absorption coefficient (babs) at 370 nm (yearly average of 30.8% ± 11.1%), with a winter maximum of 44.2% ± 4.1% and a summer minimum of 19.2% ± 4.2%. Calculation of the wavelength dependence of total babs revealed an annual mean AAE370-520 value of 4.2 ± 0.5, with slightly higher values in spring and winter. The mass absorption cross-section of BrC also exhibited higher values in winter, with an annual mean of 5.4 ± 1.9 m2/g, reflecting the impact of emissions from increased biomass burning on BrC concentrations.

Acute effects of air pollution on type II diabetes mellitus hospitalization in Lanzhou, China.

Studies on the effects of short-term air pollution exposure on hospitalization for type 2 diabetes mellitus (T2DM) are relatively scarce in developing regions. The time-series study was used to explore the acute effects of air pollutants on hospitalization for T2DM in Lanzhou, China. A distribution lag nonlinear model based on the generalized additive model was used to analyze the hospitalization impact of air pollution on T2DM. Stratified analysis by gender, age and season was obtained. The results were indicated as the relative risk (RR) with 95% confidence interval (CI) for single-day lags (from lag0 to lag7) and cumulative lag days (from lag0-1 to lag0-7). The strongest correlations (RR, 95% CI) of hospitalization for T2DM and PM10 (RR = 1.003, 95% CI 1.000, 1.001) at lag7 and NO2 (RR = 1.022, 95% CI 1.000, 1.045) at lag0-4 were observed for an increase of 10 µg/m3 in the concentrations and CO (RR = 1.091, 95% CI 1.017, 1.170) at lag0-4 for an increase of 1 mg/m3 in the concentration. The hazardous impacts of PM10, NO2 and CO were greater for females, people aged ≥ 65 years and in the cold season. However, there was no significant association between PM2.5, SO2 and O38h and the number of hospitalizations for T2DM.

Integration of Metabolome and Transcriptome Profiling Reveals the Effect of Modified Atmosphere Packaging (MAP) on the Browning of Fresh-Cut Lanzhou Lily (Lilium davidii var. unicolor) Bulbs during Storage.

The fresh-cut bulbs of the Lanzhou lily (Lilium davidii var. unicolor) experience browning problems during storage. To solve the problem of browning in the preservation of Lanzhou lily bulbs, we first investigated the optimal storage temperature and gas ratio of modified atmosphere packaging (MAP) of Lanzhou lily bulbs. Then, we tested the browning index (BD), activity of phenylalanine ammonia lyase (PAL), polyphenol oxidase (PPO) and peroxidase (POD), the content of malonaldehyde (MDA) and other physiological activity indicators related to browning. The results showed that the storage conditions of 10% O2 + 5% CO2 + 85% N2 and 4 °C were the best. To further explore the anti-browning mechanism of MAP in fresh-cut Lanzhou lily bulbs, the integration of metabolome and transcriptome analyses showed that MAP mainly retarded the unsaturated fatty acid/saturated fatty acid ratio in the cell membrane, inhibited the lipid peroxidation of the membrane and thus maintained the integrity of the cell membrane of Lanzhou lily bulbs. In addition, MAP inhibited the oxidation of phenolic substances and provided an anti-tanning effect. This study provided a preservation scheme to solve the problem of the browning of freshly cut Lanzhou lily bulbs, and discussed the mechanism of MAP in preventing browning during the storage of the bulbs.

[Accumulation Characteristics and Influencing Factors of Heavy Metals in Cultivated Land Surface Soil in Lanzhou].

In this study, As, Cd, Cr, Hg, and Pb in the surface soil of cropland in Lanzhou were studied, and the combination of descriptive statistics, single-factor accumulation index, comprehensive accumulation index, geostatistical method, and a geographically weighted regression model (GWR) was used to investigate their accumulation status, spatial distribution, and influencing factors, in order to provide scientific basis for the precise control of heavy metal accumulation risk in the study area. The results showed that:①the single-factor accumulation index showed that the accumulation of Hg and Cd in the study area was the largest, followed by that of Pb and As, and that of Cr was the smallest; the comprehensive accumulation index showed that the accumulation rate of heavy metals was as high as 98.11%, of which 54.81% was mild accumulation and 43.30% was moderate and above accumulation. However, there was no heavy metal pollution in the surface soil of cultivated land in Lanzhou. ② Spatial autocorrelation analysis showed that there was no heavy metal pollution in the surface soil of Lanzhou, but there was accumulation in a few areas. The spatial autocorrelation analysis showed that the spatial autocorrelation of the Cr, Hg, and Pb single-factor accumulation indices was moderate, indicating that they were influenced by both random and structural factors; the spatial autocorrelation of the other two heavy metals was weak, indicating that they were mainly influenced by random factors, among which human factors were more influential. The Hg single-factor accumulation index was high in the middle and low in the fourth; the integrated accumulation index increased from northwest to southeast and decreased from the middle to both sides. ③ Geographically weighted regression (GWR) analysis showed that altitude, slope length, distance from rivers, soil organic matter (SOM) content, precipitation, air temperature, and surface temperature all showed positive driving effects, whereas the rest of the factors showed negative driving effects and significant spatial heterogeneity and instability (P<0.05). The magnitudes of the factor effects were in the order of soil characteristics>topographic characteristics>climate characteristics>location characteristics>socioeconomic characteristics>vegetation characteristics, with the largest contribution of SOM content, followed by that of altitude and air temperature, and the smallest of normalized difference vegetation index (NDVI) values. Compared with the other feature factors, the location feature factors had stronger spatial heterogeneity.

Association between short-term ambient air pollution and outpatient visits for acute exacerbation of chronic obstructive pulmonary disease in Lanzhou, 2013-19.

Evidence between air pollution and hospital visits for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is inconsistent and limited in China. In this study, we constructed a time-series study to evaluate the association between air pollution and AECOPD outpatient visits. Daily hospital outpatient visits for AECOPD in three top level hospitals in Lanzhou from January 2013 to December 2019, as well as the air pollutants and meteorological data in the same period, were collected. Then, generalized additive models with quasi-Poisson regression were utilized to estimate the associations with single-day lags from lag0 to lag7 and cumulative-day lag from lag01 to lag07. For example, lag0 referred to the concentration of air pollutants at the current day and lag1 referred to the previous-day air pollutant concentration and so on. Lag01 meant the average concentration of air pollutants at the current and previous day, and lag07 corresponded to the eight-day moving average value of the current and previous 7 days. In addition, stratified analyses were performed by gender, age, and season. The risk estimates were expressed in terms of the percentage changes (PC) in AECOPD outpatient visits per 10 µg/m3 increment of air pollutants (except that CO was per 1 mg/m3) and their respective 95% confidence intervals (CIs). The strongest effect on AECOPD morbidity was found lag07 for PM2.5 (PC = 1.96, 95% CI 1.07, 2.86 per 10 µg/m3), lag03 for PM10 (PC = 0.25, 95% CI 0.01, 0.49 per 10 µg/m3), lag05 for SO2 (PC = 1.67, 95% CI 0.54, 3.93 per 10 µg/m3), and lag03 for NO2 (PC = 1.37, 95% CI 0.25, 2.51 per 10 µg/m3). No significant association of O3 and CO with AECOPD onset was found. In the subgroup analyses, the associations of PM2.5 and SO2 were more pronounced on males than female, the patients aged < 65 years were more vulnerable to PM2.5 and NO2, but 65-74 years old were more vulnerable to PM2.5, SO2, and NO2. Patients aged ≥ 75 years suffered more from PM2.5, PM10, and SO2. The associations between PM2.5, PM10, SO2, NO2, and AECOPD outpatients were stronger in the cold season than those in the hot season. From exposure-response curves, we observe linear relationships of PM2.5, SO2, NO2, O38h, and CO with hospital outpatient visits for AECOPD. The increase in PM2.5, PM10, SO2, and NO2 concentration will lead to an increase in the number of outpatient visits for AECOPD and have different influence patterns in different genders, ages, and seasons.

Clinical study on combined "lanzhou prescription" for the treatment of "syndrome of heat-toxin congestion and excessiveness" in children with acute aplastic anemias.

Purpose: The clinical efficacy of "Lanzhou prescription" plus or minus combined with western medicine in the treatment of children with acute aplastic anemia, 'excessive accumulation of heat toxin', was comprehensively and objectively evaluated. Methods: Sixty children diagnosed with acute aplastic anemia, 'excessive accumulation of heat toxin' were divided into observation group (lanzhou prescription plus or minus combined with immunosuppressive therapy) and control group (immunosuppressive therapy alone). The relief degree of clinical symptoms and signs and the change of laboratory indicators were taken as the evaluation criteria. Results: (1) After treatment, the results of remission rate of two groups treated by western medicine shows that the remission rate of the observation group was significantly higher than the control group (P< 0.05). (2) the 'cure rate' of the observation group treated for 6 months was significantly higher than treated for 3 months (P<0.05). (3) After treated for 6 months, the indexes of CD34+ cells and FOXP3+ regulatory cells in bone marrow of observation group increased, while the CD8+ cells and B cells decreased significantly, and the indexes of CD3+ cells, CD4+ cells and NK cells decreased somewhat(P<0.05). Conclusion: Compared with immunosuppressive therapy, lanzhou prescription plus or minus combined with immunosuppressive therapy can alleviate the clinical symptoms and signs of children more effectively, obviously improve the Traditional Chinese Medicine symptoms of children, and help bone marrow hematopoietic stem cells gradually restore hematopoietic function.

Study on Urban Resilience from the Perspective of the Complex Adaptive System Theory: A Case Study of the Lanzhou-Xining Urban Agglomeration.

In the context of global environmental change and continuous urbanization, enhancing urban resilience is an important way to improve urban emergency management capacity and achieve sustainable development of urban systems. It is of great significance to clarify the mechanisms and effects of urban resilience and carry out resilience measurement to improve the level of urban system resilience and alleviate the pressure of environmental disturbances on the stable operation of urban systems. As an important part of the "Belt and Road" Initiative and one of the few leading economic regions in western China, promoting the high-quality development of the Lanzhou-Xining urban agglomeration is of profound significance for strengthening ethnic unity and stabilizing the northwest and southwest regions. Based on the complex adaptive system (CAS) theory and the adaptive cycle model, this study understands urban resilience as the comprehensive result of urban system stability, self-organization, learning adaptability and transformability, constructs a multi-level open index evaluation system, and analyzes the spatio-temporal evolution characteristics of urban resilience of the Lanzhou-Xining urban agglomeration from the proposed design to the formal planning in 2010-2017. The findings are as follows: (1) Research on the urban resilience of the Lanzhou-Xining urban agglomeration verifies the applicability of the evolutionary urban resilience analysis framework and makes preliminary findings on urban resilience based on CAS theory, which provide a certain theoretical reference for the research on the spatio-temporal evolution of urban resilience. (2) From 2010 to 2017, significant differences are observed between various urban attributes. Resilience exhibits an overall upward trend, and spatial evolution changes from a double core (Lanzhou and Xining) to three cores (Lanzhou, Xining and Haidong) and polycentric modes. (3) Based on urban resilience characteristics and an urban system adaptability cycle model, this paper divides the Lanzhou-Xining urban agglomeration cities into four types (exploitation-reorganization, conservation-release, conservation-exploitation and exploitation), and proposes corresponding adaptive management countermeasures. These could be adopted as a reference to promote the high-quality development of the Lanzhou-Xining urban agglomeration.

Flavor Profile Analysis of Instant and Traditional Lanzhou Beef Bouillons Using HS-SPME-GC/MS, Electronic Nose and Electronic Tongue.

The volatile profiles and taste properties of Lanzhou beef bouillons prepared with traditional (A1−A8) and modern (B1, B2) processing methods were evaluated. A total of 133 volatiles were identified: olefins, aldehydes and alcohols from spices in traditional bouillons were significantly higher (p < 0.05) than those in instant bouillons. The characteristic volatile substances in traditional beef bouillons were eucalyptol, linalool, 2-decanone, ß-caryophyllene and geraniol; instant bouillons lacked 2-decanone and ß-caryophyllene, and the contents of the other three substances were low. PCA (principal component analysis) and CA (clustering analysis) showed that the instant bouillons have a similar volatile profile to traditional bouillons, and the results of E-nose and sensory evaluation also supported this conclusion. The E-tongue showed that the taste profiles of instant bouillons were significantly different from those of traditional bouillons, mainly due to lack of umami; however, sensory evaluation revealed that taste differences were not perceptible.

[Risk Assessment and Attribution Analysis of "Five Toxic" Heavy Metals in Cultivated Land in Lanzhou].

Heavy metals in cultivated soil may migrate and transform through the food chain to harm the ecological environment and human health. At present, the ecological environment and human health risks of heavy metals in cultivated soil in Lanzhou city remain unclear, which impacts the effective management and control of heavy metals. The potential ecological risk hazard index was used to evaluate the ecological environmental risks of As, Cd, Cr, Hg, and Pb in the surface soil of cultivated land in Lanzhou, and the health risk model proposed by USEPA and the recommended standard were used to evaluate their human health risk. The main factors influencing the spatial differentiation of human health risk were explored by using geographic detectors. The risk of heavy metals to the ecological environment of the cultivated land surface soil in the study area was mainly medium (65.25%), and small portions were low (13.80%) and high (20.95%). The low-risk areas were mainly located in the southeast of Yongdeng County, the middle and north of Yuzhong County, and the southwest of Gaolan County. Moderate risk areas were distributed in three counties and five districts. The high-risk areas were located in the north and southeast of Yongdeng County, the south of Chengguan District, the northeast of Qilihe, the east of Xigu District, and the middle of Yuzhong County. The non-carcinogenic and carcinogenic risks of five types of heavy metal exposure pathways were as follows:oral ingestion>skin contact>respiratory ingestion; generally speaking, children were at higher risk than adults. The non-carcinogenic risk in children was higher than that in adults; however, there was no such risk for local residents, as they were all less than 1. At the same time, the carcinogenic risk of As was greater than 1×10-5 (children 2.04×10-5) and less than 1×10-4 (adults 1.91×10-5), respectively. This indicated an acceptable medium risk to the local residents, and the risk to children was again greater than that to adults. Geographical detector analysis showed that average precipitation during the sampling season had the greatest impact on the spatial differentiation of human health risks of As and Cd, GDP had the greatest impact on the spatial differentiation of human health risks of Cr, and distance from the railway had the greatest impact on the spatial differentiation of human health risks of Hg and Pb. Interaction detection showed that all factors were enhanced by double factors. In addition to leading factors, other factors such as pH, slope, and altitude also enhanced the influence of leading factors on the spatial differentiation of heavy metal risk in cultivated soil.