RESUMO
BACKGROUND: Cigarette smoke contains a large number of types of oxygen free radicals and cytotoxic components. Passive smoking will impair respiratory and cardiovascular system functions, and result in oxidative damage of skeletal muscle and decreased exercise ability. OBJECTIVE; To investigate the effect of phellinus igniarius crude polysaccharides on the exercise capacity and free radical metabolism of skeletal muscle in mice suffering passive smoking, so as to provide ideas for the prevention and treatment of peroxidative damage of skeletal muscle and depression of exercise capacity in rats suffering passive smoking. METHODS: Twenty-one male Kunming mice were randomly assigned to three groups: Gavage with phellinus igniarius crude polysaccharides and suffering passive smoking (phellinus group), gavage with distilled water and suffering passive smoking (control group), and only gavage with distilled water (blank group). After 4 consecutive weeks, the mice were forced to take an exhausted swimming, and sacrificed subsequently. Exhausted swimming time was recorded. The bilateral gastrocnemius muscle tissues were obtained, in which the vitality of superoxide dismutase, catalase, glutathion reductase and Ca2+-Mg2+-ATP and Na+-K+-ATP activity, and the concentration of malonaldehyde were measured. RESULTS AND CONCLUSION: (1) The swimming time of mice in the control group was shorter than that in the blank group (P 0.6, P 0.6, P < 0.05), and negatively correlated with the concentration of malonaldehyde (r < -0.6, P < 0.05). (5) In summary, phellinus igniarius crude polysaccharides can improve the antioxidative enzyme activity of skeletal muscle, inhibit lipid peroxidation reaction, and thus increase exercise ability of mice suffering passive smoking. The study was approved by the Ethical Committee of Jiangxi Normal University, approval No. 201703.
RESUMO
A simple model based on physically evident assumptions was constructed that may predict the strong effect of low intensity magnetic fields (MFs) on living systems. As a model system, we studied MF effect on lipid peroxidation reaction under steady state conditions. It was assumed that external MF affects rate constants of radical reactions taking place in elementary stages of lipid peroxidation reaction. It was shown that under certain conditions, low intensity MF may provoke a bifurcation transition in the system followed by a significant change in its characteristics. This means that, in principle, an external MF may play a critical role in lipid peroxidation reaction and a cell life.
