A descriptive analysis of human milk dispensed by the Leipzig Donor Human Milk Bank for neonates between 2012 and 2019.

Background: Human milk banking has become an important aspect of Nutritional medicine. It is not just about the provision of mother's own milk (MOM) or donor human milk (DHM) in the hospital, but also a strategy to encourage breastfeeding in the clinical setting and beyond. Objective: To describe the feeding patterns of hospitalised infants including human milk dispensed by the Leipzig Donor Human Milk Bank (LMB). Design: A descriptive analysis of daily data on milk feeds dispensed by LMB for hospitalised infants distinguishing between MOM or DHM, either fresh or frozen, and raw/pasteurised milk from 2012-2019. Results: We included 2,562 infants with median hospitalisation of 23 days, for whom human milk was dispensed on median 76% of those days and other nutrition on the remaining days. Raw MOM and raw DHM comprised 52% and 8% of the dispensed milk, respectively. Dispensing exclusive DHM instead of MOM for at least one full day was required for 55% of the infants, mostly at the beginning but also later during hospitalisation. Exclusive raw DHM was dispensed on at least 1 day for 37% of the infants, in different birthweight strata <1,000 g: 10%, 1,000-1500 g: 11%, 1,500-2500 g: 13% and > 2,500 g: 3%. At discharge, MOM was dispensed for more than 60% of the infants. Conclusion: During an infant's hospital stay, LMB dispenses various human milk feeds with interspersed DHM resulting in complex intra-individual and time-variant feeding patterns. LMB dispenses raw MOM and especially raw DHM with the intention to retain the properties of human milk unlike a diet containing pasteurised DHM and/or formula. Although raw DHM comprises a small percentage of all dispensed milk, raw DHM is dispensed for a substantial portion of infants. Our results document that dispensing raw DHM, is possible in routine settings.

EEG wakefulness regulation in transdiagnostic patients after a recent suicide attempt.

OBJECTIVE: Decades of research have not yet produced statistically reliable predictors of preparatory behavior eventually leading to suicide attempts or deaths by suicide. As the nature of suicidal behavior is complex, it is best investigated in a transdiagnostic approach, while assessing objective markers, as proposed by the Research Domain Criteria (Cuthbert, 2013). METHODS: A 15-min resting-state EEG was recorded in 45 healthy controls, and 49 transdiagnostic in-patients with a recent (<6 months) suicide attempt. Brain arousal regulation in eyes-closed condition was assessed with the Vigilance Algorithm Leipzig (VIGALL) (Sander et al., 2015). RESULTS: A significant incline of median vigilance and vigilance slope was observed in patients within the first 3-min of the EEG recording. Additionally, a significant positive correlation of self-reported suicidal ideation with the vigilance slope over 15-min recording time, as well as a significant negative correlation with EEG vigilance stage A1 during the first 3-min was found. CONCLUSIONS: Transdiagnostic patients with a recent suicide attempt show a distinct vigilance regulation pattern. Further studies including a control group consisting of patients without life-time suicide attempts are needed to increase the clinical utility of the findings. SIGNIFICANCE: These findings might serve as potential objective markers of suicidal behavior.

The big four of plant taxonomy - a comparison of global checklists of vascular plant names.

Taxonomic checklists used to verify published plant names and identify synonyms are a cornerstone of biological research. Four global authoritative checklists for vascular plants exist: Leipzig Catalogue of Vascular Plants, World Checklist of Vascular Plants, World Flora Online (successor of The Plant List, TPL), and WorldPlants. We compared these four checklists in terms of size and differences across taxa. We matched taxon names of these checklists and TPL against each other, identified differences across checklists, and evaluated the consistency of accepted names linked to individual taxon names. We assessed geographic and phylogenetic patterns of variance. All checklists differed strongly compared with TPL and provided identical information on c. 60% of plant names. Geographically, differences in checklists increased from low to high latitudes. Phylogenetically, we detected strong variability across families. A comparison of name-matching performance on taxon names submitted to the functional trait database TRY, and a check of completeness of accepted names evaluated against an independent, expert-curated checklist of the family Meliaceae, showed a similar performance across checklists. This study raises awareness on the differences in data and approach across these checklists potentially impacting analyses. We propose ideas on the way forward exploring synergies and harmonizing the four global checklists.

Memorias de un laboratorio: Wilhelm Wundt y la psicología experimental / Memories of a laboratory: Wilhelm Wundt and Experimental Psychology

RESUMEN El médico, fisiólogo y psicólogo alemán Wilhelm Wundt ha sido y es considerado el creador de la llamada psicología experimental, por su abordaje de conceptos psicológicos hasta entonces intuitivos, mediante métodos propios de la fisiología del siglo xix. Emergió de esta manera una nueva disciplina, la psicología científica, en el contexto físico de un laboratorio de ciencias en la ciudad alemana de Leipzig. Sin embargo, la labor de Wundt no se limitó únicamente al estudio de la psicología desde un punto de vista científico. Por una parte, se ha destacado su gran capacidad de convocatoria, aglutinadora y organizativa de un laboratorio original donde pudieron formarse investigadores de varias partes del mundo; y, por otra, modificó sustancialmente el modo de analizar la psicología, centrando la atención de los investigadores en el estudio pormenorizado de la consciencia mediante la utilización del método introspectivo.

ABSTRACT The physician, physiologist and psychologist Wilhelm Wundt has been and is considered the founder of experimental psychology due to his approach to psychological subjects, until then intuitive, through the XIX century methods. Thus, a new discipline, the Scientific Psychology, emerged in the venue of a laboratory in the town of Leipzig, Germany. Nevertheless, Wundt´s labor was not restricted to the study of psychology from a scientific perspective: on one hand, his great convocational, organizing and group-working capacity attracted lots of investigators from around the world to be trained. In n original laboratory, On the other, he substantially modified the study of psychology centering the researchers' attention in the detailed analysis of consciousness through the use of the method called introspection.

Running a dense air temperature measurement field campaign at the urban neighbourhood level: Protocol and lessons learned.

The cooling capacity of urban green spaces constitutes a key measure for cities to mitigate heat events, which is gaining importance in climate change adaptation and mitigation. In this protocol article, we present details on two field campaigns aiming at collecting dense air temperature data in two urban inner city parks in Leipzig, Germany, under unprecedented heat and drought conditions. We introduce all the steps required to plan and conduct qualified fieldwork in environmental research, including study design, technical and logistical preparations, on-site work and data management steps from data acquisition, transfer into research outcomes to dissemination. We further share valuable lessons learned before, during and after fieldwork that helped us improve our work and that could support and improve similar future project campaigns.

Late onset Wilson Disease with normal neuro-psychiatric status: A case report.

Introduction: Late onset Wilson disease (WD) is a rare form of WD. WD has variability of clinical presentations from acute liver failure to chronic liver disease (CLD). The hepatic and neurological variants of WD have wider variations. Case presentation: A 55-year-old female, known case of CLD, presenting with generalized body swelling and abdominal pain, was diagnosed with late onset WD with normal neuro-psychiatric status. She was treated with zinc and considered for liver transplantation. Clinical discussion: Late onset WD is itself a rare form of WD. Within it, neurological manifestations are common in late onset WD, which was quite opposite as compared to our case. Similarly, diagnostic delay has been a concern in late onset WD with CLD as with our case. Conclusions: In spite of being uncommon in later age, WD and its different variations like with normal neuro-psychiatric status should be considered as an etiology in cases of unexplained liver diseases.

Impact of detector selection on commissioning of Leipzig surface applicators with improving immobilization in high-dose-rate brachytherapy.

PURPOSE: Commission and treatment setup of Leipzig surface applicators, because of the steep dose gradient and lack of robust immobilization, is challenging. We aim to improve commissioning reliability by investigating the impact of detector choice on percentage depth dose (PDD) verifications, and to enhance accuracy and reproducibility in calibration/treatment setup through a simple and novel immobilization device. METHODS AND MATERIALS: PDD distributions were measured with radiochromic films, optically stimulated luminescent dosimeters (OSLDs), a diode detector, and both cylindrical and parallel plate ionization chambers. The films were aligned to the applicators in parallel and transverse orientations. PDD data from a benchmarking Monte Carlo (MC) study were compared with the measured results, where surface doses were acquired from extrapolation. To improve setup accuracy and reproducibility, a custom-designed immobilization prototype device was made with cost-effective materials using a 3D printer. RESULTS: The measured PDD data with different detectors had an overall good agreement (<±10%). The parallel plate ionization chamber reported unreliable doses for the smallest applicator. There was no remarkable dose difference between the two film setups. The two-in-one prototype device provided a rigid immobilization and a flexible positioning of the applicator. It enhanced accuracy and reproducibility in calibration and treatment setup. CONCLUSION: We recommend using radiochromic films in the transverse orientation for a reliable and efficient PDD verification. The applicator's clinical applicability has been limited by a lack of robust immobilization. We expect this economical, easy-to-use prototype device can promote the use of Leipzig applicators in surface brachytherapy.

Innsbruck's histological institute in the third Reich: Specimens from NS-victims.

As elsewhere, the cadavers of Nazi victims were used at the 'Alpenunversität Innsbruck' for the education of medical students. They were also used by members of the Institute of Anatomy and the Institute of Histology for scientific research and publications. In 2018, over 300 drawers were discovered in a laboratory anteroom of the Innsbruck Histological Institute containing around 15,000 histological slides. After a closer examination, 237 slides were found to have human tissues from victims of the 3rd Reich possibly. These 237 slides were produced between May 1938 and March 1944. All 237 slides were digitized, the labels carefully analysed, and some of the victims were identified. Several specimens come from the tissues of three Nazi victims who were executed in Munich-Stadelheim and whose bodies were brought to the Innsbruck Anatomical Institute. From there, the organs were passed on to the Histological Institute Innsbruck. Inscriptions on other slides such as "Cl[ara]. 40", "hing[erichtet]. Clara" or "Hinger[ichtet]. Cl[ara]." prove that the specimens were most likely sent to the Institute by the histologist Max Clara. At this time, Clara was Director of the Leipzig Anatomical Institute and still had close ties to the Innsbruck Institute, where he had been trained. Based on several sources, some Nazi victims could be identified by name; biographical traces complement this identification. Under what political and sociological conditions future generations will look at the crimes of the Nazi dictatorship is not yet foreseeable. As anatomists and scientists, we must be cautious about removing evidence from this terrible time. Therefore, we will bury all slides where relatives wish to do so or where it is clear that Rabbi Polak's "Vienna Protocol" must be applied. However, the remaining slides will be kept safe for eventual further investigation.

Wilson's Disease: Facing the Challenge of Diagnosing a Rare Disease.

Wilson disease (WD) is a rare disorder caused by mutations in ATP7B, which leads to the defective biliary excretion of copper. The subsequent gradual accumulation of copper in different organs produces an extremely variable clinical picture, which comprises hepatic, neurological psychiatric, ophthalmological, and other disturbances. WD has a specific treatment, so that early diagnosis is crucial to avoid disease progression and its devastating consequences. The clinical diagnosis is based on the Leipzig score, which considers clinical, histological, biochemical, and genetic data. However, even patients with an initial WD diagnosis based on a high Leipzig score may harbor other conditions that mimic the WD's phenotype (Wilson-like). Many patients are diagnosed using current available methods, but others remain in an uncertain area because of bordering ceruloplasmin levels, inconclusive genetic findings and unclear phenotypes. Currently, the available biomarkers for WD are ceruloplasmin and copper in the liver or in 24 h urine, but they are not solid enough. Therefore, the characterization of biomarkers that allow us to anticipate the evolution of the disease and the monitoring of new drugs is essential to improve its diagnosis and prognosis.

Evaluation of bone dose arising from skin cancer brachytherapy: A comparison between 192Ir and 60Co sources through Monte Carlo simulations.

PURPOSE: This study aimed to calculate and compare absorbed dose to bone following exposure to 192Ir and 60Co sources in high dose rate (HDR) skin brachytherapy. Moreover, effects of the bone thickness and soft tissue thickness before the bone on absorbed dose to the bone are evaluated . MATERIALS AND METHODS: 192Ir and 60Co sources inserted in Leipzig applicators with internal diameters of 1, 2 and 3 cm with/without their optimal flattening filters were simulated by MCNPX Monte Carlo code. Then, heterogeneous phantoms (including skin, soft tissue before and after the bone, cortical bone and bone marrow) were defined. Finally, relative depth dose values for the bone and other tissues in the heterogeneous phantoms were obtained and compared. RESULTS: The average relative depth dose values of the skin, soft tissue before and after bone and bone marrow were almost similar for both 192Ir and 60Co sources, with a maximum difference less than 2%. However, a 0.1-6.8% difference was observed between average relative depth dose values of these two sources for the cortical bone. The results showed that with increasing the bone thickness and bone distance from the skin surface, the average relative depth dose values of the bone marrow and cortical bone decreased for both 192Ir and 60Co sources inserted in the applicators without/with their optimal flattening filters. For most of evaluated the applicators without/with their flattening filters, the average relative depth dose values of the bone marrow arisen from the 60Co source were higher than those obtained from the 192Ir source, while an opposite trend was observed for the cortical bone . CONCLUSION: The obtained findings showed that the average relative depth dose values of 192Ir and 60Co sources at the corresponding depths of the designed heterogeneous phantoms were almost similar (expect for the cortical bone). Hence, it is concluded that 60Co source can be used instead of 192Ir source in HDR skin brachytherapy, particularly in developing countries.

Undiagnosed Wilson's Disease and Fibromyalgia Masking Bowel Perforation.

Wilson's disease is a complex multi-organ disease characterized by impaired biliary excretion of copper and resulting deposition of excess copper in the liver and other organs. It has a wide range of clinical presentations, and diagnosis often requires a high degree of clinical suspicion, especially in patients with multiple other comorbidities. We present the case of a 37-year-old woman with a complex medical and psychiatric history who was admitted for chronic diarrhea, hepatic enzyme elevation, electrolyte abnormalities, hyperammonemia, and methicillin-sensitive Staphylococcus aureus bacteremia. She was eventually found to have low serum ceruloplasmin level and elevated urine copper levels. Though confirmatory liver biopsy was not performed due to bowel wall rupture and septic shock, most of her symptoms and lab abnormalities could be explained by an underlying diagnosis of Wilson's disease. We present this case primarily as a cautionary tale. This patient was not lacking in medical attention prior to this prolonged hospitalization; however, her psychiatric issues and fibromyalgia management were the predominant foci during her frequent primary care office visits and likely distracted from the patient's chronic laboratory abnormalities. More vigilant laboratory evaluation of underlying medical conditions in psychiatric patients may be warranted in order to prevent serious complications of such conditions.

Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.

BACKGROUND & AIMS: Both existing clinical criteria and genetic testing have significant limitations for the diagnosis of Wilson disease (WD), often creating ambiguities in patient identification and leading to delayed diagnosis and ineffective management. ATP7B protein concentration, indicated by direct measurement of surrogate peptides from patient dried blood spot samples, could provide primary evidence of WD. ATP7B concentrations were measured in patient samples from diverse backgrounds, diagnostic potential is determined, and results are compared with biochemical and genetic results from individual patients. METHODS: Two hundred and sixty-four samples from biorepositories at 3 international and 2 domestic academic centers and 150 normal controls were obtained after Institutional Review Board approval. Genetically or clinically confirmed WD patients with a Leipzig score >3 and obligate heterozygote (carriers) from affected family members were included. ATP7B peptide measurements were made by immunoaffinity enrichment mass spectrometry. RESULTS: Two ATP7B peptides were used to measure ATP7B protein concentration. Receiver operating characteristics curve analysis generates an area under the curve of 0.98. ATP7B peptide analysis of the sequence ATP7B 887 was found to have a sensitivity of 91.2%, specificity of 98.1%, positive predictive value of 98.0%, and a negative predictive value of 91.5%. In patients with normal ceruloplasmin concentrations (>20 mg/dL), 14 of 16 (87.5%) were ATP7B-deficient. In patients without clear genetic results, 94% were ATP7B-deficient. CONCLUSIONS: Quantification of ATP7B peptide effectively identified WD patients in 92.1% of presented cases and reduced ambiguities resulting from ceruloplasmin and genetic analysis. Clarity is brought to patients with ambiguous genetic results, significantly aiding in noninvasive diagnosis. A proposed diagnostic score and algorithm incorporating ATP7B peptide concentrations can be rapidly diagnostic and supplemental to current Leipzig scoring systems.

Clinically-implementable template plans for multidwell treatments using Leipzig-style applicators in 192Ir surface brachytherapy.

PURPOSE: Multiple dwell positions ("multidwell") within a Leipzig-style applicator can be used to increase dose uniformity and treatment area. Model-based dose calculation algorithms (MBDCAs) are necessary for accurate calculations involving these applicators because of their nonwater equivalency and complex geometry. The purpose of this work was to create template plans from MBDCA calculations and present their dwell times and positions for users of these applicators without access to MBDCAs. METHODS AND MATERIALS: The Leipzig-style solid applicator model within our treatment planning system was used to design template plans. Five template plans, normalized to 0.3 cm depth within a water phantom, were optimized using the treatment planning system MBDCA. Each template plan contained unique dwell positions, times, and active lengths (0.5-1.5 cm). A single-dwell distribution was optimized for comparison. The stem of this applicator stops within the shell; therefore, one template plan contained an intrafraction rotation to determine the largest dose distribution achievable. Effects of imperfect applicator rotation were quantified by inserting rotational offsets and comparing the V100%, D95%, and minimum dose coverage for planning target volumes created from 80%/90% isodose lines. RESULTS: The 90% (80%) isodose line dimensions at 0.3 cm depth for single-dwell increased from 0.94 × 0.97 (1.53 × 1.57) cm2 to 2.09 × 1.24 (2.75 × 1.88) cm2 in the largest template plan. Manually inserted angular offsets up to ±10° for the template plan requiring rotation preserved V100%, D95%, and minimum dose within 2.0%, 1.9%, and 8.0%, respectively. CONCLUSION: A set of template plans was created to provide accessibility to the multidwell methodology, even for users without access to MBDCAs. Each template plan should be reviewed before clinical implementation.

Design and characterization of flattening filter for high dose rate 192Ir and 60Co Leipzig applicators used in skin cancer brachytherapy: A Monte Carlo study.

PURPOSE: This study aimed to design optimal flattening filters for high dose rate (HDR) 192Ir and 60Co Leipzig applicators which are used to treat skin cancer. MATERIALS AND METHODS: MCNPX Monte Carlo code was used to design flattening filters for Leipzig applicators with inner diameters of 1, 2 and 3 cm. Then, their dosimetric characterizations such as dose distribution, dose profile, percentage depth dose, flatness, symmetry and homogeneity were evaluated in a 20 × 20 × 20 cm3 water phantom and compared with those without the flattening filter. RESULTS: The flattening filter thickness varied from 0 mm (at the edge) to the maximum values of 0.30, 1.18, and 2.41 mm for the 192Ir Leipzig applicators of H1, H2, and H3 type, respectively. This quantity has maximum values of 0.96, 6.27, and 12.31 mm for the 60Co double wall applicators of D1, D2, and D3 type, respectively. The dose profile flatness values for the H1, H2, and H3 192Ir Leipzig applicators with the optimal flattening filters were 0.76, 1.26, and 1.85%, respectively. Furthermore, the dose profile flatness values for the D1, D2, and D3 60Co double wall applicators with the optimal flattening filters were 1.11, 2.10 and 3.12%, respectively. The dose profile symmetry values obtained from various source-applicator combinations were less than 1.02. Compared to the applicators without flattening filter, the homogeneity values for the H1, H2, and H3 192Ir Leipzig applicators with the optimal flattening filters were improved 1.68, 6.51, and 13.17 times, respectively, and for the D1, D2, and D3 60Co double wall applicators were improved 1.23, 6.21 and 9.54 times, respectively. CONCLUSION: The findings revealed that the inhomogeneous dose distribution resulted from the Leipzig applicators without the optimal flattening filter at the treatment surface could be improved by insertion of optimal lead flattening filters between the sources and treatment surface.

Feasibility of using multiple-dwell positions in 192Ir Leipzig-style brachytherapy surface applicators to expand target coverage and clinical application.

PURPOSE: Leipzig-style applicators for surface brachytherapy are traditionally used with a single-source dwell position. This study explores the feasibility of using multiple-source dwell positions ("multidwell") to improve the dose coverage and applicability of Leipzig-style applicators. METHODS AND MATERIALS: A virtual model of the Leipzig-style applicator was commissioned for a model-based dose calculation algorithm (MBDCA) and compared against American Association of Physicists in Medicine working group 186 benchmarking data sets and ionization chamber point measurements. An absolute dosimetry technique based on radiochromic film was used to validate both single-dwell and multidwell plans. RESULTS: Dose distributions generated from the MBDCA-based virtual model were consistent with working group data sets, ion chamber measurements, and radiochromic film analysis. In one multidwell configuration, at 3 mm prescription depth, the 80% isodose width was increased to 25 mm, compared with 15 mm in the same dimension for a single-dwell delivery. In the same multidwell configuration, the flatness, measured as >98% isodose line, was more than doubled to 8 mm, compared with 3 mm in the same dimension. For multidwell plans, 2-D planar agreement between radiochromic film and MBDCA exceeded 93% in gamma analysis (3%/1 mm criteria). Submillimeter positional agreement was found, with a total dosimetric uncertainty of 4.5% estimated for the entire system. CONCLUSIONS: Leipzig-style surface applicators with multiple-source dwell positions have been benchmarked against radiochromic film dosimetry. Results show that the clinically viable coverage area can be increased significantly.

[The dermatologist Edmund Lesser (1852-1918) : Teaching and learning in Leipzig]. / Der Dermatologe Edmund Lesser (1852­1918) : Lehren und Lernen in Leipzig.

Edmund Lesser was one of the most influential German dermatologists of his time. After the death of his academic teacher Oscar Simon in Breslau, the later director of the dermatology hospital at the Charité moved to Leipzig in 1882. At the University of Leipzig he quickly completed his habilitation in June of the same year and continued the course for dermatology and venereology started by Neisser. Later he also went into private practice, where he recruited patients for his lectures. In Leipzig Lesser also published his well-received handbook on skin diseases and venereology and organized the third meeting of the German Society of Dermatology in 1891. Despite his hope and his undisputable achievements, he was not granted professorship by the faculty of medicine in Leipzig. For this he had to become head of dermatology at the University of Bern in 1892. This manuscript deals with his ten important years in Leipzig as a prerequisite for his later merits in Berlin as well as the development of academic dermatology at the University of Leipzig.

[Fame alone is not enough : How the renowned discoverer Albert Neisser (1855-1916) came to academic honors in dermatology in Leipzig]. / Ruhm alleine reicht nicht : Wie der gefeierte Entdecker Albert Neisser (1855­1916) in Leipzig zu akademischen Weihen in der Dermatologie kam.

Despite his scientific achievements while still in medical school, Albert Neisser was not accepted into internal medicine. This was typical for this period, as Jewish doctors were not allowed into esteemed disciplines such as internal medicine and surgery. Due to his important discoveries as a resident in dermatology he rose to international fame; however, he had to move to Leipzig to boost his later career in Germany. This step has been somewhat neglected and is therefore the topic of this article.

The dilemma to diagnose Wilson disease by genetic testing alone.

BACKGROUND: Wilson disease (WD) is an autosomal recessive disorder of hepatic copper excretion. About sixty per cent of patients present with liver disease. WD is considered a fatal disease if undiagnosed and/or untreated but recent data indicate that disease penetrance may not be 100%. MATERIALS AND METHODS: All patients underwent liver biopsy as part of the diagnostic workup. Genetic testing for ATP7B was performed by Sanger sequencing. RESULTS: We report on a large family with multiple affected siblings. The first patient (male, 31 years) underwent orthotopic liver transplantation (OLT) because of fulminant WD. He was homozygous for p.G710A. One asymptomatic brother (37 years) had the same mutation. He is doing well on chelation therapy. Fifteen years later, a second-degree sibling (female, 16 years) presented with fulminant WD and underwent OLT. She was compound heterozygote (p.G710A/p.G710S). Further family screening revealed a third mutation (p.V536A) in a female (21 years) and male (16 years) compound-heterozygote sibling (p.G710A/p.V536A). In both, serum ceruloplasmin and 24-hour urinary copper excretion were normal. Liver biopsy showed normal histology and a quantitative hepatic copper content within the normal range or only slightly elevated (19 and 75 µg/g dry weight, respectively). No decoppering treatment was initiated so far. CONCLUSION: Genetic testing alone is not always sufficient to diagnose WD in asymptomatic patients, and human mutation databases should be used with caution. Even patients carrying two disease-causing mutations do not necessarily have demonstrable alteration of copper metabolism. Asymptomatic siblings diagnosed by genetic screening require further testing before initiating treatment.

[Johann Heinrich Rille (1864-1956): the long way to the chair in dermatology in Leipzig 100 years ago]. / Johann Heinrich Rille (1864­1956): der lange Weg zum Leipziger Ordinariat vor 100 Jahren.

Johann Heinrich Rille, also characterized as a renowned nestor of German-speaking dermatovenereology, was named as extraordinary professor for syphilis and skin diseases in Leipzig in 1902, the second oldest university in Germany. Although the chair of dermatology was promised this was postponed for many years, not only because of World War I but also due to an ongoing struggle for dermatology to be accepted as an independent specialty in Germany. Finally, in 1919, the long overdue promotion to full professor was granted. Rille commented on this as "successful partial coping with the ordeal of German dermatology in Leipzig".