RESUMO
Objective: To study the chemical constituents from the aerial parts of Ligusticum sinense cv. chaxiong. Methods: The chemical constituents were separated and purified by silica gel, ODS column chromatography, and preparative HPLC. Their structures were determined by various of spectroscopic analyses. Results: Fourteen compounds were isolated from the petrol ester and CH2Cl2 fractions of 95% ethanol extract of the aerial parts of L. sinense cv. chaxiong, and their structures were identified as 5-hydroxy-3- butylphthalide (1), 3-hydroxy-octa-1, 5-dien-7-one (2), umbelliferone (3), pumbinernoid A (4), crocinervolide (5), (3R, 6R, 7E)-3- hydroxy-4, 7-megastignadien-9-one (6), senkyunolide G (7), scopoletin (8), (2Z)-3-(3, 4-dihydroxyphenyl)-2-propenal (9), (3S, 5R, 6S, 7E, 9R)-5, 6-epoxy-3, 9-dihydroxy-7-megastigmene (10), vomifoliol (11), dihydroactinidiolide (12), 7-hydroxy-3-butylphthalide (13), and senkyunolide A (14). Conclusion: Compounds 1-13 are isolated from this plant for the first time, compounds 1, 2, 4-6, and 9-13 are found from the plants of genus Ligusticum L. for the first time, and compound 1 is a new natural product.
RESUMO
Object To perform detail studies on different species of Ligusticum L (Uumbelliferae) currently prescribing in Yunnan Province for the purpose to clarify the claotic state of its clinical use Methods By literature retrieval, field and market center inspection and pharmacognostic identification in comparison with those documented in classical literatures to arrive at a reasonable evaluation Results Two varieties of Ligusticum L., the Huanggaoben and Heigaoben were currently in common use in Yunnan Province Huanggaoben, the yellow ligusticum, was originated from Sinodielsia yunnanensis Wolff and Ligusticum delavayi Franch Heigaoben, the balck ligusticum, was oringinated from Ligusticum pteridophyllum Franch Conclusion The study may provide references for the further study and clinical use of this medicinal plant
